YER006W / NUG1

GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER006W / NUG1

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:-3.17|P-value:5.29E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.33|P-value:2.87E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.38|P-value:1.31E-8 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.18|P-value:5.20E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.12|P-value:6.22E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.04|P-value:8.48E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:3.07|P-value:7.30E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.26|P-value:3.67E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.26|P-value:3.68E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.89|P-value:2.09E-7 ID:SGTC_532|Compound:1548-0774|FD-Score:3.57|P-value:1.08E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.23|P-value:4.06E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.00|P-value:9.46E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-4.59|P-value:1.07E-6 ID:SGTC_705|Compound:1124-0212|FD-Score:3.62|P-value:9.07E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.88|P-value:2.90E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:3.77|P-value:4.79E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.13|P-value:6.17E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.30|P-value:3.23E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.03|P-value:8.58E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:10.20|P-value:3.10E-26 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.57|P-value:1.08E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-2.99|P-value:9.99E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-3.07|P-value:7.53E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.44|P-value:1.85E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.21|P-value:4.53E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:5.00|P-value:1.15E-7 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.03|P-value:8.67E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.58|P-value:1.06E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.77|P-value:4.74E-5 ID:SGTC_1555|Compound:citronellol|FD-Score:3.22|P-value:4.24E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.47|P-value:1.64E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.35|P-value:2.67E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.28|P-value:3.45E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-4.48|P-value:1.86E-6 ID:SGTC_1635|Compound:st007035|FD-Score:5.41|P-value:1.10E-8 ID:SGTC_1636|Compound:st007707|FD-Score:-3.32|P-value:2.99E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.26|P-value:3.63E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-4.64|P-value:8.22E-7 ID:SGTC_1735|Compound:st034310|FD-Score:-3.16|P-value:5.59E-4 ID:SGTC_1810|Compound:st050138|FD-Score:4.85|P-value:2.62E-7 ID:SGTC_1967|Compound:st070177|FD-Score:3.48|P-value:1.56E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.02|P-value:8.71E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.82|P-value:3.10E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.12|P-value:6.07E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.63|P-value:8.51E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-3.71|P-value:6.31E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.52|P-value:1.39E-4 ID:SGTC_2376|Compound:9072922|FD-Score:4.52|P-value:1.43E-6 ID:SGTC_2458|Compound:5808907|FD-Score:4.56|P-value:1.18E-6 ID:SGTC_2467|Compound:5474540|FD-Score:3.18|P-value:5.04E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.06|P-value:7.74E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.75|P-value:4.30E-7 ID:SGTC_2557|Compound:derrustone|FD-Score:3.70|P-value:6.33E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:6.56|P-value:5.62E-12 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.94|P-value:2.36E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.08|P-value:7.11E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.41|P-value:2.45E-6 ID:SGTC_2890|Compound:9046729|FD-Score:-4.11|P-value:1.10E-5 ID:SGTC_2892|Compound:9047358|FD-Score:-3.17|P-value:5.25E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.48|P-value:7.19E-9 ID:SGTC_2959|Compound:9079155|FD-Score:5.06|P-value:8.02E-8 ID:SGTC_2964|Compound:9083345|FD-Score:5.93|P-value:4.27E-10 ID:SGTC_2965|Compound:9082772|FD-Score:3.15|P-value:5.56E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:4.07|P-value:1.25E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.19|P-value:4.83E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.39|P-value:2.24E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.76|P-value:5.01E-5 ID:SGTC_3207|Compound:9114163|FD-Score:5.29|P-value:2.22E-8 ID:SGTC_3208|Compound:9114115|FD-Score:4.30|P-value:4.22E-6 ID:SGTC_3337|Compound:9144342|FD-Score:3.67|P-value:7.17E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.17|P-value:5.29E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.33|P-value:2.87E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.38|P-value:1.31E-8 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.18|P-value:5.20E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.12|P-value:6.22E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.04|P-value:8.48E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:3.07|P-value:7.30E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.26|P-value:3.67E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.26|P-value:3.68E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.89|P-value:2.09E-7 ID:SGTC_532|Compound:1548-0774|FD-Score:3.57|P-value:1.08E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.23|P-value:4.06E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.00|P-value:9.46E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-4.59|P-value:1.07E-6 ID:SGTC_705|Compound:1124-0212|FD-Score:3.62|P-value:9.07E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.88|P-value:2.90E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:3.77|P-value:4.79E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.13|P-value:6.17E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.30|P-value:3.23E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.03|P-value:8.58E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:10.20|P-value:3.10E-26 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.57|P-value:1.08E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-2.99|P-value:9.99E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-3.07|P-value:7.53E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.44|P-value:1.85E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.21|P-value:4.53E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:5.00|P-value:1.15E-7 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.03|P-value:8.67E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.58|P-value:1.06E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.77|P-value:4.74E-5 ID:SGTC_1555|Compound:citronellol|FD-Score:3.22|P-value:4.24E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.47|P-value:1.64E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.35|P-value:2.67E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.28|P-value:3.45E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-4.48|P-value:1.86E-6 ID:SGTC_1635|Compound:st007035|FD-Score:5.41|P-value:1.10E-8 ID:SGTC_1636|Compound:st007707|FD-Score:-3.32|P-value:2.99E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.26|P-value:3.63E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-4.64|P-value:8.22E-7 ID:SGTC_1735|Compound:st034310|FD-Score:-3.16|P-value:5.59E-4 ID:SGTC_1810|Compound:st050138|FD-Score:4.85|P-value:2.62E-7 ID:SGTC_1967|Compound:st070177|FD-Score:3.48|P-value:1.56E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.02|P-value:8.71E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.82|P-value:3.10E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.12|P-value:6.07E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.63|P-value:8.51E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-3.71|P-value:6.31E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.52|P-value:1.39E-4 ID:SGTC_2376|Compound:9072922|FD-Score:4.52|P-value:1.43E-6 ID:SGTC_2458|Compound:5808907|FD-Score:4.56|P-value:1.18E-6 ID:SGTC_2467|Compound:5474540|FD-Score:3.18|P-value:5.04E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.06|P-value:7.74E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.75|P-value:4.30E-7 ID:SGTC_2557|Compound:derrustone|FD-Score:3.70|P-value:6.33E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:6.56|P-value:5.62E-12 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.94|P-value:2.36E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.08|P-value:7.11E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.41|P-value:2.45E-6 ID:SGTC_2890|Compound:9046729|FD-Score:-4.11|P-value:1.10E-5 ID:SGTC_2892|Compound:9047358|FD-Score:-3.17|P-value:5.25E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.48|P-value:7.19E-9 ID:SGTC_2959|Compound:9079155|FD-Score:5.06|P-value:8.02E-8 ID:SGTC_2964|Compound:9083345|FD-Score:5.93|P-value:4.27E-10 ID:SGTC_2965|Compound:9082772|FD-Score:3.15|P-value:5.56E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:4.07|P-value:1.25E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.19|P-value:4.83E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.39|P-value:2.24E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.76|P-value:5.01E-5 ID:SGTC_3207|Compound:9114163|FD-Score:5.29|P-value:2.22E-8 ID:SGTC_3208|Compound:9114115|FD-Score:4.30|P-value:4.22E-6 ID:SGTC_3337|Compound:9144342|FD-Score:3.67|P-value:7.17E-5

Top fitness defect scores for YER006W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_969 1313-0238 10.20 134.0 µM 3.10E-26 mitochondrial processes 2 1.22E-24 1.43
2 SGTC_2586 curcumin 6.56 80.0 µM 5.62E-12 iron homeostasis 2 2.66E-11 0.65
3 SGTC_2964 9083345 5.93 53.4 µM 4.27E-10 4 1.53E-9 0.19
4 SGTC_2896 9052656 5.48 71.4 µM 7.19E-9 endomembrane recycling 13 2.16E-8 0.08
5 SGTC_1635 st007035 5.41 42.4 µM 1.10E-8 10 3.22E-8 0.14
6 SGTC_146 3448-8650 5.38 53.1 µM 1.31E-8 NEO1-PIK1 6 3.78E-8 0.29
7 SGTC_3207 9114163 5.29 49.5 µM 2.22E-8 4 6.18E-8 0.45
8 SGTC_2959 9079155 5.06 11.0 µM 8.02E-8 5 2.06E-7 0.26
9 SGTC_1330 1469-0054 5.00 61.8 µM 1.15E-7 iron homeostasis 2 2.88E-7 0.26
10 SGTC_431 k089-0097 4.89 107.0 µM 2.09E-7 iron homeostasis 6 5.05E-7 0.26
11 SGTC_1810 st050138 4.85 53.0 µM 2.62E-7 PDR1 2 6.25E-7 0.86
12 SGTC_2131 toluylene red 4.82 5.3 µM 3.10E-7 60S ribosome export 10 7.30E-7 0.33
13 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 4.75 92.6 µM 4.30E-7 6 9.93E-7 0.06
14 SGTC_2458 5808907 4.56 16.4 µM 1.18E-6 1 2.56E-6 0.32
15 SGTC_2376 9072922 4.52 81.3 µM 1.43E-6 2 3.07E-6 0.46
16 SGTC_2757 clomiphene 4.41 4.2 µM 2.45E-6 fatty acid desaturase (OLE1) 5 5.07E-6 0.00
17 SGTC_3208 9114115 4.30 49.5 µM 4.22E-6 7 8.44E-6 0.11
18 SGTC_3061 glucosamine 4.07 200.0 µM 1.25E-5 1 2.33E-5 0.38
19 SGTC_706 4262-0057 3.88 46.9 µM 2.90E-5 fatty acid desaturase (OLE1) 10 5.14E-5 0.39
20 SGTC_1524 corynanthine 3.77 62.1 µM 4.74E-5 6 8.14E-5 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.13E-14 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.120 3.21E-12 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.112 7.03E-11 YAL037W_p YAL037W_p hom Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication
0.111 9.82E-11 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.110 1.72E-10 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.110 1.72E-10 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.107 5.80E-10 YNL044W YIP3 hom Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
0.101 3.93E-9 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.100 5.73E-9 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.100 6.50E-9 YMR043W MCM1 het Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
0.100 6.61E-9 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.097 1.69E-8 YDR256C CTA1 hom Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation
0.097 1.86E-8 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.097 2.12E-8 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.095 3.33E-8 YDR289C RTT103 hom Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition