YHR096C / HXT5

Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR096C / HXT5

Click on Significant Values for Screen Details ID:SGTC_123|Compound:0083-0120|FD-Score:3.87|P-value:8.37E-5 ID:SGTC_401|Compound:neomycin|FD-Score:3.22|P-value:8.94E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.11|P-value:9.64E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.39|P-value:5.04E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.73|P-value:1.48E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.65|P-value:1.99E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:4.30|P-value:1.47E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.33|P-value:6.25E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.70|P-value:1.61E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-4.29|P-value:1.01E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.53|P-value:3.06E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:5.20|P-value:2.01E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.50|P-value:2.43E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-4.40|P-value:6.17E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:3.53|P-value:3.09E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.93|P-value:6.79E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.77|P-value:1.25E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.99|P-value:5.28E-5 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.25|P-value:1.82E-5 ID:SGTC_1604|Compound:st002052|FD-Score:3.77|P-value:1.23E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.82|P-value:1.02E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.27|P-value:7.56E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.17|P-value:8.01E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.90|P-value:7.61E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.29|P-value:7.05E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.15|P-value:8.56E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.20|P-value:9.70E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.48|P-value:3.70E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.53|P-value:5.22E-6 ID:SGTC_3048|Compound:9093155|FD-Score:-3.26|P-value:5.85E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.08|P-value:3.65E-5 ID:SGTC_3351|Compound:9150312|FD-Score:3.52|P-value:3.19E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.87|P-value:8.37E-5 ID:SGTC_401|Compound:neomycin|FD-Score:3.22|P-value:8.94E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.11|P-value:9.64E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.39|P-value:5.04E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.73|P-value:1.48E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.65|P-value:1.99E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:4.30|P-value:1.47E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.33|P-value:6.25E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.70|P-value:1.61E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-4.29|P-value:1.01E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.53|P-value:3.06E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:5.20|P-value:2.01E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.50|P-value:2.43E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-4.40|P-value:6.17E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:3.53|P-value:3.09E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.93|P-value:6.79E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.77|P-value:1.25E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.99|P-value:5.28E-5 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.25|P-value:1.82E-5 ID:SGTC_1604|Compound:st002052|FD-Score:3.77|P-value:1.23E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.82|P-value:1.02E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.27|P-value:7.56E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.17|P-value:8.01E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.90|P-value:7.61E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.29|P-value:7.05E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.15|P-value:8.56E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.20|P-value:9.70E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.48|P-value:3.70E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.53|P-value:5.22E-6 ID:SGTC_3048|Compound:9093155|FD-Score:-3.26|P-value:5.85E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.08|P-value:3.65E-5 ID:SGTC_3351|Compound:9150312|FD-Score:3.52|P-value:3.19E-4

Top fitness defect scores for YHR096C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_946 3434-1334 5.20 87.4 µM 2.01E-7 11 9.89E-8
2 SGTC_2950 9072895 4.53 21.5 µM 5.22E-6 22 2.95E-6
3 SGTC_606 k015-0008 4.30 38.6 µM 1.47E-5 6 8.68E-6
4 SGTC_1481 3346-2004 4.25 36.0 µM 1.82E-5 8 1.09E-5
5 SGTC_3099 9120367 4.08 49.5 µM 3.65E-5 17 2.25E-5
6 SGTC_1280 0880-0253 3.99 10.1 µM 5.28E-5 16 3.30E-5
7 SGTC_1165 k072-0275 3.93 30.3 µM 6.79E-5 45 4.30E-5
8 SGTC_1974 st069448 3.90 26.9 µM 7.61E-5 26 4.84E-5
9 SGTC_123 0083-0120 3.87 66.7 µM 8.37E-5 51 5.35E-5
10 SGTC_1752 st044819 3.82 83.0 µM 1.02E-4 26 6.58E-5
11 SGTC_1604 st002052 3.77 72.4 µM 1.23E-4 TSC3-RPN4 33 8.02E-5
12 SGTC_1272 0839-0021 3.77 27.0 µM 1.25E-4 23 8.12E-5
13 SGTC_974 1326-0144 3.73 138.0 µM 1.46E-4 ERG2 48 9.58E-5
14 SGTC_538 2922-0838 3.73 53.3 µM 1.48E-4 Golgi 35 9.69E-5
15 SGTC_823 0417-1665 3.70 178.0 µM 1.61E-4 45 1.06E-4
16 SGTC_577 r071-0003 3.65 38.6 µM 1.99E-4 fatty acid desaturase (OLE1) 72 1.32E-4
17 SGTC_944 3370-0224 3.53 231.0 µM 3.06E-4 38 2.07E-4
18 SGTC_984 1492-0255 3.53 2.9 µM 3.09E-4 SWF1 & branched chain AA biosynthesis 42 2.09E-4
19 SGTC_3351 9150312 3.52 21.6 µM 3.19E-4 cell wall 45 2.16E-4
20 SGTC_2917 7979103 3.48 53.8 µM 3.70E-4 46 2.53E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 7.61E-14 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.105 8.93E-10 YJL141C YAK1 hom Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose
0.090 1.71E-7 YER129W SAK1 hom Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
0.084 1.14E-6 YJL029C VPS53 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
0.078 5.78E-6 YLR058C SHM2 hom Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
0.076 1.02E-5 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.073 2.36E-5 YGR061C ADE6 hom Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.072 3.21E-5 YGL234W ADE5,7 hom Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
0.071 4.04E-5 YFR047C BNA6 hom Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.070 4.53E-5 YDL178W DLD2 hom D-lactate dehydrogenase, located in the mitochondrial matrix
0.070 5.32E-5 YKL053C-A MDM35 hom Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.068 9.08E-5 YAL013W DEP1 hom Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation
0.067 9.45E-5 YLL025W PAU17 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene
0.066 1.24E-4 YJR125C ENT3 hom Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p
0.066 1.33E-4 YER148W SPT15 het TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability