YER184C_p

Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source

Zygosity: Homozygous strain
fixedexpanded
Profile for YER184C / YER184C

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:3.40|P-value:4.41E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.14|P-value:9.32E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.14|P-value:2.48E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:3.87|P-value:7.52E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:3.26|P-value:7.10E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.89|P-value:7.02E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.48|P-value:2.80E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.38|P-value:9.03E-6 ID:SGTC_459|Compound:nigericin|FD-Score:3.29|P-value:6.43E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:4.19|P-value:2.01E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:3.58|P-value:2.35E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:6.76|P-value:1.64E-11 ID:SGTC_845|Compound:0330-0138|FD-Score:3.90|P-value:6.79E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:4.56|P-value:3.95E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:4.08|P-value:3.31E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.27|P-value:7.04E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.25|P-value:7.33E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.15|P-value:2.41E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.66|P-value:1.68E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.23|P-value:8.02E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.20|P-value:8.82E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:6.64|P-value:3.72E-11 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.34|P-value:5.47E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.48|P-value:3.36E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.51|P-value:3.01E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.41|P-value:4.29E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.57|P-value:2.37E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.27|P-value:7.07E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.93|P-value:6.11E-5 ID:SGTC_1950|Compound:st077106|FD-Score:4.19|P-value:2.07E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.38|P-value:4.71E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.62|P-value:1.98E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.27|P-value:1.48E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.24|P-value:7.83E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.32|P-value:4.95E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.40|P-value:4.43E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.91|P-value:6.61E-5 ID:SGTC_2792|Compound:7535235|FD-Score:5.64|P-value:1.65E-8 ID:SGTC_2793|Compound:7325131|FD-Score:3.83|P-value:8.98E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.32|P-value:5.96E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.12|P-value:9.99E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.39|P-value:6.47E-8 ID:SGTC_2975|Compound:9084847|FD-Score:4.54|P-value:4.31E-6 ID:SGTC_2989|Compound:9073649|FD-Score:3.25|P-value:7.37E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.41|P-value:3.65E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.40|P-value:4.41E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.14|P-value:9.32E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.14|P-value:2.48E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:3.87|P-value:7.52E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:3.26|P-value:7.10E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.89|P-value:7.02E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.48|P-value:2.80E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.38|P-value:9.03E-6 ID:SGTC_459|Compound:nigericin|FD-Score:3.29|P-value:6.43E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:4.19|P-value:2.01E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:3.58|P-value:2.35E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:6.76|P-value:1.64E-11 ID:SGTC_845|Compound:0330-0138|FD-Score:3.90|P-value:6.79E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:4.56|P-value:3.95E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:4.08|P-value:3.31E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.27|P-value:7.04E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.25|P-value:7.33E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.15|P-value:2.41E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.66|P-value:1.68E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.23|P-value:8.02E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.20|P-value:8.82E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:6.64|P-value:3.72E-11 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.34|P-value:5.47E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.48|P-value:3.36E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.51|P-value:3.01E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.41|P-value:4.29E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.57|P-value:2.37E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.27|P-value:7.07E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.93|P-value:6.11E-5 ID:SGTC_1950|Compound:st077106|FD-Score:4.19|P-value:2.07E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.38|P-value:4.71E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.62|P-value:1.98E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.27|P-value:1.48E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.24|P-value:7.83E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.32|P-value:4.95E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.40|P-value:4.43E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.91|P-value:6.61E-5 ID:SGTC_2792|Compound:7535235|FD-Score:5.64|P-value:1.65E-8 ID:SGTC_2793|Compound:7325131|FD-Score:3.83|P-value:8.98E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.32|P-value:5.96E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.12|P-value:9.99E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.39|P-value:6.47E-8 ID:SGTC_2975|Compound:9084847|FD-Score:4.54|P-value:4.31E-6 ID:SGTC_2989|Compound:9073649|FD-Score:3.25|P-value:7.37E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.41|P-value:3.65E-4

Top fitness defect scores for YER184C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_645 0845-0943 6.76 5.4 µM 1.64E-11 60S ribosome export 1 6.81E-12
2 SGTC_1449 4112-4002 6.64 201.0 µM 3.72E-11 RPP1 & pyrimidine depletion 4 1.59E-11
3 SGTC_2792 7535235 5.64 81.8 µM 1.65E-8 fatty acid desaturase (OLE1) 11 8.71E-9
4 SGTC_2968 9090663 5.39 33.4 µM 6.47E-8 11 3.59E-8
5 SGTC_850 0388-0143 4.56 75.9 µM 3.95E-6 7 2.53E-6
6 SGTC_2975 9084847 4.54 53.7 µM 4.31E-6 12 2.78E-6
7 SGTC_431 k089-0097 4.38 107.0 µM 9.03E-6 iron homeostasis 25 5.97E-6
8 SGTC_2163 5671233 4.27 125.0 µM 1.48E-5 16 9.96E-6
9 SGTC_590 k048-0076 4.19 22.4 µM 2.01E-5 RSC & ERG11 10 1.37E-5
10 SGTC_1950 st077106 4.19 7.2 µM 2.07E-5 RNA processing & uracil transport 23 1.41E-5
11 SGTC_1357 1503-1303 4.15 39.5 µM 2.41E-5 25 1.65E-5
12 SGTC_68 0986-0284 4.14 82.8 µM 2.48E-5 61 1.70E-5
13 SGTC_932 2857-0803 4.08 154.0 µM 3.31E-5 24 2.29E-5
14 SGTC_1949 st076024 3.93 69.1 µM 6.11E-5 25 4.32E-5
15 SGTC_2749 bexarotene 3.91 57.4 µM 6.61E-5 25 4.70E-5
16 SGTC_845 0330-0138 3.90 4.5 µM 6.79E-5 18 4.83E-5
17 SGTC_421 streptovitacin 3.89 30.0 mM 7.02E-5 23 5.00E-5
18 SGTC_319 1348-1596 3.87 45.5 µM 7.52E-5 RSC & ERG11 21 5.36E-5
19 SGTC_2793 7325131 3.83 81.8 µM 8.98E-5 18 6.45E-5
20 SGTC_2364 9055074 3.78 200.0 µM 1.10E-4 23 7.95E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.96E-10 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.098 1.10E-8 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.097 2.03E-8 YIL086C_d YIL086C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 7.76E-8 YOL138C RTC1 hom Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif
0.092 9.43E-8 YJL119C_d YJL119C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.94E-7 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.082 2.07E-6 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.076 1.04E-5 YGR232W NAS6 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
0.076 1.15E-5 YPR025C CCL1 het Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
0.076 1.16E-5 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.074 1.68E-5 YCR091W KIN82 hom Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p
0.071 3.52E-5 YLR303W MET17 hom Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis
0.070 4.50E-5 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.070 4.63E-5 YMR226C YMR226C hom NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments
0.069 7.12E-5 YPR052C NHP6A hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress