YER164W / CHD1

Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes

Zygosity: Homozygous strain
fixedexpanded
Profile for YER164W / CHD1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.64|P-value:4.39E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.08|P-value:9.53E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.43|P-value:8.12E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.59|P-value:5.19E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.06|P-value:1.03E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:4.76|P-value:6.81E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.95|P-value:1.49E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.83|P-value:2.20E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.93|P-value:1.64E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.20|P-value:6.04E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:5.03|P-value:2.06E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.82|P-value:2.31E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.67|P-value:3.97E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.44|P-value:8.33E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.61|P-value:4.84E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.82|P-value:5.12E-6 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.25|P-value:5.06E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:-4.09|P-value:8.63E-5 ID:SGTC_1602|Compound:st001878|FD-Score:3.64|P-value:4.44E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.42|P-value:2.64E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.15|P-value:7.48E-5 ID:SGTC_1702|Compound:st027038|FD-Score:4.00|P-value:1.29E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.37|P-value:4.43E-7 ID:SGTC_1738|Compound:st035555|FD-Score:3.42|P-value:8.75E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.93|P-value:1.65E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.43|P-value:2.56E-5 ID:SGTC_1902|Compound:st060212|FD-Score:3.50|P-value:6.89E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.60|P-value:4.93E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.67|P-value:3.98E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.98|P-value:1.36E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.12|P-value:8.26E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.91|P-value:1.73E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-3.75|P-value:2.88E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.82|P-value:2.29E-4 ID:SGTC_2239|Compound:6685329|FD-Score:5.09|P-value:1.63E-6 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.60|P-value:1.28E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.77|P-value:2.72E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.86|P-value:4.42E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:6.27|P-value:4.85E-9 ID:SGTC_2601|Compound:securinine|FD-Score:3.71|P-value:3.47E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.76|P-value:6.56E-6 ID:SGTC_2643|Compound:anethole|FD-Score:3.73|P-value:3.30E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.41|P-value:9.10E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.41|P-value:8.65E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.02|P-value:1.19E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.41|P-value:8.64E-4 ID:SGTC_2996|Compound:9066192|FD-Score:9.18|P-value:2.20E-17 ID:SGTC_2998|Compound:9066762|FD-Score:-4.36|P-value:3.19E-5 ID:SGTC_3075|Compound:9116269|FD-Score:5.16|P-value:1.18E-6 ID:SGTC_3127|Compound:9126946|FD-Score:4.88|P-value:4.08E-6 ID:SGTC_3152|Compound:9099253|FD-Score:7.20|P-value:2.27E-11 ID:SGTC_3157|Compound:9099274|FD-Score:-6.48|P-value:1.40E-9 ID:SGTC_3158|Compound:9100007|FD-Score:4.26|P-value:4.85E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.40|P-value:9.28E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.83|P-value:2.30E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.64|P-value:4.39E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.08|P-value:9.53E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.43|P-value:8.12E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.59|P-value:5.19E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.06|P-value:1.03E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:4.76|P-value:6.81E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.95|P-value:1.49E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.83|P-value:2.20E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.93|P-value:1.64E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.20|P-value:6.04E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:5.03|P-value:2.06E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.82|P-value:2.31E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.67|P-value:3.97E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.44|P-value:8.33E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.61|P-value:4.84E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.82|P-value:5.12E-6 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.25|P-value:5.06E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:-4.09|P-value:8.63E-5 ID:SGTC_1602|Compound:st001878|FD-Score:3.64|P-value:4.44E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.42|P-value:2.64E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.15|P-value:7.48E-5 ID:SGTC_1702|Compound:st027038|FD-Score:4.00|P-value:1.29E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.37|P-value:4.43E-7 ID:SGTC_1738|Compound:st035555|FD-Score:3.42|P-value:8.75E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.93|P-value:1.65E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.43|P-value:2.56E-5 ID:SGTC_1902|Compound:st060212|FD-Score:3.50|P-value:6.89E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.60|P-value:4.93E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.67|P-value:3.98E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.98|P-value:1.36E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.12|P-value:8.26E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.91|P-value:1.73E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-3.75|P-value:2.88E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.82|P-value:2.29E-4 ID:SGTC_2239|Compound:6685329|FD-Score:5.09|P-value:1.63E-6 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.60|P-value:1.28E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.77|P-value:2.72E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.86|P-value:4.42E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:6.27|P-value:4.85E-9 ID:SGTC_2601|Compound:securinine|FD-Score:3.71|P-value:3.47E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.76|P-value:6.56E-6 ID:SGTC_2643|Compound:anethole|FD-Score:3.73|P-value:3.30E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.41|P-value:9.10E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.41|P-value:8.65E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.02|P-value:1.19E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.41|P-value:8.64E-4 ID:SGTC_2996|Compound:9066192|FD-Score:9.18|P-value:2.20E-17 ID:SGTC_2998|Compound:9066762|FD-Score:-4.36|P-value:3.19E-5 ID:SGTC_3075|Compound:9116269|FD-Score:5.16|P-value:1.18E-6 ID:SGTC_3127|Compound:9126946|FD-Score:4.88|P-value:4.08E-6 ID:SGTC_3152|Compound:9099253|FD-Score:7.20|P-value:2.27E-11 ID:SGTC_3157|Compound:9099274|FD-Score:-6.48|P-value:1.40E-9 ID:SGTC_3158|Compound:9100007|FD-Score:4.26|P-value:4.85E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.40|P-value:9.28E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.83|P-value:2.30E-4

Top fitness defect scores for YER164W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2996 9066192 9.18 71.4 µM 2.20E-17 2 2.17E-20
2 SGTC_3152 9099253 7.20 49.5 µM 2.27E-11 NEO1-PIK1 39 3.10E-13
3 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 6.27 100.0 µM 4.85E-9 4 1.81E-10
4 SGTC_1707 st032323 5.37 6.3 µM 4.43E-7 DNA damage response 28 3.86E-8
5 SGTC_3075 9116269 5.16 49.5 µM 1.18E-6 7 1.24E-7
6 SGTC_2239 6685329 5.09 187.6 µM 1.63E-6 8 1.81E-7
7 SGTC_684 1140-0066 5.03 328.0 µM 2.06E-6 Golgi 9 2.39E-7
8 SGTC_3127 9126946 4.88 49.5 µM 4.08E-6 ERG2 7 5.38E-7
9 SGTC_2575 plumbagin 4.86 510.0 nM 4.42E-6 superoxide 21 5.91E-7
10 SGTC_1279 0874-0590 4.82 65.2 µM 5.12E-6 19 7.04E-7
11 SGTC_2617 dihydrotanshinone i 4.76 20.8 µM 6.56E-6 copper-dependent oxidative stress 16 9.45E-7
12 SGTC_370 0180-0345 4.76 38.7 µM 6.81E-6 DNA intercalators 6 9.88E-7
13 SGTC_2512 diallyl trisulfide 4.60 49.2 µM 1.28E-5 2 2.08E-6
14 SGTC_1844 rapamycin 4.43 4.0 nM 2.56E-5 132 4.75E-6
15 SGTC_1613 st002381 4.42 52.1 µM 2.64E-5 14 4.93E-6
16 SGTC_3158 9100007 4.26 49.5 µM 4.85E-5 13 1.01E-5
17 SGTC_1339 1486-1321 4.25 22.7 µM 5.06E-5 ERG2 13 1.06E-5
18 SGTC_625 k213-0058 4.20 121.0 µM 6.04E-5 translation 90 1.31E-5
19 SGTC_1616 st002734 4.15 56.1 µM 7.48E-5 25 1.69E-5
20 SGTC_2054 5233173 4.12 129.0 µM 8.26E-5 mitochondrial response to ROS 49 1.90E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 5.99E-19 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.103 1.86E-9 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.103 2.46E-9 YDL083C RPS16B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication
0.101 5.08E-9 YOR141C ARP8 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
0.097 1.95E-8 YLL061W MMP1 hom High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
0.092 8.09E-8 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.092 8.29E-8 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.092 1.08E-7 YBR088C POL30 het Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
0.088 3.40E-7 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.087 4.95E-7 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.084 1.11E-6 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.084 1.14E-6 YCR051W_p YCR051W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene
0.083 1.47E-6 YBL071C_d YBL071C_d hom Dubious open reading frame, predicted protein contains a peroxisomal targeting signal
0.082 2.11E-6 YLL026W HSP104 hom Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.079 4.82E-6 YJL187C SWE1 hom Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate