YGR278W / CWC22

Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR278W / CWC22

Click on Significant Values for Screen Details ID:SGTC_90|Compound:0870-0863|FD-Score:2.92|P-value:3.43E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.18|P-value:8.94E-7 ID:SGTC_264|Compound:promethazine|FD-Score:-2.94|P-value:4.03E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.09|P-value:1.58E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.80|P-value:7.25E-6 ID:SGTC_552|Compound:k242-0005|FD-Score:2.80|P-value:5.58E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:-3.40|P-value:5.25E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:3.35|P-value:4.90E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.45|P-value:4.26E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.51|P-value:3.15E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.30|P-value:8.44E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:2.66|P-value:9.66E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.26|P-value:7.51E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.46|P-value:2.92E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.06|P-value:1.82E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.84|P-value:4.75E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-2.78|P-value:7.71E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:-2.77|P-value:8.26E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.16|P-value:1.56E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-4.32|P-value:3.97E-7 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.82|P-value:5.01E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-2.74|P-value:9.25E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.29|P-value:6.42E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.03|P-value:2.07E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.14|P-value:2.00E-9 ID:SGTC_1515|Compound:3460-0031|FD-Score:-2.91|P-value:4.60E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-2.97|P-value:3.60E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.93|P-value:4.35E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.43|P-value:3.36E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:-2.90|P-value:4.76E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.93|P-value:4.18E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:-2.79|P-value:7.59E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.80|P-value:7.37E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.06|P-value:1.81E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.21|P-value:1.26E-4 ID:SGTC_2057|Compound:5236571|FD-Score:6.12|P-value:7.05E-13 ID:SGTC_2065|Compound:5221596|FD-Score:3.36|P-value:4.76E-5 ID:SGTC_2123|Compound:5259487|FD-Score:3.05|P-value:1.90E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.49|P-value:2.54E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-8.28|P-value:1.10E-21 ID:SGTC_2340|Compound:7987427|FD-Score:-4.18|P-value:9.25E-7 ID:SGTC_2341|Compound:7987486|FD-Score:4.56|P-value:6.25E-8 ID:SGTC_2351|Compound:9026858|FD-Score:2.79|P-value:5.67E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.34|P-value:5.26E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.26|P-value:7.55E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:2.76|P-value:6.56E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:2.98|P-value:2.56E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:2.92|P-value:3.43E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.18|P-value:8.94E-7 ID:SGTC_264|Compound:promethazine|FD-Score:-2.94|P-value:4.03E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.09|P-value:1.58E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.80|P-value:7.25E-6 ID:SGTC_552|Compound:k242-0005|FD-Score:2.80|P-value:5.58E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:-3.40|P-value:5.25E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:3.35|P-value:4.90E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.45|P-value:4.26E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.51|P-value:3.15E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.30|P-value:8.44E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:2.66|P-value:9.66E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.26|P-value:7.51E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.46|P-value:2.92E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.06|P-value:1.82E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.84|P-value:4.75E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-2.78|P-value:7.71E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:-2.77|P-value:8.26E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.16|P-value:1.56E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-4.32|P-value:3.97E-7 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.82|P-value:5.01E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-2.74|P-value:9.25E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.29|P-value:6.42E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.03|P-value:2.07E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.14|P-value:2.00E-9 ID:SGTC_1515|Compound:3460-0031|FD-Score:-2.91|P-value:4.60E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-2.97|P-value:3.60E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.93|P-value:4.35E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.43|P-value:3.36E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:-2.90|P-value:4.76E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.93|P-value:4.18E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:-2.79|P-value:7.59E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.80|P-value:7.37E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.06|P-value:1.81E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.21|P-value:1.26E-4 ID:SGTC_2057|Compound:5236571|FD-Score:6.12|P-value:7.05E-13 ID:SGTC_2065|Compound:5221596|FD-Score:3.36|P-value:4.76E-5 ID:SGTC_2123|Compound:5259487|FD-Score:3.05|P-value:1.90E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.49|P-value:2.54E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-8.28|P-value:1.10E-21 ID:SGTC_2340|Compound:7987427|FD-Score:-4.18|P-value:9.25E-7 ID:SGTC_2341|Compound:7987486|FD-Score:4.56|P-value:6.25E-8 ID:SGTC_2351|Compound:9026858|FD-Score:2.79|P-value:5.67E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.34|P-value:5.26E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.26|P-value:7.55E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:2.76|P-value:6.56E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:2.98|P-value:2.56E-4

Top fitness defect scores for YGR278W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2057 5236571 6.12 38.3 µM 7.05E-13 RPP1 & pyrimidine depletion 7 4.70E-10 0.47
2 SGTC_2341 7987486 4.56 176.7 µM 6.25E-8 2 2.58E-6 0.07
3 SGTC_2332 7982454 3.49 138.9 µM 2.54E-5 15 2.45E-4 0.09
4 SGTC_1151 3909-8316 3.46 15.3 µM 2.92E-5 9 2.72E-4 0.01
5 SGTC_1532 4',5'-dihydroxyflavone 3.43 78.7 µM 3.36E-5 Golgi 13 3.03E-4 0.21
6 SGTC_2065 5221596 3.36 34.3 µM 4.76E-5 9 3.95E-4 0.23
7 SGTC_653 0203-0016 3.35 55.2 µM 4.90E-5 5 4.04E-4 0.06
8 SGTC_2382 9035899 3.34 200.0 µM 5.26E-5 60S ribosome export 9 4.26E-4 0.12
9 SGTC_1448 4255-0083 3.29 152.0 µM 6.42E-5 ERG2 12 4.95E-4 0.06
10 SGTC_1063 disulfiram 3.26 1.8 µM 7.51E-5 16 5.58E-4 0.01
11 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.26 92.6 µM 7.55E-5 20 5.61E-4 0.01
12 SGTC_369 0957-0393 3.09 4.5 µM 1.58E-4 cell wall signaling 17 9.85E-4 0.07
13 SGTC_1875 nocodazole 3.06 6.0 µM 1.81E-4 tubulin folding & SWR complex 25 0.00109 0.01
14 SGTC_1232 0279-0259 3.06 161.0 µM 1.82E-4 14 0.00109 0.01
15 SGTC_2123 5259487 3.05 200.0 µM 1.90E-4 8 0.00113 0.06
16 SGTC_2779 methotrexate 2.98 400.0 µM 2.56E-4 31 0.00142 0.04
17 SGTC_90 0870-0863 2.92 4.6 µM 3.43E-4 17 0.00177 0.05
18 SGTC_1246 0422-0085 2.84 105.0 µM 4.75E-4 25 0.00227 0.01
19 SGTC_1338 1486-1223 2.82 76.0 µM 5.01E-4 14 0.00237 0.03
20 SGTC_552 k242-0005 2.80 476.0 µM 5.58E-4 15 0.00257 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.217 5.02E-37 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.212 2.44E-35 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.211 4.85E-35 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.206 2.89E-33 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.197 1.17E-30 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.187 7.67E-28 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.183 1.48E-26 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.182 2.37E-26 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.171 2.45E-23 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.166 4.96E-22 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.165 7.06E-22 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.164 1.35E-21 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.164 2.02E-21 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.162 3.12E-21 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.162 3.05E-21 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress