YGR110W / CLD1

Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR110W / CLD1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.27|P-value:8.62E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.77|P-value:1.31E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.45|P-value:4.07E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.62|P-value:2.58E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.60|P-value:2.42E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.58|P-value:2.66E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:5.77|P-value:1.49E-8 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.93|P-value:8.25E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.51|P-value:3.87E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.67|P-value:2.19E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:-3.40|P-value:4.94E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:4.05|P-value:5.04E-5 ID:SGTC_1782|Compound:st039423|FD-Score:3.29|P-value:8.15E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.27|P-value:8.79E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-4.20|P-value:2.40E-5 ID:SGTC_1935|Compound:st074532|FD-Score:-3.47|P-value:3.81E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.23|P-value:8.74E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.26|P-value:7.87E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-4.09|P-value:3.75E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.62|P-value:2.29E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-3.29|P-value:7.15E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.49|P-value:3.54E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.87|P-value:8.90E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.32|P-value:7.44E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.95|P-value:6.49E-5 ID:SGTC_2474|Compound:5321570|FD-Score:-3.43|P-value:4.50E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.82|P-value:1.26E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.33|P-value:6.27E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.36|P-value:1.44E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:-5.37|P-value:1.02E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.73|P-value:1.52E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.31|P-value:7.63E-4 ID:SGTC_2898|Compound:9056270|FD-Score:-3.30|P-value:6.91E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.47|P-value:3.85E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.28|P-value:7.42E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.27|P-value:8.62E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.77|P-value:1.31E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.45|P-value:4.07E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.62|P-value:2.58E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.60|P-value:2.42E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.58|P-value:2.66E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:5.77|P-value:1.49E-8 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.93|P-value:8.25E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.51|P-value:3.87E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.67|P-value:2.19E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:-3.40|P-value:4.94E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:4.05|P-value:5.04E-5 ID:SGTC_1782|Compound:st039423|FD-Score:3.29|P-value:8.15E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.27|P-value:8.79E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-4.20|P-value:2.40E-5 ID:SGTC_1935|Compound:st074532|FD-Score:-3.47|P-value:3.81E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.23|P-value:8.74E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.26|P-value:7.87E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-4.09|P-value:3.75E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.62|P-value:2.29E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-3.29|P-value:7.15E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.49|P-value:3.54E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.87|P-value:8.90E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.32|P-value:7.44E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.95|P-value:6.49E-5 ID:SGTC_2474|Compound:5321570|FD-Score:-3.43|P-value:4.50E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.82|P-value:1.26E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.33|P-value:6.27E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.36|P-value:1.44E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:-5.37|P-value:1.02E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.73|P-value:1.52E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.31|P-value:7.63E-4 ID:SGTC_2898|Compound:9056270|FD-Score:-3.30|P-value:6.91E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.47|P-value:3.85E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.28|P-value:7.42E-4

Top fitness defect scores for YGR110W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_961 1252-1571 5.77 372.0 µM 1.49E-8 9 3.93E-9
2 SGTC_2762 leflunomide 4.36 42.1 µM 1.44E-5 18 6.52E-6
3 SGTC_1458 k015-0034 4.05 6.3 µM 5.04E-5 15 2.51E-5
4 SGTC_1065 prochlorperazine maleate 3.93 2.5 µM 8.25E-5 12 4.27E-5
5 SGTC_2607 solasodine 3.82 47.4 µM 1.26E-4 64 6.72E-5
6 SGTC_1085 doxorubicin 3.67 7.7 µM 2.19E-4 anthracycline transcription coupled DNA repair 27 1.22E-4
7 SGTC_121 0557-0495 3.62 61.3 µM 2.58E-4 calcium & mitochondrial duress 73 1.45E-4
8 SGTC_1067 clotrimazole 3.51 1.4 µM 3.87E-4 azole & statin 56 2.26E-4
9 SGTC_2422 chlorphenesin carbamate 3.32 384.2 µM 7.44E-4 64 4.56E-4
10 SGTC_2777 climbazole 3.31 1.5 µM 7.63E-4 iron homeostasis 79 4.69E-4
11 SGTC_1782 st039423 3.29 80.6 µM 8.15E-4 45 5.03E-4
12 SGTC_6 0844-0013 3.27 19.8 µM 8.62E-4 165 5.35E-4
13 SGTC_1816 st051957 3.27 91.6 µM 8.79E-4 24 5.46E-4
14 SGTC_2796 7949634 3.20 45.5 µM 0.00110 53 6.92E-4
15 SGTC_962 1254-0300 3.20 21.5 µM 0.00110 53 6.94E-4
16 SGTC_741 4582-0002 3.19 126.0 µM 0.00114 39 7.20E-4
17 SGTC_2137 5261020 3.07 140.0 µM 0.00166 71 0.00108
18 SGTC_2528 xanthyletin 3.05 44.8 µM 0.00174 51 0.00114
19 SGTC_367 0335-0881 3.05 7.1 µM 0.00175 ubiquinone biosynthesis & proteasome 138 0.00115
20 SGTC_1013 4112-3890 3.04 241.0 µM 0.00178 TSC3-RPN4 82 0.00116

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.229 2.84E-41 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.180 8.14E-26 YKL215C OXP1 hom 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.178 3.51E-25 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.172 8.77E-24 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.165 5.82E-22 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.150 2.36E-18 YDR465C RMT2 hom Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress
0.147 1.46E-17 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.144 4.51E-17 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.140 3.24E-16 YOR308C SNU66 hom Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1
0.139 6.88E-16 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.137 1.80E-15 YLR120C YPS1 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.131 2.42E-14 YPR082C DIB1 het 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
0.129 7.45E-14 YGL125W MET13 hom Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
0.125 3.28E-13 YKR039W GAP1 hom General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth
0.122 1.12E-12 YPR140W TAZ1 hom Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome