YGL207W / SPT16

Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL207W / SPT16

Click on Significant Values for Screen Details ID:SGTC_282|Compound:k297-0036|FD-Score:-3.55|P-value:3.91E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:-4.90|P-value:2.01E-6 ID:SGTC_877|Compound:0771-0151|FD-Score:3.41|P-value:9.18E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:4.55|P-value:1.52E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:7.83|P-value:2.49E-13 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.57|P-value:5.51E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:6.11|P-value:9.18E-9 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.66|P-value:4.06E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.61|P-value:6.90E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.95|P-value:1.51E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.92|P-value:1.09E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.53|P-value:6.31E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-5.42|P-value:1.71E-7 ID:SGTC_1720|Compound:st037298|FD-Score:4.29|P-value:4.25E-5 ID:SGTC_1725|Compound:st036284|FD-Score:4.18|P-value:6.41E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-3.45|P-value:5.57E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.16|P-value:6.90E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-4.12|P-value:5.08E-5 ID:SGTC_1778|Compound:st046819|FD-Score:4.49|P-value:1.94E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-4.07|P-value:6.06E-5 ID:SGTC_2153|Compound:5569715|FD-Score:4.22|P-value:5.57E-5 ID:SGTC_2359|Compound:9039622|FD-Score:4.08|P-value:9.48E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.62|P-value:4.68E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.32|P-value:8.27E-4 ID:SGTC_2805|Compound:7950783|FD-Score:4.02|P-value:1.16E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-5.84|P-value:2.06E-8 ID:SGTC_2924|Compound:9010168|FD-Score:4.19|P-value:6.07E-5 ID:SGTC_3127|Compound:9126946|FD-Score:-5.11|P-value:7.61E-7 ID:SGTC_3131|Compound:9127911|FD-Score:6.17|P-value:6.86E-9 ID:SGTC_3153|Compound:9100258|FD-Score:-3.62|P-value:3.14E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.72|P-value:3.38E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.82|P-value:2.40E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.55|P-value:3.91E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:-4.90|P-value:2.01E-6 ID:SGTC_877|Compound:0771-0151|FD-Score:3.41|P-value:9.18E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:4.55|P-value:1.52E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:7.83|P-value:2.49E-13 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.57|P-value:5.51E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:6.11|P-value:9.18E-9 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.66|P-value:4.06E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.61|P-value:6.90E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.95|P-value:1.51E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.92|P-value:1.09E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.53|P-value:6.31E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-5.42|P-value:1.71E-7 ID:SGTC_1720|Compound:st037298|FD-Score:4.29|P-value:4.25E-5 ID:SGTC_1725|Compound:st036284|FD-Score:4.18|P-value:6.41E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-3.45|P-value:5.57E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.16|P-value:6.90E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-4.12|P-value:5.08E-5 ID:SGTC_1778|Compound:st046819|FD-Score:4.49|P-value:1.94E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-4.07|P-value:6.06E-5 ID:SGTC_2153|Compound:5569715|FD-Score:4.22|P-value:5.57E-5 ID:SGTC_2359|Compound:9039622|FD-Score:4.08|P-value:9.48E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.62|P-value:4.68E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.32|P-value:8.27E-4 ID:SGTC_2805|Compound:7950783|FD-Score:4.02|P-value:1.16E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-5.84|P-value:2.06E-8 ID:SGTC_2924|Compound:9010168|FD-Score:4.19|P-value:6.07E-5 ID:SGTC_3127|Compound:9126946|FD-Score:-5.11|P-value:7.61E-7 ID:SGTC_3131|Compound:9127911|FD-Score:6.17|P-value:6.86E-9 ID:SGTC_3153|Compound:9100258|FD-Score:-3.62|P-value:3.14E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.72|P-value:3.38E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.82|P-value:2.40E-4

Top fitness defect scores for YGL207W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_996 3970-0799 7.83 1.8 µM 2.49E-13 6 2.39E-15 1.12
2 SGTC_3131 9127911 6.17 49.5 µM 6.86E-9 1 3.49E-10 0.57
3 SGTC_1125 tnp00248 6.11 1.3 µM 9.18E-9 3 4.89E-10 0.56
4 SGTC_981 1488-1094 4.55 54.9 µM 1.52E-5 1 2.72E-6 0.56
5 SGTC_1778 st046819 4.49 58.9 µM 1.94E-5 4 3.61E-6 0.58
6 SGTC_1720 st037298 4.29 9.5 µM 4.25E-5 9 9.04E-6 0.21
7 SGTC_2153 5569715 4.22 200.0 µM 5.57E-5 iron homeostasis 3 1.24E-5 0.38
8 SGTC_2924 9010168 4.19 62.8 µM 6.07E-5 cell wall signaling 5 1.37E-5 0.30
9 SGTC_1725 st036284 4.18 20.6 µM 6.41E-5 5 1.46E-5 0.55
10 SGTC_1743 st037606 4.16 46.4 µM 6.90E-5 6 1.59E-5 0.34
11 SGTC_2359 9039622 4.08 200.0 µM 9.48E-5 endomembrane recycling 2 2.30E-5 0.06
12 SGTC_2805 7950783 4.02 58.4 µM 1.16E-4 8 2.90E-5 0.19
13 SGTC_1376 2910-0861 3.95 41.3 µM 1.51E-4 2 3.96E-5 0.29
14 SGTC_3316 9136639 3.82 10.6 µM 2.40E-4 6 6.77E-5 0.07
15 SGTC_3217 9129673 3.72 49.5 µM 3.38E-4 14 1.01E-4 0.14
16 SGTC_1278 0874-0585 3.66 172.0 µM 4.06E-4 10 1.25E-4 0.02
17 SGTC_2367 9070478 3.62 135.4 µM 4.68E-4 cell wall 12 1.47E-4 0.05
18 SGTC_1121 fusaric acid 3.57 630.5 nM 5.51E-4 4 1.78E-4 0.10
19 SGTC_1431 4049-0260 3.53 9.1 µM 6.31E-4 3 2.08E-4 0.29
20 SGTC_877 0771-0151 3.41 33.1 µM 9.18E-4 2 3.23E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.277 3.27E-60 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.221 2.16E-38 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.186 1.55E-27 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.181 3.27E-26 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.174 3.22E-24 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.171 2.51E-23 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.169 7.09E-23 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.161 5.28E-21 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.158 3.69E-20 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.153 4.83E-19 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.148 6.17E-18 YAL032C PRP45 het Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
0.147 1.12E-17 YGR048W UFD1 het Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
0.146 1.46E-17 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.146 1.95E-17 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.144 5.96E-17 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p