YHR079C / IRE1

Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR079C / IRE1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:-3.52|P-value:4.43E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:31.40|P-value:4.00E-189 ID:SGTC_22|Compound:0964-0034|FD-Score:24.30|P-value:8.62E-114 ID:SGTC_36|Compound:0335-0881|FD-Score:27.00|P-value:2.19E-140 ID:SGTC_38|Compound:0929-0051|FD-Score:3.82|P-value:2.08E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.69|P-value:2.46E-4 ID:SGTC_57|Compound:miconazole|FD-Score:5.20|P-value:7.06E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:6.86|P-value:9.44E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:10.10|P-value:1.93E-21 ID:SGTC_86|Compound:0417-1630|FD-Score:12.30|P-value:1.38E-30 ID:SGTC_107|Compound:0358-0022|FD-Score:5.80|P-value:3.70E-8 ID:SGTC_108|Compound:0509-0257|FD-Score:6.23|P-value:3.59E-9 ID:SGTC_112|Compound:phenothiazine|FD-Score:7.23|P-value:9.53E-12 ID:SGTC_113|Compound:0099-0221|FD-Score:3.67|P-value:3.48E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:9.84|P-value:2.76E-20 ID:SGTC_143|Compound:4032-1194|FD-Score:9.25|P-value:3.81E-18 ID:SGTC_158|Compound:k038-0087|FD-Score:13.40|P-value:2.96E-36 ID:SGTC_163|Compound:1327-0036|FD-Score:6.78|P-value:1.54E-10 ID:SGTC_165|Compound:k038-0023|FD-Score:11.00|P-value:7.51E-25 ID:SGTC_178|Compound:4092-0806|FD-Score:5.27|P-value:5.17E-7 ID:SGTC_193|Compound:1273-0060|FD-Score:3.68|P-value:3.36E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:9.94|P-value:1.10E-20 ID:SGTC_207|Compound:4185-0010|FD-Score:4.57|P-value:1.15E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:14.90|P-value:5.94E-44 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.86|P-value:3.33E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:7.34|P-value:4.53E-12 ID:SGTC_255|Compound:tunicamycin|FD-Score:26.30|P-value:2.50E-133 ID:SGTC_278|Compound:4092-0821|FD-Score:4.69|P-value:6.93E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:6.77|P-value:1.61E-10 ID:SGTC_298|Compound:1391-0729|FD-Score:4.59|P-value:1.05E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:3.79|P-value:2.33E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:4.28|P-value:3.77E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:21.40|P-value:6.35E-89 ID:SGTC_367|Compound:0335-0881|FD-Score:7.99|P-value:5.60E-14 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.43|P-value:7.80E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:4.30|P-value:3.39E-5 ID:SGTC_480|Compound:am 92016|FD-Score:4.30|P-value:3.43E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.43|P-value:7.82E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:15.40|P-value:6.28E-47 ID:SGTC_531|Compound:3788-1495|FD-Score:36.90|P-value:1.15E-260 ID:SGTC_635|Compound:k038-0028|FD-Score:5.46|P-value:2.06E-7 ID:SGTC_658|Compound:3253-0951|FD-Score:5.90|P-value:2.19E-8 ID:SGTC_662|Compound:k832-1615|FD-Score:3.47|P-value:6.76E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.71|P-value:5.92E-8 ID:SGTC_830|Compound:4076-0286|FD-Score:3.54|P-value:5.39E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:9.73|P-value:7.25E-20 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.53|P-value:1.38E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.50|P-value:6.23E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.44|P-value:1.98E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.99|P-value:1.11E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.71|P-value:3.01E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:38.10|P-value:2.31E-277 ID:SGTC_1712|Compound:st032288|FD-Score:5.24|P-value:6.03E-7 ID:SGTC_1754|Compound:st042065|FD-Score:6.43|P-value:1.20E-9 ID:SGTC_1760|Compound:st045453|FD-Score:6.18|P-value:4.92E-9 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.09|P-value:7.85E-5 ID:SGTC_1800|Compound:st050079|FD-Score:4.52|P-value:1.44E-5 ID:SGTC_1801|Compound:st050089|FD-Score:4.86|P-value:3.34E-6 ID:SGTC_1803|Compound:st050068|FD-Score:5.14|P-value:9.28E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:8.19|P-value:1.33E-14 ID:SGTC_1892|Compound:st058411|FD-Score:3.66|P-value:3.59E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.96|P-value:9.42E-5 ID:SGTC_2117|Compound:5521686|FD-Score:-3.59|P-value:3.43E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.34|P-value:7.99E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.95|P-value:2.29E-6 ID:SGTC_2302|Compound:7771753|FD-Score:3.35|P-value:9.86E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-4.61|P-value:6.90E-6 ID:SGTC_2400|Compound:5203494|FD-Score:-3.98|P-value:8.70E-5 ID:SGTC_2413|Compound:inermin|FD-Score:5.42|P-value:2.56E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.89|P-value:1.63E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.75|P-value:2.60E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.95|P-value:2.29E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.44|P-value:5.67E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.70|P-value:1.55E-23 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.02|P-value:1.01E-4 ID:SGTC_2794|Compound:7785382|FD-Score:6.70|P-value:2.43E-10 ID:SGTC_2795|Compound:7780010|FD-Score:7.34|P-value:4.52E-12 ID:SGTC_2823|Compound:7987624|FD-Score:3.60|P-value:4.42E-4 ID:SGTC_2997|Compound:9067075|FD-Score:16.50|P-value:2.01E-53 ID:SGTC_3059|Compound:1327-0034|FD-Score:9.70|P-value:8.97E-20 ID:SGTC_3060|Compound:1327-0027|FD-Score:10.10|P-value:3.20E-21 ID:SGTC_3063|Compound:1327-0034|FD-Score:7.44|P-value:2.30E-12 ID:SGTC_3064|Compound:1327-0027|FD-Score:5.08|P-value:1.27E-6 ID:SGTC_3078|Compound:9116413|FD-Score:18.00|P-value:2.77E-63 ID:SGTC_3157|Compound:9099274|FD-Score:3.58|P-value:4.78E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.65|P-value:2.79E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.66|P-value:3.64E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.51|P-value:5.94E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:-3.52|P-value:4.43E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:31.40|P-value:4.00E-189 ID:SGTC_22|Compound:0964-0034|FD-Score:24.30|P-value:8.62E-114 ID:SGTC_36|Compound:0335-0881|FD-Score:27.00|P-value:2.19E-140 ID:SGTC_38|Compound:0929-0051|FD-Score:3.82|P-value:2.08E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.69|P-value:2.46E-4 ID:SGTC_57|Compound:miconazole|FD-Score:5.20|P-value:7.06E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:6.86|P-value:9.44E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:10.10|P-value:1.93E-21 ID:SGTC_86|Compound:0417-1630|FD-Score:12.30|P-value:1.38E-30 ID:SGTC_107|Compound:0358-0022|FD-Score:5.80|P-value:3.70E-8 ID:SGTC_108|Compound:0509-0257|FD-Score:6.23|P-value:3.59E-9 ID:SGTC_112|Compound:phenothiazine|FD-Score:7.23|P-value:9.53E-12 ID:SGTC_113|Compound:0099-0221|FD-Score:3.67|P-value:3.48E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:9.84|P-value:2.76E-20 ID:SGTC_143|Compound:4032-1194|FD-Score:9.25|P-value:3.81E-18 ID:SGTC_158|Compound:k038-0087|FD-Score:13.40|P-value:2.96E-36 ID:SGTC_163|Compound:1327-0036|FD-Score:6.78|P-value:1.54E-10 ID:SGTC_165|Compound:k038-0023|FD-Score:11.00|P-value:7.51E-25 ID:SGTC_178|Compound:4092-0806|FD-Score:5.27|P-value:5.17E-7 ID:SGTC_193|Compound:1273-0060|FD-Score:3.68|P-value:3.36E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:9.94|P-value:1.10E-20 ID:SGTC_207|Compound:4185-0010|FD-Score:4.57|P-value:1.15E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:14.90|P-value:5.94E-44 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.86|P-value:3.33E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:7.34|P-value:4.53E-12 ID:SGTC_255|Compound:tunicamycin|FD-Score:26.30|P-value:2.50E-133 ID:SGTC_278|Compound:4092-0821|FD-Score:4.69|P-value:6.93E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:6.77|P-value:1.61E-10 ID:SGTC_298|Compound:1391-0729|FD-Score:4.59|P-value:1.05E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:3.79|P-value:2.33E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:4.28|P-value:3.77E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:21.40|P-value:6.35E-89 ID:SGTC_367|Compound:0335-0881|FD-Score:7.99|P-value:5.60E-14 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.43|P-value:7.80E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:4.30|P-value:3.39E-5 ID:SGTC_480|Compound:am 92016|FD-Score:4.30|P-value:3.43E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.43|P-value:7.82E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:15.40|P-value:6.28E-47 ID:SGTC_531|Compound:3788-1495|FD-Score:36.90|P-value:1.15E-260 ID:SGTC_635|Compound:k038-0028|FD-Score:5.46|P-value:2.06E-7 ID:SGTC_658|Compound:3253-0951|FD-Score:5.90|P-value:2.19E-8 ID:SGTC_662|Compound:k832-1615|FD-Score:3.47|P-value:6.76E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.71|P-value:5.92E-8 ID:SGTC_830|Compound:4076-0286|FD-Score:3.54|P-value:5.39E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:9.73|P-value:7.25E-20 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.53|P-value:1.38E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.50|P-value:6.23E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.44|P-value:1.98E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.99|P-value:1.11E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.71|P-value:3.01E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:38.10|P-value:2.31E-277 ID:SGTC_1712|Compound:st032288|FD-Score:5.24|P-value:6.03E-7 ID:SGTC_1754|Compound:st042065|FD-Score:6.43|P-value:1.20E-9 ID:SGTC_1760|Compound:st045453|FD-Score:6.18|P-value:4.92E-9 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.09|P-value:7.85E-5 ID:SGTC_1800|Compound:st050079|FD-Score:4.52|P-value:1.44E-5 ID:SGTC_1801|Compound:st050089|FD-Score:4.86|P-value:3.34E-6 ID:SGTC_1803|Compound:st050068|FD-Score:5.14|P-value:9.28E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:8.19|P-value:1.33E-14 ID:SGTC_1892|Compound:st058411|FD-Score:3.66|P-value:3.59E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.96|P-value:9.42E-5 ID:SGTC_2117|Compound:5521686|FD-Score:-3.59|P-value:3.43E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.34|P-value:7.99E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.95|P-value:2.29E-6 ID:SGTC_2302|Compound:7771753|FD-Score:3.35|P-value:9.86E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-4.61|P-value:6.90E-6 ID:SGTC_2400|Compound:5203494|FD-Score:-3.98|P-value:8.70E-5 ID:SGTC_2413|Compound:inermin|FD-Score:5.42|P-value:2.56E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.89|P-value:1.63E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.75|P-value:2.60E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.95|P-value:2.29E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.44|P-value:5.67E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.70|P-value:1.55E-23 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.02|P-value:1.01E-4 ID:SGTC_2794|Compound:7785382|FD-Score:6.70|P-value:2.43E-10 ID:SGTC_2795|Compound:7780010|FD-Score:7.34|P-value:4.52E-12 ID:SGTC_2823|Compound:7987624|FD-Score:3.60|P-value:4.42E-4 ID:SGTC_2997|Compound:9067075|FD-Score:16.50|P-value:2.01E-53 ID:SGTC_3059|Compound:1327-0034|FD-Score:9.70|P-value:8.97E-20 ID:SGTC_3060|Compound:1327-0027|FD-Score:10.10|P-value:3.20E-21 ID:SGTC_3063|Compound:1327-0034|FD-Score:7.44|P-value:2.30E-12 ID:SGTC_3064|Compound:1327-0027|FD-Score:5.08|P-value:1.27E-6 ID:SGTC_3078|Compound:9116413|FD-Score:18.00|P-value:2.77E-63 ID:SGTC_3157|Compound:9099274|FD-Score:3.58|P-value:4.78E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.65|P-value:2.79E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.66|P-value:3.64E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.51|P-value:5.94E-4

Top fitness defect scores for YHR079C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1239 0337-0584 38.10 35.4 µM 2.31E-277 unfolded protein response 2 0
2 SGTC_531 3788-1495 36.90 174.0 µM 1.15E-260 unfolded protein response 1 5.69E-299
3 SGTC_16 erodoxin 31.40 22.8 µM 4.00E-189 unfolded protein response 3 6.60E-217
4 SGTC_36 0335-0881 27.00 14.2 µM 2.19E-140 ubiquinone biosynthesis & proteasome 1 5.42E-161
5 SGTC_255 tunicamycin 26.30 200.5 nM 2.50E-133 unfolded protein response 2 6.77E-153
6 SGTC_22 0964-0034 24.30 14.5 µM 8.62E-114 unfolded protein response 2 1.77E-130
7 SGTC_353 1988-1175 21.40 58.3 µM 6.35E-89 unfolded protein response 2 6.10E-102
8 SGTC_3078 9116413 18.00 49.5 µM 2.77E-63 unfolded protein response 1 1.63E-72
9 SGTC_2997 9067075 16.50 71.4 µM 2.01E-53 unfolded protein response 1 3.40E-61
10 SGTC_513 4245-1575 15.40 41.7 µM 6.28E-47 unfolded protein response 6 9.75E-54
11 SGTC_216 k038-0035 14.90 28.4 µM 5.94E-44 ubiquinone biosynthesis & proteasome 2 2.55E-50
12 SGTC_158 k038-0087 13.40 26.4 µM 2.96E-36 ubiquinone biosynthesis & proteasome 15 1.76E-41
13 SGTC_86 0417-1630 12.30 471.9 µM 1.38E-30 ubiquinone biosynthesis & proteasome 27 5.70E-35
14 SGTC_165 k038-0023 11.00 64.4 µM 7.51E-25 ubiquinone biosynthesis & proteasome 6 2.20E-28
15 SGTC_2651 1327-0036 10.70 5.0 µM 1.55E-23 19 7.14E-27
16 SGTC_67 0335-0847 10.10 266.0 µM 1.93E-21 ubiquinone biosynthesis & proteasome 22 1.81E-24
17 SGTC_3060 1327-0027 10.10 12.5 µM 3.20E-21 7 3.25E-24
18 SGTC_200 k038-0079 9.94 37.5 µM 1.10E-20 ubiquinone biosynthesis & proteasome 7 1.34E-23
19 SGTC_137 0438-0332 9.84 85.4 µM 2.76E-20 ubiquinone biosynthesis & proteasome 24 3.86E-23
20 SGTC_852 0418-0143 9.73 439.0 µM 7.25E-20 calcium & mitochondrial duress 10 1.17E-22

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.765 0 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.759 0 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.474 5.58E-188 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.340 1.31E-91 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.314 1.12E-77 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.301 3.69E-71 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.298 6.07E-70 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.294 8.24E-68 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.288 3.62E-65 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.287 8.08E-65 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.286 4.52E-64 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.285 5.50E-64 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.281 7.91E-62 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.278 9.56E-61 YLR292C SEC72 hom Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.275 4.23E-59 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder