YGR014W / MSB2

Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR014W / MSB2

Click on Significant Values for Screen Details ID:SGTC_108|Compound:0509-0257|FD-Score:6.97|P-value:1.12E-9 ID:SGTC_114|Compound:0364-0001|FD-Score:4.27|P-value:1.22E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:-4.05|P-value:2.69E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.20|P-value:1.56E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.63|P-value:9.31E-4 ID:SGTC_448|Compound:monastrol|FD-Score:4.21|P-value:1.54E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:3.68|P-value:7.96E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.77|P-value:3.75E-7 ID:SGTC_521|Compound:r062-0005|FD-Score:6.41|P-value:1.94E-8 ID:SGTC_524|Compound:r073-0010|FD-Score:3.94|P-value:3.66E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:4.03|P-value:2.70E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:4.27|P-value:1.24E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.73|P-value:2.47E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.44|P-value:7.10E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.66|P-value:8.84E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.69|P-value:7.98E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.85|P-value:4.82E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.94|P-value:3.63E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.28|P-value:1.20E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.27|P-value:1.24E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.70|P-value:7.75E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.85|P-value:4.90E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:4.31|P-value:1.08E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.26|P-value:1.33E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.05|P-value:2.64E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.69|P-value:8.06E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-4.75|P-value:2.42E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-4.72|P-value:2.66E-5 ID:SGTC_3051|Compound:9093778|FD-Score:4.05|P-value:2.57E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-4.37|P-value:9.22E-5 ID:SGTC_3105|Compound:9121040|FD-Score:-3.85|P-value:4.97E-4 ID:SGTC_3162|Compound:9099653|FD-Score:-3.77|P-value:6.37E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.62|P-value:9.49E-4 ID:SGTC_3302|Compound:9125395|FD-Score:4.82|P-value:1.80E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:6.97|P-value:1.12E-9 ID:SGTC_114|Compound:0364-0001|FD-Score:4.27|P-value:1.22E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:-4.05|P-value:2.69E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.20|P-value:1.56E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.63|P-value:9.31E-4 ID:SGTC_448|Compound:monastrol|FD-Score:4.21|P-value:1.54E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:3.68|P-value:7.96E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.77|P-value:3.75E-7 ID:SGTC_521|Compound:r062-0005|FD-Score:6.41|P-value:1.94E-8 ID:SGTC_524|Compound:r073-0010|FD-Score:3.94|P-value:3.66E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:4.03|P-value:2.70E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:4.27|P-value:1.24E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.73|P-value:2.47E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.44|P-value:7.10E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.66|P-value:8.84E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.69|P-value:7.98E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.85|P-value:4.82E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.94|P-value:3.63E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.28|P-value:1.20E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.27|P-value:1.24E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.70|P-value:7.75E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.85|P-value:4.90E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:4.31|P-value:1.08E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.26|P-value:1.33E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.05|P-value:2.64E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.69|P-value:8.06E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-4.75|P-value:2.42E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-4.72|P-value:2.66E-5 ID:SGTC_3051|Compound:9093778|FD-Score:4.05|P-value:2.57E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-4.37|P-value:9.22E-5 ID:SGTC_3105|Compound:9121040|FD-Score:-3.85|P-value:4.97E-4 ID:SGTC_3162|Compound:9099653|FD-Score:-3.77|P-value:6.37E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.62|P-value:9.49E-4 ID:SGTC_3302|Compound:9125395|FD-Score:4.82|P-value:1.80E-5

Top fitness defect scores for YGR014W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_108 0509-0257 6.97 621.1 µM 1.12E-9 8 1.54E-12
2 SGTC_521 r062-0005 6.41 13.8 µM 1.94E-8 2 7.28E-11
3 SGTC_514 4466-0038 5.77 2.6 nM 3.75E-7 cell wall 81 3.98E-9
4 SGTC_3302 9125395 4.82 16.4 µM 1.80E-5 2 7.31E-7
5 SGTC_1091 telmisartan 4.73 47.6 µM 2.47E-5 3 1.12E-6
6 SGTC_1274 0865-0114 4.44 173.0 µM 7.10E-5 15 4.60E-6
7 SGTC_2764 methyldopa 4.31 94.7 µM 1.08E-4 12 8.05E-6
8 SGTC_2425 5628681 4.28 7.8 µM 1.20E-4 14 9.30E-6
9 SGTC_114 0364-0001 4.27 490.3 µM 1.22E-4 41 9.57E-6
10 SGTC_850 0388-0143 4.27 75.9 µM 1.24E-4 8 9.70E-6
11 SGTC_2597 laccaic acid a 4.27 100.0 µM 1.24E-4 29 9.71E-6
12 SGTC_448 monastrol 4.21 171.0 µM 1.54E-4 8 1.30E-5
13 SGTC_129 0088-0017 4.20 176.6 µM 1.56E-4 64 1.33E-5
14 SGTC_3051 9093778 4.05 49.5 µM 2.57E-4 2 2.58E-5
15 SGTC_802 4112-3352 4.03 742.0 µM 2.70E-4 23 2.76E-5
16 SGTC_2136 5328288 3.94 199.3 µM 3.63E-4 21 4.09E-5
17 SGTC_524 r073-0010 3.94 27.8 µM 3.66E-4 52 4.14E-5
18 SGTC_1931 st074438 3.85 57.1 µM 4.82E-4 20 5.98E-5
19 SGTC_460 trequinsin 3.68 123.0 µM 7.96E-4 6 1.17E-4
20 SGTC_304 1310-0298 3.63 97.0 µM 9.31E-4 cell wall 74 1.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.61E-16 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.127 1.67E-13 YGR099W TEL2 het Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
0.116 1.76E-11 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.102 3.24E-9 YGR130C YGR130C hom Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
0.099 9.34E-9 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.097 1.73E-8 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.095 3.65E-8 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.094 4.53E-8 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.093 5.79E-8 YLR183C TOS4 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication
0.092 9.15E-8 YDR346C SVF1 hom Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance
0.092 1.07E-7 YKR050W TRK2 hom Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication
0.090 2.01E-7 YFL034C-B MOB2 het Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.089 2.65E-7 YOR015W_d YOR015W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 5.38E-7 YNL328C MDJ2 hom Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
0.086 6.19E-7 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene