YER056C-A / RPL34A

Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER056C-A / RPL34A

Click on Significant Values for Screen Details ID:SGTC_84|Compound:0443-0269|FD-Score:3.01|P-value:9.01E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.95|P-value:2.48E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:4.19|P-value:8.58E-6 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.36|P-value:6.13E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.68|P-value:2.60E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.22|P-value:4.36E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.13|P-value:6.09E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:5.78|P-value:2.10E-9 ID:SGTC_357|Compound:1325-0123|FD-Score:3.82|P-value:4.27E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.61|P-value:1.00E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.33|P-value:2.91E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.15|P-value:5.61E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.34|P-value:2.82E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.74|P-value:5.91E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:4.51|P-value:1.96E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:3.75|P-value:5.71E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.12|P-value:6.27E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.27|P-value:3.69E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:4.01|P-value:1.93E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:5.82|P-value:1.61E-9 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.22|P-value:9.67E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.90|P-value:9.68E-10 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.75|P-value:5.68E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.99|P-value:1.73E-7 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.00|P-value:1.98E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.86|P-value:3.61E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.56|P-value:1.23E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:4.16|P-value:1.01E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.45|P-value:4.31E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-4.27|P-value:1.67E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.45|P-value:1.89E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.00|P-value:9.48E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.52|P-value:1.43E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.40|P-value:3.26E-6 ID:SGTC_1782|Compound:st039423|FD-Score:3.38|P-value:2.49E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-3.35|P-value:6.34E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.29|P-value:3.42E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.39|P-value:2.32E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.61|P-value:1.01E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.47|P-value:4.06E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.12|P-value:6.27E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.49|P-value:2.17E-6 ID:SGTC_2172|Compound:5754775|FD-Score:3.30|P-value:3.26E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.83|P-value:4.08E-7 ID:SGTC_2177|Compound:5811945|FD-Score:3.00|P-value:9.44E-4 ID:SGTC_2187|Compound:6125751|FD-Score:-3.49|P-value:3.78E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.70|P-value:7.92E-7 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:2.99|P-value:9.92E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.30|P-value:3.28E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.05|P-value:7.86E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.36|P-value:5.96E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.27|P-value:8.31E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.37|P-value:5.77E-4 ID:SGTC_2806|Compound:7952793|FD-Score:4.32|P-value:4.90E-6 ID:SGTC_2808|Compound:7946468|FD-Score:3.77|P-value:5.37E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.47|P-value:1.73E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.71|P-value:1.65E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.24|P-value:4.08E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.01|P-value:9.01E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.95|P-value:2.48E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:4.19|P-value:8.58E-6 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.36|P-value:6.13E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.68|P-value:2.60E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.22|P-value:4.36E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.13|P-value:6.09E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:5.78|P-value:2.10E-9 ID:SGTC_357|Compound:1325-0123|FD-Score:3.82|P-value:4.27E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.61|P-value:1.00E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.33|P-value:2.91E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.15|P-value:5.61E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.34|P-value:2.82E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.74|P-value:5.91E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:4.51|P-value:1.96E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:3.75|P-value:5.71E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.12|P-value:6.27E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.27|P-value:3.69E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:4.01|P-value:1.93E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:5.82|P-value:1.61E-9 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.22|P-value:9.67E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.90|P-value:9.68E-10 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.75|P-value:5.68E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.99|P-value:1.73E-7 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.00|P-value:1.98E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.86|P-value:3.61E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.56|P-value:1.23E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:4.16|P-value:1.01E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.45|P-value:4.31E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-4.27|P-value:1.67E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.45|P-value:1.89E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.00|P-value:9.48E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.52|P-value:1.43E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.40|P-value:3.26E-6 ID:SGTC_1782|Compound:st039423|FD-Score:3.38|P-value:2.49E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-3.35|P-value:6.34E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.29|P-value:3.42E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.39|P-value:2.32E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.61|P-value:1.01E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.47|P-value:4.06E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.12|P-value:6.27E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.49|P-value:2.17E-6 ID:SGTC_2172|Compound:5754775|FD-Score:3.30|P-value:3.26E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.83|P-value:4.08E-7 ID:SGTC_2177|Compound:5811945|FD-Score:3.00|P-value:9.44E-4 ID:SGTC_2187|Compound:6125751|FD-Score:-3.49|P-value:3.78E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.70|P-value:7.92E-7 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:2.99|P-value:9.92E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.30|P-value:3.28E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.05|P-value:7.86E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.36|P-value:5.96E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.27|P-value:8.31E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.37|P-value:5.77E-4 ID:SGTC_2806|Compound:7952793|FD-Score:4.32|P-value:4.90E-6 ID:SGTC_2808|Compound:7946468|FD-Score:3.77|P-value:5.37E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.47|P-value:1.73E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.71|P-value:1.65E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.24|P-value:4.08E-4

Top fitness defect scores for YER056C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1247 0448-0043 5.90 5.8 µM 9.68E-10 ERG2 11 1.79E-9
2 SGTC_972 1319-0219 5.82 195.0 µM 1.61E-9 5 2.96E-9
3 SGTC_237 nikkomycin 5.78 200.0 µM 2.10E-9 RSC complex & mRNA processing 4 3.83E-9
4 SGTC_1271 0832-2808 4.99 169.0 µM 1.73E-7 2 2.95E-7
5 SGTC_2174 5790901 4.83 200.0 µM 4.08E-7 tubulin folding & SWR complex 22 6.88E-7
6 SGTC_2412 st077135 4.70 33.4 µM 7.92E-7 9 1.32E-6
7 SGTC_691 1548-0686 4.51 185.0 µM 1.96E-6 19 3.21E-6
8 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 4.49 49.5 µM 2.17E-6 14 3.55E-6
9 SGTC_1781 st038725 4.40 66.3 µM 3.26E-6 NEO1 84 5.30E-6
10 SGTC_2806 7952793 4.32 58.4 µM 4.90E-6 14 7.89E-6
11 SGTC_150 3970-0969 4.19 77.2 µM 8.58E-6 54 1.37E-5
12 SGTC_1490 4089-0339 4.16 670.0 nM 1.01E-5 6 1.61E-5
13 SGTC_895 0964-0006 4.01 13.7 µM 1.93E-5 14 3.03E-5
14 SGTC_1275 0867-0008 4.00 21.1 µM 1.98E-5 13 3.10E-5
15 SGTC_100 0086-0128 3.95 49.6 µM 2.48E-5 copper-dependent oxidative stress 50 3.87E-5
16 SGTC_1336 1486-0901 3.86 104.0 µM 3.61E-5 23 5.59E-5
17 SGTC_357 1325-0123 3.82 420.0 µM 4.27E-5 9 6.58E-5
18 SGTC_2808 7946468 3.77 45.5 µM 5.37E-5 29 8.24E-5
19 SGTC_1249 0481-0015 3.75 10.2 µM 5.68E-5 30 8.71E-5
20 SGTC_710 3448-4187 3.75 58.0 µM 5.71E-5 fatty acid desaturase (OLE1) 66 8.75E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.41E-9 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.102 2.96E-9 YKL181W PRS1 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
0.096 2.69E-8 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.091 1.19E-7 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.087 4.45E-7 YJL016W_p YJL016W_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species
0.082 1.83E-6 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.079 4.52E-6 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.079 5.21E-6 YMR290W-A_d YMR290W-A_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
0.077 8.09E-6 YMR138W CIN4 hom GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
0.075 1.20E-5 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.075 1.25E-5 YLR287C-A RPS30A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication
0.074 1.70E-5 YGL088W_d YGL088W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
0.072 2.63E-5 YML024W RPS17A hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication
0.072 3.21E-5 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.070 5.29E-5 YDR071C PAA1 hom Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication