YEL008W_d

Hypothetical protein predicted to be involved in metabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL008W / YEL008W

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.23|P-value:2.42E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.20|P-value:2.84E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.04|P-value:5.04E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.90|P-value:8.56E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.33|P-value:1.59E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:2.91|P-value:8.22E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.34|P-value:1.53E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:2.91|P-value:8.16E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:-2.90|P-value:8.53E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:-3.00|P-value:5.84E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.15|P-value:3.65E-6 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.28|P-value:1.97E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.05|P-value:4.81E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.19|P-value:2.78E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.14|P-value:3.77E-6 ID:SGTC_1748|Compound:st037455|FD-Score:3.01|P-value:5.69E-4 ID:SGTC_1754|Compound:st042065|FD-Score:2.90|P-value:8.64E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.14|P-value:3.43E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-8.11|P-value:9.32E-19 ID:SGTC_2102|Compound:5377816|FD-Score:2.98|P-value:6.47E-4 ID:SGTC_2126|Compound:5251174|FD-Score:5.11|P-value:1.66E-8 ID:SGTC_2128|Compound:5255449|FD-Score:-3.56|P-value:6.07E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:2.98|P-value:6.37E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.17|P-value:3.10E-4 ID:SGTC_2384|Compound:9036245|FD-Score:2.90|P-value:8.68E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.35|P-value:1.47E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.88|P-value:9.30E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.05|P-value:4.92E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.62|P-value:4.57E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.22|P-value:2.52E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.75|P-value:2.51E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.70|P-value:3.61E-10 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.61|P-value:4.71E-5 ID:SGTC_2792|Compound:7535235|FD-Score:-3.19|P-value:2.85E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.81|P-value:1.93E-5 ID:SGTC_2835|Compound:9006588|FD-Score:6.88|P-value:5.40E-14 ID:SGTC_2841|Compound:9004761|FD-Score:-3.37|P-value:1.37E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.92|P-value:1.15E-5 ID:SGTC_2844|Compound:9010103|FD-Score:4.17|P-value:3.23E-6 ID:SGTC_2955|Compound:9076254|FD-Score:2.90|P-value:8.59E-4 ID:SGTC_2989|Compound:9073649|FD-Score:7.30|P-value:1.47E-15 ID:SGTC_3137|Compound:9097352|FD-Score:3.48|P-value:8.64E-5 ID:SGTC_3181|Compound:9108277|FD-Score:-2.98|P-value:6.44E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.08|P-value:4.44E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-4.03|P-value:6.82E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:3.23|P-value:2.42E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.20|P-value:2.84E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.04|P-value:5.04E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.90|P-value:8.56E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.33|P-value:1.59E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:2.91|P-value:8.22E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.34|P-value:1.53E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:2.91|P-value:8.16E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:-2.90|P-value:8.53E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:-3.00|P-value:5.84E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.15|P-value:3.65E-6 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.28|P-value:1.97E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.05|P-value:4.81E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.19|P-value:2.78E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.14|P-value:3.77E-6 ID:SGTC_1748|Compound:st037455|FD-Score:3.01|P-value:5.69E-4 ID:SGTC_1754|Compound:st042065|FD-Score:2.90|P-value:8.64E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.14|P-value:3.43E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-8.11|P-value:9.32E-19 ID:SGTC_2102|Compound:5377816|FD-Score:2.98|P-value:6.47E-4 ID:SGTC_2126|Compound:5251174|FD-Score:5.11|P-value:1.66E-8 ID:SGTC_2128|Compound:5255449|FD-Score:-3.56|P-value:6.07E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:2.98|P-value:6.37E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.17|P-value:3.10E-4 ID:SGTC_2384|Compound:9036245|FD-Score:2.90|P-value:8.68E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.35|P-value:1.47E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.88|P-value:9.30E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.05|P-value:4.92E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.62|P-value:4.57E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.22|P-value:2.52E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.75|P-value:2.51E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.70|P-value:3.61E-10 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.61|P-value:4.71E-5 ID:SGTC_2792|Compound:7535235|FD-Score:-3.19|P-value:2.85E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.81|P-value:1.93E-5 ID:SGTC_2835|Compound:9006588|FD-Score:6.88|P-value:5.40E-14 ID:SGTC_2841|Compound:9004761|FD-Score:-3.37|P-value:1.37E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.92|P-value:1.15E-5 ID:SGTC_2844|Compound:9010103|FD-Score:4.17|P-value:3.23E-6 ID:SGTC_2955|Compound:9076254|FD-Score:2.90|P-value:8.59E-4 ID:SGTC_2989|Compound:9073649|FD-Score:7.30|P-value:1.47E-15 ID:SGTC_3137|Compound:9097352|FD-Score:3.48|P-value:8.64E-5 ID:SGTC_3181|Compound:9108277|FD-Score:-2.98|P-value:6.44E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.08|P-value:4.44E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-4.03|P-value:6.82E-6

Top fitness defect scores for YEL008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2989 9073649 7.30 71.4 µM 1.47E-15 4 1.39E-13
2 SGTC_2835 9006588 6.88 71.4 µM 5.40E-14 4 3.08E-12
3 SGTC_2752 diclazuril 5.70 33.1 µM 3.61E-10 61 5.95E-9
4 SGTC_2126 5251174 5.11 33.9 µM 1.66E-8 7 1.60E-7
5 SGTC_65 0798-0905 4.20 35.0 µM 2.84E-6 calcium & mitochondrial duress 79 1.34E-5
6 SGTC_2844 9010103 4.17 26.0 µM 3.23E-6 29 1.50E-5
7 SGTC_1128 3448-9350 4.15 235.0 µM 3.65E-6 20 1.66E-5
8 SGTC_1738 st035555 4.14 74.0 µM 3.77E-6 TSC3-RPN4 26 1.71E-5
9 SGTC_2688 kanamycin b 3.75 96.7 µM 2.51E-5 calcium & mitochondrial duress 401 8.78E-5
10 SGTC_2758 dehydroepiandrosterone 3.61 69.3 µM 4.71E-5 50 1.51E-4
11 SGTC_3137 9097352 3.48 49.5 µM 8.64E-5 59 2.55E-4
12 SGTC_456 gingerol 3.34 170.0 µM 1.53E-4 40 4.17E-4
13 SGTC_1209 2323-2347 3.28 50.3 µM 1.97E-4 31 5.20E-4
14 SGTC_64 000l-0018 3.23 272.1 µM 2.42E-4 ubiquinone biosynthesis & proteasome 198 6.21E-4
15 SGTC_1727 st034309 3.19 9.9 µM 2.78E-4 87 7.00E-4
16 SGTC_2375 9072683 3.17 200.0 µM 3.10E-4 mitochondrial processes 52 7.71E-4
17 SGTC_2004 4023728 3.14 41.9 µM 3.43E-4 67 8.39E-4
18 SGTC_1227 3909-8010 3.05 46.6 µM 4.81E-4 58 0.00113
19 SGTC_2563 tomatine 3.05 8.5 µM 4.92E-4 106 0.00115
20 SGTC_1748 st037455 3.01 53.6 µM 5.69E-4 80 0.00130

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 8.17E-20 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.147 1.47E-17 YLR109W AHP1 hom Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
0.144 5.54E-17 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.141 2.95E-16 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.134 6.97E-15 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.116 1.48E-11 YGR194C XKS1 hom Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
0.116 1.48E-11 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.116 1.49E-11 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.115 2.47E-11 YOR161C-C_p YOR161C-C_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.113 5.53E-11 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.113 5.37E-11 YEL042W GDA1 hom Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.112 9.76E-11 YNL130C CPT1 hom Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication
0.111 1.06E-10 YPR025C CCL1 het Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
0.109 2.11E-10 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.108 4.04E-10 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p