YDR334W / SWR1

Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR334W / SWR1

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:4.39|P-value:8.96E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:4.30|P-value:1.21E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:7.94|P-value:5.65E-12 ID:SGTC_138|Compound:0850-0259|FD-Score:5.53|P-value:1.16E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:10.20|P-value:1.80E-18 ID:SGTC_149|Compound:3970-0822|FD-Score:4.79|P-value:2.14E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:4.40|P-value:8.57E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:7.91|P-value:6.53E-12 ID:SGTC_207|Compound:4185-0010|FD-Score:4.28|P-value:1.30E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:14.40|P-value:3.72E-35 ID:SGTC_212|Compound:3807-4682|FD-Score:11.20|P-value:3.85E-22 ID:SGTC_216|Compound:k038-0035|FD-Score:5.88|P-value:2.54E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:16.50|P-value:1.72E-45 ID:SGTC_227|Compound:fluconazole|FD-Score:5.72|P-value:4.98E-7 ID:SGTC_229|Compound:benomyl|FD-Score:8.88|P-value:1.55E-14 ID:SGTC_286|Compound:k060-0067|FD-Score:6.60|P-value:8.53E-9 ID:SGTC_294|Compound:k038-0071|FD-Score:4.27|P-value:1.34E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.75|P-value:6.77E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:5.22|P-value:4.03E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:3.92|P-value:4.13E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.90|P-value:4.33E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.93|P-value:4.01E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:7.22|P-value:3.36E-10 ID:SGTC_375|Compound:3970-0961|FD-Score:5.70|P-value:5.59E-7 ID:SGTC_379|Compound:3970-0972|FD-Score:4.90|P-value:1.40E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:4.00|P-value:3.21E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:5.11|P-value:6.23E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.71|P-value:2.85E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.16|P-value:1.91E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.77|P-value:2.31E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:8.35|P-value:4.71E-13 ID:SGTC_535|Compound:2293-4129|FD-Score:3.82|P-value:5.56E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.05|P-value:7.91E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:3.99|P-value:3.29E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.96|P-value:1.14E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:4.32|P-value:1.13E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.20|P-value:1.67E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:9.72|P-value:4.77E-17 ID:SGTC_696|Compound:1560-0013|FD-Score:-4.15|P-value:1.85E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.53|P-value:5.38E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:5.15|P-value:5.40E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:7.02|P-value:9.64E-10 ID:SGTC_825|Compound:1988-2224|FD-Score:9.40|P-value:4.38E-16 ID:SGTC_928|Compound:2764-0428|FD-Score:7.56|P-value:4.98E-11 ID:SGTC_1090|Compound:efavirenz|FD-Score:6.23|P-value:5.06E-8 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.14|P-value:2.00E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.59|P-value:4.48E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:11.60|P-value:1.35E-23 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.94|P-value:3.89E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.55|P-value:5.03E-5 ID:SGTC_1433|Compound:4060-0023|FD-Score:4.34|P-value:1.04E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:4.32|P-value:1.11E-4 ID:SGTC_1643|Compound:st009866|FD-Score:8.87|P-value:1.62E-14 ID:SGTC_1712|Compound:st032288|FD-Score:6.16|P-value:7.01E-8 ID:SGTC_1723|Compound:st034307|FD-Score:3.92|P-value:4.11E-4 ID:SGTC_1754|Compound:st042065|FD-Score:8.53|P-value:1.45E-13 ID:SGTC_1760|Compound:st045453|FD-Score:6.88|P-value:2.04E-9 ID:SGTC_1788|Compound:fluconazole|FD-Score:6.88|P-value:2.04E-9 ID:SGTC_1800|Compound:st050079|FD-Score:7.54|P-value:5.80E-11 ID:SGTC_1801|Compound:st050089|FD-Score:8.20|P-value:1.18E-12 ID:SGTC_1803|Compound:st050068|FD-Score:12.20|P-value:1.31E-25 ID:SGTC_1818|Compound:st052136|FD-Score:4.29|P-value:1.26E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-3.80|P-value:5.59E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-3.95|P-value:3.53E-4 ID:SGTC_1854|Compound:st056233|FD-Score:4.03|P-value:2.93E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.70|P-value:7.48E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:12.50|P-value:5.44E-27 ID:SGTC_1884|Compound:5633444|FD-Score:4.14|P-value:2.00E-4 ID:SGTC_1903|Compound:st060211|FD-Score:4.43|P-value:7.75E-5 ID:SGTC_1930|Compound:st074634|FD-Score:5.98|P-value:1.61E-7 ID:SGTC_1979|Compound:st071809|FD-Score:-6.90|P-value:1.62E-9 ID:SGTC_2077|Compound:5212015|FD-Score:5.38|P-value:2.12E-6 ID:SGTC_2090|Compound:5301565|FD-Score:5.29|P-value:3.14E-6 ID:SGTC_2098|Compound:5376439|FD-Score:4.45|P-value:7.21E-5 ID:SGTC_2125|Compound:5246583|FD-Score:6.73|P-value:4.26E-9 ID:SGTC_2141|Compound:5621638|FD-Score:9.45|P-value:3.10E-16 ID:SGTC_2158|Compound:5657123|FD-Score:3.77|P-value:6.50E-4 ID:SGTC_2161|Compound:5662504|FD-Score:4.88|P-value:1.55E-5 ID:SGTC_2166|Compound:5933061|FD-Score:9.55|P-value:1.55E-16 ID:SGTC_2174|Compound:5790901|FD-Score:21.50|P-value:4.30E-76 ID:SGTC_2186|Compound:6124449|FD-Score:5.17|P-value:4.90E-6 ID:SGTC_2200|Compound:6600604|FD-Score:13.30|P-value:4.27E-30 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.36|P-value:2.35E-6 ID:SGTC_2246|Compound:7293507|FD-Score:8.28|P-value:7.10E-13 ID:SGTC_2254|Compound:7938975|FD-Score:4.75|P-value:2.44E-5 ID:SGTC_2277|Compound:7947813|FD-Score:4.67|P-value:3.36E-5 ID:SGTC_2319|Compound:6033012|FD-Score:22.00|P-value:4.22E-79 ID:SGTC_2322|Compound:7413319|FD-Score:3.97|P-value:3.49E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.67|P-value:8.68E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.40|P-value:8.54E-5 ID:SGTC_2352|Compound:9027995|FD-Score:6.22|P-value:5.32E-8 ID:SGTC_2396|Compound:5342950|FD-Score:4.95|P-value:1.16E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.02|P-value:3.00E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.33|P-value:1.08E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.77|P-value:6.41E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-4.57|P-value:4.33E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.72|P-value:7.05E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.86|P-value:2.77E-7 ID:SGTC_2678|Compound:equilin|FD-Score:-3.89|P-value:4.23E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.62|P-value:9.93E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.57|P-value:4.76E-5 ID:SGTC_2952|Compound:9073731|FD-Score:5.23|P-value:3.90E-6 ID:SGTC_3101|Compound:9120531|FD-Score:4.64|P-value:3.73E-5 ID:SGTC_3154|Compound:9100113|FD-Score:4.13|P-value:2.12E-4 ID:SGTC_3181|Compound:9108277|FD-Score:4.63|P-value:3.81E-5 ID:SGTC_3216|Compound:9129716|FD-Score:4.39|P-value:8.94E-5 ID:SGTC_3221|Compound:9128209|FD-Score:5.88|P-value:2.50E-7 ID:SGTC_3282|Compound:9108498|FD-Score:4.16|P-value:1.92E-4 ID:SGTC_3288|Compound:9119690|FD-Score:4.89|P-value:1.47E-5 ID:SGTC_3294|Compound:9122953|FD-Score:7.45|P-value:9.21E-11 ID:SGTC_3350|Compound:9150499|FD-Score:3.76|P-value:6.61E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.39|P-value:8.96E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:4.30|P-value:1.21E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:7.94|P-value:5.65E-12 ID:SGTC_138|Compound:0850-0259|FD-Score:5.53|P-value:1.16E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:10.20|P-value:1.80E-18 ID:SGTC_149|Compound:3970-0822|FD-Score:4.79|P-value:2.14E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:4.40|P-value:8.57E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:7.91|P-value:6.53E-12 ID:SGTC_207|Compound:4185-0010|FD-Score:4.28|P-value:1.30E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:14.40|P-value:3.72E-35 ID:SGTC_212|Compound:3807-4682|FD-Score:11.20|P-value:3.85E-22 ID:SGTC_216|Compound:k038-0035|FD-Score:5.88|P-value:2.54E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:16.50|P-value:1.72E-45 ID:SGTC_227|Compound:fluconazole|FD-Score:5.72|P-value:4.98E-7 ID:SGTC_229|Compound:benomyl|FD-Score:8.88|P-value:1.55E-14 ID:SGTC_286|Compound:k060-0067|FD-Score:6.60|P-value:8.53E-9 ID:SGTC_294|Compound:k038-0071|FD-Score:4.27|P-value:1.34E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.75|P-value:6.77E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:5.22|P-value:4.03E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:3.92|P-value:4.13E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.90|P-value:4.33E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.93|P-value:4.01E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:7.22|P-value:3.36E-10 ID:SGTC_375|Compound:3970-0961|FD-Score:5.70|P-value:5.59E-7 ID:SGTC_379|Compound:3970-0972|FD-Score:4.90|P-value:1.40E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:4.00|P-value:3.21E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:5.11|P-value:6.23E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.71|P-value:2.85E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.16|P-value:1.91E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.77|P-value:2.31E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:8.35|P-value:4.71E-13 ID:SGTC_535|Compound:2293-4129|FD-Score:3.82|P-value:5.56E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.05|P-value:7.91E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:3.99|P-value:3.29E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.96|P-value:1.14E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:4.32|P-value:1.13E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.20|P-value:1.67E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:9.72|P-value:4.77E-17 ID:SGTC_696|Compound:1560-0013|FD-Score:-4.15|P-value:1.85E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.53|P-value:5.38E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:5.15|P-value:5.40E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:7.02|P-value:9.64E-10 ID:SGTC_825|Compound:1988-2224|FD-Score:9.40|P-value:4.38E-16 ID:SGTC_928|Compound:2764-0428|FD-Score:7.56|P-value:4.98E-11 ID:SGTC_1090|Compound:efavirenz|FD-Score:6.23|P-value:5.06E-8 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.14|P-value:2.00E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.59|P-value:4.48E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:11.60|P-value:1.35E-23 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.94|P-value:3.89E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.55|P-value:5.03E-5 ID:SGTC_1433|Compound:4060-0023|FD-Score:4.34|P-value:1.04E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:4.32|P-value:1.11E-4 ID:SGTC_1643|Compound:st009866|FD-Score:8.87|P-value:1.62E-14 ID:SGTC_1712|Compound:st032288|FD-Score:6.16|P-value:7.01E-8 ID:SGTC_1723|Compound:st034307|FD-Score:3.92|P-value:4.11E-4 ID:SGTC_1754|Compound:st042065|FD-Score:8.53|P-value:1.45E-13 ID:SGTC_1760|Compound:st045453|FD-Score:6.88|P-value:2.04E-9 ID:SGTC_1788|Compound:fluconazole|FD-Score:6.88|P-value:2.04E-9 ID:SGTC_1800|Compound:st050079|FD-Score:7.54|P-value:5.80E-11 ID:SGTC_1801|Compound:st050089|FD-Score:8.20|P-value:1.18E-12 ID:SGTC_1803|Compound:st050068|FD-Score:12.20|P-value:1.31E-25 ID:SGTC_1818|Compound:st052136|FD-Score:4.29|P-value:1.26E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-3.80|P-value:5.59E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-3.95|P-value:3.53E-4 ID:SGTC_1854|Compound:st056233|FD-Score:4.03|P-value:2.93E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.70|P-value:7.48E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:12.50|P-value:5.44E-27 ID:SGTC_1884|Compound:5633444|FD-Score:4.14|P-value:2.00E-4 ID:SGTC_1903|Compound:st060211|FD-Score:4.43|P-value:7.75E-5 ID:SGTC_1930|Compound:st074634|FD-Score:5.98|P-value:1.61E-7 ID:SGTC_1979|Compound:st071809|FD-Score:-6.90|P-value:1.62E-9 ID:SGTC_2077|Compound:5212015|FD-Score:5.38|P-value:2.12E-6 ID:SGTC_2090|Compound:5301565|FD-Score:5.29|P-value:3.14E-6 ID:SGTC_2098|Compound:5376439|FD-Score:4.45|P-value:7.21E-5 ID:SGTC_2125|Compound:5246583|FD-Score:6.73|P-value:4.26E-9 ID:SGTC_2141|Compound:5621638|FD-Score:9.45|P-value:3.10E-16 ID:SGTC_2158|Compound:5657123|FD-Score:3.77|P-value:6.50E-4 ID:SGTC_2161|Compound:5662504|FD-Score:4.88|P-value:1.55E-5 ID:SGTC_2166|Compound:5933061|FD-Score:9.55|P-value:1.55E-16 ID:SGTC_2174|Compound:5790901|FD-Score:21.50|P-value:4.30E-76 ID:SGTC_2186|Compound:6124449|FD-Score:5.17|P-value:4.90E-6 ID:SGTC_2200|Compound:6600604|FD-Score:13.30|P-value:4.27E-30 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.36|P-value:2.35E-6 ID:SGTC_2246|Compound:7293507|FD-Score:8.28|P-value:7.10E-13 ID:SGTC_2254|Compound:7938975|FD-Score:4.75|P-value:2.44E-5 ID:SGTC_2277|Compound:7947813|FD-Score:4.67|P-value:3.36E-5 ID:SGTC_2319|Compound:6033012|FD-Score:22.00|P-value:4.22E-79 ID:SGTC_2322|Compound:7413319|FD-Score:3.97|P-value:3.49E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.67|P-value:8.68E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.40|P-value:8.54E-5 ID:SGTC_2352|Compound:9027995|FD-Score:6.22|P-value:5.32E-8 ID:SGTC_2396|Compound:5342950|FD-Score:4.95|P-value:1.16E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.02|P-value:3.00E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.33|P-value:1.08E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.77|P-value:6.41E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-4.57|P-value:4.33E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.72|P-value:7.05E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.86|P-value:2.77E-7 ID:SGTC_2678|Compound:equilin|FD-Score:-3.89|P-value:4.23E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.62|P-value:9.93E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.57|P-value:4.76E-5 ID:SGTC_2952|Compound:9073731|FD-Score:5.23|P-value:3.90E-6 ID:SGTC_3101|Compound:9120531|FD-Score:4.64|P-value:3.73E-5 ID:SGTC_3154|Compound:9100113|FD-Score:4.13|P-value:2.12E-4 ID:SGTC_3181|Compound:9108277|FD-Score:4.63|P-value:3.81E-5 ID:SGTC_3216|Compound:9129716|FD-Score:4.39|P-value:8.94E-5 ID:SGTC_3221|Compound:9128209|FD-Score:5.88|P-value:2.50E-7 ID:SGTC_3282|Compound:9108498|FD-Score:4.16|P-value:1.92E-4 ID:SGTC_3288|Compound:9119690|FD-Score:4.89|P-value:1.47E-5 ID:SGTC_3294|Compound:9122953|FD-Score:7.45|P-value:9.21E-11 ID:SGTC_3350|Compound:9150499|FD-Score:3.76|P-value:6.61E-4

Top fitness defect scores for YDR334W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2319 6033012 22.00 152.6 µM 4.22E-79 tubulin folding & SWR complex 3 3.47E-107
2 SGTC_2174 5790901 21.50 200.0 µM 4.30E-76 tubulin folding & SWR complex 3 4.40E-103
3 SGTC_221 trifluoperazine 16.50 10.3 µM 1.72E-45 NEO1-PIK1 18 2.32E-61
4 SGTC_210 3551-0445 14.40 56.8 µM 3.72E-35 9 2.81E-47
5 SGTC_2200 6600604 13.30 21.9 µM 4.27E-30 tubulin folding & SWR complex 7 2.21E-40
6 SGTC_1875 nocodazole 12.50 6.0 µM 5.44E-27 tubulin folding & SWR complex 9 3.75E-36
7 SGTC_1803 st050068 12.20 52.4 µM 1.31E-25 NEO1-PIK1 13 2.85E-34
8 SGTC_1326 1431-2094 11.60 10.8 µM 1.35E-23 tubulin folding & SWR complex 4 1.57E-31
9 SGTC_212 3807-4682 11.20 38.8 µM 3.85E-22 tubulin folding & SWR complex 5 1.51E-29
10 SGTC_142 0335-0849 10.20 62.7 µM 1.80E-18 ubiquinone biosynthesis & proteasome 27 1.49E-24
11 SGTC_673 1082-0474 9.72 110.0 µM 4.77E-17 RSC complex & mRNA processing 9 1.29E-22
12 SGTC_2166 5933061 9.55 31.5 µM 1.55E-16 tubulin folding & SWR complex 3 6.41E-22
13 SGTC_2141 5621638 9.45 7.7 µM 3.10E-16 tubulin folding & SWR complex 7 1.65E-21
14 SGTC_825 1988-2224 9.40 89.6 µM 4.38E-16 cell wall signaling 6 2.63E-21
15 SGTC_229 benomyl 8.88 22.9 µM 1.55E-14 tubulin folding & SWR complex 11 3.35E-19
16 SGTC_1643 st009866 8.87 20.2 µM 1.62E-14 12 3.58E-19
17 SGTC_1754 st042065 8.53 16.1 µM 1.45E-13 NEO1-PIK1 49 7.04E-18
18 SGTC_528 3492-0019 8.35 172.0 µM 4.71E-13 calcium & mitochondrial duress 64 3.49E-17
19 SGTC_2246 7293507 8.28 91.6 µM 7.10E-13 6 6.08E-17
20 SGTC_1801 st050089 8.20 28.4 µM 1.18E-12 NEO1-PIK1 24 1.21E-16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.672 0 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.663 0 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.614 0 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.608 0 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.567 3.33E-285 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.523 1.08E-234 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.451 6.02E-168 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.421 2.99E-144 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.416 1.56E-140 YOL012C HTZ1 hom Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.386 9.74E-120 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.322 7.08E-82 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.318 6.03E-80 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.263 3.31E-54 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.253 3.24E-50 YNL246W VPS75 hom NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.252 6.91E-50 YNL107W YAF9 hom Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain