YER051W / JHD1

JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe

Zygosity: Homozygous strain
fixedexpanded
Profile for YER051W / JHD1

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:3.65|P-value:1.26E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.46|P-value:2.94E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.03|P-value:2.63E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.08|P-value:9.79E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.36|P-value:3.71E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.40|P-value:5.13E-6 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.93|P-value:4.80E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.58|P-value:1.89E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.91|P-value:4.37E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.32|P-value:4.34E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.62|P-value:1.39E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.67|P-value:1.17E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:5.56|P-value:1.29E-8 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.69|P-value:1.09E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.15|P-value:7.86E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.05|P-value:2.87E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-3.53|P-value:2.31E-4 ID:SGTC_1607|Compound:st000305|FD-Score:-3.26|P-value:6.12E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.86|P-value:5.44E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-4.10|P-value:2.34E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.66|P-value:1.20E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.41|P-value:3.07E-4 ID:SGTC_1887|Compound:st057648|FD-Score:-3.45|P-value:3.10E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.15|P-value:7.80E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.36|P-value:3.67E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.21|P-value:6.25E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.36|P-value:3.79E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.89|P-value:4.86E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-3.39|P-value:3.87E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-4.22|P-value:1.34E-5 ID:SGTC_2477|Compound:5967686|FD-Score:5.96|P-value:1.20E-9 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.41|P-value:5.03E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.78|P-value:8.61E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.16|P-value:8.40E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-5.00|P-value:3.28E-7 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.19|P-value:1.33E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.53|P-value:1.95E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-4.78|P-value:9.79E-7 ID:SGTC_2797|Compound:7859098|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.40|P-value:3.65E-4 ID:SGTC_2861|Compound:9024595|FD-Score:3.73|P-value:9.19E-5 ID:SGTC_3278|Compound:9139605|FD-Score:3.25|P-value:5.44E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.65|P-value:1.26E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.46|P-value:2.94E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.03|P-value:2.63E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.08|P-value:9.79E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.36|P-value:3.71E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.40|P-value:5.13E-6 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.93|P-value:4.80E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.58|P-value:1.89E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.91|P-value:4.37E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.32|P-value:4.34E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.62|P-value:1.39E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.67|P-value:1.17E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:5.56|P-value:1.29E-8 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.69|P-value:1.09E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.15|P-value:7.86E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.05|P-value:2.87E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-3.53|P-value:2.31E-4 ID:SGTC_1607|Compound:st000305|FD-Score:-3.26|P-value:6.12E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.86|P-value:5.44E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-4.10|P-value:2.34E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.66|P-value:1.20E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.41|P-value:3.07E-4 ID:SGTC_1887|Compound:st057648|FD-Score:-3.45|P-value:3.10E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.15|P-value:7.80E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.36|P-value:3.67E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.21|P-value:6.25E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.36|P-value:3.79E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.89|P-value:4.86E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-3.39|P-value:3.87E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-4.22|P-value:1.34E-5 ID:SGTC_2477|Compound:5967686|FD-Score:5.96|P-value:1.20E-9 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.41|P-value:5.03E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.78|P-value:8.61E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.16|P-value:8.40E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-5.00|P-value:3.28E-7 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.19|P-value:1.33E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.53|P-value:1.95E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-4.78|P-value:9.79E-7 ID:SGTC_2797|Compound:7859098|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.40|P-value:3.65E-4 ID:SGTC_2861|Compound:9024595|FD-Score:3.73|P-value:9.19E-5 ID:SGTC_3278|Compound:9139605|FD-Score:3.25|P-value:5.44E-4

Top fitness defect scores for YER051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2477 5967686 5.96 25.2 µM 1.20E-9 7 1.27E-9
2 SGTC_1203 3992-3522 5.56 103.0 µM 1.29E-8 7 1.35E-8
3 SGTC_2583 asiatic acid 4.41 100.0 µM 5.03E-6 26 5.28E-6
4 SGTC_580 1123-0028 4.40 41.0 µM 5.13E-6 DNA damage response 27 5.38E-6
5 SGTC_2771 fluoxetine 4.19 41.0 µM 1.33E-5 14 1.39E-5
6 SGTC_436 n,n-dimethylsphingosine 4.03 3.3 µM 2.63E-5 24 2.76E-5
7 SGTC_664 1222-0054 3.91 14.9 µM 4.37E-5 sphingolipid biosynthesis & PDR1 39 4.58E-5
8 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 3.89 49.5 µM 4.86E-5 23 5.09E-5
9 SGTC_1737 st035557 3.86 69.7 µM 5.44E-5 19 5.71E-5
10 SGTC_2861 9024595 3.73 19.5 µM 9.19E-5 4 9.63E-5
11 SGTC_1226 3909-7979 3.69 35.4 µM 1.09E-4 49 1.14E-4
12 SGTC_1159 4092-0538 3.67 61.2 µM 1.17E-4 39 1.22E-4
13 SGTC_1769 st044406 3.66 64.4 µM 1.20E-4 24 1.26E-4
14 SGTC_46 0329-0187a 3.65 2.2 µM 1.26E-4 86 1.32E-4
15 SGTC_892 0929-0076 3.62 29.0 µM 1.39E-4 TRP & mitochondrial translation 55 1.45E-4
16 SGTC_2778 tioconazole 3.53 65.1 nM 1.95E-4 ergosterol depletion effects on membrane 78 2.04E-4
17 SGTC_2797 7859098 3.42 81.8 µM 2.95E-4 43 3.09E-4
18 SGTC_1785 bathophenanthroline 3.41 24.0 µM 3.07E-4 heme requiring 76 3.22E-4
19 SGTC_2104 5389443 3.36 200.0 µM 3.67E-4 37 3.84E-4
20 SGTC_453 enantio-paf c16 3.36 10.0 µM 3.71E-4 202 3.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.185 3.85E-27 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.174 4.17E-24 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.163 2.08E-21 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.152 7.13E-19 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.145 3.05E-17 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.145 2.77E-17 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.144 6.63E-17 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.142 1.10E-16 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.139 7.82E-16 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.137 1.43E-15 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.134 8.42E-15 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.131 3.18E-14 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.130 5.19E-14 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.127 1.57E-13 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.120 2.53E-12 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex