YFR037C / RSC8

Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFR037C / RSC8

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:6.98|P-value:4.97E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:7.97|P-value:2.36E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:5.19|P-value:4.92E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:9.11|P-value:4.40E-9 ID:SGTC_69|Compound:0096-0274|FD-Score:8.91|P-value:9.35E-9 ID:SGTC_86|Compound:0417-1630|FD-Score:7.72|P-value:5.26E-7 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.23|P-value:4.52E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.98|P-value:5.01E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:5.54|P-value:2.19E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:9.25|P-value:2.62E-9 ID:SGTC_158|Compound:k038-0087|FD-Score:8.07|P-value:1.69E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:8.74|P-value:1.70E-8 ID:SGTC_203|Compound:k066-0004|FD-Score:4.87|P-value:9.92E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:8.33|P-value:7.17E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.77|P-value:1.26E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:15.50|P-value:7.18E-23 ID:SGTC_237|Compound:nikkomycin|FD-Score:10.20|P-value:5.47E-11 ID:SGTC_248|Compound:streptozotocin|FD-Score:10.50|P-value:1.52E-11 ID:SGTC_257|Compound:daunorubicin|FD-Score:8.95|P-value:8.01E-9 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:5.50|P-value:2.42E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:8.91|P-value:9.41E-9 ID:SGTC_272|Compound:doxorubicin|FD-Score:6.24|P-value:3.89E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:5.68|P-value:1.58E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:6.00|P-value:7.10E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:5.67|P-value:1.63E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:5.05|P-value:6.74E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:5.03|P-value:7.07E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:6.86|P-value:7.06E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:5.02|P-value:7.22E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:5.66|P-value:1.67E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:5.15|P-value:5.37E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.12|P-value:5.71E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:4.92|P-value:8.84E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:6.21|P-value:4.22E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:19.40|P-value:1.79E-34 ID:SGTC_673|Compound:1082-0474|FD-Score:11.10|P-value:1.20E-12 ID:SGTC_709|Compound:3807-1509|FD-Score:9.84|P-value:2.74E-10 ID:SGTC_746|Compound:1095-0025|FD-Score:5.59|P-value:1.95E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:5.72|P-value:1.42E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:5.01|P-value:7.26E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:8.97|P-value:7.45E-9 ID:SGTC_885|Compound:0865-0106|FD-Score:7.20|P-value:2.62E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:6.80|P-value:8.35E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:6.52|P-value:1.81E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:8.44|P-value:4.83E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.33|P-value:3.05E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.77|P-value:1.28E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:8.30|P-value:7.89E-8 ID:SGTC_1133|Compound:3473-0247|FD-Score:8.15|P-value:1.31E-7 ID:SGTC_1168|Compound:k815-0004|FD-Score:8.58|P-value:3.02E-8 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.11|P-value:5.86E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:5.95|P-value:8.09E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.70|P-value:1.49E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:5.96|P-value:7.91E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:10.80|P-value:5.50E-12 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.91|P-value:6.20E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.97|P-value:7.91E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-5.13|P-value:7.66E-4 ID:SGTC_1651|Compound:st011928|FD-Score:7.90|P-value:3.02E-7 ID:SGTC_1652|Compound:st011932|FD-Score:14.00|P-value:7.65E-19 ID:SGTC_1693|Compound:xanthone|FD-Score:9.98|P-value:1.56E-10 ID:SGTC_1707|Compound:st032323|FD-Score:10.40|P-value:3.07E-11 ID:SGTC_1803|Compound:st050068|FD-Score:7.09|P-value:3.62E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.00|P-value:7.51E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.79|P-value:8.69E-6 ID:SGTC_1915|Compound:st067105|FD-Score:5.28|P-value:4.00E-4 ID:SGTC_1936|Compound:st074407|FD-Score:5.13|P-value:5.62E-4 ID:SGTC_1952|Compound:st077036|FD-Score:5.32|P-value:3.66E-4 ID:SGTC_1991|Compound:st073000|FD-Score:7.21|P-value:2.56E-6 ID:SGTC_1992|Compound:st073643|FD-Score:4.92|P-value:8.85E-4 ID:SGTC_2029|Compound:5175081|FD-Score:7.20|P-value:2.63E-6 ID:SGTC_2038|Compound:4100038|FD-Score:-5.67|P-value:2.30E-4 ID:SGTC_2041|Compound:5107442|FD-Score:14.20|P-value:1.93E-19 ID:SGTC_2043|Compound:5101342|FD-Score:6.16|P-value:4.82E-5 ID:SGTC_2051|Compound:5263410|FD-Score:8.04|P-value:1.91E-7 ID:SGTC_2056|Compound:5235370|FD-Score:-12.30|P-value:7.93E-15 ID:SGTC_2092|Compound:5303694|FD-Score:5.41|P-value:3.02E-4 ID:SGTC_2109|Compound:5483026|FD-Score:9.88|P-value:2.29E-10 ID:SGTC_2111|Compound:5486399|FD-Score:7.62|P-value:7.33E-7 ID:SGTC_2180|Compound:6301957|FD-Score:6.29|P-value:3.36E-5 ID:SGTC_2186|Compound:6124449|FD-Score:14.00|P-value:5.46E-19 ID:SGTC_2225|Compound:6654152|FD-Score:12.30|P-value:3.78E-15 ID:SGTC_2229|Compound:7354935|FD-Score:9.84|P-value:2.69E-10 ID:SGTC_2233|Compound:sulbentine|FD-Score:12.00|P-value:1.92E-14 ID:SGTC_2336|Compound:9001819|FD-Score:7.93|P-value:2.67E-7 ID:SGTC_2344|Compound:7990960|FD-Score:9.27|P-value:2.47E-9 ID:SGTC_2346|Compound:9031566|FD-Score:8.97|P-value:7.35E-9 ID:SGTC_2348|Compound:9022543|FD-Score:13.50|P-value:1.10E-17 ID:SGTC_2361|Compound:9034121|FD-Score:11.40|P-value:4.14E-13 ID:SGTC_2375|Compound:9072683|FD-Score:7.39|P-value:1.49E-6 ID:SGTC_2378|Compound:9074213|FD-Score:13.20|P-value:5.25E-17 ID:SGTC_2387|Compound:9077560|FD-Score:7.21|P-value:2.52E-6 ID:SGTC_2396|Compound:5342950|FD-Score:5.23|P-value:4.47E-4 ID:SGTC_2400|Compound:5203494|FD-Score:6.52|P-value:1.81E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.47|P-value:2.62E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:10.60|P-value:1.05E-11 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:6.66|P-value:1.26E-5 ID:SGTC_2534|Compound:helenine|FD-Score:12.90|P-value:2.27E-16 ID:SGTC_2544|Compound:sphondin|FD-Score:10.30|P-value:4.91E-11 ID:SGTC_2575|Compound:plumbagin|FD-Score:9.95|P-value:1.72E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:5.15|P-value:5.39E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.99|P-value:7.61E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:6.78|P-value:9.00E-6 ID:SGTC_2830|Compound:7992007|FD-Score:5.21|P-value:4.72E-4 ID:SGTC_2890|Compound:9046729|FD-Score:6.44|P-value:2.27E-5 ID:SGTC_2912|Compound:7964298|FD-Score:13.60|P-value:6.32E-18 ID:SGTC_2928|Compound:9011484|FD-Score:5.05|P-value:6.70E-4 ID:SGTC_2930|Compound:9013230|FD-Score:10.10|P-value:1.08E-10 ID:SGTC_2962|Compound:9082311|FD-Score:7.07|P-value:3.87E-6 ID:SGTC_2974|Compound:9094440|FD-Score:5.17|P-value:5.12E-4 ID:SGTC_3120|Compound:9124077|FD-Score:4.92|P-value:8.82E-4 ID:SGTC_3285|Compound:9112818|FD-Score:6.11|P-value:5.45E-5 ID:SGTC_3288|Compound:9119690|FD-Score:9.94|P-value:1.84E-10 ID:SGTC_3304|Compound:9125678|FD-Score:10.60|P-value:1.40E-11 ID:SGTC_3321|Compound:9137793|FD-Score:9.47|P-value:1.15E-9 ID:SGTC_16|Compound:erodoxin|FD-Score:6.98|P-value:4.97E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:7.97|P-value:2.36E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:5.19|P-value:4.92E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:9.11|P-value:4.40E-9 ID:SGTC_69|Compound:0096-0274|FD-Score:8.91|P-value:9.35E-9 ID:SGTC_86|Compound:0417-1630|FD-Score:7.72|P-value:5.26E-7 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.23|P-value:4.52E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.98|P-value:5.01E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:5.54|P-value:2.19E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:9.25|P-value:2.62E-9 ID:SGTC_158|Compound:k038-0087|FD-Score:8.07|P-value:1.69E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:8.74|P-value:1.70E-8 ID:SGTC_203|Compound:k066-0004|FD-Score:4.87|P-value:9.92E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:8.33|P-value:7.17E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.77|P-value:1.26E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:15.50|P-value:7.18E-23 ID:SGTC_237|Compound:nikkomycin|FD-Score:10.20|P-value:5.47E-11 ID:SGTC_248|Compound:streptozotocin|FD-Score:10.50|P-value:1.52E-11 ID:SGTC_257|Compound:daunorubicin|FD-Score:8.95|P-value:8.01E-9 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:5.50|P-value:2.42E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:8.91|P-value:9.41E-9 ID:SGTC_272|Compound:doxorubicin|FD-Score:6.24|P-value:3.89E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:5.68|P-value:1.58E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:6.00|P-value:7.10E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:5.67|P-value:1.63E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:5.05|P-value:6.74E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:5.03|P-value:7.07E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:6.86|P-value:7.06E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:5.02|P-value:7.22E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:5.66|P-value:1.67E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:5.15|P-value:5.37E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.12|P-value:5.71E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:4.92|P-value:8.84E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:6.21|P-value:4.22E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:19.40|P-value:1.79E-34 ID:SGTC_673|Compound:1082-0474|FD-Score:11.10|P-value:1.20E-12 ID:SGTC_709|Compound:3807-1509|FD-Score:9.84|P-value:2.74E-10 ID:SGTC_746|Compound:1095-0025|FD-Score:5.59|P-value:1.95E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:5.72|P-value:1.42E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:5.01|P-value:7.26E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:8.97|P-value:7.45E-9 ID:SGTC_885|Compound:0865-0106|FD-Score:7.20|P-value:2.62E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:6.80|P-value:8.35E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:6.52|P-value:1.81E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:8.44|P-value:4.83E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.33|P-value:3.05E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.77|P-value:1.28E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:8.30|P-value:7.89E-8 ID:SGTC_1133|Compound:3473-0247|FD-Score:8.15|P-value:1.31E-7 ID:SGTC_1168|Compound:k815-0004|FD-Score:8.58|P-value:3.02E-8 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.11|P-value:5.86E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:5.95|P-value:8.09E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.70|P-value:1.49E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:5.96|P-value:7.91E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:10.80|P-value:5.50E-12 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.91|P-value:6.20E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.97|P-value:7.91E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-5.13|P-value:7.66E-4 ID:SGTC_1651|Compound:st011928|FD-Score:7.90|P-value:3.02E-7 ID:SGTC_1652|Compound:st011932|FD-Score:14.00|P-value:7.65E-19 ID:SGTC_1693|Compound:xanthone|FD-Score:9.98|P-value:1.56E-10 ID:SGTC_1707|Compound:st032323|FD-Score:10.40|P-value:3.07E-11 ID:SGTC_1803|Compound:st050068|FD-Score:7.09|P-value:3.62E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.00|P-value:7.51E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.79|P-value:8.69E-6 ID:SGTC_1915|Compound:st067105|FD-Score:5.28|P-value:4.00E-4 ID:SGTC_1936|Compound:st074407|FD-Score:5.13|P-value:5.62E-4 ID:SGTC_1952|Compound:st077036|FD-Score:5.32|P-value:3.66E-4 ID:SGTC_1991|Compound:st073000|FD-Score:7.21|P-value:2.56E-6 ID:SGTC_1992|Compound:st073643|FD-Score:4.92|P-value:8.85E-4 ID:SGTC_2029|Compound:5175081|FD-Score:7.20|P-value:2.63E-6 ID:SGTC_2038|Compound:4100038|FD-Score:-5.67|P-value:2.30E-4 ID:SGTC_2041|Compound:5107442|FD-Score:14.20|P-value:1.93E-19 ID:SGTC_2043|Compound:5101342|FD-Score:6.16|P-value:4.82E-5 ID:SGTC_2051|Compound:5263410|FD-Score:8.04|P-value:1.91E-7 ID:SGTC_2056|Compound:5235370|FD-Score:-12.30|P-value:7.93E-15 ID:SGTC_2092|Compound:5303694|FD-Score:5.41|P-value:3.02E-4 ID:SGTC_2109|Compound:5483026|FD-Score:9.88|P-value:2.29E-10 ID:SGTC_2111|Compound:5486399|FD-Score:7.62|P-value:7.33E-7 ID:SGTC_2180|Compound:6301957|FD-Score:6.29|P-value:3.36E-5 ID:SGTC_2186|Compound:6124449|FD-Score:14.00|P-value:5.46E-19 ID:SGTC_2225|Compound:6654152|FD-Score:12.30|P-value:3.78E-15 ID:SGTC_2229|Compound:7354935|FD-Score:9.84|P-value:2.69E-10 ID:SGTC_2233|Compound:sulbentine|FD-Score:12.00|P-value:1.92E-14 ID:SGTC_2336|Compound:9001819|FD-Score:7.93|P-value:2.67E-7 ID:SGTC_2344|Compound:7990960|FD-Score:9.27|P-value:2.47E-9 ID:SGTC_2346|Compound:9031566|FD-Score:8.97|P-value:7.35E-9 ID:SGTC_2348|Compound:9022543|FD-Score:13.50|P-value:1.10E-17 ID:SGTC_2361|Compound:9034121|FD-Score:11.40|P-value:4.14E-13 ID:SGTC_2375|Compound:9072683|FD-Score:7.39|P-value:1.49E-6 ID:SGTC_2378|Compound:9074213|FD-Score:13.20|P-value:5.25E-17 ID:SGTC_2387|Compound:9077560|FD-Score:7.21|P-value:2.52E-6 ID:SGTC_2396|Compound:5342950|FD-Score:5.23|P-value:4.47E-4 ID:SGTC_2400|Compound:5203494|FD-Score:6.52|P-value:1.81E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.47|P-value:2.62E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:10.60|P-value:1.05E-11 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:6.66|P-value:1.26E-5 ID:SGTC_2534|Compound:helenine|FD-Score:12.90|P-value:2.27E-16 ID:SGTC_2544|Compound:sphondin|FD-Score:10.30|P-value:4.91E-11 ID:SGTC_2575|Compound:plumbagin|FD-Score:9.95|P-value:1.72E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:5.15|P-value:5.39E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.99|P-value:7.61E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:6.78|P-value:9.00E-6 ID:SGTC_2830|Compound:7992007|FD-Score:5.21|P-value:4.72E-4 ID:SGTC_2890|Compound:9046729|FD-Score:6.44|P-value:2.27E-5 ID:SGTC_2912|Compound:7964298|FD-Score:13.60|P-value:6.32E-18 ID:SGTC_2928|Compound:9011484|FD-Score:5.05|P-value:6.70E-4 ID:SGTC_2930|Compound:9013230|FD-Score:10.10|P-value:1.08E-10 ID:SGTC_2962|Compound:9082311|FD-Score:7.07|P-value:3.87E-6 ID:SGTC_2974|Compound:9094440|FD-Score:5.17|P-value:5.12E-4 ID:SGTC_3120|Compound:9124077|FD-Score:4.92|P-value:8.82E-4 ID:SGTC_3285|Compound:9112818|FD-Score:6.11|P-value:5.45E-5 ID:SGTC_3288|Compound:9119690|FD-Score:9.94|P-value:1.84E-10 ID:SGTC_3304|Compound:9125678|FD-Score:10.60|P-value:1.40E-11 ID:SGTC_3321|Compound:9137793|FD-Score:9.47|P-value:1.15E-9

Top fitness defect scores for YFR037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_643 k048-0106 19.40 28.4 µM 1.79E-34 RSC & ERG11 2 4.56E-84 3.98
2 SGTC_227 fluconazole 15.50 33.5 µM 7.18E-23 azole & statin 7 9.54E-55 2.44
3 SGTC_2041 5107442 14.20 45.3 µM 1.93E-19 RSC complex & mRNA processing 2 4.20E-46 1.03
4 SGTC_2186 6124449 14.00 200.0 µM 5.46E-19 RSC complex & mRNA processing 3 5.78E-45 0.40
5 SGTC_1652 st011932 14.00 78.0 µM 7.65E-19 RSC complex & mRNA processing 7 1.35E-44 1.31
6 SGTC_2912 7964298 13.60 10.9 µM 6.32E-18 cell wall 7 2.75E-42 1.26
7 SGTC_2348 9022543 13.50 33.4 µM 1.10E-17 mitochondrial processes 4 1.11E-41 0.46
8 SGTC_2378 9074213 13.20 121.4 µM 5.25E-17 RSC complex & mRNA processing 2 5.66E-40 2.32
9 SGTC_2534 helenine 12.90 20.1 µM 2.27E-16 RSC complex & mRNA processing 2 2.24E-38 0.48
10 SGTC_2225 6654152 12.30 15.4 µM 3.78E-15 4 2.63E-35 0.58
11 SGTC_2233 sulbentine 12.00 40.4 µM 1.92E-14 6 1.57E-33 0.41
12 SGTC_2361 9034121 11.40 116.0 µM 4.14E-13 RSC complex & mRNA processing 1 3.45E-30 1.48
13 SGTC_673 1082-0474 11.10 110.0 µM 1.20E-12 RSC complex & mRNA processing 8 5.01E-29 0.82
14 SGTC_1374 2889-5571 10.80 141.0 µM 5.50E-12 RSC complex & mRNA processing 12 2.25E-27 0.99
15 SGTC_2408 sulbentine 10.60 18.4 µM 1.05E-11 3 1.13E-26 0.31
16 SGTC_3304 9125678 10.60 46.1 µM 1.40E-11 11 2.32E-26 0.98
17 SGTC_248 streptozotocin 10.50 5.2 mM 1.52E-11 DNA damage response 1 2.85E-26 1.85
18 SGTC_1707 st032323 10.40 6.3 µM 3.07E-11 DNA damage response 7 1.65E-25 0.14
19 SGTC_2544 sphondin 10.30 68.5 µM 4.91E-11 RNA pol III & RNase P/MRP 6 5.37E-25 1.51
20 SGTC_237 nikkomycin 10.20 200.0 µM 5.47E-11 RSC complex & mRNA processing 1 7.02E-25 2.46

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.707 0 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.644 0 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.521 2.51E-233 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.509 7.93E-221 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.482 3.18E-195 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.474 7.39E-188 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.441 1.28E-159 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.437 7.54E-156 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.424 1.10E-146 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.370 1.92E-109 YAL001C TFC3 het Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
0.353 2.67E-99 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.347 1.13E-95 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.343 3.06E-93 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.316 1.48E-78 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.305 2.16E-73 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress