YGR118W / RPS23A

Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR118W / RPS23A

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-3.25|P-value:9.50E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.81|P-value:2.04E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.44|P-value:4.92E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.53|P-value:3.62E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.67|P-value:2.24E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.60|P-value:2.84E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.38|P-value:6.14E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.51|P-value:3.95E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:3.43|P-value:5.11E-4 ID:SGTC_510|Compound:ag-490|FD-Score:4.12|P-value:3.99E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:3.79|P-value:1.41E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.27|P-value:8.63E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.01|P-value:6.19E-5 ID:SGTC_630|Compound:4356-0227|FD-Score:3.61|P-value:2.79E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:-3.24|P-value:9.64E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.67|P-value:3.90E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.69|P-value:2.07E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.70|P-value:1.96E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.80|P-value:1.41E-8 ID:SGTC_888|Compound:0916-0002|FD-Score:3.86|P-value:1.12E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.79|P-value:1.41E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:5.02|P-value:7.66E-7 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.55|P-value:3.37E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.97|P-value:7.35E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.40|P-value:5.64E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:-5.27|P-value:2.36E-7 ID:SGTC_943|Compound:3253-1379|FD-Score:-5.47|P-value:8.17E-8 ID:SGTC_949|Compound:1165-0505|FD-Score:6.95|P-value:1.46E-11 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.70|P-value:2.03E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:-3.25|P-value:9.45E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.35|P-value:6.79E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.52|P-value:3.73E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.02|P-value:6.06E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-3.65|P-value:2.42E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.10|P-value:4.41E-5 ID:SGTC_1933|Compound:st074711|FD-Score:3.27|P-value:8.61E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.51|P-value:3.87E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.84|P-value:1.20E-4 ID:SGTC_2134|Compound:5324836|FD-Score:4.43|P-value:1.13E-5 ID:SGTC_2136|Compound:5328288|FD-Score:3.46|P-value:4.58E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.30|P-value:7.94E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.27|P-value:8.78E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.37|P-value:6.31E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.32|P-value:7.39E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.30|P-value:1.90E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.50|P-value:3.97E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.99|P-value:6.60E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.45|P-value:4.76E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.45|P-value:4.74E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.89|P-value:9.83E-5 ID:SGTC_3255|Compound:9139072|FD-Score:-3.39|P-value:5.90E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.25|P-value:9.50E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.81|P-value:2.04E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.44|P-value:4.92E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.53|P-value:3.62E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.67|P-value:2.24E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.60|P-value:2.84E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.38|P-value:6.14E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.51|P-value:3.95E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:3.43|P-value:5.11E-4 ID:SGTC_510|Compound:ag-490|FD-Score:4.12|P-value:3.99E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:3.79|P-value:1.41E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.27|P-value:8.63E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.01|P-value:6.19E-5 ID:SGTC_630|Compound:4356-0227|FD-Score:3.61|P-value:2.79E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:-3.24|P-value:9.64E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.67|P-value:3.90E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.69|P-value:2.07E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.70|P-value:1.96E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.80|P-value:1.41E-8 ID:SGTC_888|Compound:0916-0002|FD-Score:3.86|P-value:1.12E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.79|P-value:1.41E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:5.02|P-value:7.66E-7 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.55|P-value:3.37E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.97|P-value:7.35E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.40|P-value:5.64E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:-5.27|P-value:2.36E-7 ID:SGTC_943|Compound:3253-1379|FD-Score:-5.47|P-value:8.17E-8 ID:SGTC_949|Compound:1165-0505|FD-Score:6.95|P-value:1.46E-11 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.70|P-value:2.03E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:-3.25|P-value:9.45E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.35|P-value:6.79E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.52|P-value:3.73E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.02|P-value:6.06E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-3.65|P-value:2.42E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.10|P-value:4.41E-5 ID:SGTC_1933|Compound:st074711|FD-Score:3.27|P-value:8.61E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.51|P-value:3.87E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.84|P-value:1.20E-4 ID:SGTC_2134|Compound:5324836|FD-Score:4.43|P-value:1.13E-5 ID:SGTC_2136|Compound:5328288|FD-Score:3.46|P-value:4.58E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.30|P-value:7.94E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.27|P-value:8.78E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.37|P-value:6.31E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.32|P-value:7.39E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.30|P-value:1.90E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.50|P-value:3.97E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.99|P-value:6.60E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.45|P-value:4.76E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.45|P-value:4.74E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.89|P-value:9.83E-5 ID:SGTC_3255|Compound:9139072|FD-Score:-3.39|P-value:5.90E-4

Top fitness defect scores for YGR118W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_949 1165-0505 6.95 146.0 µM 1.46E-11 5 1.84E-12
2 SGTC_800 3448-7362 5.80 155.0 µM 1.41E-8 translation 55 3.28E-9
3 SGTC_906 1165-0455 5.02 526.0 µM 7.66E-7 3 2.55E-7
4 SGTC_118 0083-0097 4.81 135.3 µM 2.04E-6 translation 70 7.39E-7
5 SGTC_754 3474-0146 4.67 171.0 µM 3.90E-6 copper-dependent oxidative stress 12 1.50E-6
6 SGTC_2134 5324836 4.43 1.5 µM 1.13E-5 12 4.78E-6
7 SGTC_2688 kanamycin b 4.30 96.7 µM 1.90E-5 calcium & mitochondrial duress 322 8.40E-6
8 SGTC_510 ag-490 4.12 170.0 µM 3.99E-5 1 1.88E-5
9 SGTC_1920 st075728 4.10 45.7 µM 4.41E-5 20 2.10E-5
10 SGTC_1746 st038117 4.02 42.0 µM 6.06E-5 32 2.96E-5
11 SGTC_625 k213-0058 4.01 121.0 µM 6.19E-5 translation 100 3.03E-5
12 SGTC_3043 9092303 3.99 49.5 µM 6.60E-5 15 3.25E-5
13 SGTC_915 methyl methanesulfonate (MMS) 3.97 110.0 mM 7.35E-5 DNA damage response 43 3.65E-5
14 SGTC_3249 9135183 3.89 49.5 µM 9.83E-5 60S ribosome export 12 5.01E-5
15 SGTC_888 0916-0002 3.86 7.0 µM 1.12E-4 NEO1 46 5.77E-5
16 SGTC_2042 p-Dimethylaminoacetophenone 3.84 200.0 µM 1.20E-4 20 6.24E-5
17 SGTC_900 1112-0045 3.79 141.0 µM 1.41E-4 NEO1 26 7.40E-5
18 SGTC_541 4513-1321 3.79 94.0 µM 1.41E-4 23 7.41E-5
19 SGTC_797 k781-0471 3.70 270.0 µM 1.96E-4 RPP1 & pyrimidine depletion 31 1.06E-4
20 SGTC_364 0083-0097 3.67 67.7 µM 2.24E-4 33 1.23E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 7.08E-20 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.138 8.80E-16 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.134 5.92E-15 YPL239W YAR1 hom Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
0.131 2.25E-14 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.128 1.18E-13 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.123 7.68E-13 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.121 2.16E-12 YBL071C-B_p YBL071C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.120 2.67E-12 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.118 5.96E-12 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.117 1.12E-11 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.116 1.34E-11 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.113 6.28E-11 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.111 1.02E-10 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.111 1.04E-10 YBR267W REI1 hom Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
0.110 1.82E-10 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p