YGL255W / ZRT1

High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL255W / ZRT1

Click on Significant Values for Screen Details ID:SGTC_356|Compound:1634-0012|FD-Score:3.30|P-value:7.97E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:2.72|P-value:9.15E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.29|P-value:8.48E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:2.81|P-value:6.48E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:2.93|P-value:3.91E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:-2.86|P-value:5.37E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.08|P-value:1.52E-6 ID:SGTC_656|Compound:4090-1979|FD-Score:3.97|P-value:2.70E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:3.67|P-value:1.34E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:4.66|P-value:4.99E-8 ID:SGTC_735|Compound:3076-0345|FD-Score:2.72|P-value:9.33E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.71|P-value:9.99E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.32|P-value:7.31E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:3.02|P-value:2.77E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.05|P-value:2.39E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.49|P-value:3.41E-5 ID:SGTC_917|Compound:harmaline|FD-Score:3.51|P-value:3.01E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:5.40|P-value:3.16E-10 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.91|P-value:4.28E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-2.98|P-value:3.26E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.97|P-value:6.59E-9 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.21|P-value:1.21E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.76|P-value:7.96E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.34|P-value:6.91E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.18|P-value:1.39E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.43|P-value:4.25E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.27|P-value:9.09E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-9.38|P-value:4.11E-27 ID:SGTC_2423|Compound:st077119|FD-Score:-4.87|P-value:1.27E-8 ID:SGTC_2428|Compound:5615643|FD-Score:-5.82|P-value:1.43E-11 ID:SGTC_2429|Compound:5902844|FD-Score:5.65|P-value:5.24E-11 ID:SGTC_2430|Compound:5571206|FD-Score:7.40|P-value:1.27E-17 ID:SGTC_2432|Compound:5630864|FD-Score:-3.87|P-value:4.97E-6 ID:SGTC_2434|Compound:5670830|FD-Score:-3.62|P-value:1.74E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.33|P-value:6.81E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.80|P-value:6.70E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.76|P-value:8.32E-6 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.59|P-value:7.64E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-6.44|P-value:8.82E-14 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.96|P-value:3.64E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.94|P-value:3.75E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.41|P-value:2.20E-7 ID:SGTC_2802|Compound:7925815|FD-Score:-5.10|P-value:2.87E-9 ID:SGTC_2839|Compound:9003951|FD-Score:3.66|P-value:1.39E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-2.78|P-value:7.47E-4 ID:SGTC_2963|Compound:9082507|FD-Score:2.87|P-value:5.12E-4 ID:SGTC_3014|Compound:9081533|FD-Score:2.72|P-value:9.09E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.30|P-value:7.97E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:2.72|P-value:9.15E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.29|P-value:8.48E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:2.81|P-value:6.48E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:2.93|P-value:3.91E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:-2.86|P-value:5.37E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.08|P-value:1.52E-6 ID:SGTC_656|Compound:4090-1979|FD-Score:3.97|P-value:2.70E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:3.67|P-value:1.34E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:4.66|P-value:4.99E-8 ID:SGTC_735|Compound:3076-0345|FD-Score:2.72|P-value:9.33E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.71|P-value:9.99E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.32|P-value:7.31E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:3.02|P-value:2.77E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.05|P-value:2.39E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.49|P-value:3.41E-5 ID:SGTC_917|Compound:harmaline|FD-Score:3.51|P-value:3.01E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:5.40|P-value:3.16E-10 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.91|P-value:4.28E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-2.98|P-value:3.26E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.97|P-value:6.59E-9 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.21|P-value:1.21E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.76|P-value:7.96E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.34|P-value:6.91E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.18|P-value:1.39E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.43|P-value:4.25E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.27|P-value:9.09E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-9.38|P-value:4.11E-27 ID:SGTC_2423|Compound:st077119|FD-Score:-4.87|P-value:1.27E-8 ID:SGTC_2428|Compound:5615643|FD-Score:-5.82|P-value:1.43E-11 ID:SGTC_2429|Compound:5902844|FD-Score:5.65|P-value:5.24E-11 ID:SGTC_2430|Compound:5571206|FD-Score:7.40|P-value:1.27E-17 ID:SGTC_2432|Compound:5630864|FD-Score:-3.87|P-value:4.97E-6 ID:SGTC_2434|Compound:5670830|FD-Score:-3.62|P-value:1.74E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.33|P-value:6.81E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.80|P-value:6.70E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.76|P-value:8.32E-6 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.59|P-value:7.64E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-6.44|P-value:8.82E-14 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.96|P-value:3.64E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.94|P-value:3.75E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.41|P-value:2.20E-7 ID:SGTC_2802|Compound:7925815|FD-Score:-5.10|P-value:2.87E-9 ID:SGTC_2839|Compound:9003951|FD-Score:3.66|P-value:1.39E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-2.78|P-value:7.47E-4 ID:SGTC_2963|Compound:9082507|FD-Score:2.87|P-value:5.12E-4 ID:SGTC_3014|Compound:9081533|FD-Score:2.72|P-value:9.09E-4

Top fitness defect scores for YGL255W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2430 5571206 7.40 200.0 µM 1.27E-17 12 6.81E-14
2 SGTC_2429 5902844 5.65 64.4 µM 5.24E-11 6 8.23E-9
3 SGTC_996 3970-0799 5.40 1.8 µM 3.16E-10 46 3.28E-8
4 SGTC_1283 0922-0125 4.97 16.4 µM 6.59E-9 6 3.40E-7
5 SGTC_695 3505-6186 4.66 243.0 µM 4.99E-8 16 1.62E-6
6 SGTC_2693 st077581 4.41 40.7 µM 2.20E-7 22 5.08E-6
7 SGTC_651 3253-0966 4.08 34.4 µM 1.52E-6 calcium & mitochondrial duress 29 2.26E-5
8 SGTC_656 4090-1979 3.97 187.0 µM 2.70E-6 16 3.53E-5
9 SGTC_2576 guaiol 3.76 23.1 µM 8.32E-6 26 8.43E-5
10 SGTC_657 3534-0529 3.67 86.7 µM 1.34E-5 21 1.22E-4
11 SGTC_2839 9003951 3.66 26.0 µM 1.39E-5 15 1.26E-4
12 SGTC_917 harmaline 3.51 728.1 nM 3.01E-5 ergosterol biosynthesis 45 2.28E-4
13 SGTC_2338 7999974 3.43 200.0 µM 4.25E-5 41 2.98E-4
14 SGTC_2438 5259590 3.33 200.0 µM 6.81E-5 31 4.30E-4
15 SGTC_786 4544-0069 3.32 423.0 µM 7.31E-5 60 4.54E-4
16 SGTC_356 1634-0012 3.30 32.5 µM 7.97E-5 48 4.86E-4
17 SGTC_551 k048-0028 3.29 34.9 µM 8.48E-5 44 5.09E-4
18 SGTC_2394 5221648 3.27 200.0 µM 9.09E-5 50 5.38E-4
19 SGTC_1359 1582-0056 3.21 520.0 nM 1.21E-4 46 6.72E-4
20 SGTC_2316 5844804 3.18 197.4 µM 1.39E-4 77 7.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.206 2.02E-33 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.180 6.81E-26 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.172 1.33E-23 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.167 1.95E-22 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.160 1.25E-20 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.159 1.79E-20 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.155 1.72E-19 YDL171C GLT1 hom NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
0.150 2.08E-18 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.145 2.95E-17 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
0.135 5.67E-15 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.130 4.36E-14 YBR071W YBR071W hom Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking
0.130 5.14E-14 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.130 5.39E-14 YIL164C NIT1 hom Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
0.129 7.29E-14 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.128 1.31E-13 YNL277W-A_p YNL277W-A_p hom Putative protein of unknown function