YDR320C / SWA2

Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR320C / SWA2

Click on Significant Values for Screen Details ID:SGTC_117|Compound:lucigenin|FD-Score:6.14|P-value:1.05E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:7.01|P-value:2.96E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:4.54|P-value:2.22E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:-4.16|P-value:6.42E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-5.00|P-value:5.32E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.87|P-value:3.42E-12 ID:SGTC_337|Compound:1315-0038|FD-Score:6.69|P-value:1.15E-7 ID:SGTC_342|Compound:k048-0088|FD-Score:5.54|P-value:9.18E-6 ID:SGTC_345|Compound:1362-0200|FD-Score:-4.16|P-value:6.37E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-5.90|P-value:2.44E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:8.23|P-value:9.66E-11 ID:SGTC_391|Compound:gliotoxin|FD-Score:6.53|P-value:2.24E-7 ID:SGTC_413|Compound:propylparaben|FD-Score:4.39|P-value:3.49E-4 ID:SGTC_459|Compound:nigericin|FD-Score:5.86|P-value:2.91E-6 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.51|P-value:1.02E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-8.31|P-value:6.19E-11 ID:SGTC_528|Compound:3492-0019|FD-Score:9.26|P-value:4.11E-13 ID:SGTC_625|Compound:k213-0058|FD-Score:7.31|P-value:7.88E-9 ID:SGTC_663|Compound:1486-0733|FD-Score:8.94|P-value:2.41E-12 ID:SGTC_697|Compound:0508-1955|FD-Score:7.83|P-value:7.20E-10 ID:SGTC_706|Compound:4262-0057|FD-Score:-5.10|P-value:3.95E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:-4.67|P-value:1.49E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.58|P-value:2.03E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.68|P-value:1.50E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:5.04|P-value:4.84E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:4.96|P-value:6.34E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:-5.20|P-value:2.81E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.44|P-value:1.32E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:4.31|P-value:4.35E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:7.59|P-value:2.21E-9 ID:SGTC_908|Compound:3448-7491|FD-Score:6.39|P-value:3.89E-7 ID:SGTC_934|Compound:2950-0684|FD-Score:-5.54|P-value:8.79E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:4.27|P-value:4.78E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-5.76|P-value:4.02E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:4.81|P-value:1.01E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-4.25|P-value:4.98E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-4.41|P-value:3.14E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:-4.01|P-value:9.47E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.27|P-value:4.86E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-5.36|P-value:1.68E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:6.56|P-value:1.97E-7 ID:SGTC_1643|Compound:st009866|FD-Score:-4.99|P-value:5.50E-5 ID:SGTC_1649|Compound:st011737|FD-Score:-7.98|P-value:3.31E-10 ID:SGTC_1672|Compound:st016598|FD-Score:-4.97|P-value:5.85E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:7.36|P-value:6.28E-9 ID:SGTC_1687|Compound:st020778|FD-Score:12.80|P-value:2.69E-23 ID:SGTC_1689|Compound:st020265|FD-Score:4.33|P-value:4.15E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.61|P-value:1.83E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.08|P-value:7.86E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-4.62|P-value:1.74E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-4.67|P-value:1.49E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-4.16|P-value:6.43E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-5.92|P-value:2.32E-6 ID:SGTC_1846|Compound:st056244|FD-Score:4.77|P-value:1.13E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.58|P-value:2.03E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.96|P-value:3.78E-8 ID:SGTC_1874|Compound:staurosporine|FD-Score:5.93|P-value:2.26E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.76|P-value:1.15E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-4.07|P-value:8.02E-4 ID:SGTC_1973|Compound:st070275|FD-Score:-4.03|P-value:9.01E-4 ID:SGTC_1993|Compound:st073995|FD-Score:-4.15|P-value:6.55E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-6.22|P-value:7.44E-7 ID:SGTC_2006|Compound:4011487|FD-Score:-5.39|P-value:1.48E-5 ID:SGTC_2009|Compound:4012297|FD-Score:5.49|P-value:1.10E-5 ID:SGTC_2077|Compound:5212015|FD-Score:4.02|P-value:9.38E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-5.83|P-value:3.13E-6 ID:SGTC_2111|Compound:5486399|FD-Score:-5.86|P-value:2.86E-6 ID:SGTC_2119|Compound:5528445|FD-Score:-6.67|P-value:1.22E-7 ID:SGTC_2150|Compound:5556613|FD-Score:4.42|P-value:3.19E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:4.14|P-value:6.82E-4 ID:SGTC_2242|Compound:6630449|FD-Score:4.95|P-value:6.58E-5 ID:SGTC_2283|Compound:7944793|FD-Score:-5.27|P-value:2.27E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-4.74|P-value:1.21E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-5.00|P-value:5.45E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-4.00|P-value:9.74E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.00|P-value:9.90E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.52|P-value:2.41E-4 ID:SGTC_2488|Compound:5268135|FD-Score:5.88|P-value:2.70E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:9.00|P-value:1.71E-12 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.30|P-value:8.98E-16 ID:SGTC_2576|Compound:guaiol|FD-Score:4.40|P-value:3.41E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.84|P-value:9.23E-5 ID:SGTC_2671|Compound:danthron|FD-Score:4.12|P-value:7.20E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.27|P-value:2.33E-5 ID:SGTC_2838|Compound:9002687|FD-Score:-7.76|P-value:9.24E-10 ID:SGTC_2910|Compound:7948405|FD-Score:-6.46|P-value:2.79E-7 ID:SGTC_2916|Compound:7875993|FD-Score:-4.63|P-value:1.66E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.90|P-value:7.58E-5 ID:SGTC_2918|Compound:7977171|FD-Score:4.84|P-value:9.27E-5 ID:SGTC_2938|Compound:9059746|FD-Score:-4.24|P-value:5.18E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-5.45|P-value:1.22E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-5.52|P-value:9.52E-6 ID:SGTC_2950|Compound:9072895|FD-Score:-6.10|P-value:1.14E-6 ID:SGTC_3012|Compound:9080433|FD-Score:4.13|P-value:7.02E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-5.08|P-value:4.20E-5 ID:SGTC_3062|Compound:9077494|FD-Score:5.24|P-value:2.53E-5 ID:SGTC_3071|Compound:9117417|FD-Score:-4.49|P-value:2.50E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.88|P-value:8.18E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-5.48|P-value:1.11E-5 ID:SGTC_3219|Compound:9131112|FD-Score:4.83|P-value:9.50E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-4.53|P-value:2.23E-4 ID:SGTC_3225|Compound:9130819|FD-Score:7.06|P-value:2.44E-8 ID:SGTC_3277|Compound:9138724|FD-Score:4.31|P-value:4.39E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-6.25|P-value:6.57E-7 ID:SGTC_3308|Compound:9128332|FD-Score:-5.57|P-value:8.18E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:6.14|P-value:1.05E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:7.01|P-value:2.96E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:4.54|P-value:2.22E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:-4.16|P-value:6.42E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-5.00|P-value:5.32E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.87|P-value:3.42E-12 ID:SGTC_337|Compound:1315-0038|FD-Score:6.69|P-value:1.15E-7 ID:SGTC_342|Compound:k048-0088|FD-Score:5.54|P-value:9.18E-6 ID:SGTC_345|Compound:1362-0200|FD-Score:-4.16|P-value:6.37E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-5.90|P-value:2.44E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:8.23|P-value:9.66E-11 ID:SGTC_391|Compound:gliotoxin|FD-Score:6.53|P-value:2.24E-7 ID:SGTC_413|Compound:propylparaben|FD-Score:4.39|P-value:3.49E-4 ID:SGTC_459|Compound:nigericin|FD-Score:5.86|P-value:2.91E-6 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.51|P-value:1.02E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-8.31|P-value:6.19E-11 ID:SGTC_528|Compound:3492-0019|FD-Score:9.26|P-value:4.11E-13 ID:SGTC_625|Compound:k213-0058|FD-Score:7.31|P-value:7.88E-9 ID:SGTC_663|Compound:1486-0733|FD-Score:8.94|P-value:2.41E-12 ID:SGTC_697|Compound:0508-1955|FD-Score:7.83|P-value:7.20E-10 ID:SGTC_706|Compound:4262-0057|FD-Score:-5.10|P-value:3.95E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:-4.67|P-value:1.49E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.58|P-value:2.03E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.68|P-value:1.50E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:5.04|P-value:4.84E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:4.96|P-value:6.34E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:-5.20|P-value:2.81E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.44|P-value:1.32E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:4.31|P-value:4.35E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:7.59|P-value:2.21E-9 ID:SGTC_908|Compound:3448-7491|FD-Score:6.39|P-value:3.89E-7 ID:SGTC_934|Compound:2950-0684|FD-Score:-5.54|P-value:8.79E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:4.27|P-value:4.78E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-5.76|P-value:4.02E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:4.81|P-value:1.01E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-4.25|P-value:4.98E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-4.41|P-value:3.14E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:-4.01|P-value:9.47E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.27|P-value:4.86E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-5.36|P-value:1.68E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:6.56|P-value:1.97E-7 ID:SGTC_1643|Compound:st009866|FD-Score:-4.99|P-value:5.50E-5 ID:SGTC_1649|Compound:st011737|FD-Score:-7.98|P-value:3.31E-10 ID:SGTC_1672|Compound:st016598|FD-Score:-4.97|P-value:5.85E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:7.36|P-value:6.28E-9 ID:SGTC_1687|Compound:st020778|FD-Score:12.80|P-value:2.69E-23 ID:SGTC_1689|Compound:st020265|FD-Score:4.33|P-value:4.15E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.61|P-value:1.83E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.08|P-value:7.86E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-4.62|P-value:1.74E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-4.67|P-value:1.49E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-4.16|P-value:6.43E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-5.92|P-value:2.32E-6 ID:SGTC_1846|Compound:st056244|FD-Score:4.77|P-value:1.13E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.58|P-value:2.03E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.96|P-value:3.78E-8 ID:SGTC_1874|Compound:staurosporine|FD-Score:5.93|P-value:2.26E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.76|P-value:1.15E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-4.07|P-value:8.02E-4 ID:SGTC_1973|Compound:st070275|FD-Score:-4.03|P-value:9.01E-4 ID:SGTC_1993|Compound:st073995|FD-Score:-4.15|P-value:6.55E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-6.22|P-value:7.44E-7 ID:SGTC_2006|Compound:4011487|FD-Score:-5.39|P-value:1.48E-5 ID:SGTC_2009|Compound:4012297|FD-Score:5.49|P-value:1.10E-5 ID:SGTC_2077|Compound:5212015|FD-Score:4.02|P-value:9.38E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-5.83|P-value:3.13E-6 ID:SGTC_2111|Compound:5486399|FD-Score:-5.86|P-value:2.86E-6 ID:SGTC_2119|Compound:5528445|FD-Score:-6.67|P-value:1.22E-7 ID:SGTC_2150|Compound:5556613|FD-Score:4.42|P-value:3.19E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:4.14|P-value:6.82E-4 ID:SGTC_2242|Compound:6630449|FD-Score:4.95|P-value:6.58E-5 ID:SGTC_2283|Compound:7944793|FD-Score:-5.27|P-value:2.27E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-4.74|P-value:1.21E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-5.00|P-value:5.45E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-4.00|P-value:9.74E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.00|P-value:9.90E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.52|P-value:2.41E-4 ID:SGTC_2488|Compound:5268135|FD-Score:5.88|P-value:2.70E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:9.00|P-value:1.71E-12 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.30|P-value:8.98E-16 ID:SGTC_2576|Compound:guaiol|FD-Score:4.40|P-value:3.41E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.84|P-value:9.23E-5 ID:SGTC_2671|Compound:danthron|FD-Score:4.12|P-value:7.20E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.27|P-value:2.33E-5 ID:SGTC_2838|Compound:9002687|FD-Score:-7.76|P-value:9.24E-10 ID:SGTC_2910|Compound:7948405|FD-Score:-6.46|P-value:2.79E-7 ID:SGTC_2916|Compound:7875993|FD-Score:-4.63|P-value:1.66E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.90|P-value:7.58E-5 ID:SGTC_2918|Compound:7977171|FD-Score:4.84|P-value:9.27E-5 ID:SGTC_2938|Compound:9059746|FD-Score:-4.24|P-value:5.18E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-5.45|P-value:1.22E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-5.52|P-value:9.52E-6 ID:SGTC_2950|Compound:9072895|FD-Score:-6.10|P-value:1.14E-6 ID:SGTC_3012|Compound:9080433|FD-Score:4.13|P-value:7.02E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-5.08|P-value:4.20E-5 ID:SGTC_3062|Compound:9077494|FD-Score:5.24|P-value:2.53E-5 ID:SGTC_3071|Compound:9117417|FD-Score:-4.49|P-value:2.50E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.88|P-value:8.18E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-5.48|P-value:1.11E-5 ID:SGTC_3219|Compound:9131112|FD-Score:4.83|P-value:9.50E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-4.53|P-value:2.23E-4 ID:SGTC_3225|Compound:9130819|FD-Score:7.06|P-value:2.44E-8 ID:SGTC_3277|Compound:9138724|FD-Score:4.31|P-value:4.39E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-6.25|P-value:6.57E-7 ID:SGTC_3308|Compound:9128332|FD-Score:-5.57|P-value:8.18E-6

Top fitness defect scores for YDR320C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1687 st020778 12.80 55.4 µM 2.69E-23 32 1.22E-37
2 SGTC_2567 aureobasidin a 10.30 60.0 nM 8.98E-16 14 4.02E-25
3 SGTC_528 3492-0019 9.26 172.0 µM 4.11E-13 calcium & mitochondrial duress 48 1.05E-20
4 SGTC_2514 salinomycin 9.00 42.7 µM 1.71E-12 7 1.12E-19
5 SGTC_663 1486-0733 8.94 13.9 µM 2.41E-12 cell wall signaling 14 1.98E-19
6 SGTC_275 trichlorophene 8.87 5.7 µM 3.42E-12 mitochondrial stress 58 3.54E-19
7 SGTC_352 k048-0007 8.23 5.1 µM 9.66E-11 ERAD & cell cycle 16 8.99E-17
8 SGTC_697 0508-1955 7.83 564.0 µM 7.20E-10 4 2.50E-15
9 SGTC_841 0251-0215 7.59 91.2 µM 2.21E-9 24 1.60E-14
10 SGTC_1679 4130-1276 7.36 6.7 µM 6.28E-9 Golgi 17 9.01E-14
11 SGTC_625 k213-0058 7.31 121.0 µM 7.88E-9 translation 20 1.31E-13
12 SGTC_3225 9130819 7.06 49.5 µM 2.44E-8 amide catabolism 4 8.48E-13
13 SGTC_119 0121-0043 7.01 24.8 µM 2.96E-8 mitochondrial stress 15 1.17E-12
14 SGTC_1873 rapamycin 6.96 2.0 nM 3.78E-8 20 1.75E-12
15 SGTC_337 1315-0038 6.69 354.0 µM 1.15E-7 amide catabolism 7 1.10E-11
16 SGTC_1525 8-methoxypsoralen 6.56 92.5 µM 1.97E-7 DNA damage response 8 2.67E-11
17 SGTC_391 gliotoxin 6.53 8.3 µM 2.24E-7 18 3.31E-11
18 SGTC_908 3448-7491 6.39 47.7 µM 3.89E-7 mitochondrial stress 38 8.20E-11
19 SGTC_117 lucigenin 6.14 22.1 µM 1.05E-6 redox potentiating 38 4.18E-10
20 SGTC_1874 staurosporine 5.93 7.6 µM 2.26E-6 cell wall signaling 12 1.49E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.337 4.43E-90 YGR167W CLC1 hom Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W
0.314 1.36E-77 YDR136C_d VPS61_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
0.306 1.20E-73 YDR137W RGP1 hom Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.298 1.09E-69 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.281 5.92E-62 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.276 1.54E-59 YLR261C_d VPS63_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
0.245 3.57E-47 YLR039C RIC1 hom Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.239 1.20E-44 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.231 6.54E-42 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.225 7.98E-40 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.213 1.23E-35 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.212 2.61E-35 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.208 3.08E-34 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.208 6.32E-34 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.206 1.35E-33 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase