HIPHOP chemogenomics database

YGR189C / CRH1

Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR189C / CRH1

Click on Significant Values for Screen Details

Top fitness defect scores for YGR189C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2415	st077333	8.69	57.7 µM	1.43E-21		3	1.81E-18
2	SGTC_1170	0310-0127	4.49	64.8 µM	5.00E-7		11	3.54E-6
3	SGTC_2136	5328288	4.17	199.3 µM	2.77E-6		17	1.51E-5
4	SGTC_394	menadione	3.85	8.3 µM	1.36E-5	superoxide	36	5.84E-5
5	SGTC_2761	levamisole	3.78	97.9 µM	1.90E-5		19	7.75E-5
6	SGTC_1175	0741-0056	3.77	27.6 µM	2.02E-5		22	8.17E-5
7	SGTC_2419	paclitaxel	3.76	166.5 µM	2.12E-5		49	8.52E-5
8	SGTC_2542	2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene	3.71	100.0 µM	2.65E-5		28	1.03E-4
9	SGTC_3063	1327-0034	3.68	4.0 µM	3.05E-5		51	1.16E-4
10	SGTC_1951	sophoraflavanone G	3.68	9.2 µM	3.08E-5	RNA processing & uracil transport	35	1.17E-4
11	SGTC_3207	9114163	3.67	49.5 µM	3.27E-5		40	1.23E-4
12	SGTC_2349	9023730	3.67	187.1 µM	3.28E-5		36	1.23E-4
13	SGTC_2006	4011487	3.53	200.0 µM	6.04E-5	endomembrane recycling	104	2.07E-4
14	SGTC_555	4296-0685	3.36	37.0 µM	1.25E-4	ergosterol biosynthesis	26	3.85E-4
15	SGTC_2119	5528445	3.36	120.6 µM	1.26E-4		42	3.87E-4
16	SGTC_1404	3909-7820	3.36	48.3 µM	1.29E-4	60S ribosome export	22	3.96E-4
17	SGTC_1630	st005209	3.31	31.3 µM	1.57E-4		52	4.67E-4
18	SGTC_143	4032-1194	3.27	15.7 µM	1.83E-4		106	5.32E-4
19	SGTC_1028	k015-0029	3.25	4.8 µM	2.02E-4		48	5.79E-4
20	SGTC_2757	clomiphene	3.17	4.2 µM	2.78E-4	fatty acid desaturase (OLE1)	78	7.60E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.212	2.26E-35	YDL174C	DLD1	hom	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.186	1.51E-27	YJR116W_p	TDA4_p	hom	Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.155	1.96E-19	YKL171W	NNK1	hom	Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.143	6.92E-17	YLR272C	YCS4	het	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.138	8.36E-16	YBR207W	FTH1	hom	Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.132	1.39E-14	YOR062C_p	YOR062C_p	hom	Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.129	7.22E-14	YHR065C	RRP3	het	Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
0.126	2.26E-13	YEL058W	PCM1	het	Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.118	6.05E-12	YOR219C	STE13	hom	Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
0.116	1.71E-11	YFR039C_p	YFR039C_p	hom	Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces
0.114	3.26E-11	YPR025C	CCL1	het	Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
0.114	3.48E-11	YJR147W	HMS2	hom	Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
0.112	6.68E-11	YDR099W	BMH2	hom	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.111	1.30E-10	YEL016C	NPP2	hom	Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication
0.111	1.37E-10	YMR007W_d	YMR007W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data