YER073W / ALD5

Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed

Zygosity: Homozygous strain
fixedexpanded
Profile for YER073W / ALD5

Click on Significant Values for Screen Details ID:SGTC_165|Compound:k038-0023|FD-Score:4.81|P-value:1.52E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.86|P-value:8.81E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:5.16|P-value:2.80E-7 ID:SGTC_560|Compound:2332-1943|FD-Score:3.32|P-value:6.31E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.36|P-value:5.56E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.84|P-value:9.70E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.96|P-value:6.14E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.86|P-value:8.91E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:3.79|P-value:1.17E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.47|P-value:3.78E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.51|P-value:3.28E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.22|P-value:8.93E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.31|P-value:1.44E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.43|P-value:4.37E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.29|P-value:6.95E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.70|P-value:1.62E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.72|P-value:1.54E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.87|P-value:8.47E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:7.83|P-value:1.46E-14 ID:SGTC_1724|Compound:st037281|FD-Score:3.35|P-value:5.81E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.30|P-value:6.82E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.55|P-value:2.80E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.63|P-value:2.13E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.47|P-value:3.78E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.50|P-value:3.41E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.46|P-value:3.89E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.78|P-value:1.23E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.73|P-value:2.18E-6 ID:SGTC_2944|Compound:9067346|FD-Score:3.62|P-value:2.18E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.22|P-value:8.99E-4 ID:SGTC_3140|Compound:9094243|FD-Score:6.79|P-value:2.17E-11 ID:SGTC_3145|Compound:9085516|FD-Score:4.12|P-value:3.21E-5 ID:SGTC_3242|Compound:9133940|FD-Score:-3.24|P-value:8.43E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.81|P-value:1.52E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.86|P-value:8.81E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:5.16|P-value:2.80E-7 ID:SGTC_560|Compound:2332-1943|FD-Score:3.32|P-value:6.31E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.36|P-value:5.56E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.84|P-value:9.70E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.96|P-value:6.14E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.86|P-value:8.91E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:3.79|P-value:1.17E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.47|P-value:3.78E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.51|P-value:3.28E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.22|P-value:8.93E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.31|P-value:1.44E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.43|P-value:4.37E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.29|P-value:6.95E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.70|P-value:1.62E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.72|P-value:1.54E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.87|P-value:8.47E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:7.83|P-value:1.46E-14 ID:SGTC_1724|Compound:st037281|FD-Score:3.35|P-value:5.81E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.30|P-value:6.82E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.55|P-value:2.80E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.63|P-value:2.13E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.47|P-value:3.78E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.50|P-value:3.41E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.46|P-value:3.89E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.78|P-value:1.23E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.73|P-value:2.18E-6 ID:SGTC_2944|Compound:9067346|FD-Score:3.62|P-value:2.18E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.22|P-value:8.99E-4 ID:SGTC_3140|Compound:9094243|FD-Score:6.79|P-value:2.17E-11 ID:SGTC_3145|Compound:9085516|FD-Score:4.12|P-value:3.21E-5 ID:SGTC_3242|Compound:9133940|FD-Score:-3.24|P-value:8.43E-4

Top fitness defect scores for YER073W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1718 roemerine 7.83 11.9 µM 1.46E-14 redox potentiating 9 2.42E-15
2 SGTC_3140 9094243 6.79 49.5 µM 2.17E-11 4 5.57E-12
3 SGTC_504 lovastatin 5.16 124.0 µM 2.80E-7 4 1.27E-7
4 SGTC_165 k038-0023 4.81 64.4 µM 1.52E-6 ubiquinone biosynthesis & proteasome 48 7.59E-7
5 SGTC_2931 9014674 4.73 55.7 µM 2.18E-6 10 1.11E-6
6 SGTC_1362 1611-0397 4.31 101.0 µM 1.44E-5 13 8.18E-6
7 SGTC_3145 9085516 4.12 49.5 µM 3.21E-5 fatty acid desaturase (OLE1) 24 1.92E-5
8 SGTC_695 3505-6186 3.96 243.0 µM 6.14E-5 23 3.81E-5
9 SGTC_977 1348-1378 3.86 135.0 µM 8.91E-5 25 5.64E-5
10 SGTC_660 4031-1742 3.84 102.0 µM 9.70E-5 redox potentiating 51 6.18E-5
11 SGTC_984 1492-0255 3.79 2.9 µM 1.17E-4 SWF1 & branched chain AA biosynthesis 31 7.56E-5
12 SGTC_2800 7887935 3.78 81.8 µM 1.23E-4 RPP1 & pyrimidine depletion 40 7.92E-5
13 SGTC_1703 st026983 3.70 48.3 µM 1.62E-4 13 1.06E-4
14 SGTC_2944 9067346 3.62 25.6 µM 2.18E-4 35 1.45E-4
15 SGTC_1915 st067105 3.55 30.6 µM 2.80E-4 RNA pol III & RNase P/MRP 62 1.89E-4
16 SGTC_1164 k060-0068 3.51 93.7 µM 3.28E-4 44 2.24E-4
17 SGTC_2383 9036125 3.47 200.0 µM 3.78E-4 13 2.60E-4
18 SGTC_2595 hexamethylquercetagetin 3.46 100.0 µM 3.89E-4 43 2.68E-4
19 SGTC_1724 st037281 3.35 8.3 µM 5.81E-4 68 4.10E-4
20 SGTC_560 2332-1943 3.32 155.0 µM 6.31E-4 26 4.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.05E-22 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.140 4.66E-16 YGR144W THI4 hom Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents
0.133 1.02E-14 YDL178W DLD2 hom D-lactate dehydrogenase, located in the mitochondrial matrix
0.117 1.03E-11 YLR329W REC102 hom Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
0.115 2.18E-11 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.113 6.07E-11 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.111 1.15E-10 YDR520C_p URC2_p hom Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism
0.110 1.65E-10 YDR018C_p YDR018C_p hom Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication
0.095 3.22E-8 YDR513W GRX2 hom Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication
0.094 5.45E-8 YDR284C DPP1 hom Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
0.093 6.98E-8 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.091 1.33E-7 YFR021W ATG18 hom Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
0.091 1.39E-7 YDL127W PCL2 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth
0.090 2.03E-7 YBR247C ENP1 het Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
0.086 5.99E-7 YMR295C YMR295C hom Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene; protein abundance increases in response to DNA replication stress