YEL040W / UTR2

Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL040W / UTR2

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-4.14|P-value:1.33E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.22|P-value:5.45E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-5.85|P-value:1.41E-9 ID:SGTC_181|Compound:1447-1644|FD-Score:3.03|P-value:9.66E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.39|P-value:2.65E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.07|P-value:8.41E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.50|P-value:1.73E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-7.92|P-value:4.17E-16 ID:SGTC_790|Compound:1575-0012|FD-Score:-4.53|P-value:2.17E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.19|P-value:6.11E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.36|P-value:2.95E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.37|P-value:3.19E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.30|P-value:3.73E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.13|P-value:6.89E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.08|P-value:8.31E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-4.23|P-value:8.88E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-6.96|P-value:7.85E-13 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.53|P-value:1.87E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:3.76|P-value:6.14E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-4.80|P-value:5.50E-7 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.22|P-value:8.09E-6 ID:SGTC_2791|Compound:5663188|FD-Score:-3.41|P-value:2.79E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.66|P-value:9.39E-5 ID:SGTC_2805|Compound:7950783|FD-Score:4.51|P-value:2.10E-6 ID:SGTC_2807|Compound:7945238|FD-Score:3.35|P-value:3.13E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-4.65|P-value:1.23E-6 ID:SGTC_2857|Compound:9024691|FD-Score:5.13|P-value:8.18E-8 ID:SGTC_2859|Compound:9028643|FD-Score:-3.35|P-value:3.46E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.44|P-value:2.18E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.68|P-value:9.71E-5 ID:SGTC_2962|Compound:9082311|FD-Score:3.39|P-value:2.68E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.80|P-value:5.23E-5 ID:SGTC_3096|Compound:9117468|FD-Score:-3.05|P-value:9.97E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-3.08|P-value:9.09E-4 ID:SGTC_3128|Compound:9127691|FD-Score:-3.82|P-value:5.29E-5 ID:SGTC_3203|Compound:9113543|FD-Score:5.68|P-value:3.51E-9 ID:SGTC_3205|Compound:9113483|FD-Score:-5.38|P-value:2.42E-8 ID:SGTC_3208|Compound:9114115|FD-Score:-4.69|P-value:9.59E-7 ID:SGTC_3297|Compound:9117502|FD-Score:-3.13|P-value:7.55E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-5.19|P-value:7.08E-8 ID:SGTC_61|Compound:0978-8327|FD-Score:-4.14|P-value:1.33E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.22|P-value:5.45E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-5.85|P-value:1.41E-9 ID:SGTC_181|Compound:1447-1644|FD-Score:3.03|P-value:9.66E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.39|P-value:2.65E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.07|P-value:8.41E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.50|P-value:1.73E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-7.92|P-value:4.17E-16 ID:SGTC_790|Compound:1575-0012|FD-Score:-4.53|P-value:2.17E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.19|P-value:6.11E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.36|P-value:2.95E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.37|P-value:3.19E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.30|P-value:3.73E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.13|P-value:6.89E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.08|P-value:8.31E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-4.23|P-value:8.88E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-6.96|P-value:7.85E-13 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.53|P-value:1.87E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:3.76|P-value:6.14E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-4.80|P-value:5.50E-7 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.22|P-value:8.09E-6 ID:SGTC_2791|Compound:5663188|FD-Score:-3.41|P-value:2.79E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.66|P-value:9.39E-5 ID:SGTC_2805|Compound:7950783|FD-Score:4.51|P-value:2.10E-6 ID:SGTC_2807|Compound:7945238|FD-Score:3.35|P-value:3.13E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-4.65|P-value:1.23E-6 ID:SGTC_2857|Compound:9024691|FD-Score:5.13|P-value:8.18E-8 ID:SGTC_2859|Compound:9028643|FD-Score:-3.35|P-value:3.46E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.44|P-value:2.18E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.68|P-value:9.71E-5 ID:SGTC_2962|Compound:9082311|FD-Score:3.39|P-value:2.68E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.80|P-value:5.23E-5 ID:SGTC_3096|Compound:9117468|FD-Score:-3.05|P-value:9.97E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-3.08|P-value:9.09E-4 ID:SGTC_3128|Compound:9127691|FD-Score:-3.82|P-value:5.29E-5 ID:SGTC_3203|Compound:9113543|FD-Score:5.68|P-value:3.51E-9 ID:SGTC_3205|Compound:9113483|FD-Score:-5.38|P-value:2.42E-8 ID:SGTC_3208|Compound:9114115|FD-Score:-4.69|P-value:9.59E-7 ID:SGTC_3297|Compound:9117502|FD-Score:-3.13|P-value:7.55E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-5.19|P-value:7.08E-8

Top fitness defect scores for YEL040W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3203 9113543 5.68 49.5 µM 3.51E-9 6 6.91E-9
2 SGTC_2857 9024691 5.13 58.4 µM 8.18E-8 8 1.44E-7
3 SGTC_2582 agaric acid 4.53 100.0 µM 1.87E-6 redox potentiating 253 2.95E-6
4 SGTC_2805 7950783 4.51 58.4 µM 2.10E-6 16 3.30E-6
5 SGTC_2762 leflunomide 4.22 42.1 µM 8.09E-6 21 1.21E-5
6 SGTC_2969 9091408 3.80 28.7 µM 5.23E-5 30 7.31E-5
7 SGTC_2607 solasodine 3.76 47.4 µM 6.14E-5 65 8.52E-5
8 SGTC_2799 7812892 3.66 81.8 µM 9.39E-5 superoxide 37 1.28E-4
9 SGTC_360 0957-0399 3.50 1.0 µM 1.73E-4 cell wall 63 2.32E-4
10 SGTC_2930 9013230 3.44 14.9 µM 2.18E-4 heme biosynthesis & mitochondrial translocase 60 2.89E-4
11 SGTC_343 4130-2827 3.39 29.8 µM 2.65E-4 49 3.49E-4
12 SGTC_2962 9082311 3.39 13.2 µM 2.68E-4 40 3.52E-4
13 SGTC_1033 k072-0102 3.36 21.3 µM 2.95E-4 60S ribosome export 44 3.87E-4
14 SGTC_2807 7945238 3.35 52.0 µM 3.13E-4 52 4.10E-4
15 SGTC_1321 1326-2144 3.30 215.0 µM 3.73E-4 25 4.85E-4
16 SGTC_1815 st051655 3.13 58.2 µM 6.89E-4 TSC3-RPN4 28 8.77E-4
17 SGTC_1905 st060207 3.08 84.5 µM 8.31E-4 33 0.00105
18 SGTC_350 k064-0020 3.07 19.8 µM 8.41E-4 heme requiring 58 0.00106
19 SGTC_181 1447-1644 3.03 8.1 µM 9.66E-4 endomembrane recycling 75 0.00121
20 SGTC_1747 st037496 2.94 66.6 µM 0.00131 69 0.00162

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 3.48E-28 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.186 1.39E-27 YIR010W DSN1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
0.175 1.65E-24 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.166 3.19E-22 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.163 1.73E-21 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.159 2.24E-20 YLR280C_d YLR280C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.158 4.49E-20 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.157 6.83E-20 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.156 1.23E-19 YPR140W TAZ1 hom Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome
0.153 4.84E-19 YGL145W TIP20 het Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
0.153 5.91E-19 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.150 2.43E-18 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.149 5.13E-18 YDR244W PEX5 hom Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
0.147 1.01E-17 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.147 1.13E-17 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p