YIL005W / EPS1

ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL005W / EPS1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-4.26|P-value:1.28E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:7.83|P-value:2.82E-15 ID:SGTC_65|Compound:0798-0905|FD-Score:3.14|P-value:8.21E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.47|P-value:2.56E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.16|P-value:7.67E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.66|P-value:1.24E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.79|P-value:7.46E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:3.79|P-value:7.28E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:5.09|P-value:1.84E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.17|P-value:7.53E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:4.17|P-value:1.48E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:3.83|P-value:6.36E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:4.29|P-value:8.74E-6 ID:SGTC_856|Compound:0433-0016|FD-Score:3.13|P-value:8.47E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.39|P-value:4.09E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.26|P-value:5.35E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:4.20|P-value:1.35E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.83|P-value:7.88E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:10.20|P-value:1.88E-24 ID:SGTC_997|Compound:3996-0078|FD-Score:3.68|P-value:1.17E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-5.17|P-value:1.61E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.68|P-value:1.39E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.15|P-value:8.01E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.43|P-value:2.97E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.46|P-value:4.11E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.79|P-value:8.45E-7 ID:SGTC_1220|Compound:1838-0075|FD-Score:4.92|P-value:4.40E-7 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.69|P-value:1.33E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:-3.42|P-value:3.72E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:-3.44|P-value:3.42E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.97|P-value:3.33E-7 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.50|P-value:2.74E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.80|P-value:1.02E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:8.49|P-value:1.28E-17 ID:SGTC_1611|Compound:st001856|FD-Score:3.12|P-value:8.79E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.27|P-value:5.16E-4 ID:SGTC_1636|Compound:st007707|FD-Score:-3.28|P-value:6.08E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.12|P-value:8.66E-4 ID:SGTC_1741|Compound:st038134|FD-Score:8.57|P-value:6.66E-18 ID:SGTC_1745|Compound:st081495|FD-Score:-3.42|P-value:3.72E-4 ID:SGTC_1783|Compound:st039459|FD-Score:-3.38|P-value:4.30E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.85|P-value:5.90E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.50|P-value:2.28E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-3.28|P-value:6.15E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.04|P-value:2.67E-5 ID:SGTC_1897|Compound:st060201|FD-Score:3.36|P-value:3.87E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.44|P-value:3.41E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.93|P-value:4.13E-5 ID:SGTC_1966|Compound:st070145|FD-Score:3.10|P-value:9.28E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.63|P-value:1.40E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.97|P-value:3.52E-5 ID:SGTC_2028|Compound:5153890|FD-Score:-3.51|P-value:2.72E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.15|P-value:7.99E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.13|P-value:1.83E-5 ID:SGTC_2133|Compound:5320837|FD-Score:-3.15|P-value:9.48E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.88|P-value:5.08E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-6.95|P-value:2.97E-12 ID:SGTC_2416|Compound:tofa|FD-Score:3.17|P-value:7.33E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.13|P-value:8.51E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.32|P-value:1.37E-13 ID:SGTC_2585|Compound:alliin|FD-Score:-3.84|P-value:7.46E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.01|P-value:2.96E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.96|P-value:4.68E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.18|P-value:7.18E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.01|P-value:3.01E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-4.87|P-value:7.48E-7 ID:SGTC_2785|Compound:7756463|FD-Score:6.77|P-value:7.20E-12 ID:SGTC_2797|Compound:7859098|FD-Score:3.65|P-value:1.27E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.18|P-value:1.44E-5 ID:SGTC_2846|Compound:9008642|FD-Score:5.20|P-value:1.03E-7 ID:SGTC_2888|Compound:9058547|FD-Score:-4.07|P-value:2.97E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.88|P-value:5.06E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.48|P-value:2.46E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.15|P-value:9.52E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.51|P-value:2.21E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-3.29|P-value:5.81E-4 ID:SGTC_3116|Compound:9124943|FD-Score:4.48|P-value:3.66E-6 ID:SGTC_3158|Compound:9100007|FD-Score:3.64|P-value:1.33E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.20|P-value:6.77E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.30|P-value:4.73E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-4.01|P-value:3.79E-5 ID:SGTC_3299|Compound:9121982|FD-Score:8.42|P-value:2.37E-17 ID:SGTC_3303|Compound:9125618|FD-Score:-3.59|P-value:2.00E-4 ID:SGTC_3304|Compound:9125678|FD-Score:6.17|P-value:3.72E-10 ID:SGTC_3307|Compound:9126885|FD-Score:-7.25|P-value:3.59E-13 ID:SGTC_3339|Compound:9145883|FD-Score:3.23|P-value:5.98E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-4.26|P-value:1.28E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:7.83|P-value:2.82E-15 ID:SGTC_65|Compound:0798-0905|FD-Score:3.14|P-value:8.21E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.47|P-value:2.56E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.16|P-value:7.67E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.66|P-value:1.24E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.79|P-value:7.46E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:3.79|P-value:7.28E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:5.09|P-value:1.84E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.17|P-value:7.53E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:4.17|P-value:1.48E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:3.83|P-value:6.36E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:4.29|P-value:8.74E-6 ID:SGTC_856|Compound:0433-0016|FD-Score:3.13|P-value:8.47E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.39|P-value:4.09E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.26|P-value:5.35E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:4.20|P-value:1.35E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.83|P-value:7.88E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:10.20|P-value:1.88E-24 ID:SGTC_997|Compound:3996-0078|FD-Score:3.68|P-value:1.17E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-5.17|P-value:1.61E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.68|P-value:1.39E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.15|P-value:8.01E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.43|P-value:2.97E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.46|P-value:4.11E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.79|P-value:8.45E-7 ID:SGTC_1220|Compound:1838-0075|FD-Score:4.92|P-value:4.40E-7 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.69|P-value:1.33E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:-3.42|P-value:3.72E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:-3.44|P-value:3.42E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.97|P-value:3.33E-7 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.50|P-value:2.74E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.80|P-value:1.02E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:8.49|P-value:1.28E-17 ID:SGTC_1611|Compound:st001856|FD-Score:3.12|P-value:8.79E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.27|P-value:5.16E-4 ID:SGTC_1636|Compound:st007707|FD-Score:-3.28|P-value:6.08E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.12|P-value:8.66E-4 ID:SGTC_1741|Compound:st038134|FD-Score:8.57|P-value:6.66E-18 ID:SGTC_1745|Compound:st081495|FD-Score:-3.42|P-value:3.72E-4 ID:SGTC_1783|Compound:st039459|FD-Score:-3.38|P-value:4.30E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.85|P-value:5.90E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.50|P-value:2.28E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-3.28|P-value:6.15E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.04|P-value:2.67E-5 ID:SGTC_1897|Compound:st060201|FD-Score:3.36|P-value:3.87E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.44|P-value:3.41E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.93|P-value:4.13E-5 ID:SGTC_1966|Compound:st070145|FD-Score:3.10|P-value:9.28E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.63|P-value:1.40E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.97|P-value:3.52E-5 ID:SGTC_2028|Compound:5153890|FD-Score:-3.51|P-value:2.72E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.15|P-value:7.99E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.13|P-value:1.83E-5 ID:SGTC_2133|Compound:5320837|FD-Score:-3.15|P-value:9.48E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.88|P-value:5.08E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-6.95|P-value:2.97E-12 ID:SGTC_2416|Compound:tofa|FD-Score:3.17|P-value:7.33E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.13|P-value:8.51E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.32|P-value:1.37E-13 ID:SGTC_2585|Compound:alliin|FD-Score:-3.84|P-value:7.46E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.01|P-value:2.96E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.96|P-value:4.68E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.18|P-value:7.18E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.01|P-value:3.01E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-4.87|P-value:7.48E-7 ID:SGTC_2785|Compound:7756463|FD-Score:6.77|P-value:7.20E-12 ID:SGTC_2797|Compound:7859098|FD-Score:3.65|P-value:1.27E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.18|P-value:1.44E-5 ID:SGTC_2846|Compound:9008642|FD-Score:5.20|P-value:1.03E-7 ID:SGTC_2888|Compound:9058547|FD-Score:-4.07|P-value:2.97E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.88|P-value:5.06E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.48|P-value:2.46E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.15|P-value:9.52E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.51|P-value:2.21E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-3.29|P-value:5.81E-4 ID:SGTC_3116|Compound:9124943|FD-Score:4.48|P-value:3.66E-6 ID:SGTC_3158|Compound:9100007|FD-Score:3.64|P-value:1.33E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.20|P-value:6.77E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.30|P-value:4.73E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-4.01|P-value:3.79E-5 ID:SGTC_3299|Compound:9121982|FD-Score:8.42|P-value:2.37E-17 ID:SGTC_3303|Compound:9125618|FD-Score:-3.59|P-value:2.00E-4 ID:SGTC_3304|Compound:9125678|FD-Score:6.17|P-value:3.72E-10 ID:SGTC_3307|Compound:9126885|FD-Score:-7.25|P-value:3.59E-13 ID:SGTC_3339|Compound:9145883|FD-Score:3.23|P-value:5.98E-4

Top fitness defect scores for YIL005W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_991 3996-0057 10.20 64.7 µM 1.88E-24 1 1.32E-24
2 SGTC_1741 st038134 8.57 10.2 µM 6.66E-18 2 5.38E-18
3 SGTC_1374 2889-5571 8.49 141.0 µM 1.28E-17 RSC complex & mRNA processing 2 1.04E-17
4 SGTC_3299 9121982 8.42 43.1 µM 2.37E-17 4 1.93E-17
5 SGTC_58 0957-0393 7.83 9.0 µM 2.82E-15 cell wall 131 2.40E-15
6 SGTC_2582 agaric acid 7.32 100.0 µM 1.37E-13 redox potentiating 117 1.21E-13
7 SGTC_2785 7756463 6.77 72.7 µM 7.20E-12 1 6.54E-12
8 SGTC_3304 9125678 6.17 46.1 µM 3.72E-10 12 3.49E-10
9 SGTC_2846 9008642 5.20 19.5 µM 1.03E-7 7 1.00E-7
10 SGTC_429 1112-0049 5.09 25.5 µM 1.84E-7 DNA damage response 20 1.80E-7
11 SGTC_1231 0242-0792 4.97 125.0 µM 3.33E-7 8 3.28E-7
12 SGTC_1220 1838-0075 4.92 193.0 µM 4.40E-7 6 4.33E-7
13 SGTC_1183 1254-0324 4.79 198.0 µM 8.45E-7 9 8.36E-7
14 SGTC_3116 9124943 4.48 49.5 µM 3.66E-6 10 3.65E-6
15 SGTC_1097 itavastatin 4.46 7.2 µM 4.11E-6 azole & statin 13 4.10E-6
16 SGTC_785 1270-0111 4.29 65.3 µM 8.74E-6 19 8.77E-6
17 SGTC_981 1488-1094 4.20 54.9 µM 1.35E-5 17 1.36E-5
18 SGTC_2838 9002687 4.18 71.4 µM 1.44E-5 fatty acid desaturase (OLE1) 19 1.45E-5
19 SGTC_656 4090-1979 4.17 187.0 µM 1.48E-5 13 1.49E-5
20 SGTC_2064 5220758 4.13 200.0 µM 1.83E-5 30 1.84E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 3.00E-24 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.171 1.70E-23 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.155 1.48E-19 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.153 4.01E-19 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.152 1.06E-18 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.148 7.04E-18 YKL048C ELM1 hom Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring
0.146 1.74E-17 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.146 1.89E-17 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.146 2.00E-17 YKL028W TFA1 het TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
0.145 3.87E-17 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.142 1.19E-16 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.141 2.06E-16 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.140 3.59E-16 YJL187C SWE1 hom Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
0.140 4.70E-16 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.140 4.55E-16 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm