YGR119C / NUP57

FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR119C / NUP57

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:4.55|P-value:9.46E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:4.29|P-value:2.13E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:5.71|P-value:1.37E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:4.52|P-value:1.05E-4 ID:SGTC_269|Compound:exalamide|FD-Score:4.07|P-value:4.17E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.79|P-value:9.38E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.75|P-value:4.80E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:3.81|P-value:8.80E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.83|P-value:8.23E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.09|P-value:3.94E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.05|P-value:4.38E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.58|P-value:8.51E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:6.57|P-value:3.41E-8 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.57|P-value:8.67E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:6.40|P-value:7.26E-8 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.52|P-value:1.04E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.91|P-value:2.74E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.97|P-value:5.53E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.51|P-value:1.06E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.81|P-value:3.97E-5 ID:SGTC_1838|Compound:st055369|FD-Score:5.26|P-value:7.80E-6 ID:SGTC_1911|Compound:st060208|FD-Score:8.24|P-value:6.50E-12 ID:SGTC_1917|Compound:st066507|FD-Score:-4.08|P-value:4.00E-4 ID:SGTC_1932|Compound:st074806|FD-Score:6.34|P-value:9.52E-8 ID:SGTC_2045|Compound:5106652|FD-Score:3.92|P-value:6.45E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.24|P-value:2.48E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.46|P-value:1.26E-4 ID:SGTC_2140|Compound:5586273|FD-Score:5.99|P-value:4.29E-7 ID:SGTC_2207|Compound:7258803|FD-Score:5.15|P-value:1.16E-5 ID:SGTC_2290|Compound:7904846|FD-Score:4.14|P-value:3.42E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.30|P-value:2.08E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-5.47|P-value:3.60E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-11.30|P-value:6.29E-21 ID:SGTC_2576|Compound:guaiol|FD-Score:4.65|P-value:6.74E-5 ID:SGTC_2591|Compound:skatole|FD-Score:6.74|P-value:1.53E-8 ID:SGTC_2663|Compound:amphotericin b|FD-Score:5.76|P-value:1.13E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.95|P-value:5.98E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:5.85|P-value:7.91E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.66|P-value:6.55E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.92|P-value:6.38E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.67|P-value:6.25E-5 ID:SGTC_2882|Compound:9058044|FD-Score:4.01|P-value:4.94E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-4.36|P-value:1.73E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-3.88|P-value:7.23E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.04|P-value:4.55E-4 ID:SGTC_3201|Compound:9113999|FD-Score:5.09|P-value:1.44E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-4.09|P-value:3.91E-4 ID:SGTC_3305|Compound:9127027|FD-Score:4.05|P-value:4.43E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.55|P-value:9.46E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:4.29|P-value:2.13E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:5.71|P-value:1.37E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:4.52|P-value:1.05E-4 ID:SGTC_269|Compound:exalamide|FD-Score:4.07|P-value:4.17E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.79|P-value:9.38E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.75|P-value:4.80E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:3.81|P-value:8.80E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.83|P-value:8.23E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.09|P-value:3.94E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.05|P-value:4.38E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.58|P-value:8.51E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:6.57|P-value:3.41E-8 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.57|P-value:8.67E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:6.40|P-value:7.26E-8 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.52|P-value:1.04E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.91|P-value:2.74E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.97|P-value:5.53E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.51|P-value:1.06E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.81|P-value:3.97E-5 ID:SGTC_1838|Compound:st055369|FD-Score:5.26|P-value:7.80E-6 ID:SGTC_1911|Compound:st060208|FD-Score:8.24|P-value:6.50E-12 ID:SGTC_1917|Compound:st066507|FD-Score:-4.08|P-value:4.00E-4 ID:SGTC_1932|Compound:st074806|FD-Score:6.34|P-value:9.52E-8 ID:SGTC_2045|Compound:5106652|FD-Score:3.92|P-value:6.45E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.24|P-value:2.48E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.46|P-value:1.26E-4 ID:SGTC_2140|Compound:5586273|FD-Score:5.99|P-value:4.29E-7 ID:SGTC_2207|Compound:7258803|FD-Score:5.15|P-value:1.16E-5 ID:SGTC_2290|Compound:7904846|FD-Score:4.14|P-value:3.42E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.30|P-value:2.08E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-5.47|P-value:3.60E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-11.30|P-value:6.29E-21 ID:SGTC_2576|Compound:guaiol|FD-Score:4.65|P-value:6.74E-5 ID:SGTC_2591|Compound:skatole|FD-Score:6.74|P-value:1.53E-8 ID:SGTC_2663|Compound:amphotericin b|FD-Score:5.76|P-value:1.13E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.95|P-value:5.98E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:5.85|P-value:7.91E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.66|P-value:6.55E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.92|P-value:6.38E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.67|P-value:6.25E-5 ID:SGTC_2882|Compound:9058044|FD-Score:4.01|P-value:4.94E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-4.36|P-value:1.73E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-3.88|P-value:7.23E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.04|P-value:4.55E-4 ID:SGTC_3201|Compound:9113999|FD-Score:5.09|P-value:1.44E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-4.09|P-value:3.91E-4 ID:SGTC_3305|Compound:9127027|FD-Score:4.05|P-value:4.43E-4

Top fitness defect scores for YGR119C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1911 st060208 8.24 74.3 µM 6.50E-12 1 8.33E-17 2.35
2 SGTC_2591 skatole 6.74 100.0 µM 1.53E-8 1 7.69E-12 2.17
3 SGTC_1129 3453-1384 6.57 223.0 µM 3.41E-8 3 2.48E-11 0.59
4 SGTC_1294 1000-1494 6.40 117.0 µM 7.26E-8 4 7.54E-11 0.36
5 SGTC_1932 st074806 6.34 40.9 µM 9.52E-8 2 1.12E-10 0.67
6 SGTC_2140 5586273 5.99 200.0 µM 4.29E-7 RSC complex & mRNA processing 5 1.02E-9 0.03
7 SGTC_2718 lomofungin 5.85 53.0 µM 7.91E-7 mitochondrial processes 2 2.51E-9 1.07
8 SGTC_2663 amphotericin b 5.76 100.0 µM 1.13E-6 1 4.25E-9 0.81
9 SGTC_182 3448-4371 5.71 550.5 µM 1.37E-6 1 5.59E-9 1.28
10 SGTC_1838 st055369 5.26 84.5 µM 7.80E-6 3 7.15E-8 0.98
11 SGTC_2207 7258803 5.15 200.0 µM 1.16E-5 1 1.27E-7 1.81
12 SGTC_3201 9113999 5.09 49.5 µM 1.44E-5 2 1.76E-7 0.44
13 SGTC_1469 k284-2957 4.91 126.0 µM 2.74E-5 9 4.47E-7 0.72
14 SGTC_1583 clindamycin 4.81 39.6 µM 3.97E-5 mitochondrial processes 2 7.70E-7 0.24
15 SGTC_672 1441-0018 4.75 53.7 µM 4.80E-5 1 1.01E-6 0.48
16 SGTC_2857 9024691 4.67 58.4 µM 6.25E-5 4 1.49E-6 1.03
17 SGTC_2576 guaiol 4.65 23.1 µM 6.74E-5 6 1.67E-6 0.86
18 SGTC_1089 terbinafine 4.58 2.2 µM 8.51E-5 4 2.34E-6 0.03
19 SGTC_1204 4049-0315 4.57 18.3 µM 8.67E-5 5 2.40E-6 0.07
20 SGTC_93 0109-0045 4.55 59.2 µM 9.46E-5 DNA damage response 12 2.73E-6 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.42E-15 YGL172W NUP49 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
0.131 2.75E-14 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.089 2.57E-7 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.086 6.93E-7 YMR312W ELP6 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.082 1.88E-6 YER177W BMH1 hom 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.082 1.88E-6 YKL186C MTR2 het mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
0.081 2.43E-6 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.080 3.15E-6 YPL169C MEX67 het Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
0.079 5.21E-6 YOR066W MSA1 hom Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
0.078 6.05E-6 YOR224C RPB8 het RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
0.077 7.08E-6 YGL127C SOH1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
0.077 7.59E-6 YGL184C STR3 hom Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p
0.077 8.56E-6 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.075 1.44E-5 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.074 1.69E-5 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation