YHR203C / RPS4B

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR203C / RPS4B

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.44|P-value:9.44E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.09|P-value:1.27E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:4.02|P-value:1.63E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.48|P-value:9.26E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.03|P-value:1.55E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:4.32|P-value:5.54E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.91|P-value:2.33E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.10|P-value:1.22E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.96|P-value:1.96E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:5.59|P-value:2.70E-7 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.54|P-value:7.73E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.42|P-value:9.97E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.17|P-value:9.51E-5 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.60|P-value:5.78E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.73|P-value:4.29E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.73|P-value:4.21E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-4.44|P-value:3.01E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.29|P-value:8.66E-9 ID:SGTC_1594|Compound:piperine|FD-Score:-5.05|P-value:2.57E-6 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-4.74|P-value:9.46E-6 ID:SGTC_1750|Compound:st081859|FD-Score:-3.79|P-value:3.08E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.80|P-value:3.45E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.93|P-value:2.18E-4 ID:SGTC_2122|Compound:5258151|FD-Score:4.04|P-value:1.49E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.49|P-value:8.00E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-3.55|P-value:6.71E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.90|P-value:2.41E-4 ID:SGTC_2336|Compound:9001819|FD-Score:6.04|P-value:3.06E-8 ID:SGTC_2380|Compound:9035439|FD-Score:3.64|P-value:5.60E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.62|P-value:1.75E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.71|P-value:4.01E-4 ID:SGTC_2570|Compound:licareol|FD-Score:5.39|P-value:6.81E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.46|P-value:9.78E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.51|P-value:8.56E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.54|P-value:2.04E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.85|P-value:4.17E-10 ID:SGTC_2786|Compound:7743617|FD-Score:4.23|P-value:7.80E-5 ID:SGTC_2917|Compound:7979103|FD-Score:4.61|P-value:1.82E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-6.44|P-value:3.23E-9 ID:SGTC_2931|Compound:9014674|FD-Score:4.02|P-value:1.61E-4 ID:SGTC_2946|Compound:9065502|FD-Score:5.67|P-value:1.89E-7 ID:SGTC_2969|Compound:9091408|FD-Score:4.53|P-value:2.56E-5 ID:SGTC_3054|Compound:9094397|FD-Score:3.73|P-value:4.28E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-4.28|P-value:5.59E-5 ID:SGTC_3090|Compound:9117696|FD-Score:3.65|P-value:5.52E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-4.63|P-value:1.47E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-4.18|P-value:7.89E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.44|P-value:9.44E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.09|P-value:1.27E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:4.02|P-value:1.63E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.48|P-value:9.26E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.03|P-value:1.55E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:4.32|P-value:5.54E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.91|P-value:2.33E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.10|P-value:1.22E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.96|P-value:1.96E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:5.59|P-value:2.70E-7 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.54|P-value:7.73E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.42|P-value:9.97E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.17|P-value:9.51E-5 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.60|P-value:5.78E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.73|P-value:4.29E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.73|P-value:4.21E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-4.44|P-value:3.01E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.29|P-value:8.66E-9 ID:SGTC_1594|Compound:piperine|FD-Score:-5.05|P-value:2.57E-6 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-4.74|P-value:9.46E-6 ID:SGTC_1750|Compound:st081859|FD-Score:-3.79|P-value:3.08E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.80|P-value:3.45E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.93|P-value:2.18E-4 ID:SGTC_2122|Compound:5258151|FD-Score:4.04|P-value:1.49E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.49|P-value:8.00E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-3.55|P-value:6.71E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.90|P-value:2.41E-4 ID:SGTC_2336|Compound:9001819|FD-Score:6.04|P-value:3.06E-8 ID:SGTC_2380|Compound:9035439|FD-Score:3.64|P-value:5.60E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.62|P-value:1.75E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.71|P-value:4.01E-4 ID:SGTC_2570|Compound:licareol|FD-Score:5.39|P-value:6.81E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.46|P-value:9.78E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.51|P-value:8.56E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.54|P-value:2.04E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.85|P-value:4.17E-10 ID:SGTC_2786|Compound:7743617|FD-Score:4.23|P-value:7.80E-5 ID:SGTC_2917|Compound:7979103|FD-Score:4.61|P-value:1.82E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-6.44|P-value:3.23E-9 ID:SGTC_2931|Compound:9014674|FD-Score:4.02|P-value:1.61E-4 ID:SGTC_2946|Compound:9065502|FD-Score:5.67|P-value:1.89E-7 ID:SGTC_2969|Compound:9091408|FD-Score:4.53|P-value:2.56E-5 ID:SGTC_3054|Compound:9094397|FD-Score:3.73|P-value:4.28E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-4.28|P-value:5.59E-5 ID:SGTC_3090|Compound:9117696|FD-Score:3.65|P-value:5.52E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-4.63|P-value:1.47E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-4.18|P-value:7.89E-5

Top fitness defect scores for YHR203C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 6.85 96.7 µM 4.17E-10 calcium & mitochondrial duress 111 3.74E-12
2 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 6.29 54.9 µM 8.66E-9 redox potentiating 30 1.58E-10
3 SGTC_2336 9001819 6.04 198.7 µM 3.06E-8 heme biosynthesis & mitochondrial translocase 7 7.51E-10
4 SGTC_2946 9065502 5.67 71.4 µM 1.89E-7 1 7.13E-9
5 SGTC_1238 0333-0287 5.59 48.8 µM 2.70E-7 Golgi 9 1.10E-8
6 SGTC_2570 licareol 5.39 100.0 µM 6.81E-7 9 3.46E-8
7 SGTC_2385 9074692 4.62 200.0 µM 1.75E-5 27 1.88E-6
8 SGTC_2917 7979103 4.61 53.8 µM 1.82E-5 15 1.98E-6
9 SGTC_2969 9091408 4.53 28.7 µM 2.56E-5 15 3.02E-6
10 SGTC_757 1066-0008 4.32 322.0 µM 5.54E-5 Golgi 13 7.80E-6
11 SGTC_2786 7743617 4.23 45.5 µM 7.80E-5 21 1.19E-5
12 SGTC_1473 k844-0725 4.17 134.0 µM 9.51E-5 7 1.52E-5
13 SGTC_1222 0366-0074 4.10 1.2 µM 1.22E-4 TSC3-RPN4 10 2.05E-5
14 SGTC_168 3970-0862 4.09 530.5 µM 1.27E-4 114 2.16E-5
15 SGTC_2122 5258151 4.04 111.7 µM 1.49E-4 22 2.63E-5
16 SGTC_629 3448-6466 4.03 76.7 µM 1.55E-4 17 2.76E-5
17 SGTC_2931 9014674 4.02 55.7 µM 1.61E-4 20 2.90E-5
18 SGTC_335 4077-0256 4.02 27.6 µM 1.63E-4 15 2.94E-5
19 SGTC_1232 0279-0259 3.96 161.0 µM 1.96E-4 17 3.69E-5
20 SGTC_2096 5468907 3.93 200.0 µM 2.18E-4 6 4.20E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 9.19E-17 YDL061C RPS29B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication
0.137 1.45E-15 YMR143W RPS16A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication
0.137 1.71E-15 YBR181C RPS6B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
0.132 2.04E-14 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.131 2.19E-14 YGR081C SLX9 hom Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
0.126 2.82E-13 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.115 2.81E-11 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.113 5.98E-11 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.112 7.52E-11 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.111 1.39E-10 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.108 3.05E-10 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.106 8.24E-10 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.105 1.01E-9 YEL042W GDA1 hom Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.104 1.41E-9 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.103 2.37E-9 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication