YGR201C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR201C / YGR201C

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:-3.73|P-value:2.06E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-2.93|P-value:6.32E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.15|P-value:2.68E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.31|P-value:1.07E-6 ID:SGTC_456|Compound:gingerol|FD-Score:-2.97|P-value:5.48E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.15|P-value:2.69E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:2.91|P-value:6.95E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.12|P-value:3.07E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.01|P-value:4.72E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.32|P-value:1.32E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.17|P-value:2.44E-4 ID:SGTC_1563|Compound:conessine|FD-Score:4.07|P-value:3.78E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:4.21|P-value:1.87E-6 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.91|P-value:8.54E-6 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.41|P-value:8.89E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-5.28|P-value:3.30E-9 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.23|P-value:1.88E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.67|P-value:2.72E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-4.64|P-value:1.75E-7 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.04|P-value:4.24E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-4.85|P-value:4.91E-8 ID:SGTC_1658|Compound:st012944|FD-Score:3.01|P-value:4.67E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.15|P-value:2.64E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.24|P-value:1.87E-4 ID:SGTC_1931|Compound:st074438|FD-Score:-3.47|P-value:7.01E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-4.20|P-value:1.93E-6 ID:SGTC_1953|Compound:st076800|FD-Score:-3.26|P-value:1.73E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.52|P-value:5.39E-5 ID:SGTC_2297|Compound:7971671|FD-Score:2.89|P-value:7.34E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.95|P-value:7.15E-6 ID:SGTC_2427|Compound:5545055|FD-Score:3.01|P-value:4.69E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.72|P-value:2.18E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.62|P-value:3.49E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.37|P-value:1.08E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.94|P-value:6.09E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.96|P-value:5.65E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.62|P-value:3.43E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:2.89|P-value:7.53E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.04|P-value:4.14E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.52|P-value:5.56E-5 ID:SGTC_2963|Compound:9082507|FD-Score:2.97|P-value:5.46E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.39|P-value:9.56E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.10|P-value:3.22E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.04|P-value:4.08E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.10|P-value:3.33E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.73|P-value:2.06E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-2.93|P-value:6.32E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.15|P-value:2.68E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.31|P-value:1.07E-6 ID:SGTC_456|Compound:gingerol|FD-Score:-2.97|P-value:5.48E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.15|P-value:2.69E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:2.91|P-value:6.95E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.12|P-value:3.07E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.01|P-value:4.72E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.32|P-value:1.32E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.17|P-value:2.44E-4 ID:SGTC_1563|Compound:conessine|FD-Score:4.07|P-value:3.78E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:4.21|P-value:1.87E-6 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.91|P-value:8.54E-6 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.41|P-value:8.89E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-5.28|P-value:3.30E-9 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.23|P-value:1.88E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.67|P-value:2.72E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-4.64|P-value:1.75E-7 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.04|P-value:4.24E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-4.85|P-value:4.91E-8 ID:SGTC_1658|Compound:st012944|FD-Score:3.01|P-value:4.67E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.15|P-value:2.64E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.24|P-value:1.87E-4 ID:SGTC_1931|Compound:st074438|FD-Score:-3.47|P-value:7.01E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-4.20|P-value:1.93E-6 ID:SGTC_1953|Compound:st076800|FD-Score:-3.26|P-value:1.73E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.52|P-value:5.39E-5 ID:SGTC_2297|Compound:7971671|FD-Score:2.89|P-value:7.34E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.95|P-value:7.15E-6 ID:SGTC_2427|Compound:5545055|FD-Score:3.01|P-value:4.69E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.72|P-value:2.18E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.62|P-value:3.49E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.37|P-value:1.08E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.94|P-value:6.09E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.96|P-value:5.65E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.62|P-value:3.43E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:2.89|P-value:7.53E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.04|P-value:4.14E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.52|P-value:5.56E-5 ID:SGTC_2963|Compound:9082507|FD-Score:2.97|P-value:5.46E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.39|P-value:9.56E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.10|P-value:3.22E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.04|P-value:4.08E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.10|P-value:3.33E-4

Top fitness defect scores for YGR201C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_453 enantio-paf c16 4.31 10.0 µM 1.07E-6 119 8.13E-6
2 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 4.21 85.4 µM 1.87E-6 18 1.29E-5
3 SGTC_1563 conessine 4.07 56.1 µM 3.78E-6 11 2.32E-5
4 SGTC_2419 paclitaxel 3.95 166.5 µM 7.15E-6 41 3.96E-5
5 SGTC_1569 carminic acid 3.91 40.6 µM 8.54E-6 15 4.59E-5
6 SGTC_2468 5987765 3.72 72.9 µM 2.18E-5 21 1.00E-4
7 SGTC_1587 estradiol valerate 3.67 56.1 µM 2.72E-5 17 1.21E-4
8 SGTC_2514 salinomycin 3.62 42.7 µM 3.49E-5 65 1.49E-4
9 SGTC_2206 7254556 3.52 147.0 µM 5.39E-5 60S ribosome export 6 2.14E-4
10 SGTC_2917 7979103 3.52 53.8 µM 5.56E-5 45 2.20E-4
11 SGTC_1572 epiandrosterone 3.41 68.9 µM 8.89E-5 44 3.25E-4
12 SGTC_2975 9084847 3.39 53.7 µM 9.56E-5 46 3.45E-4
13 SGTC_1418 3966-3099 3.32 2.4 µM 1.32E-4 45 4.51E-4
14 SGTC_1924 st058459 3.24 75.1 µM 1.87E-4 28 6.05E-4
15 SGTC_1584 6-fluoro-dl-tryptophan 3.23 90.0 µM 1.88E-4 mitochondrial processes 40 6.09E-4
16 SGTC_1477 0139-0234 3.17 16.0 µM 2.44E-4 27 7.58E-4
17 SGTC_494 Boc-Gly-Val-Val-CHO 3.15 140.0 µM 2.69E-4 26 8.22E-4
18 SGTC_2978 9011784 3.10 43.0 µM 3.22E-4 74 9.54E-4
19 SGTC_3324 9138759 3.10 60.8 µM 3.33E-4 49 9.82E-4
20 SGTC_3025 9087895 3.04 49.5 µM 4.08E-4 PDR1 69 0.00117

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 7.93E-41 YDR306C_p YDR306C_p hom F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
0.222 1.28E-38 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.177 5.78E-25 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.165 5.15E-22 YDR096W GIS1 hom Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
0.153 5.88E-19 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.152 6.97E-19 YBL002W HTB2 hom Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.139 6.11E-16 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.137 1.87E-15 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.134 5.63E-15 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.129 7.00E-14 YLR394W CST9 hom SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate
0.114 4.01E-11 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.112 7.16E-11 YDR063W AIM7 hom Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss
0.112 7.47E-11 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.112 8.79E-11 YLR349W_d YLR349W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
0.107 4.65E-10 YLR287C_p YLR287C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene