YGR241C / YAP1802

Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR241C / YAP1802

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.46|P-value:4.88E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.31|P-value:8.14E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.77|P-value:1.63E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.59|P-value:6.13E-6 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.32|P-value:7.79E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.96|P-value:7.57E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:5.49|P-value:8.38E-8 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.39|P-value:1.34E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:3.75|P-value:1.75E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.64|P-value:2.62E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.67|P-value:2.41E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.63|P-value:5.15E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:3.31|P-value:8.05E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.41|P-value:5.87E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.93|P-value:8.92E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.26|P-value:9.53E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:6.06|P-value:3.80E-9 ID:SGTC_1675|Compound:st018485|FD-Score:4.10|P-value:4.70E-5 ID:SGTC_1774|Compound:st048371|FD-Score:3.27|P-value:9.39E-4 ID:SGTC_1778|Compound:st046819|FD-Score:6.05|P-value:3.95E-9 ID:SGTC_1838|Compound:st055369|FD-Score:3.62|P-value:2.81E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.89|P-value:1.06E-4 ID:SGTC_1855|Compound:st056195|FD-Score:6.38|P-value:5.99E-10 ID:SGTC_2137|Compound:5261020|FD-Score:6.21|P-value:1.62E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.26|P-value:9.53E-4 ID:SGTC_2281|Compound:7943571|FD-Score:4.06|P-value:5.52E-5 ID:SGTC_2285|Compound:7945142|FD-Score:4.14|P-value:3.93E-5 ID:SGTC_2305|Compound:7443522|FD-Score:4.04|P-value:5.83E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.60|P-value:3.05E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.33|P-value:7.56E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.84|P-value:1.96E-6 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.32|P-value:7.95E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.49|P-value:4.45E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.49|P-value:4.11E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.88|P-value:1.10E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.83|P-value:1.32E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.48|P-value:4.67E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.90|P-value:1.02E-4 ID:SGTC_2846|Compound:9008642|FD-Score:3.43|P-value:5.49E-4 ID:SGTC_2868|Compound:9035608|FD-Score:4.37|P-value:1.57E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.16|P-value:3.68E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.26|P-value:9.66E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.59|P-value:3.18E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.29|P-value:2.16E-5 ID:SGTC_3158|Compound:9100007|FD-Score:3.25|P-value:9.86E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.46|P-value:4.88E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.31|P-value:8.14E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.77|P-value:1.63E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.59|P-value:6.13E-6 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.32|P-value:7.79E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.96|P-value:7.57E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:5.49|P-value:8.38E-8 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.39|P-value:1.34E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:3.75|P-value:1.75E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.64|P-value:2.62E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.67|P-value:2.41E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.63|P-value:5.15E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:3.31|P-value:8.05E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.41|P-value:5.87E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.93|P-value:8.92E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.26|P-value:9.53E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:6.06|P-value:3.80E-9 ID:SGTC_1675|Compound:st018485|FD-Score:4.10|P-value:4.70E-5 ID:SGTC_1774|Compound:st048371|FD-Score:3.27|P-value:9.39E-4 ID:SGTC_1778|Compound:st046819|FD-Score:6.05|P-value:3.95E-9 ID:SGTC_1838|Compound:st055369|FD-Score:3.62|P-value:2.81E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.89|P-value:1.06E-4 ID:SGTC_1855|Compound:st056195|FD-Score:6.38|P-value:5.99E-10 ID:SGTC_2137|Compound:5261020|FD-Score:6.21|P-value:1.62E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.26|P-value:9.53E-4 ID:SGTC_2281|Compound:7943571|FD-Score:4.06|P-value:5.52E-5 ID:SGTC_2285|Compound:7945142|FD-Score:4.14|P-value:3.93E-5 ID:SGTC_2305|Compound:7443522|FD-Score:4.04|P-value:5.83E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.60|P-value:3.05E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.33|P-value:7.56E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.84|P-value:1.96E-6 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.32|P-value:7.95E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.49|P-value:4.45E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.49|P-value:4.11E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.88|P-value:1.10E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.83|P-value:1.32E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.48|P-value:4.67E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.90|P-value:1.02E-4 ID:SGTC_2846|Compound:9008642|FD-Score:3.43|P-value:5.49E-4 ID:SGTC_2868|Compound:9035608|FD-Score:4.37|P-value:1.57E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.16|P-value:3.68E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.26|P-value:9.66E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.59|P-value:3.18E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.29|P-value:2.16E-5 ID:SGTC_3158|Compound:9100007|FD-Score:3.25|P-value:9.86E-4

Top fitness defect scores for YGR241C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1855 st056195 6.38 39.6 µM 5.99E-10 60S ribosome export 1 9.00E-11
2 SGTC_2137 5261020 6.21 140.0 µM 1.62E-9 12 2.69E-10
3 SGTC_1454 4239-0054 6.06 42.6 µM 3.80E-9 4 6.82E-10
4 SGTC_1778 st046819 6.05 58.9 µM 3.95E-9 6 7.12E-10
5 SGTC_543 3844-1095 5.49 191.0 µM 8.38E-8 ERG2 22 2.02E-8
6 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.84 3.7 µM 1.96E-6 34 6.37E-7
7 SGTC_922 1866-0035 4.63 480.0 µM 5.15E-6 excess fatty acid 32 1.84E-6
8 SGTC_455 paf C-16 4.59 10.0 µM 6.13E-6 20 2.22E-6
9 SGTC_2868 9035608 4.37 32.5 µM 1.57E-5 10 6.24E-6
10 SGTC_3152 9099253 4.29 49.5 µM 2.16E-5 NEO1-PIK1 112 8.84E-6
11 SGTC_3059 1327-0034 4.16 3.0 µM 3.68E-5 48 1.58E-5
12 SGTC_2285 7945142 4.14 200.0 µM 3.93E-5 18 1.70E-5
13 SGTC_1675 st018485 4.10 24.5 µM 4.70E-5 60S ribosome export 22 2.07E-5
14 SGTC_2281 7943571 4.06 200.0 µM 5.52E-5 8 2.47E-5
15 SGTC_2305 7443522 4.04 69.2 µM 5.83E-5 13 2.62E-5
16 SGTC_1362 1611-0397 3.93 101.0 µM 8.92E-5 21 4.17E-5
17 SGTC_2842 9000675 3.90 19.5 µM 1.02E-4 22 4.81E-5
18 SGTC_1848 st056003 3.89 16.4 µM 1.06E-4 17 5.06E-5
19 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.88 92.6 µM 1.10E-4 29 5.27E-5
20 SGTC_2531 methyl deoxycholate 3.83 70.1 µM 1.32E-4 29 6.42E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.14E-9 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.094 5.39E-8 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.094 5.40E-8 YKL173W SNU114 het GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
0.093 7.45E-8 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.092 9.37E-8 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.090 1.81E-7 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
0.087 4.35E-7 YOR272W YTM1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
0.083 1.44E-6 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.082 2.26E-6 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.081 2.93E-6 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.080 3.25E-6 YIL153W RRD1 hom Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.080 3.57E-6 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.079 4.23E-6 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.079 4.25E-6 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.078 6.06E-6 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress