YER091C-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YER091C-A / YER091C-A

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:5.30|P-value:2.74E-7 ID:SGTC_41|Compound:0478-0632|FD-Score:3.64|P-value:2.90E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.12|P-value:4.50E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-3.30|P-value:8.36E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.11|P-value:5.18E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:4.91|P-value:1.74E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:3.59|P-value:3.50E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.37|P-value:1.79E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:5.27|P-value:3.19E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:3.44|P-value:5.87E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.28|P-value:9.80E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.91|P-value:1.10E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.44|P-value:5.80E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.62|P-value:3.09E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.84|P-value:1.44E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:4.91|P-value:1.76E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:-4.15|P-value:3.97E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.75|P-value:1.95E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.65|P-value:2.86E-4 ID:SGTC_1675|Compound:st018485|FD-Score:9.14|P-value:2.44E-18 ID:SGTC_1771|Compound:st048882|FD-Score:3.53|P-value:4.23E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.85|P-value:1.36E-4 ID:SGTC_1949|Compound:st076024|FD-Score:5.24|P-value:3.67E-7 ID:SGTC_2020|Compound:4017018|FD-Score:-3.69|P-value:2.23E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.23|P-value:3.23E-5 ID:SGTC_2267|Compound:7931562|FD-Score:3.49|P-value:4.95E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.48|P-value:5.13E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.34|P-value:7.37E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.90|P-value:1.06E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.86|P-value:1.31E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.57|P-value:7.88E-6 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.40|P-value:6.67E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.41|P-value:1.54E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.83|P-value:1.48E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.12|P-value:4.50E-5 ID:SGTC_2968|Compound:9090663|FD-Score:4.00|P-value:7.87E-5 ID:SGTC_2973|Compound:9094665|FD-Score:4.62|P-value:6.35E-6 ID:SGTC_2984|Compound:9022109|FD-Score:3.81|P-value:1.61E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-4.66|P-value:4.68E-6 ID:SGTC_3028|Compound:9087778|FD-Score:4.04|P-value:6.73E-5 ID:SGTC_3100|Compound:9120536|FD-Score:4.07|P-value:5.93E-5 ID:SGTC_3101|Compound:9120531|FD-Score:3.33|P-value:8.21E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-5.48|P-value:9.61E-8 ID:SGTC_3304|Compound:9125678|FD-Score:-3.60|P-value:3.04E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:5.30|P-value:2.74E-7 ID:SGTC_41|Compound:0478-0632|FD-Score:3.64|P-value:2.90E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.12|P-value:4.50E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-3.30|P-value:8.36E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.11|P-value:5.18E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:4.91|P-value:1.74E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:3.59|P-value:3.50E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.37|P-value:1.79E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:5.27|P-value:3.19E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:3.44|P-value:5.87E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.28|P-value:9.80E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.91|P-value:1.10E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.44|P-value:5.80E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.62|P-value:3.09E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.84|P-value:1.44E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:4.91|P-value:1.76E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:-4.15|P-value:3.97E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.75|P-value:1.95E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.65|P-value:2.86E-4 ID:SGTC_1675|Compound:st018485|FD-Score:9.14|P-value:2.44E-18 ID:SGTC_1771|Compound:st048882|FD-Score:3.53|P-value:4.23E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.85|P-value:1.36E-4 ID:SGTC_1949|Compound:st076024|FD-Score:5.24|P-value:3.67E-7 ID:SGTC_2020|Compound:4017018|FD-Score:-3.69|P-value:2.23E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.23|P-value:3.23E-5 ID:SGTC_2267|Compound:7931562|FD-Score:3.49|P-value:4.95E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.48|P-value:5.13E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.34|P-value:7.37E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.90|P-value:1.06E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.86|P-value:1.31E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.57|P-value:7.88E-6 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.40|P-value:6.67E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.41|P-value:1.54E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.83|P-value:1.48E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.12|P-value:4.50E-5 ID:SGTC_2968|Compound:9090663|FD-Score:4.00|P-value:7.87E-5 ID:SGTC_2973|Compound:9094665|FD-Score:4.62|P-value:6.35E-6 ID:SGTC_2984|Compound:9022109|FD-Score:3.81|P-value:1.61E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-4.66|P-value:4.68E-6 ID:SGTC_3028|Compound:9087778|FD-Score:4.04|P-value:6.73E-5 ID:SGTC_3100|Compound:9120536|FD-Score:4.07|P-value:5.93E-5 ID:SGTC_3101|Compound:9120531|FD-Score:3.33|P-value:8.21E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-5.48|P-value:9.61E-8 ID:SGTC_3304|Compound:9125678|FD-Score:-3.60|P-value:3.04E-4

Top fitness defect scores for YER091C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1675 st018485 9.14 24.5 µM 2.44E-18 60S ribosome export 1 2.98E-20
2 SGTC_24 0417-1663 5.30 219.0 µM 2.74E-7 8 5.90E-8
3 SGTC_686 1319-0111 5.27 510.0 µM 3.19E-7 60S ribosome export 6 6.99E-8
4 SGTC_1949 st076024 5.24 69.1 µM 3.67E-7 9 8.16E-8
5 SGTC_530 4358-1714 4.91 28.0 µM 1.74E-6 18 4.60E-7
6 SGTC_1323 1348-1351 4.91 11.2 µM 1.76E-6 2 4.65E-7
7 SGTC_2973 9094665 4.62 18.0 µM 6.35E-6 NEO1 21 1.94E-6
8 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 4.57 100.0 µM 7.88E-6 21 2.46E-6
9 SGTC_2684 capsaicin 4.41 100.0 µM 1.54E-5 15 5.18E-6
10 SGTC_536 3852-0578 4.37 10.6 µM 1.79E-5 18 6.13E-6
11 SGTC_2163 5671233 4.23 125.0 µM 3.23E-5 19 1.18E-5
12 SGTC_527 4476-4215 4.11 268.0 µM 5.18E-5 PDR1 29 2.00E-5
13 SGTC_3100 9120536 4.07 49.5 µM 5.93E-5 11 2.32E-5
14 SGTC_3028 9087778 4.04 49.5 µM 6.73E-5 11 2.67E-5
15 SGTC_2968 9090663 4.00 33.4 µM 7.87E-5 27 3.17E-5
16 SGTC_726 3448-4391 3.91 34.2 µM 1.10E-4 13 4.59E-5
17 SGTC_2524 avocatin b 3.86 10.6 µM 1.31E-4 25 5.61E-5
18 SGTC_1936 st074407 3.85 74.3 µM 1.36E-4 DNA damage response 39 5.84E-5
19 SGTC_1226 3909-7979 3.84 35.4 µM 1.44E-4 41 6.20E-5
20 SGTC_2811 7967822 3.83 32.5 µM 1.48E-4 24 6.38E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 3.59E-9 YLR437C DIF1 hom Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein
0.090 1.52E-7 YBR032W_d YBR032W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.088 3.73E-7 YHR170W NMD3 het Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
0.079 4.25E-6 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.077 8.77E-6 YNL045W LAP2 hom Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.076 1.06E-5 YBR114W RAD16 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.076 1.18E-5 YPR152C URN1 hom Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase
0.075 1.43E-5 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.075 1.48E-5 YHR094C HXT1 hom Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication
0.070 4.86E-5 YCR082W AHC2 hom Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex
0.069 5.89E-5 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.069 6.91E-5 YAL046C AIM1 hom Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss
0.068 7.60E-5 YOL082W ATG19 hom Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles
0.068 8.73E-5 YNR034W SOL1 hom Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.068 8.78E-5 YER184C_p YER184C_p hom Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source