HIPHOP chemogenomics database

YGR196C / FYV8

Protein of unknown function, required for survival upon exposure to K1 killer toxin

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR196C / FYV8

Click on Significant Values for Screen Details

Top fitness defect scores for YGR196C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_255	tunicamycin	28.40	200.5 nM	7.65E-179	unfolded protein response	1	2.35E-177
2	SGTC_2009	4012297	25.00	12.1 µM	4.22E-139	cell wall signaling	2	5.92E-138
3	SGTC_663	1486-0733	20.50	13.9 µM	2.94E-94	cell wall signaling	4	1.71E-93
4	SGTC_2007	4011539	19.80	71.8 µM	6.42E-88	cell wall signaling	4	3.30E-87
5	SGTC_58	0957-0393	17.80	9.0 µM	1.41E-71	cell wall	19	5.28E-71
6	SGTC_2399	5884133	13.50	200.0 µM	2.58E-42	cell wall signaling	7	5.47E-42
7	SGTC_2582	agaric acid	13.10	100.0 µM	7.87E-40	redox potentiating	26	1.59E-39
8	SGTC_299	1273-0059	7.63	1.4 µM	9.11E-15		3	1.14E-14
9	SGTC_2289	7946404	7.17	165.1 µM	3.12E-13		26	3.81E-13
10	SGTC_2055	5235184	6.44	200.0 µM	4.97E-11	ERG2	5	5.82E-11
11	SGTC_531	3788-1495	6.37	174.0 µM	7.89E-11	unfolded protein response	6	9.20E-11
12	SGTC_2272	7805186	5.87	180.0 µM	1.93E-9	cell wall signaling	7	2.20E-9
13	SGTC_2149	5554786	5.79	194.8 µM	3.17E-9	cell wall signaling	10	3.59E-9
14	SGTC_2028	5153890	5.52	36.4 µM	1.55E-8	cell wall signaling	14	1.73E-8
15	SGTC_353	1988-1175	5.22	58.3 µM	8.10E-8	unfolded protein response	10	8.95E-8
16	SGTC_2619	obliquin	5.22	87.9 µM	8.29E-8	cell wall	94	9.16E-8
17	SGTC_500	h-89	5.03	112.0 µM	2.19E-7	cell wall signaling	18	2.40E-7
18	SGTC_63	0099-0242	4.95	26.7 µM	3.35E-7	mitochondrial stress	58	3.66E-7
19	SGTC_457	grayanotoxin iii	4.87	135.0 µM	5.08E-7		31	5.54E-7
20	SGTC_2286	7945697	4.84	125.0 µM	5.94E-7		30	6.46E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.656	0	YBR260C	RGD1	hom	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.527	3.14E-239	YDL203C	ACK1	hom	Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.459	4.14E-174	YLR332W	MID2	hom	O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.456	3.27E-172	YOR231W	MKK1	hom	MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.434	5.69E-154	YLR331C_d	JIP3_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.375	1.75E-112	YKR042W	UTH1	hom	Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.363	6.57E-105	YNL322C	KRE1	hom	Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.355	2.57E-100	YAL056C-A_d	YAL056C-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.316	1.79E-78	YBR243C	ALG7	het	UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.311	5.18E-76	YJL095W	BCK1	hom	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.307	1.40E-73	YHR030C	SLT2	hom	Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.302	1.25E-71	YAL053W	FLC2	hom	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.281	5.75E-62	YOR008C	SLG1	hom	Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
0.281	9.92E-62	YNL084C	END3	hom	EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.273	2.36E-58	YMR200W	ROT1	het	Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation