YGL123W / RPS2

Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL123W / RPS2

Click on Significant Values for Screen Details ID:SGTC_97|Compound:0535-0701|FD-Score:-5.17|P-value:5.24E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:4.48|P-value:1.16E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.95|P-value:5.98E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.20|P-value:9.04E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.76|P-value:6.16E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.81|P-value:2.00E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-3.80|P-value:5.58E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.89|P-value:4.22E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:6.99|P-value:3.66E-9 ID:SGTC_596|Compound:1155-0152|FD-Score:5.07|P-value:1.49E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.62|P-value:9.24E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.16|P-value:3.23E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-4.91|P-value:1.38E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.65|P-value:1.56E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:4.47|P-value:1.20E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:4.78|P-value:4.20E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.85|P-value:8.00E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.94|P-value:2.35E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.44|P-value:3.61E-6 ID:SGTC_1189|Compound:1431-2119|FD-Score:6.92|P-value:5.15E-9 ID:SGTC_1209|Compound:2323-2347|FD-Score:-4.03|P-value:2.73E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.95|P-value:3.49E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:-3.94|P-value:3.59E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-4.34|P-value:1.04E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:-4.89|P-value:1.49E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:-4.21|P-value:1.55E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:-3.71|P-value:7.28E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.53|P-value:9.75E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:-4.16|P-value:1.84E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.75|P-value:4.59E-5 ID:SGTC_1522|Compound:st012842|FD-Score:-3.99|P-value:3.10E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.31|P-value:1.11E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.32|P-value:1.10E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.78|P-value:5.88E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.59|P-value:4.29E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-4.00|P-value:3.03E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-5.45|P-value:1.69E-6 ID:SGTC_1621|Compound:st003705|FD-Score:-3.63|P-value:8.96E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.91|P-value:3.97E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.87|P-value:7.54E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.82|P-value:8.81E-4 ID:SGTC_1763|Compound:st044482|FD-Score:4.69|P-value:5.79E-5 ID:SGTC_1775|Compound:st081588|FD-Score:-5.15|P-value:5.52E-6 ID:SGTC_1781|Compound:st038725|FD-Score:5.66|P-value:1.52E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.53|P-value:5.45E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-4.45|P-value:6.96E-5 ID:SGTC_1796|Compound:st049173|FD-Score:5.89|P-value:5.68E-7 ID:SGTC_1798|Compound:st045719|FD-Score:5.53|P-value:2.57E-6 ID:SGTC_1815|Compound:st051655|FD-Score:3.92|P-value:6.69E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.60|P-value:9.99E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.89|P-value:2.87E-5 ID:SGTC_2179|Compound:6298986|FD-Score:-5.47|P-value:1.60E-6 ID:SGTC_2183|Compound:6420625|FD-Score:-3.91|P-value:3.96E-4 ID:SGTC_2240|Compound:6690706|FD-Score:5.61|P-value:1.81E-6 ID:SGTC_2255|Compound:7941087|FD-Score:3.87|P-value:7.58E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.16|P-value:1.07E-5 ID:SGTC_2404|Compound:5161160|FD-Score:-4.95|P-value:1.20E-5 ID:SGTC_2411|Compound:st077133|FD-Score:-4.11|P-value:2.16E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.03|P-value:2.78E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-4.06|P-value:2.53E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.10|P-value:3.89E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.28|P-value:1.23E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.41|P-value:4.01E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.78|P-value:2.24E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.37|P-value:9.34E-5 ID:SGTC_2798|Compound:7813637|FD-Score:5.71|P-value:1.22E-6 ID:SGTC_2799|Compound:7812892|FD-Score:-4.32|P-value:1.09E-4 ID:SGTC_2801|Compound:7907800|FD-Score:5.23|P-value:8.27E-6 ID:SGTC_2950|Compound:9072895|FD-Score:5.06|P-value:1.55E-5 ID:SGTC_2972|Compound:9093619|FD-Score:5.22|P-value:8.54E-6 ID:SGTC_3000|Compound:9075062|FD-Score:-4.67|P-value:3.24E-5 ID:SGTC_3010|Compound:9080089|FD-Score:4.50|P-value:1.08E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.71|P-value:7.31E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.62|P-value:9.28E-4 ID:SGTC_3030|Compound:9087619|FD-Score:5.26|P-value:7.15E-6 ID:SGTC_3032|Compound:9089427|FD-Score:-9.79|P-value:6.01E-17 ID:SGTC_3038|Compound:9091290|FD-Score:-6.45|P-value:2.07E-8 ID:SGTC_3249|Compound:9135183|FD-Score:-5.39|P-value:2.21E-6 ID:SGTC_3287|Compound:9117173|FD-Score:-3.79|P-value:5.79E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-5.17|P-value:5.24E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:4.48|P-value:1.16E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.95|P-value:5.98E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.20|P-value:9.04E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.76|P-value:6.16E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.81|P-value:2.00E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-3.80|P-value:5.58E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.89|P-value:4.22E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:6.99|P-value:3.66E-9 ID:SGTC_596|Compound:1155-0152|FD-Score:5.07|P-value:1.49E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.62|P-value:9.24E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.16|P-value:3.23E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-4.91|P-value:1.38E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.65|P-value:1.56E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:4.47|P-value:1.20E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:4.78|P-value:4.20E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.85|P-value:8.00E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.94|P-value:2.35E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.44|P-value:3.61E-6 ID:SGTC_1189|Compound:1431-2119|FD-Score:6.92|P-value:5.15E-9 ID:SGTC_1209|Compound:2323-2347|FD-Score:-4.03|P-value:2.73E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.95|P-value:3.49E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:-3.94|P-value:3.59E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-4.34|P-value:1.04E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:-4.89|P-value:1.49E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:-4.21|P-value:1.55E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:-3.71|P-value:7.28E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.53|P-value:9.75E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:-4.16|P-value:1.84E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.75|P-value:4.59E-5 ID:SGTC_1522|Compound:st012842|FD-Score:-3.99|P-value:3.10E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.31|P-value:1.11E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.32|P-value:1.10E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.78|P-value:5.88E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.59|P-value:4.29E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-4.00|P-value:3.03E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-5.45|P-value:1.69E-6 ID:SGTC_1621|Compound:st003705|FD-Score:-3.63|P-value:8.96E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.91|P-value:3.97E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.87|P-value:7.54E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.82|P-value:8.81E-4 ID:SGTC_1763|Compound:st044482|FD-Score:4.69|P-value:5.79E-5 ID:SGTC_1775|Compound:st081588|FD-Score:-5.15|P-value:5.52E-6 ID:SGTC_1781|Compound:st038725|FD-Score:5.66|P-value:1.52E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.53|P-value:5.45E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-4.45|P-value:6.96E-5 ID:SGTC_1796|Compound:st049173|FD-Score:5.89|P-value:5.68E-7 ID:SGTC_1798|Compound:st045719|FD-Score:5.53|P-value:2.57E-6 ID:SGTC_1815|Compound:st051655|FD-Score:3.92|P-value:6.69E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.60|P-value:9.99E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.89|P-value:2.87E-5 ID:SGTC_2179|Compound:6298986|FD-Score:-5.47|P-value:1.60E-6 ID:SGTC_2183|Compound:6420625|FD-Score:-3.91|P-value:3.96E-4 ID:SGTC_2240|Compound:6690706|FD-Score:5.61|P-value:1.81E-6 ID:SGTC_2255|Compound:7941087|FD-Score:3.87|P-value:7.58E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.16|P-value:1.07E-5 ID:SGTC_2404|Compound:5161160|FD-Score:-4.95|P-value:1.20E-5 ID:SGTC_2411|Compound:st077133|FD-Score:-4.11|P-value:2.16E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.03|P-value:2.78E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-4.06|P-value:2.53E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.10|P-value:3.89E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.28|P-value:1.23E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.41|P-value:4.01E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.78|P-value:2.24E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.37|P-value:9.34E-5 ID:SGTC_2798|Compound:7813637|FD-Score:5.71|P-value:1.22E-6 ID:SGTC_2799|Compound:7812892|FD-Score:-4.32|P-value:1.09E-4 ID:SGTC_2801|Compound:7907800|FD-Score:5.23|P-value:8.27E-6 ID:SGTC_2950|Compound:9072895|FD-Score:5.06|P-value:1.55E-5 ID:SGTC_2972|Compound:9093619|FD-Score:5.22|P-value:8.54E-6 ID:SGTC_3000|Compound:9075062|FD-Score:-4.67|P-value:3.24E-5 ID:SGTC_3010|Compound:9080089|FD-Score:4.50|P-value:1.08E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.71|P-value:7.31E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.62|P-value:9.28E-4 ID:SGTC_3030|Compound:9087619|FD-Score:5.26|P-value:7.15E-6 ID:SGTC_3032|Compound:9089427|FD-Score:-9.79|P-value:6.01E-17 ID:SGTC_3038|Compound:9091290|FD-Score:-6.45|P-value:2.07E-8 ID:SGTC_3249|Compound:9135183|FD-Score:-5.39|P-value:2.21E-6 ID:SGTC_3287|Compound:9117173|FD-Score:-3.79|P-value:5.79E-4

Top fitness defect scores for YGL123W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_535 2293-4129 6.99 48.2 µM 3.66E-9 NEO1 2 1.40E-12 1.04
2 SGTC_1189 1431-2119 6.92 7.3 µM 5.15E-9 4 2.29E-12 1.46
3 SGTC_1796 st049173 5.89 110.4 µM 5.68E-7 1 1.89E-9 1.17
4 SGTC_2798 7813637 5.71 45.5 µM 1.22E-6 3 5.67E-9 0.25
5 SGTC_1781 st038725 5.66 66.3 µM 1.52E-6 NEO1 5 7.74E-9 0.67
6 SGTC_800 3448-7362 5.65 155.0 µM 1.56E-6 translation 27 8.03E-9 0.02
7 SGTC_2240 6690706 5.61 185.9 µM 1.81E-6 1 9.87E-9 0.75
8 SGTC_1798 st045719 5.53 61.0 µM 2.57E-6 1 1.64E-8 0.88
9 SGTC_1178 0988-0033 5.44 191.0 µM 3.61E-6 2 2.65E-8 0.93
10 SGTC_2658 polymyxin b sulfate 5.41 77.0 µM 4.01E-6 NEO1 7 3.08E-8 0.23
11 SGTC_3030 9087619 5.26 49.5 µM 7.15E-6 2 7.03E-8 0.53
12 SGTC_2801 7907800 5.23 81.8 µM 8.27E-6 4 8.66E-8 0.98
13 SGTC_2972 9093619 5.22 59.9 µM 8.54E-6 2 9.07E-8 0.11
14 SGTC_241 5hr heat shock (37°C) + cantharidin 5.20 155.4 µM 9.04E-6 cell wall signaling 10 9.82E-8 0.69
15 SGTC_2307 7538926 5.16 6.3 µM 1.07E-5 13 1.25E-7 0.46
16 SGTC_596 1155-0152 5.07 116.0 µM 1.49E-5 TRP & mitochondrial translation 3 2.00E-7 0.44
17 SGTC_2950 9072895 5.06 21.5 µM 1.55E-5 5 2.13E-7 0.08
18 SGTC_1132 3456-3614 4.94 2.5 µM 2.35E-5 tubulin folding & SWR complex 4 3.85E-7 0.37
19 SGTC_2040 5100729 4.89 123.0 µM 2.87E-5 3 5.10E-7 0.83
20 SGTC_901 1112-0062 4.78 60.1 µM 4.20E-5 2 8.78E-7 0.33

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.305 2.52E-73 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.302 8.54E-72 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.288 3.71E-65 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.252 9.37E-50 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.212 2.57E-35 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.199 3.56E-31 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.182 2.45E-26 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.182 2.66E-26 YML031W NDC1 het Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.174 3.88E-24 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.173 7.15E-24 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.168 1.55E-22 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.163 1.71E-21 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.161 6.89E-21 YDR449C UTP6 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.161 7.46E-21 YLR222C UTP13 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.158 3.14E-20 YMR093W UTP15 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA