YGL001C / ERG26

C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL001C / ERG26

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.33|P-value:1.96E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.03|P-value:6.35E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.04|P-value:5.92E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.39|P-value:1.53E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.32|P-value:2.66E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.05|P-value:5.72E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.51|P-value:9.60E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:3.78|P-value:2.97E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:5.76|P-value:5.00E-10 ID:SGTC_558|Compound:k064-0027|FD-Score:3.29|P-value:2.33E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:2.91|P-value:9.76E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.60|P-value:6.34E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.31|P-value:2.13E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.20|P-value:3.30E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.27|P-value:2.53E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.39|P-value:1.58E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.32|P-value:2.07E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.94|P-value:8.17E-8 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.50|P-value:8.92E-7 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.50|P-value:9.73E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.37|P-value:2.18E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-2.97|P-value:9.88E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-3.30|P-value:2.88E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.19|P-value:3.39E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.61|P-value:6.16E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.45|P-value:1.22E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.84|P-value:2.91E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.18|P-value:3.59E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:2.96|P-value:8.06E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.09|P-value:6.92E-6 ID:SGTC_1970|Compound:st070122|FD-Score:2.93|P-value:8.97E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.91|P-value:1.66E-5 ID:SGTC_2050|Compound:5263056|FD-Score:4.68|P-value:3.38E-7 ID:SGTC_2058|Compound:5236698|FD-Score:-3.14|P-value:5.21E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.77|P-value:3.00E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.03|P-value:6.31E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.65|P-value:5.22E-5 ID:SGTC_2472|Compound:5377652|FD-Score:4.60|P-value:5.31E-7 ID:SGTC_2486|Compound:5283202|FD-Score:3.17|P-value:3.73E-4 ID:SGTC_2517|Compound:totarol|FD-Score:15.80|P-value:4.54E-63 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.39|P-value:1.55E-6 ID:SGTC_2703|Compound:st077852|FD-Score:3.38|P-value:1.64E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.33|P-value:2.15E-6 ID:SGTC_2878|Compound:9043973|FD-Score:-3.22|P-value:3.93E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.60|P-value:6.57E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.81|P-value:2.55E-5 ID:SGTC_3324|Compound:9138759|FD-Score:3.12|P-value:4.43E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.46|P-value:1.18E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.33|P-value:1.96E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.03|P-value:6.35E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.04|P-value:5.92E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.39|P-value:1.53E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.32|P-value:2.66E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.05|P-value:5.72E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.51|P-value:9.60E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:3.78|P-value:2.97E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:5.76|P-value:5.00E-10 ID:SGTC_558|Compound:k064-0027|FD-Score:3.29|P-value:2.33E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:2.91|P-value:9.76E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.60|P-value:6.34E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.31|P-value:2.13E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.20|P-value:3.30E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.27|P-value:2.53E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.39|P-value:1.58E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.32|P-value:2.07E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.94|P-value:8.17E-8 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.50|P-value:8.92E-7 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.50|P-value:9.73E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.37|P-value:2.18E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-2.97|P-value:9.88E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-3.30|P-value:2.88E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.19|P-value:3.39E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.61|P-value:6.16E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.45|P-value:1.22E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.84|P-value:2.91E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.18|P-value:3.59E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:2.96|P-value:8.06E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.09|P-value:6.92E-6 ID:SGTC_1970|Compound:st070122|FD-Score:2.93|P-value:8.97E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.91|P-value:1.66E-5 ID:SGTC_2050|Compound:5263056|FD-Score:4.68|P-value:3.38E-7 ID:SGTC_2058|Compound:5236698|FD-Score:-3.14|P-value:5.21E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.77|P-value:3.00E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.03|P-value:6.31E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.65|P-value:5.22E-5 ID:SGTC_2472|Compound:5377652|FD-Score:4.60|P-value:5.31E-7 ID:SGTC_2486|Compound:5283202|FD-Score:3.17|P-value:3.73E-4 ID:SGTC_2517|Compound:totarol|FD-Score:15.80|P-value:4.54E-63 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.39|P-value:1.55E-6 ID:SGTC_2703|Compound:st077852|FD-Score:3.38|P-value:1.64E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.33|P-value:2.15E-6 ID:SGTC_2878|Compound:9043973|FD-Score:-3.22|P-value:3.93E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.60|P-value:6.57E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.81|P-value:2.55E-5 ID:SGTC_3324|Compound:9138759|FD-Score:3.12|P-value:4.43E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.46|P-value:1.18E-4

Top fitness defect scores for YGL001C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2517 totarol 15.80 10.0 µM 4.54E-63 1 9.84E-57 11.00
2 SGTC_545 4218-0007 5.76 221.0 µM 5.00E-10 1 4.12E-9 0.87
3 SGTC_1058 3448-5425 4.94 97.3 µM 8.17E-8 4 3.99E-7 0.09
4 SGTC_2050 5263056 4.68 171.0 µM 3.38E-7 fatty acid desaturase (OLE1) 16 1.43E-6 0.07
5 SGTC_2472 5377652 4.60 49.4 µM 5.31E-7 TRP & mitochondrial translation 4 2.14E-6 0.08
6 SGTC_1086 cerivastatin 4.50 2.2 µM 8.92E-7 azole & statin 2 3.41E-6 0.24
7 SGTC_2567 aureobasidin a 4.39 60.0 nM 1.55E-6 37 5.60E-6 0.12
8 SGTC_2794 7785382 4.33 27.3 µM 2.15E-6 10 7.52E-6 0.10
9 SGTC_1801 st050089 4.09 28.4 µM 6.92E-6 NEO1-PIK1 8 2.15E-5 0.06
10 SGTC_2035 5154463 3.91 94.6 µM 1.66E-5 12 4.69E-5 0.11
11 SGTC_3189 9110682 3.81 49.5 µM 2.55E-5 9 6.92E-5 0.01
12 SGTC_543 3844-1095 3.78 191.0 µM 2.97E-5 ERG2 8 7.92E-5 0.29
13 SGTC_2246 7293507 3.77 91.6 µM 3.00E-5 12 8.00E-5 0.06
14 SGTC_2467 5474540 3.65 200.0 µM 5.22E-5 8 1.32E-4 0.02
15 SGTC_1533 dihydroergotamine mesylate 3.61 29.4 µM 6.16E-5 DNA intercalators 8 1.53E-4 0.04
16 SGTC_696 1560-0013 3.60 611.0 µM 6.34E-5 13 1.57E-4 0.17
17 SGTC_2997 9067075 3.60 71.4 µM 6.57E-5 unfolded protein response 26 1.62E-4 0.15
18 SGTC_485 niflumic acid 3.51 177.0 µM 9.60E-5 5 2.27E-4 0.20
19 SGTC_1169 aniline yellow 3.50 25.8 µM 9.73E-5 2 2.30E-4 0.23
20 SGTC_3344 9148862 3.46 3.9 µM 1.18E-4 6 2.75E-4 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.34E-18 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.145 3.57E-17 YHR129C ARP1 hom Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin
0.136 2.66E-15 YMR294W-A_d YMR294W-A_d hom Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents
0.129 6.19E-14 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.126 2.44E-13 YPR018W RLF2 hom Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.125 4.40E-13 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.099 8.88E-9 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.099 1.06E-8 YDR390C UBA2 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.098 1.21E-8 YLR070C XYL2 hom Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect
0.092 9.97E-8 YPL048W CAM1 hom Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma
0.092 1.08E-7 YBR223C TDP1 hom Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI
0.088 3.07E-7 YKL020C SPT23 hom ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
0.088 3.44E-7 YBR055C PRP6 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.087 4.89E-7 YKR101W SIR1 hom Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
0.086 5.42E-7 YNR029C_p YNR029C_p hom Putative protein of unknown function, deletion confers reduced fitness in saline