YGR093W_p

Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR093W / YGR093W

Click on Significant Values for Screen Details ID:SGTC_131|Compound:0141-0277|FD-Score:-3.26|P-value:4.72E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.18|P-value:5.80E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.20|P-value:5.55E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:6.50|P-value:1.83E-11 ID:SGTC_610|Compound:4215-0184|FD-Score:5.05|P-value:1.35E-7 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.50|P-value:2.50E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-5.17|P-value:7.61E-8 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.07|P-value:9.21E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.26|P-value:4.41E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.11|P-value:7.55E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.18|P-value:5.86E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.28|P-value:4.13E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-3.23|P-value:5.25E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.47|P-value:1.99E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.36|P-value:3.02E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.08|P-value:8.47E-4 ID:SGTC_1685|Compound:st024049|FD-Score:-3.24|P-value:5.19E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.15|P-value:6.49E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-3.11|P-value:8.02E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.31|P-value:3.60E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.83|P-value:4.64E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-3.47|P-value:2.15E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.38|P-value:2.79E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-3.11|P-value:8.06E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.20|P-value:5.49E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.47|P-value:2.00E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-4.00|P-value:2.50E-5 ID:SGTC_2154|Compound:5570129|FD-Score:4.40|P-value:3.69E-6 ID:SGTC_2221|Compound:6807166|FD-Score:3.24|P-value:4.66E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:3.05|P-value:9.36E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.15|P-value:7.10E-4 ID:SGTC_2298|Compound:7976326|FD-Score:5.60|P-value:5.71E-9 ID:SGTC_2351|Compound:9026858|FD-Score:4.44|P-value:3.01E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.82|P-value:4.86E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.17|P-value:1.08E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.22|P-value:5.16E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.67|P-value:9.22E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.85|P-value:4.37E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.89|P-value:3.68E-5 ID:SGTC_2789|Compound:5281112|FD-Score:6.20|P-value:1.33E-10 ID:SGTC_2840|Compound:9008771|FD-Score:4.08|P-value:1.60E-5 ID:SGTC_2886|Compound:9058944|FD-Score:3.17|P-value:6.08E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.10|P-value:7.81E-4 ID:SGTC_3013|Compound:9080133|FD-Score:8.40|P-value:6.21E-18 ID:SGTC_3021|Compound:9087658|FD-Score:3.86|P-value:4.09E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.52|P-value:1.81E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.26|P-value:4.72E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.18|P-value:5.80E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.20|P-value:5.55E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:6.50|P-value:1.83E-11 ID:SGTC_610|Compound:4215-0184|FD-Score:5.05|P-value:1.35E-7 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.50|P-value:2.50E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-5.17|P-value:7.61E-8 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.07|P-value:9.21E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.26|P-value:4.41E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.11|P-value:7.55E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.18|P-value:5.86E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.28|P-value:4.13E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-3.23|P-value:5.25E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.47|P-value:1.99E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.36|P-value:3.02E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.08|P-value:8.47E-4 ID:SGTC_1685|Compound:st024049|FD-Score:-3.24|P-value:5.19E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.15|P-value:6.49E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-3.11|P-value:8.02E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.31|P-value:3.60E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.83|P-value:4.64E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-3.47|P-value:2.15E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.38|P-value:2.79E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-3.11|P-value:8.06E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.20|P-value:5.49E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.47|P-value:2.00E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-4.00|P-value:2.50E-5 ID:SGTC_2154|Compound:5570129|FD-Score:4.40|P-value:3.69E-6 ID:SGTC_2221|Compound:6807166|FD-Score:3.24|P-value:4.66E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:3.05|P-value:9.36E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.15|P-value:7.10E-4 ID:SGTC_2298|Compound:7976326|FD-Score:5.60|P-value:5.71E-9 ID:SGTC_2351|Compound:9026858|FD-Score:4.44|P-value:3.01E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.82|P-value:4.86E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.17|P-value:1.08E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.22|P-value:5.16E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.67|P-value:9.22E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.85|P-value:4.37E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.89|P-value:3.68E-5 ID:SGTC_2789|Compound:5281112|FD-Score:6.20|P-value:1.33E-10 ID:SGTC_2840|Compound:9008771|FD-Score:4.08|P-value:1.60E-5 ID:SGTC_2886|Compound:9058944|FD-Score:3.17|P-value:6.08E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.10|P-value:7.81E-4 ID:SGTC_3013|Compound:9080133|FD-Score:8.40|P-value:6.21E-18 ID:SGTC_3021|Compound:9087658|FD-Score:3.86|P-value:4.09E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.52|P-value:1.81E-4

Top fitness defect scores for YGR093W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3013 9080133 8.40 71.4 µM 6.21E-18 1 2.30E-17
2 SGTC_593 1203-0218 6.50 61.7 µM 1.83E-11 1 4.11E-11
3 SGTC_2789 5281112 6.20 71.4 µM 1.33E-10 3 2.80E-10
4 SGTC_2298 7976326 5.60 193.8 µM 5.71E-9 1 1.06E-8
5 SGTC_610 4215-0184 5.05 155.0 µM 1.35E-7 exosome 1 2.25E-7
6 SGTC_2351 9026858 4.44 72.3 µM 3.01E-6 RNA processing & uracil transport 19 4.50E-6
7 SGTC_2154 5570129 4.40 200.0 µM 3.69E-6 4 5.48E-6
8 SGTC_2560 caryophyllene 4.17 100.0 µM 1.08E-5 14 1.54E-5
9 SGTC_2840 9008771 4.08 71.4 µM 1.60E-5 7 2.26E-5
10 SGTC_2608 thymoquinone 3.89 42.7 µM 3.68E-5 17 5.06E-5
11 SGTC_3021 9087658 3.86 49.5 µM 4.09E-5 7 5.60E-5
12 SGTC_2606 farnesol 3.85 9.8 µM 4.37E-5 19 5.97E-5
13 SGTC_1897 st060201 3.83 15.0 µM 4.64E-5 mitochondrial processes 20 6.33E-5
14 SGTC_2406 ethylparaben 3.82 405.7 µM 4.86E-5 45 6.62E-5
15 SGTC_2605 digitonin 3.67 300.0 nM 9.22E-5 41 1.23E-4
16 SGTC_1349 flufenamic acid 3.47 69.0 µM 1.99E-4 28 2.59E-4
17 SGTC_2080 5212524 3.47 12.4 µM 2.00E-4 copper-dependent oxidative stress 28 2.60E-4
18 SGTC_2054 5233173 3.38 129.0 µM 2.79E-4 mitochondrial response to ROS 82 3.58E-4
19 SGTC_1459 k035-0031 3.36 35.7 µM 3.02E-4 DNA intercalators 39 3.87E-4
20 SGTC_1773 st048542 3.31 73.6 µM 3.60E-4 74 4.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 7.84E-16 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.132 1.92E-14 YOR083W WHI5 hom Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
0.127 1.78E-13 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.119 5.33E-12 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.112 6.73E-11 YPL121C MEI5 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
0.111 1.16E-10 YGR003W CUL3 hom Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3
0.109 2.14E-10 YBR071W YBR071W hom Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking
0.105 1.10E-9 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.100 5.97E-9 YKL162C_p YKL162C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.099 9.83E-9 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.098 1.48E-8 YKL129C MYO3 hom One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.091 1.44E-7 YGL235W_p YGL235W_p hom Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.085 7.51E-7 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.084 1.05E-6 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.081 2.64E-6 YGR066C_p YGR066C_p hom Putative protein of unknown function