YEL041W / YEF1

ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL041W / YEF1

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:3.73|P-value:3.29E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.40|P-value:2.88E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:5.67|P-value:1.09E-7 ID:SGTC_443|Compound:clozapine|FD-Score:-3.49|P-value:6.29E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.30|P-value:4.24E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.69|P-value:3.81E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:4.37|P-value:3.27E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:4.07|P-value:9.94E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:4.40|P-value:2.87E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:4.79|P-value:5.93E-6 ID:SGTC_891|Compound:0929-0073|FD-Score:4.15|P-value:7.41E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:3.43|P-value:8.81E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.43|P-value:8.73E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.58|P-value:5.40E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.48|P-value:2.15E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:3.58|P-value:5.37E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.49|P-value:1.70E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-9.68|P-value:2.48E-19 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.87|P-value:4.30E-6 ID:SGTC_1269|Compound:0831-0796|FD-Score:-5.90|P-value:2.60E-8 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.44|P-value:7.42E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.08|P-value:9.78E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.34|P-value:3.68E-5 ID:SGTC_1690|Compound:st023502|FD-Score:3.57|P-value:5.57E-4 ID:SGTC_1892|Compound:st058411|FD-Score:4.27|P-value:4.84E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-4.20|P-value:5.17E-5 ID:SGTC_1930|Compound:st074634|FD-Score:3.72|P-value:3.48E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.46|P-value:6.92E-4 ID:SGTC_1976|Compound:st070609|FD-Score:-3.83|P-value:2.01E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.56|P-value:5.88E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.42|P-value:9.03E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.51|P-value:5.89E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.97|P-value:1.45E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.50|P-value:6.98E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.49|P-value:7.22E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.65|P-value:4.35E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-7.25|P-value:1.23E-11 ID:SGTC_3157|Compound:9099274|FD-Score:-3.80|P-value:2.23E-4 ID:SGTC_3158|Compound:9100007|FD-Score:4.14|P-value:7.87E-5 ID:SGTC_3159|Compound:9100096|FD-Score:5.37|P-value:4.57E-7 ID:SGTC_3188|Compound:9110789|FD-Score:4.08|P-value:9.71E-5 ID:SGTC_3268|Compound:9137683|FD-Score:4.45|P-value:2.37E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:3.73|P-value:3.29E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.40|P-value:2.88E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:5.67|P-value:1.09E-7 ID:SGTC_443|Compound:clozapine|FD-Score:-3.49|P-value:6.29E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.30|P-value:4.24E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.69|P-value:3.81E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:4.37|P-value:3.27E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:4.07|P-value:9.94E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:4.40|P-value:2.87E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:4.79|P-value:5.93E-6 ID:SGTC_891|Compound:0929-0073|FD-Score:4.15|P-value:7.41E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:3.43|P-value:8.81E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.43|P-value:8.73E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.58|P-value:5.40E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.48|P-value:2.15E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:3.58|P-value:5.37E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.49|P-value:1.70E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-9.68|P-value:2.48E-19 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.87|P-value:4.30E-6 ID:SGTC_1269|Compound:0831-0796|FD-Score:-5.90|P-value:2.60E-8 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.44|P-value:7.42E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.08|P-value:9.78E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.34|P-value:3.68E-5 ID:SGTC_1690|Compound:st023502|FD-Score:3.57|P-value:5.57E-4 ID:SGTC_1892|Compound:st058411|FD-Score:4.27|P-value:4.84E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-4.20|P-value:5.17E-5 ID:SGTC_1930|Compound:st074634|FD-Score:3.72|P-value:3.48E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.46|P-value:6.92E-4 ID:SGTC_1976|Compound:st070609|FD-Score:-3.83|P-value:2.01E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.56|P-value:5.88E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.42|P-value:9.03E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.51|P-value:5.89E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.97|P-value:1.45E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.50|P-value:6.98E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.49|P-value:7.22E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.65|P-value:4.35E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-7.25|P-value:1.23E-11 ID:SGTC_3157|Compound:9099274|FD-Score:-3.80|P-value:2.23E-4 ID:SGTC_3158|Compound:9100007|FD-Score:4.14|P-value:7.87E-5 ID:SGTC_3159|Compound:9100096|FD-Score:5.37|P-value:4.57E-7 ID:SGTC_3188|Compound:9110789|FD-Score:4.08|P-value:9.71E-5 ID:SGTC_3268|Compound:9137683|FD-Score:4.45|P-value:2.37E-5

Top fitness defect scores for YEL041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_149 3970-0822 5.67 46.1 µM 1.09E-7 tubulin folding & SWR complex 39 7.27E-9
2 SGTC_3159 9100096 5.37 49.5 µM 4.57E-7 6 3.98E-8
3 SGTC_1165 k072-0275 4.87 30.3 µM 4.30E-6 23 5.64E-7
4 SGTC_814 3342-0569 4.79 96.0 µM 5.93E-6 11 8.26E-7
5 SGTC_1046 2001-0062 4.48 216.0 µM 2.15E-5 10 3.79E-6
6 SGTC_3268 9137683 4.45 49.5 µM 2.37E-5 4 4.25E-6
7 SGTC_813 k007-0158 4.40 173.0 µM 2.87E-5 fatty acid desaturase (OLE1) 33 5.34E-6
8 SGTC_88 0180-0332 4.40 8.7 µM 2.88E-5 15 5.36E-6
9 SGTC_578 3460-0051 4.37 92.0 µM 3.27E-5 7 6.21E-6
10 SGTC_1367 1812-0510 4.34 76.9 µM 3.68E-5 15 7.14E-6
11 SGTC_572 0960-0087 4.30 17.7 µM 4.24E-5 19 8.46E-6
12 SGTC_1892 st058411 4.27 7.4 µM 4.84E-5 15 9.88E-6
13 SGTC_891 0929-0073 4.15 133.0 µM 7.41E-5 20 1.63E-5
14 SGTC_3158 9100007 4.14 49.5 µM 7.87E-5 15 1.75E-5
15 SGTC_3188 9110789 4.08 49.5 µM 9.71E-5 iron homeostasis 20 2.25E-5
16 SGTC_1366 1683-0113 4.08 21.9 µM 9.78E-5 11 2.27E-5
17 SGTC_802 4112-3352 4.07 742.0 µM 9.94E-5 21 2.31E-5
18 SGTC_2482 5981709 3.97 142.7 µM 1.45E-4 PDR1 36 3.62E-5
19 SGTC_86 0417-1630 3.73 471.9 µM 3.29E-4 ubiquinone biosynthesis & proteasome 168 9.51E-5
20 SGTC_1930 st074634 3.72 34.3 µM 3.48E-4 RNA pol III & RNase P/MRP 45 1.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 5.10E-9 YLL047W_d YLL047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
0.087 3.86E-7 YER032W FIR1 hom Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
0.084 1.06E-6 YDL216C RRI1 hom Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling
0.079 4.02E-6 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.078 6.65E-6 YDR489W SLD5 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.077 7.01E-6 YGL028C SCW11 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
0.077 7.37E-6 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.077 7.69E-6 YGL056C SDS23 hom One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication
0.075 1.22E-5 YDL095W PMT1 hom Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen
0.075 1.21E-5 YJL077W-B_p YJL077W-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.074 1.74E-5 YDL105W NSE4 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.074 1.87E-5 YDL108W KIN28 het Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
0.073 2.21E-5 YML035C AMD1 hom AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools
0.072 3.19E-5 YDL200C MGT1 hom DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage
0.071 4.12E-5 YBR213W MET8 hom Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis