YGL190C / CDC55

Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL190C / CDC55

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:3.45|P-value:4.73E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-2.89|P-value:4.52E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.24|P-value:9.96E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.59|P-value:2.74E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.77|P-value:1.38E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.55|P-value:3.24E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.26|P-value:9.55E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.47|P-value:4.38E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-3.21|P-value:1.27E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.47|P-value:4.37E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.31|P-value:7.79E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.48|P-value:4.30E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.49|P-value:4.09E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.28|P-value:1.47E-5 ID:SGTC_1849|Compound:st056239|FD-Score:3.79|P-value:1.27E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.11|P-value:3.18E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.11|P-value:3.21E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.33|P-value:7.21E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.31|P-value:7.94E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-2.69|P-value:9.16E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.02|P-value:2.72E-4 ID:SGTC_1976|Compound:st070609|FD-Score:-2.86|P-value:5.00E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.51|P-value:3.83E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.30|P-value:8.03E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.32|P-value:7.48E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.06|P-value:2.37E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.52|P-value:4.86E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.46|P-value:4.51E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.27|P-value:9.11E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.98|P-value:5.57E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:3.55|P-value:3.22E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.48|P-value:4.19E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.32|P-value:7.55E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-3.69|P-value:1.64E-5 ID:SGTC_2952|Compound:9073731|FD-Score:3.88|P-value:8.50E-5 ID:SGTC_2963|Compound:9082507|FD-Score:-3.27|P-value:1.01E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.38|P-value:6.19E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.22|P-value:1.24E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.38|P-value:6.03E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.45|P-value:4.73E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-2.89|P-value:4.52E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.24|P-value:9.96E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.59|P-value:2.74E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.77|P-value:1.38E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.55|P-value:3.24E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.26|P-value:9.55E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.47|P-value:4.38E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-3.21|P-value:1.27E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.47|P-value:4.37E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.31|P-value:7.79E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.48|P-value:4.30E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.49|P-value:4.09E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.28|P-value:1.47E-5 ID:SGTC_1849|Compound:st056239|FD-Score:3.79|P-value:1.27E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.11|P-value:3.18E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.11|P-value:3.21E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.33|P-value:7.21E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.31|P-value:7.94E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-2.69|P-value:9.16E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.02|P-value:2.72E-4 ID:SGTC_1976|Compound:st070609|FD-Score:-2.86|P-value:5.00E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.51|P-value:3.83E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.30|P-value:8.03E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.32|P-value:7.48E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.06|P-value:2.37E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.52|P-value:4.86E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.46|P-value:4.51E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.27|P-value:9.11E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.98|P-value:5.57E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:3.55|P-value:3.22E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.48|P-value:4.19E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.32|P-value:7.55E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-3.69|P-value:1.64E-5 ID:SGTC_2952|Compound:9073731|FD-Score:3.88|P-value:8.50E-5 ID:SGTC_2963|Compound:9082507|FD-Score:-3.27|P-value:1.01E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.38|P-value:6.19E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.22|P-value:1.24E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.38|P-value:6.03E-4

Top fitness defect scores for YGL190C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2561 acetosyringone 4.52 100.0 µM 4.86E-6 13 3.11E-6
2 SGTC_1824 st053723 4.28 68.6 µM 1.47E-5 23 9.18E-6
3 SGTC_1869 3',7'-dimethoxyflavone 4.11 40.3 µM 3.18E-5 21 1.95E-5
4 SGTC_1871 st057448 4.11 67.3 µM 3.21E-5 23 1.98E-5
5 SGTC_2722 naftopidil 3.98 47.2 µM 5.57E-5 7 3.39E-5
6 SGTC_2952 9073731 3.88 13.8 µM 8.50E-5 tubulin folding & SWR complex 46 5.14E-5
7 SGTC_1849 st056239 3.79 19.2 µM 1.27E-4 RPP1 & pyrimidine depletion 31 7.63E-5
8 SGTC_943 3253-1379 3.77 105.0 µM 1.38E-4 28 8.27E-5
9 SGTC_942 3253-1115 3.59 227.0 µM 2.74E-4 41 1.63E-4
10 SGTC_2740 felodipine 3.55 17.1 µM 3.22E-4 24 1.92E-4
11 SGTC_1523 st012844 3.55 44.7 µM 3.24E-4 60S ribosome export 35 1.93E-4
12 SGTC_2255 7941087 3.51 197.4 µM 3.83E-4 45 2.27E-4
13 SGTC_1814 st052110 3.49 31.5 µM 4.09E-4 RNA processing & uracil transport 20 2.43E-4
14 SGTC_2748 diazoxide 3.48 86.7 µM 4.19E-4 18 2.49E-4
15 SGTC_1808 st050063 3.48 61.5 µM 4.30E-4 22 2.55E-4
16 SGTC_1648 st011736 3.47 69.8 µM 4.37E-4 PDR1 23 2.59E-4
17 SGTC_1596 piperlongumine 3.47 63.0 µM 4.38E-4 30 2.60E-4
18 SGTC_2564 betulinic acid 3.46 100.0 µM 4.51E-4 48 2.68E-4
19 SGTC_71 0417-1750 3.45 47.8 µM 4.73E-4 Golgi 71 2.81E-4
20 SGTC_3350 9150499 3.38 3.6 µM 6.03E-4 cell wall 79 3.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 9.39E-9 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.092 1.12E-7 YGR038W ORM1 hom Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
0.088 3.52E-7 YDR169C-A_p YDR169C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.079 5.29E-6 YER098W UBP9 hom Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication
0.077 8.39E-6 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.076 1.10E-5 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.075 1.28E-5 YNL251C NRD1 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5, to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites
0.074 1.61E-5 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.074 1.69E-5 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.074 1.73E-5 YNL100W AIM37 hom Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.074 1.80E-5 YNL097C PHO23 hom Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3
0.073 2.22E-5 YKR077W MSA2 hom Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation
0.072 2.64E-5 YIR005W IST3 hom Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing
0.070 5.20E-5 YNR061C YNR061C hom Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.069 6.06E-5 YHL047C ARN2 hom Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C