YEL061C / CIN8

Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL061C / CIN8

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.36|P-value:7.17E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.47|P-value:3.95E-10 ID:SGTC_114|Compound:0364-0001|FD-Score:4.57|P-value:7.07E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.40|P-value:6.07E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.78|P-value:2.80E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:4.79|P-value:2.63E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:4.93|P-value:1.42E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:-5.25|P-value:2.87E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:3.78|P-value:1.64E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.40|P-value:6.26E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:10.30|P-value:6.15E-23 ID:SGTC_521|Compound:r062-0005|FD-Score:4.12|P-value:4.55E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:3.36|P-value:7.01E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.28|P-value:9.18E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.82|P-value:2.29E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:3.31|P-value:8.34E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.07|P-value:5.50E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:3.57|P-value:3.52E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.68|P-value:2.34E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-4.10|P-value:4.70E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.55|P-value:7.35E-6 ID:SGTC_909|Compound:3448-9333|FD-Score:-4.43|P-value:1.24E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:11.00|P-value:7.72E-26 ID:SGTC_919|Compound:tnp00227|FD-Score:5.20|P-value:3.86E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:3.55|P-value:3.69E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.30|P-value:2.23E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:6.91|P-value:2.49E-11 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.40|P-value:6.21E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.58|P-value:3.33E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.37|P-value:6.90E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:5.57|P-value:6.01E-8 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.27|P-value:9.51E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.90|P-value:1.61E-6 ID:SGTC_1472|Compound:k841-0093|FD-Score:6.41|P-value:5.70E-10 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.95|P-value:8.81E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:5.03|P-value:8.57E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.57|P-value:3.46E-4 ID:SGTC_1614|Compound:st002383|FD-Score:4.54|P-value:8.01E-6 ID:SGTC_1646|Compound:st011709|FD-Score:3.49|P-value:4.55E-4 ID:SGTC_1772|Compound:st048439|FD-Score:5.58|P-value:5.58E-8 ID:SGTC_1792|Compound:st045773|FD-Score:3.29|P-value:8.85E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.15|P-value:4.00E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.89|P-value:1.11E-4 ID:SGTC_1865|Compound:st057639|FD-Score:4.46|P-value:1.11E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.32|P-value:2.16E-7 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.54|P-value:3.81E-4 ID:SGTC_1927|Compound:st060202|FD-Score:9.58|P-value:4.37E-20 ID:SGTC_1931|Compound:st074438|FD-Score:4.00|P-value:7.20E-5 ID:SGTC_1937|Compound:st074714|FD-Score:-3.28|P-value:9.04E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.83|P-value:1.34E-4 ID:SGTC_1942|Compound:st076330|FD-Score:5.12|P-value:5.80E-7 ID:SGTC_1949|Compound:st076024|FD-Score:3.77|P-value:1.72E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.41|P-value:1.38E-5 ID:SGTC_2005|Compound:4024620|FD-Score:4.16|P-value:3.85E-5 ID:SGTC_2020|Compound:4017018|FD-Score:3.37|P-value:6.79E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.87|P-value:1.81E-6 ID:SGTC_2067|Compound:5224629|FD-Score:3.30|P-value:8.54E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.27|P-value:9.32E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.23|P-value:2.89E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.74|P-value:1.92E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-3.33|P-value:7.59E-4 ID:SGTC_2134|Compound:5324836|FD-Score:4.78|P-value:2.76E-6 ID:SGTC_2136|Compound:5328288|FD-Score:-4.80|P-value:2.45E-6 ID:SGTC_2167|Compound:5876490|FD-Score:4.52|P-value:8.56E-6 ID:SGTC_2210|Compound:7115885|FD-Score:3.50|P-value:4.38E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.39|P-value:6.33E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.26|P-value:2.91E-7 ID:SGTC_2403|Compound:6032726|FD-Score:3.63|P-value:2.81E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.47|P-value:1.09E-5 ID:SGTC_2448|Compound:5185112|FD-Score:3.32|P-value:8.19E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.87|P-value:1.19E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.06|P-value:7.45E-7 ID:SGTC_2532|Compound:xanthone|FD-Score:3.72|P-value:2.05E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.54|P-value:7.88E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:4.97|P-value:1.14E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:11.20|P-value:1.19E-26 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.10|P-value:4.77E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:8.21|P-value:3.04E-15 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.36|P-value:6.76E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.83|P-value:1.53E-8 ID:SGTC_2991|Compound:9074669|FD-Score:-3.51|P-value:4.17E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.58|P-value:3.36E-4 ID:SGTC_3094|Compound:9117742|FD-Score:4.42|P-value:1.32E-5 ID:SGTC_3137|Compound:9097352|FD-Score:4.59|P-value:6.42E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.42|P-value:5.70E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.43|P-value:1.20E-7 ID:SGTC_3321|Compound:9137793|FD-Score:6.96|P-value:1.82E-11 ID:SGTC_3350|Compound:9150499|FD-Score:4.40|P-value:1.43E-5 ID:SGTC_14|Compound:0354-0009|FD-Score:3.36|P-value:7.17E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.47|P-value:3.95E-10 ID:SGTC_114|Compound:0364-0001|FD-Score:4.57|P-value:7.07E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.40|P-value:6.07E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.78|P-value:2.80E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:4.79|P-value:2.63E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:4.93|P-value:1.42E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:-5.25|P-value:2.87E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:3.78|P-value:1.64E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.40|P-value:6.26E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:10.30|P-value:6.15E-23 ID:SGTC_521|Compound:r062-0005|FD-Score:4.12|P-value:4.55E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:3.36|P-value:7.01E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.28|P-value:9.18E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.82|P-value:2.29E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:3.31|P-value:8.34E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.07|P-value:5.50E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:3.57|P-value:3.52E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.68|P-value:2.34E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-4.10|P-value:4.70E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.55|P-value:7.35E-6 ID:SGTC_909|Compound:3448-9333|FD-Score:-4.43|P-value:1.24E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:11.00|P-value:7.72E-26 ID:SGTC_919|Compound:tnp00227|FD-Score:5.20|P-value:3.86E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:3.55|P-value:3.69E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.30|P-value:2.23E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:6.91|P-value:2.49E-11 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.40|P-value:6.21E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.58|P-value:3.33E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.37|P-value:6.90E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:5.57|P-value:6.01E-8 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.27|P-value:9.51E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.90|P-value:1.61E-6 ID:SGTC_1472|Compound:k841-0093|FD-Score:6.41|P-value:5.70E-10 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.95|P-value:8.81E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:5.03|P-value:8.57E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.57|P-value:3.46E-4 ID:SGTC_1614|Compound:st002383|FD-Score:4.54|P-value:8.01E-6 ID:SGTC_1646|Compound:st011709|FD-Score:3.49|P-value:4.55E-4 ID:SGTC_1772|Compound:st048439|FD-Score:5.58|P-value:5.58E-8 ID:SGTC_1792|Compound:st045773|FD-Score:3.29|P-value:8.85E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.15|P-value:4.00E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.89|P-value:1.11E-4 ID:SGTC_1865|Compound:st057639|FD-Score:4.46|P-value:1.11E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.32|P-value:2.16E-7 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.54|P-value:3.81E-4 ID:SGTC_1927|Compound:st060202|FD-Score:9.58|P-value:4.37E-20 ID:SGTC_1931|Compound:st074438|FD-Score:4.00|P-value:7.20E-5 ID:SGTC_1937|Compound:st074714|FD-Score:-3.28|P-value:9.04E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.83|P-value:1.34E-4 ID:SGTC_1942|Compound:st076330|FD-Score:5.12|P-value:5.80E-7 ID:SGTC_1949|Compound:st076024|FD-Score:3.77|P-value:1.72E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.41|P-value:1.38E-5 ID:SGTC_2005|Compound:4024620|FD-Score:4.16|P-value:3.85E-5 ID:SGTC_2020|Compound:4017018|FD-Score:3.37|P-value:6.79E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.87|P-value:1.81E-6 ID:SGTC_2067|Compound:5224629|FD-Score:3.30|P-value:8.54E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.27|P-value:9.32E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.23|P-value:2.89E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.74|P-value:1.92E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-3.33|P-value:7.59E-4 ID:SGTC_2134|Compound:5324836|FD-Score:4.78|P-value:2.76E-6 ID:SGTC_2136|Compound:5328288|FD-Score:-4.80|P-value:2.45E-6 ID:SGTC_2167|Compound:5876490|FD-Score:4.52|P-value:8.56E-6 ID:SGTC_2210|Compound:7115885|FD-Score:3.50|P-value:4.38E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.39|P-value:6.33E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.26|P-value:2.91E-7 ID:SGTC_2403|Compound:6032726|FD-Score:3.63|P-value:2.81E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.47|P-value:1.09E-5 ID:SGTC_2448|Compound:5185112|FD-Score:3.32|P-value:8.19E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.87|P-value:1.19E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.06|P-value:7.45E-7 ID:SGTC_2532|Compound:xanthone|FD-Score:3.72|P-value:2.05E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.54|P-value:7.88E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:4.97|P-value:1.14E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:11.20|P-value:1.19E-26 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.10|P-value:4.77E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:8.21|P-value:3.04E-15 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.36|P-value:6.76E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.83|P-value:1.53E-8 ID:SGTC_2991|Compound:9074669|FD-Score:-3.51|P-value:4.17E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.58|P-value:3.36E-4 ID:SGTC_3094|Compound:9117742|FD-Score:4.42|P-value:1.32E-5 ID:SGTC_3137|Compound:9097352|FD-Score:4.59|P-value:6.42E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.42|P-value:5.70E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.43|P-value:1.20E-7 ID:SGTC_3321|Compound:9137793|FD-Score:6.96|P-value:1.82E-11 ID:SGTC_3350|Compound:9150499|FD-Score:4.40|P-value:1.43E-5

Top fitness defect scores for YEL061C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2619 obliquin 11.20 87.9 µM 1.19E-26 cell wall 16 2.84E-29
2 SGTC_916 4466-0038 11.00 42.0 nM 7.72E-26 cell wall 5 2.24E-28
3 SGTC_514 4466-0038 10.30 2.6 nM 6.15E-23 cell wall 18 3.60E-25
4 SGTC_1927 st060202 9.58 13.8 µM 4.37E-20 1 5.08E-22
5 SGTC_2622 2-methoxyxanthone 8.21 59.9 µM 3.04E-15 2 1.13E-16
6 SGTC_3321 9137793 6.96 26.8 µM 1.82E-11 cell wall 24 1.67E-12
7 SGTC_974 1326-0144 6.91 138.0 µM 2.49E-11 ERG2 7 2.37E-12
8 SGTC_58 0957-0393 6.47 9.0 µM 3.95E-10 cell wall 185 5.00E-11
9 SGTC_1472 k841-0093 6.41 193.0 µM 5.70E-10 1 7.50E-11
10 SGTC_2912 7964298 5.83 10.9 µM 1.53E-8 cell wall 48 2.83E-9
11 SGTC_1772 st048439 5.58 82.2 µM 5.58E-8 12 1.18E-8
12 SGTC_1159 4092-0538 5.57 61.2 µM 6.01E-8 6 1.28E-8
13 SGTC_3311 9131146 5.43 2.9 µM 1.20E-7 cell wall 74 2.75E-8
14 SGTC_1872 amphotericin b 5.32 148.0 nM 2.16E-7 RNA pol III & RNase P/MRP 15 5.24E-8
15 SGTC_2397 5161689 5.26 200.0 µM 2.91E-7 11 7.26E-8
16 SGTC_919 tnp00227 5.20 403.6 nM 3.86E-7 RNA pol III & RNase P/MRP 11 9.94E-8
17 SGTC_1942 st076330 5.12 65.2 µM 5.80E-7 9 1.56E-7
18 SGTC_2502 avocadyne acetate 5.06 18.6 µM 7.45E-7 12 2.05E-7
19 SGTC_1559 coumarin 343 5.03 70.1 µM 8.57E-7 1 2.39E-7
20 SGTC_2584 androsterone 4.97 48.7 µM 1.14E-6 cell wall 83 3.27E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.381 5.85E-116 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.351 5.26E-98 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.338 1.67E-90 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.326 5.27E-84 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.282 3.36E-62 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.275 1.75E-59 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.274 5.76E-59 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.272 4.73E-58 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.271 1.10E-57 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.266 2.80E-55 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.261 1.60E-53 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.261 1.92E-53 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.260 5.16E-53 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.256 1.71E-51 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.256 1.78E-51 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan