JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YER051W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.185 | 3.85E-27 | YOR084W | LPX1 | hom | Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction |
0.174 | 4.17E-24 | YIL010W | DOT5 | hom | Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth |
0.163 | 2.08E-21 | YLR101C_d | YLR101C_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W |
0.152 | 7.13E-19 | YER046W | SPO73 | hom | Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis |
0.145 | 3.05E-17 | YPR180W | AOS1 | het | Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability |
0.145 | 2.77E-17 | YDL222C | FMP45 | hom | Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C |
0.144 | 6.63E-17 | YDR521W_d | YDR521W_d | hom | Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol |
0.142 | 1.10E-16 | YOR301W | RAX1 | hom | Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily |
0.139 | 7.82E-16 | YJL171C | YJL171C | hom | GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress |
0.137 | 1.43E-15 | YGR022C_d | YGR022C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W |
0.134 | 8.42E-15 | YKL166C | TPK3 | hom | cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication |
0.131 | 3.18E-14 | YNL166C | BNI5 | hom | Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner |
0.130 | 5.19E-14 | YJR137C | MET5 | hom | Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine |
0.127 | 1.57E-13 | YJR146W_p | YJR146W_p | hom | Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2 |
0.120 | 2.53E-12 | YOR297C | TIM18 | hom | Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex |