YER015W / FAA2

Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome

Zygosity: Homozygous strain
fixedexpanded
Profile for YER015W / FAA2

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.13|P-value:8.72E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.34|P-value:4.15E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:3.92|P-value:4.42E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:-6.95|P-value:1.31E-12 ID:SGTC_77|Compound:0828-0286|FD-Score:3.80|P-value:7.09E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.30|P-value:4.84E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.63|P-value:1.28E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.11|P-value:8.60E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.51|P-value:2.26E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.10|P-value:9.68E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.55|P-value:1.91E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.21|P-value:6.54E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.46|P-value:3.91E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:3.74|P-value:9.18E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:4.23|P-value:1.16E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:3.90|P-value:4.66E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.81|P-value:6.03E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.36|P-value:3.90E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.42|P-value:3.12E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.66|P-value:1.24E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.18|P-value:7.40E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.64|P-value:1.33E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.83|P-value:5.52E-5 ID:SGTC_1729|Compound:st035615|FD-Score:6.39|P-value:7.22E-11 ID:SGTC_1730|Compound:st033808|FD-Score:3.20|P-value:6.92E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.25|P-value:5.76E-4 ID:SGTC_1861|Compound:st057647|FD-Score:4.87|P-value:5.23E-7 ID:SGTC_2291|Compound:7917025|FD-Score:4.67|P-value:1.42E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.65|P-value:1.27E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.21|P-value:6.08E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.79|P-value:7.29E-5 ID:SGTC_2440|Compound:5628896|FD-Score:-3.56|P-value:1.62E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-3.17|P-value:6.97E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.85|P-value:5.91E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:4.36|P-value:6.27E-6 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.86|P-value:5.46E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.28|P-value:4.71E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-6.08|P-value:4.59E-10 ID:SGTC_2586|Compound:curcumin|FD-Score:3.53|P-value:2.03E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.19|P-value:7.04E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.32|P-value:4.43E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.79|P-value:7.41E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.30|P-value:4.37E-4 ID:SGTC_2784|Compound:7567673|FD-Score:4.08|P-value:2.15E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.39|P-value:3.52E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.86|P-value:5.05E-5 ID:SGTC_2998|Compound:9066762|FD-Score:3.23|P-value:6.14E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.77|P-value:7.27E-5 ID:SGTC_3201|Compound:9113999|FD-Score:4.21|P-value:1.23E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.53|P-value:2.05E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.13|P-value:8.72E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.34|P-value:4.15E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:3.92|P-value:4.42E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:-6.95|P-value:1.31E-12 ID:SGTC_77|Compound:0828-0286|FD-Score:3.80|P-value:7.09E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.30|P-value:4.84E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.63|P-value:1.28E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.11|P-value:8.60E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.51|P-value:2.26E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.10|P-value:9.68E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.55|P-value:1.91E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.21|P-value:6.54E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.46|P-value:3.91E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:3.74|P-value:9.18E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:4.23|P-value:1.16E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:3.90|P-value:4.66E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.81|P-value:6.03E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.36|P-value:3.90E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.42|P-value:3.12E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.66|P-value:1.24E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.18|P-value:7.40E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.64|P-value:1.33E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.83|P-value:5.52E-5 ID:SGTC_1729|Compound:st035615|FD-Score:6.39|P-value:7.22E-11 ID:SGTC_1730|Compound:st033808|FD-Score:3.20|P-value:6.92E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.25|P-value:5.76E-4 ID:SGTC_1861|Compound:st057647|FD-Score:4.87|P-value:5.23E-7 ID:SGTC_2291|Compound:7917025|FD-Score:4.67|P-value:1.42E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.65|P-value:1.27E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.21|P-value:6.08E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.79|P-value:7.29E-5 ID:SGTC_2440|Compound:5628896|FD-Score:-3.56|P-value:1.62E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-3.17|P-value:6.97E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.85|P-value:5.91E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:4.36|P-value:6.27E-6 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.86|P-value:5.46E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.28|P-value:4.71E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-6.08|P-value:4.59E-10 ID:SGTC_2586|Compound:curcumin|FD-Score:3.53|P-value:2.03E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.19|P-value:7.04E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.32|P-value:4.43E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.79|P-value:7.41E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.30|P-value:4.37E-4 ID:SGTC_2784|Compound:7567673|FD-Score:4.08|P-value:2.15E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.39|P-value:3.52E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.86|P-value:5.05E-5 ID:SGTC_2998|Compound:9066762|FD-Score:3.23|P-value:6.14E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.77|P-value:7.27E-5 ID:SGTC_3201|Compound:9113999|FD-Score:4.21|P-value:1.23E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.53|P-value:2.05E-4

Top fitness defect scores for YER015W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1729 st035615 6.39 46.0 µM 7.22E-11 8 8.06E-11
2 SGTC_1861 st057647 4.87 17.4 µM 5.23E-7 7 5.48E-7
3 SGTC_2291 7917025 4.67 104.3 µM 1.42E-6 iron homeostasis 33 1.48E-6
4 SGTC_535 2293-4129 4.46 48.2 µM 3.91E-6 NEO1 50 4.05E-6
5 SGTC_2495 cafestol 4.36 54.5 µM 6.27E-6 Golgi 18 6.47E-6
6 SGTC_947 3447-0010 4.23 211.0 µM 1.16E-5 7 1.19E-5
7 SGTC_3201 9113999 4.21 49.5 µM 1.23E-5 27 1.26E-5
8 SGTC_2784 7567673 4.08 72.7 µM 2.15E-5 iron homeostasis 24 2.20E-5
9 SGTC_52 0329-0193 3.92 875.0 nM 4.42E-5 TSC3-RPN4 35 4.51E-5
10 SGTC_963 1269-2853 3.90 151.0 µM 4.66E-5 26 4.75E-5
11 SGTC_2561 acetosyringone 3.86 100.0 µM 5.46E-5 28 5.56E-5
12 SGTC_2449 5812982 3.85 45.8 µM 5.91E-5 9 6.02E-5
13 SGTC_77 0828-0286 3.80 12.5 µM 7.09E-5 TSC3-RPN4 43 7.21E-5
14 SGTC_2379 9035213 3.79 200.0 µM 7.29E-5 24 7.42E-5
15 SGTC_2675 theaflavin digallate 3.79 100.0 µM 7.41E-5 iron homeostasis 35 7.53E-5
16 SGTC_785 1270-0111 3.74 65.3 µM 9.18E-5 33 9.33E-5
17 SGTC_1686 st019653 3.66 115.5 µM 1.24E-4 mitochondrial processes 14 1.25E-4
18 SGTC_2321 7390090 3.65 138.8 µM 1.27E-4 36 1.29E-4
19 SGTC_1713 st033146 3.64 12.8 µM 1.33E-4 34 1.35E-4
20 SGTC_402 epigallocatechin gallate 3.55 10.0 µM 1.91E-4 42 1.93E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 9.79E-21 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.132 1.87E-14 YDR409W SIZ1 hom SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
0.122 1.15E-12 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.108 3.81E-10 YBR196C-B_p YBR196C-B_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.094 4.42E-8 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.090 2.04E-7 YLR251W SYM1 hom Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
0.089 2.40E-7 YDL179W PCL9 hom Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
0.086 6.27E-7 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 8.38E-7 YOR317W FAA1 hom Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms ER foci upon DNA replication stress; FAA1 has a paralog, FAA4, that arose from the whole genome duplication
0.079 4.71E-6 YGL234W ADE5,7 hom Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
0.078 5.86E-6 YNL175C NOP13 hom Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress
0.078 6.73E-6 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.077 9.12E-6 YNL138W SRV2 hom CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis
0.077 9.13E-6 YLR268W SEC22 hom R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
0.074 1.81E-5 YMR068W AVO2 hom Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth