YHR153C / SPO16

Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR153C / SPO16

Click on Significant Values for Screen Details ID:SGTC_168|Compound:3970-0862|FD-Score:3.33|P-value:1.67E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:2.88|P-value:9.33E-4 ID:SGTC_277|Compound:nystatin|FD-Score:4.76|P-value:1.81E-7 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.13|P-value:6.40E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:4.35|P-value:1.56E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:3.24|P-value:2.44E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.23|P-value:6.09E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:3.83|P-value:1.97E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:3.58|P-value:5.94E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:3.26|P-value:2.18E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:2.97|P-value:6.70E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:-3.65|P-value:8.27E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:4.22|P-value:3.05E-6 ID:SGTC_889|Compound:0919-1524|FD-Score:3.56|P-value:6.50E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:4.03|P-value:7.54E-6 ID:SGTC_898|Compound:1000-0849|FD-Score:5.08|P-value:2.81E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.81|P-value:4.26E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.00|P-value:6.05E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.27|P-value:2.10E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.18|P-value:3.65E-6 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.00|P-value:6.05E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.02|P-value:5.58E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.91|P-value:8.38E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.24|P-value:4.15E-11 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.91|P-value:4.07E-10 ID:SGTC_1701|Compound:st028638|FD-Score:3.99|P-value:9.45E-6 ID:SGTC_1903|Compound:st060211|FD-Score:4.39|P-value:1.29E-6 ID:SGTC_1988|Compound:st071872|FD-Score:2.94|P-value:7.57E-4 ID:SGTC_2052|Compound:5265182|FD-Score:5.96|P-value:1.06E-10 ID:SGTC_2103|Compound:5378138|FD-Score:3.26|P-value:2.24E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.08|P-value:7.90E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.02|P-value:5.53E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.20|P-value:5.05E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.24|P-value:4.29E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.81|P-value:2.17E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.29|P-value:1.93E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.39|P-value:2.46E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.62|P-value:9.54E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.13|P-value:3.69E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.48|P-value:7.95E-7 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.09|P-value:4.29E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.60|P-value:1.03E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:2.99|P-value:6.32E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.99|P-value:9.38E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:4.19|P-value:3.56E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:9.07|P-value:2.84E-22 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.74|P-value:5.81E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.12|P-value:3.81E-4 ID:SGTC_2693|Compound:st077581|FD-Score:5.80|P-value:3.02E-10 ID:SGTC_3191|Compound:9110352|FD-Score:3.21|P-value:2.68E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.89|P-value:2.95E-5 ID:SGTC_3251|Compound:9135047|FD-Score:3.70|P-value:3.55E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-3.13|P-value:6.59E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.33|P-value:1.67E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:2.88|P-value:9.33E-4 ID:SGTC_277|Compound:nystatin|FD-Score:4.76|P-value:1.81E-7 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.13|P-value:6.40E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:4.35|P-value:1.56E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:3.24|P-value:2.44E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.23|P-value:6.09E-6 ID:SGTC_432|Compound:NS 1619|FD-Score:3.83|P-value:1.97E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:3.58|P-value:5.94E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:3.26|P-value:2.18E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:2.97|P-value:6.70E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:-3.65|P-value:8.27E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:4.22|P-value:3.05E-6 ID:SGTC_889|Compound:0919-1524|FD-Score:3.56|P-value:6.50E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:4.03|P-value:7.54E-6 ID:SGTC_898|Compound:1000-0849|FD-Score:5.08|P-value:2.81E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.81|P-value:4.26E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.00|P-value:6.05E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.27|P-value:2.10E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.18|P-value:3.65E-6 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.00|P-value:6.05E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.02|P-value:5.58E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.91|P-value:8.38E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.24|P-value:4.15E-11 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.91|P-value:4.07E-10 ID:SGTC_1701|Compound:st028638|FD-Score:3.99|P-value:9.45E-6 ID:SGTC_1903|Compound:st060211|FD-Score:4.39|P-value:1.29E-6 ID:SGTC_1988|Compound:st071872|FD-Score:2.94|P-value:7.57E-4 ID:SGTC_2052|Compound:5265182|FD-Score:5.96|P-value:1.06E-10 ID:SGTC_2103|Compound:5378138|FD-Score:3.26|P-value:2.24E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.08|P-value:7.90E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.02|P-value:5.53E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.20|P-value:5.05E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.24|P-value:4.29E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.81|P-value:2.17E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.29|P-value:1.93E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.39|P-value:2.46E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.62|P-value:9.54E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.13|P-value:3.69E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.48|P-value:7.95E-7 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.09|P-value:4.29E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.60|P-value:1.03E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:2.99|P-value:6.32E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.99|P-value:9.38E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:4.19|P-value:3.56E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:9.07|P-value:2.84E-22 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.74|P-value:5.81E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.12|P-value:3.81E-4 ID:SGTC_2693|Compound:st077581|FD-Score:5.80|P-value:3.02E-10 ID:SGTC_3191|Compound:9110352|FD-Score:3.21|P-value:2.68E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.89|P-value:2.95E-5 ID:SGTC_3251|Compound:9135047|FD-Score:3.70|P-value:3.55E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-3.13|P-value:6.59E-4

Top fitness defect scores for YHR153C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2608 thymoquinone 9.07 42.7 µM 2.84E-22 1 5.77E-20
2 SGTC_2052 5265182 5.96 7.1 µM 1.06E-10 3 1.29E-9
3 SGTC_2693 st077581 5.80 40.7 µM 3.02E-10 7 3.29E-9
4 SGTC_898 1000-0849 5.08 28.3 µM 2.81E-8 1 1.88E-7
5 SGTC_277 nystatin 4.76 15.5 µM 1.81E-7 3 9.91E-7
6 SGTC_2502 avocadyne acetate 4.48 18.6 µM 7.95E-7 18 3.70E-6
7 SGTC_1903 st060211 4.39 78.3 µM 1.29E-6 14 5.70E-6
8 SGTC_325 2810-4341 4.35 181.0 µM 1.56E-6 amide catabolism 7 6.75E-6
9 SGTC_857 0438-0306 4.22 1.4 µM 3.05E-6 copper-dependent oxidative stress 8 1.23E-5
10 SGTC_2605 digitonin 4.19 300.0 nM 3.56E-6 22 1.41E-5
11 SGTC_1382 3002-2117 4.18 298.0 µM 3.65E-6 7 1.44E-5
12 SGTC_895 0964-0006 4.03 13.7 µM 7.54E-6 11 2.75E-5
13 SGTC_2602 kawain 3.99 100.0 µM 9.38E-6 27 3.34E-5
14 SGTC_1701 st028638 3.99 40.4 µM 9.45E-6 13 3.36E-5
15 SGTC_432 NS 1619 3.83 61.3 µM 1.97E-5 34 6.47E-5
16 SGTC_2408 sulbentine 3.81 18.4 µM 2.17E-5 56 7.05E-5
17 SGTC_3251 9135047 3.70 49.5 µM 3.55E-5 60S ribosome export 5 1.09E-4
18 SGTC_618 k072-0232 3.58 33.2 µM 5.94E-5 60S ribosome export 13 1.73E-4
19 SGTC_889 0919-1524 3.56 82.7 µM 6.50E-5 23 1.87E-4
20 SGTC_168 3970-0862 3.33 530.5 µM 1.67E-4 171 4.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.296 5.98E-68 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.225 1.79E-39 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.215 4.33E-36 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.213 1.43E-35 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.205 1.17E-32 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.198 1.32E-30 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.195 7.75E-30 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.195 8.97E-30 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.190 1.94E-28 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.184 1.01E-26 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.181 5.65E-26 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.181 1.10E-25 YMR088C VBA1 hom Permease of basic amino acids in the vacuolar membrane
0.173 8.99E-24 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.172 1.51E-23 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.172 1.78E-23 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication