YGL232W / TAN1

Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL232W / TAN1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.42|P-value:3.87E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:22.40|P-value:1.61E-108 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.49|P-value:2.72E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.23|P-value:7.51E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:8.22|P-value:2.77E-16 ID:SGTC_384|Compound:k007-0144|FD-Score:3.29|P-value:6.11E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.66|P-value:1.45E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.24|P-value:6.65E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.53|P-value:3.64E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.83|P-value:1.01E-6 ID:SGTC_482|Compound:fipronil|FD-Score:-3.16|P-value:8.64E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:4.80|P-value:1.16E-6 ID:SGTC_612|Compound:0302-0167|FD-Score:15.40|P-value:1.71E-52 ID:SGTC_629|Compound:3448-6466|FD-Score:3.52|P-value:2.63E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.19|P-value:8.44E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.20|P-value:7.80E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.19|P-value:8.48E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.02|P-value:3.74E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.49|P-value:2.95E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.73|P-value:1.22E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-4.13|P-value:2.18E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.79|P-value:9.65E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-3.17|P-value:8.41E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-4.01|P-value:3.60E-5 ID:SGTC_1804|Compound:st050076|FD-Score:3.40|P-value:4.05E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.84|P-value:7.81E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.50|P-value:2.86E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.36|P-value:4.84E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.32|P-value:5.13E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.89|P-value:7.39E-7 ID:SGTC_2021|Compound:4019055|FD-Score:4.45|P-value:5.95E-6 ID:SGTC_2179|Compound:6298986|FD-Score:-3.87|P-value:6.32E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-3.18|P-value:8.33E-4 ID:SGTC_2297|Compound:7971671|FD-Score:5.88|P-value:3.39E-9 ID:SGTC_2340|Compound:7987427|FD-Score:3.61|P-value:1.89E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.62|P-value:1.87E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.51|P-value:2.75E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.44|P-value:3.55E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.41|P-value:3.98E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.37|P-value:4.66E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.95|P-value:4.56E-5 ID:SGTC_2678|Compound:equilin|FD-Score:-3.90|P-value:5.62E-5 ID:SGTC_2818|Compound:7996756|FD-Score:-4.55|P-value:3.37E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-3.68|P-value:1.36E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.92|P-value:5.26E-5 ID:SGTC_2893|Compound:9048488|FD-Score:-3.33|P-value:4.95E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-3.85|P-value:6.88E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.29|P-value:6.12E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.16|P-value:9.44E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.65|P-value:1.67E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.88|P-value:6.76E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:3.42|P-value:3.87E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:22.40|P-value:1.61E-108 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.49|P-value:2.72E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.23|P-value:7.51E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:8.22|P-value:2.77E-16 ID:SGTC_384|Compound:k007-0144|FD-Score:3.29|P-value:6.11E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.66|P-value:1.45E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.24|P-value:6.65E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.53|P-value:3.64E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.83|P-value:1.01E-6 ID:SGTC_482|Compound:fipronil|FD-Score:-3.16|P-value:8.64E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:4.80|P-value:1.16E-6 ID:SGTC_612|Compound:0302-0167|FD-Score:15.40|P-value:1.71E-52 ID:SGTC_629|Compound:3448-6466|FD-Score:3.52|P-value:2.63E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.19|P-value:8.44E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.20|P-value:7.80E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.19|P-value:8.48E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.02|P-value:3.74E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.49|P-value:2.95E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.73|P-value:1.22E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-4.13|P-value:2.18E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.79|P-value:9.65E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-3.17|P-value:8.41E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-4.01|P-value:3.60E-5 ID:SGTC_1804|Compound:st050076|FD-Score:3.40|P-value:4.05E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.84|P-value:7.81E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.50|P-value:2.86E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.36|P-value:4.84E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.32|P-value:5.13E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.89|P-value:7.39E-7 ID:SGTC_2021|Compound:4019055|FD-Score:4.45|P-value:5.95E-6 ID:SGTC_2179|Compound:6298986|FD-Score:-3.87|P-value:6.32E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-3.18|P-value:8.33E-4 ID:SGTC_2297|Compound:7971671|FD-Score:5.88|P-value:3.39E-9 ID:SGTC_2340|Compound:7987427|FD-Score:3.61|P-value:1.89E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.62|P-value:1.87E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.51|P-value:2.75E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.44|P-value:3.55E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.41|P-value:3.98E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.37|P-value:4.66E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.95|P-value:4.56E-5 ID:SGTC_2678|Compound:equilin|FD-Score:-3.90|P-value:5.62E-5 ID:SGTC_2818|Compound:7996756|FD-Score:-4.55|P-value:3.37E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-3.68|P-value:1.36E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.92|P-value:5.26E-5 ID:SGTC_2893|Compound:9048488|FD-Score:-3.33|P-value:4.95E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-3.85|P-value:6.88E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.29|P-value:6.12E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.16|P-value:9.44E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.65|P-value:1.67E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.88|P-value:6.76E-5

Top fitness defect scores for YGL232W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_23 0213-0011 22.40 40.0 µM 1.61E-108 copper-dependent oxidative stress 2 1.69E-111
2 SGTC_612 0302-0167 15.40 22.4 µM 1.71E-52 copper-dependent oxidative stress 2 6.27E-54
3 SGTC_318 1488-0629 8.22 67.2 µM 2.77E-16 copper-dependent oxidative stress 5 1.03E-16
4 SGTC_2297 7971671 5.88 152.3 µM 3.39E-9 RNA processing & uracil transport 7 1.99E-9
5 SGTC_2014 4013930 4.89 200.0 µM 7.39E-7 11 5.05E-7
6 SGTC_474 dl-dihydrosphingosine 4.83 5.0 µM 1.01E-6 16 6.95E-7
7 SGTC_492 tmb-8 4.80 126.0 µM 1.16E-6 3 8.03E-7
8 SGTC_2021 4019055 4.45 173.0 µM 5.95E-6 endomembrane recycling 95 4.31E-6
9 SGTC_1319 1306-0155 4.02 43.7 µM 3.74E-5 21 2.85E-5
10 SGTC_3341 9147222 3.88 25.9 µM 6.76E-5 RNA processing & uracil transport 17 5.25E-5
11 SGTC_1814 st052110 3.84 31.5 µM 7.81E-5 RNA processing & uracil transport 11 6.09E-5
12 SGTC_1624 st003710 3.79 6.2 µM 9.65E-5 calcium & mitochondrial duress 45 7.57E-5
13 SGTC_1609 st001574 3.73 46.4 µM 1.22E-4 16 9.61E-5
14 SGTC_3311 9131146 3.65 2.9 µM 1.67E-4 cell wall 132 1.33E-4
15 SGTC_2351 9026858 3.62 72.3 µM 1.87E-4 RNA processing & uracil transport 34 1.49E-4
16 SGTC_2340 7987427 3.61 183.4 µM 1.89E-4 51 1.51E-4
17 SGTC_629 3448-6466 3.52 76.7 µM 2.63E-4 32 2.12E-4
18 SGTC_2480 5767542 3.51 37.2 µM 2.75E-4 21 2.22E-4
19 SGTC_1878 temozolomide 3.50 1.0 mM 2.86E-4 15 2.31E-4
20 SGTC_1432 4049-0298 3.49 68.4 µM 2.95E-4 11 2.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.374 4.33E-112 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.237 3.34E-44 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.147 9.84E-18 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.145 3.40E-17 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
0.128 1.33E-13 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.119 4.21E-12 YCR084C TUP1 hom General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
0.114 3.79E-11 YPL103C FMP30 hom Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D
0.112 6.75E-11 YOL025W LAG2 hom Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1
0.111 9.67E-11 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.108 3.81E-10 YNL090W RHO2 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
0.105 9.28E-10 YBL096C_d YBL096C_d hom Non-essential protein of unknown function
0.097 1.62E-8 YDR126W SWF1 hom Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion
0.096 2.62E-8 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.095 3.35E-8 YNL279W PRM1 hom Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
0.094 4.62E-8 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor