YHR079C-A / SAE3

Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR079C-A / SAE3

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:3.58|P-value:3.89E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.76|P-value:2.11E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:5.12|P-value:8.35E-7 ID:SGTC_974|Compound:1326-0144|FD-Score:4.25|P-value:3.40E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.32|P-value:9.18E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.34|P-value:8.59E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.35|P-value:8.47E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.39|P-value:7.27E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.84|P-value:2.91E-6 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.86|P-value:1.48E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.60|P-value:3.68E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.89|P-value:2.40E-6 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.60|P-value:4.60E-4 ID:SGTC_1725|Compound:st036284|FD-Score:5.33|P-value:3.19E-7 ID:SGTC_1730|Compound:st033808|FD-Score:4.77|P-value:4.04E-6 ID:SGTC_1931|Compound:st074438|FD-Score:3.37|P-value:7.90E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.56|P-value:4.27E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.44|P-value:6.31E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.67|P-value:3.68E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.34|P-value:8.69E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.43|P-value:6.55E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.09|P-value:6.49E-5 ID:SGTC_2813|Compound:7971799|FD-Score:5.32|P-value:3.29E-7 ID:SGTC_2821|Compound:7996764|FD-Score:3.76|P-value:2.09E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.52|P-value:4.75E-4 ID:SGTC_2922|Compound:7999257|FD-Score:4.22|P-value:3.87E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.70|P-value:2.65E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-6.04|P-value:1.21E-8 ID:SGTC_3144|Compound:9087057|FD-Score:-4.55|P-value:1.34E-5 ID:SGTC_3290|Compound:9121031|FD-Score:-3.60|P-value:4.57E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.58|P-value:3.89E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.76|P-value:2.11E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:5.12|P-value:8.35E-7 ID:SGTC_974|Compound:1326-0144|FD-Score:4.25|P-value:3.40E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.32|P-value:9.18E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.34|P-value:8.59E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.35|P-value:8.47E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.39|P-value:7.27E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.84|P-value:2.91E-6 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.86|P-value:1.48E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.60|P-value:3.68E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.89|P-value:2.40E-6 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.60|P-value:4.60E-4 ID:SGTC_1725|Compound:st036284|FD-Score:5.33|P-value:3.19E-7 ID:SGTC_1730|Compound:st033808|FD-Score:4.77|P-value:4.04E-6 ID:SGTC_1931|Compound:st074438|FD-Score:3.37|P-value:7.90E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.56|P-value:4.27E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.44|P-value:6.31E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.67|P-value:3.68E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.34|P-value:8.69E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.43|P-value:6.55E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.09|P-value:6.49E-5 ID:SGTC_2813|Compound:7971799|FD-Score:5.32|P-value:3.29E-7 ID:SGTC_2821|Compound:7996764|FD-Score:3.76|P-value:2.09E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.52|P-value:4.75E-4 ID:SGTC_2922|Compound:7999257|FD-Score:4.22|P-value:3.87E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.70|P-value:2.65E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-6.04|P-value:1.21E-8 ID:SGTC_3144|Compound:9087057|FD-Score:-4.55|P-value:1.34E-5 ID:SGTC_3290|Compound:9121031|FD-Score:-3.60|P-value:4.57E-4

Top fitness defect scores for YHR079C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1725 st036284 5.33 20.6 µM 3.19E-7 10 5.02E-8
2 SGTC_2813 7971799 5.32 71.4 µM 3.29E-7 5 5.21E-8
3 SGTC_847 0342-0274 5.12 5.5 µM 8.35E-7 9 1.51E-7
4 SGTC_1436 4092-1007 4.89 8.3 µM 2.40E-6 2 5.07E-7
5 SGTC_1178 0988-0033 4.84 191.0 µM 2.91E-6 17 6.34E-7
6 SGTC_1730 st033808 4.77 45.1 µM 4.04E-6 15 9.21E-7
7 SGTC_974 1326-0144 4.25 138.0 µM 3.40E-5 ERG2 32 1.05E-5
8 SGTC_2922 7999257 4.22 32.5 µM 3.87E-5 8 1.22E-5
9 SGTC_2765 myclobutanil 4.09 7.7 µM 6.49E-5 azole & statin 44 2.20E-5
10 SGTC_1298 1079-1278 3.86 263.0 µM 1.48E-4 DNA damage response 18 5.65E-5
11 SGTC_2821 7996764 3.76 71.4 µM 2.09E-4 50 8.35E-5
12 SGTC_151 3013-0144 3.76 2.3 µM 2.11E-4 iron homeostasis 35 8.45E-5
13 SGTC_3027 9089541 3.70 49.5 µM 2.65E-4 fatty acid desaturase (OLE1) 26 1.09E-4
14 SGTC_1425 4048-4433 3.60 7.3 µM 3.68E-4 copper-dependent oxidative stress 48 1.59E-4
15 SGTC_60 0986-0278 3.58 202.0 µM 3.89E-4 22 1.69E-4
16 SGTC_1964 st076914 3.56 61.0 µM 4.27E-4 RPP1 & pyrimidine depletion 31 1.88E-4
17 SGTC_2844 9010103 3.52 26.0 µM 4.75E-4 44 2.13E-4
18 SGTC_2394 5221648 3.44 200.0 µM 6.31E-4 40 2.94E-4
19 SGTC_2680 butyl paraben 3.43 22.2 µM 6.55E-4 amide catabolism 16 3.07E-4
20 SGTC_1163 k060-0048 3.39 49.9 µM 7.27E-4 39 3.45E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 5.70E-13 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.110 1.69E-10 YLR032W RAD5 hom DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress
0.102 3.32E-9 YPL221W FLC1 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
0.099 7.97E-9 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.099 8.16E-9 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
0.099 9.84E-9 YER170W ADK2 hom Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
0.098 1.26E-8 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.097 1.87E-8 YLR029C RPL15A het Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
0.095 3.11E-8 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.095 3.19E-8 YNL214W PEX17 hom Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis
0.088 3.04E-7 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.33E-7 YFR028C CDC14 het Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis
0.085 9.38E-7 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.081 2.58E-6 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.076 9.88E-6 YJL181W_p YJL181W_p hom Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication