YEL018W / EAF5

Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL018W / EAF5

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:5.61|P-value:4.66E-8 ID:SGTC_62|Compound:0180-0423|FD-Score:3.89|P-value:1.08E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.57|P-value:3.48E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.94|P-value:8.94E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:3.41|P-value:5.97E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.33|P-value:7.90E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.27|P-value:9.59E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.97|P-value:8.08E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.56|P-value:7.16E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:-3.35|P-value:6.28E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:5.62|P-value:4.52E-8 ID:SGTC_1626|Compound:st003712|FD-Score:-3.32|P-value:7.09E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.34|P-value:7.56E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.41|P-value:1.37E-5 ID:SGTC_1833|Compound:st055984|FD-Score:4.01|P-value:7.04E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.18|P-value:3.55E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.31|P-value:2.11E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:5.30|P-value:2.30E-7 ID:SGTC_1964|Compound:st076914|FD-Score:3.74|P-value:1.91E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.23|P-value:9.51E-4 ID:SGTC_2123|Compound:5259487|FD-Score:4.40|P-value:1.46E-5 ID:SGTC_2376|Compound:9072922|FD-Score:3.42|P-value:5.92E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-4.42|P-value:1.12E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.29|P-value:9.09E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-4.26|P-value:2.18E-5 ID:SGTC_2829|Compound:7992743|FD-Score:-3.46|P-value:4.33E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.77|P-value:1.73E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.90|P-value:1.07E-4 ID:SGTC_2940|Compound:9060638|FD-Score:4.20|P-value:3.24E-5 ID:SGTC_3057|Compound:9095946|FD-Score:4.67|P-value:4.45E-6 ID:SGTC_3128|Compound:9127691|FD-Score:-3.41|P-value:5.15E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.42|P-value:5.76E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:5.61|P-value:4.66E-8 ID:SGTC_62|Compound:0180-0423|FD-Score:3.89|P-value:1.08E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.57|P-value:3.48E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.94|P-value:8.94E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:3.41|P-value:5.97E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.33|P-value:7.90E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.27|P-value:9.59E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.97|P-value:8.08E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.56|P-value:7.16E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:-3.35|P-value:6.28E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:5.62|P-value:4.52E-8 ID:SGTC_1626|Compound:st003712|FD-Score:-3.32|P-value:7.09E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.34|P-value:7.56E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.41|P-value:1.37E-5 ID:SGTC_1833|Compound:st055984|FD-Score:4.01|P-value:7.04E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.18|P-value:3.55E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.31|P-value:2.11E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:5.30|P-value:2.30E-7 ID:SGTC_1964|Compound:st076914|FD-Score:3.74|P-value:1.91E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.23|P-value:9.51E-4 ID:SGTC_2123|Compound:5259487|FD-Score:4.40|P-value:1.46E-5 ID:SGTC_2376|Compound:9072922|FD-Score:3.42|P-value:5.92E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-4.42|P-value:1.12E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.29|P-value:9.09E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-4.26|P-value:2.18E-5 ID:SGTC_2829|Compound:7992743|FD-Score:-3.46|P-value:4.33E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.77|P-value:1.73E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.90|P-value:1.07E-4 ID:SGTC_2940|Compound:9060638|FD-Score:4.20|P-value:3.24E-5 ID:SGTC_3057|Compound:9095946|FD-Score:4.67|P-value:4.45E-6 ID:SGTC_3128|Compound:9127691|FD-Score:-3.41|P-value:5.15E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.42|P-value:5.76E-4

Top fitness defect scores for YEL018W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1329 1447-1697 5.62 50.6 µM 4.52E-8 5 9.78E-9
2 SGTC_61 0978-8327 5.61 98.6 µM 4.66E-8 ergosterol biosynthesis 8 1.01E-8
3 SGTC_1951 sophoraflavanone G 5.30 9.2 µM 2.30E-7 RNA processing & uracil transport 3 5.84E-8
4 SGTC_3057 9095946 4.67 49.5 µM 4.45E-6 Golgi 6 1.50E-6
5 SGTC_1087 pterostilbene 4.56 9.1 µM 7.16E-6 16 2.52E-6
6 SGTC_1826 st055655 4.41 41.6 µM 1.37E-5 ERG2 30 5.13E-6
7 SGTC_2123 5259487 4.40 200.0 µM 1.46E-5 13 5.52E-6
8 SGTC_1922 5578187 4.31 25.0 µM 2.11E-5 TRP & mitochondrial translation 22 8.27E-6
9 SGTC_2940 9060638 4.20 45.9 µM 3.24E-5 amide catabolism 19 1.32E-5
10 SGTC_1916 st067606 4.18 49.2 µM 3.55E-5 29 1.46E-5
11 SGTC_1833 st055984 4.01 71.0 µM 7.04E-5 15 3.09E-5
12 SGTC_1018 4259-0013 3.97 28.1 µM 8.08E-5 17 3.59E-5
13 SGTC_268 camptothecin 3.94 39.6 µM 8.94E-5 DNA damage response 73 4.02E-5
14 SGTC_2939 9044578 3.90 71.4 µM 1.07E-4 41 4.87E-5
15 SGTC_62 0180-0423 3.89 3.2 µM 1.08E-4 60S ribosome export 18 4.92E-5
16 SGTC_2842 9000675 3.77 19.5 µM 1.73E-4 25 8.30E-5
17 SGTC_1964 st076914 3.74 61.0 µM 1.91E-4 RPP1 & pyrimidine depletion 25 9.22E-5
18 SGTC_78 0336-0123 3.57 156.8 µM 3.48E-4 30 1.78E-4
19 SGTC_3129 9127257 3.42 49.5 µM 5.76E-4 40 3.09E-4
20 SGTC_2376 9072922 3.42 81.3 µM 5.92E-4 54 3.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.70E-12 YHR130C_d YHR130C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.092 9.96E-8 YKL156W RPS27A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.088 3.86E-7 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.077 7.67E-6 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.077 8.10E-6 YNR069C BSC5 hom Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro
0.077 8.66E-6 YER047C SAP1 hom Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
0.077 9.10E-6 YJR110W YMR1 hom Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family
0.075 1.32E-5 YLR406C-A_p YLR406C-A_p hom Putative protein of unknown function
0.073 2.27E-5 YKR043C SHB17 hom Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus
0.073 2.63E-5 YFR048W RMD8 hom Cytosolic protein required for sporulation
0.070 5.37E-5 YDL054C MCH1 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.069 6.43E-5 YCL022C_d YCL022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W
0.069 6.93E-5 YGR145W ENP2 het Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
0.068 7.97E-5 YNR023W SNF12 hom 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive
0.068 8.06E-5 YFR055W_p IRC7_p hom Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner