YGL092W / NUP145

Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL092W / NUP145

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.40|P-value:7.29E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.35|P-value:8.44E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:4.89|P-value:2.50E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.21|P-value:4.10E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:4.19|P-value:4.49E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:4.50|P-value:1.34E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:3.66|P-value:3.11E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:6.42|P-value:1.11E-9 ID:SGTC_532|Compound:1548-0774|FD-Score:4.10|P-value:6.33E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:3.77|P-value:2.08E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.44|P-value:6.39E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.43|P-value:1.71E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:6.27|P-value:2.51E-9 ID:SGTC_934|Compound:2950-0684|FD-Score:3.31|P-value:9.55E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.46|P-value:5.99E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.33|P-value:8.99E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.87|P-value:1.45E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.11|P-value:6.01E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.43|P-value:6.56E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.91|P-value:2.32E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.24|P-value:5.06E-7 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.59|P-value:3.88E-4 ID:SGTC_1652|Compound:st011932|FD-Score:4.49|P-value:1.34E-5 ID:SGTC_1784|Compound:st039334|FD-Score:4.04|P-value:7.87E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.24|P-value:3.65E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:5.59|P-value:9.35E-8 ID:SGTC_1880|Compound:MG-132|FD-Score:11.20|P-value:6.89E-26 ID:SGTC_2019|Compound:4016004|FD-Score:3.59|P-value:3.88E-4 ID:SGTC_2036|Compound:5160441|FD-Score:5.10|P-value:9.78E-7 ID:SGTC_2111|Compound:5486399|FD-Score:5.55|P-value:1.11E-7 ID:SGTC_2308|Compound:7584454|FD-Score:3.42|P-value:6.89E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.95|P-value:1.09E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.38|P-value:9.67E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.60|P-value:8.86E-6 ID:SGTC_2868|Compound:9035608|FD-Score:3.82|P-value:1.76E-4 ID:SGTC_2890|Compound:9046729|FD-Score:4.02|P-value:8.56E-5 ID:SGTC_2964|Compound:9083345|FD-Score:5.74|P-value:4.40E-8 ID:SGTC_3282|Compound:9108498|FD-Score:-4.77|P-value:5.68E-6 ID:SGTC_3285|Compound:9112818|FD-Score:3.50|P-value:5.28E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.89|P-value:1.38E-4 ID:SGTC_3337|Compound:9144342|FD-Score:7.05|P-value:2.56E-11 ID:SGTC_17|Compound:0960-0276|FD-Score:3.40|P-value:7.29E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.35|P-value:8.44E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:4.89|P-value:2.50E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.21|P-value:4.10E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:4.19|P-value:4.49E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:4.50|P-value:1.34E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:3.66|P-value:3.11E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:6.42|P-value:1.11E-9 ID:SGTC_532|Compound:1548-0774|FD-Score:4.10|P-value:6.33E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:3.77|P-value:2.08E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.44|P-value:6.39E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.43|P-value:1.71E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:6.27|P-value:2.51E-9 ID:SGTC_934|Compound:2950-0684|FD-Score:3.31|P-value:9.55E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.46|P-value:5.99E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.33|P-value:8.99E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.87|P-value:1.45E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.11|P-value:6.01E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.43|P-value:6.56E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.91|P-value:2.32E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.24|P-value:5.06E-7 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.59|P-value:3.88E-4 ID:SGTC_1652|Compound:st011932|FD-Score:4.49|P-value:1.34E-5 ID:SGTC_1784|Compound:st039334|FD-Score:4.04|P-value:7.87E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.24|P-value:3.65E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:5.59|P-value:9.35E-8 ID:SGTC_1880|Compound:MG-132|FD-Score:11.20|P-value:6.89E-26 ID:SGTC_2019|Compound:4016004|FD-Score:3.59|P-value:3.88E-4 ID:SGTC_2036|Compound:5160441|FD-Score:5.10|P-value:9.78E-7 ID:SGTC_2111|Compound:5486399|FD-Score:5.55|P-value:1.11E-7 ID:SGTC_2308|Compound:7584454|FD-Score:3.42|P-value:6.89E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.95|P-value:1.09E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.38|P-value:9.67E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.60|P-value:8.86E-6 ID:SGTC_2868|Compound:9035608|FD-Score:3.82|P-value:1.76E-4 ID:SGTC_2890|Compound:9046729|FD-Score:4.02|P-value:8.56E-5 ID:SGTC_2964|Compound:9083345|FD-Score:5.74|P-value:4.40E-8 ID:SGTC_3282|Compound:9108498|FD-Score:-4.77|P-value:5.68E-6 ID:SGTC_3285|Compound:9112818|FD-Score:3.50|P-value:5.28E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.89|P-value:1.38E-4 ID:SGTC_3337|Compound:9144342|FD-Score:7.05|P-value:2.56E-11

Top fitness defect scores for YGL092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1880 MG-132 11.20 525.0 µM 6.89E-26 2 1.19E-29 1.13
2 SGTC_3337 9144342 7.05 33.5 µM 2.56E-11 4 8.89E-13 1.40
3 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.42 6.7 µM 1.11E-9 1 6.91E-11 2.03
4 SGTC_915 methyl methanesulfonate (MMS) 6.27 110.0 mM 2.51E-9 DNA damage response 3 1.77E-10 0.68
5 SGTC_2964 9083345 5.74 53.4 µM 4.40E-8 5 4.81E-9 0.42
6 SGTC_1876 myriocin 5.59 605.0 nM 9.35E-8 5 1.15E-8 1.63
7 SGTC_2111 5486399 5.55 200.0 µM 1.11E-7 16 1.40E-8 0.01
8 SGTC_1493 4348-0038 5.24 111.0 µM 5.06E-7 RSC complex & mRNA processing 24 8.04E-8 0.11
9 SGTC_2036 5160441 5.10 105.0 µM 9.78E-7 NEO1 16 1.72E-7 0.12
10 SGTC_1374 2889-5571 4.91 141.0 µM 2.32E-6 RSC complex & mRNA processing 29 4.64E-7 0.08
11 SGTC_76 0433-0009 4.89 400.3 µM 2.50E-6 4 5.05E-7 0.53
12 SGTC_2757 clomiphene 4.60 4.2 µM 8.86E-6 fatty acid desaturase (OLE1) 3 2.16E-6 0.03
13 SGTC_367 0335-0881 4.50 7.1 µM 1.34E-5 ubiquinone biosynthesis & proteasome 17 3.48E-6 0.03
14 SGTC_1652 st011932 4.49 78.0 µM 1.34E-5 RSC complex & mRNA processing 30 3.48E-6 0.09
15 SGTC_871 0574-0004 4.43 149.0 µM 1.71E-5 22 4.61E-6 0.11
16 SGTC_1789 tunicamycin 4.24 25.0 nM 3.65E-5 unfolded protein response 12 1.10E-5 0.09
17 SGTC_219 mitoxanthrone 4.21 164.4 µM 4.10E-5 DNA intercalators 12 1.26E-5 0.07
18 SGTC_268 camptothecin 4.19 39.6 µM 4.49E-5 DNA damage response 40 1.39E-5 0.10
19 SGTC_1366 1683-0113 4.11 21.9 µM 6.01E-5 2 1.95E-5 0.33
20 SGTC_532 1548-0774 4.10 215.0 µM 6.33E-5 4 2.07E-5 0.18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.194 6.06E-30 YJR042W NUP85 het Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75
0.167 1.63E-22 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.154 3.70E-19 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.140 3.38E-16 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.137 1.93E-15 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.122 1.51E-12 YMR032W HOF1 hom Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
0.121 1.65E-12 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.121 2.40E-12 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.119 3.91E-12 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.119 4.03E-12 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.117 9.54E-12 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.116 1.67E-11 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.112 6.85E-11 YPL124W SPC29 het Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication
0.112 9.50E-11 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.107 5.02E-10 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants