YIL056W / VHR1

Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL056W / VHR1

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-2.81|P-value:6.41E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.13|P-value:1.07E-6 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.28|P-value:7.67E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:2.80|P-value:6.17E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:2.87|P-value:4.71E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.38|P-value:4.84E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:3.54|P-value:2.28E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:3.08|P-value:1.91E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.28|P-value:7.96E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:3.69|P-value:1.08E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:2.81|P-value:5.86E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:2.98|P-value:2.94E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.25|P-value:9.53E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.84|P-value:5.51E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.00|P-value:2.66E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.12|P-value:2.02E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.39|P-value:2.28E-7 ID:SGTC_1500|Compound:4488-1866|FD-Score:-2.90|P-value:4.36E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:2.89|P-value:4.35E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.92|P-value:3.14E-6 ID:SGTC_1637|Compound:st007924|FD-Score:-3.02|P-value:2.70E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-2.91|P-value:4.25E-4 ID:SGTC_1831|Compound:st055328|FD-Score:2.74|P-value:7.92E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.01|P-value:2.56E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.21|P-value:1.06E-4 ID:SGTC_2005|Compound:4024620|FD-Score:2.71|P-value:8.77E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.01|P-value:2.64E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.72|P-value:9.81E-6 ID:SGTC_2315|Compound:7733312|FD-Score:-2.86|P-value:5.23E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-5.43|P-value:2.21E-10 ID:SGTC_2336|Compound:9001819|FD-Score:3.23|P-value:1.00E-4 ID:SGTC_2355|Compound:9061122|FD-Score:2.68|P-value:9.81E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.63|P-value:4.59E-11 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.59|P-value:1.92E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.93|P-value:3.66E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.96|P-value:3.16E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-2.79|P-value:6.99E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.35|P-value:2.99E-7 ID:SGTC_2973|Compound:9094665|FD-Score:6.18|P-value:5.41E-13 ID:SGTC_2974|Compound:9094440|FD-Score:8.04|P-value:1.08E-20 ID:SGTC_3272|Compound:9137413|FD-Score:-3.48|P-value:3.27E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-4.33|P-value:3.29E-7 ID:SGTC_72|Compound:0744-0168|FD-Score:-2.81|P-value:6.41E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.13|P-value:1.07E-6 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.28|P-value:7.67E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:2.80|P-value:6.17E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:2.87|P-value:4.71E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.38|P-value:4.84E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:3.54|P-value:2.28E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:3.08|P-value:1.91E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.28|P-value:7.96E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:3.69|P-value:1.08E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:2.81|P-value:5.86E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:2.98|P-value:2.94E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.25|P-value:9.53E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.84|P-value:5.51E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.00|P-value:2.66E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.12|P-value:2.02E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.39|P-value:2.28E-7 ID:SGTC_1500|Compound:4488-1866|FD-Score:-2.90|P-value:4.36E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:2.89|P-value:4.35E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.92|P-value:3.14E-6 ID:SGTC_1637|Compound:st007924|FD-Score:-3.02|P-value:2.70E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-2.91|P-value:4.25E-4 ID:SGTC_1831|Compound:st055328|FD-Score:2.74|P-value:7.92E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.01|P-value:2.56E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.21|P-value:1.06E-4 ID:SGTC_2005|Compound:4024620|FD-Score:2.71|P-value:8.77E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.01|P-value:2.64E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.72|P-value:9.81E-6 ID:SGTC_2315|Compound:7733312|FD-Score:-2.86|P-value:5.23E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-5.43|P-value:2.21E-10 ID:SGTC_2336|Compound:9001819|FD-Score:3.23|P-value:1.00E-4 ID:SGTC_2355|Compound:9061122|FD-Score:2.68|P-value:9.81E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.63|P-value:4.59E-11 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.59|P-value:1.92E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.93|P-value:3.66E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.96|P-value:3.16E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-2.79|P-value:6.99E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.35|P-value:2.99E-7 ID:SGTC_2973|Compound:9094665|FD-Score:6.18|P-value:5.41E-13 ID:SGTC_2974|Compound:9094440|FD-Score:8.04|P-value:1.08E-20 ID:SGTC_3272|Compound:9137413|FD-Score:-3.48|P-value:3.27E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-4.33|P-value:3.29E-7

Top fitness defect scores for YIL056W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2974 9094440 8.04 9.7 µM 1.08E-20 ergosterol biosynthesis 2 4.54E-16
2 SGTC_2973 9094665 6.18 18.0 µM 5.41E-13 NEO1 6 3.15E-10
3 SGTC_2582 agaric acid 5.63 100.0 µM 4.59E-11 redox potentiating 180 9.21E-9
4 SGTC_1632 st005650 3.92 90.0 µM 3.14E-6 31 4.44E-5
5 SGTC_929 2805-0021 3.69 398.0 µM 1.08E-5 17 1.14E-4
6 SGTC_544 k015-0020 3.54 52.4 µM 2.28E-5 19 2.02E-4
7 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.38 8.0 µM 4.84E-5 47 3.60E-4
8 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 3.28 44.4 nM 7.67E-5 DNA damage response 44 5.12E-4
9 SGTC_775 4577-0580 3.28 57.3 µM 7.96E-5 24 5.27E-4
10 SGTC_2336 9001819 3.23 198.7 µM 1.00E-4 heme biosynthesis & mitochondrial translocase 84 6.30E-4
11 SGTC_2002 4023503 3.21 131.0 µM 1.06E-4 mitochondrial processes 68 6.56E-4
12 SGTC_774 k060-0086 3.08 136.0 µM 1.91E-4 50 0.00103
13 SGTC_1989 st071868 3.01 50.2 µM 2.56E-4 40 0.00129
14 SGTC_2120 5538279 3.01 152.0 µM 2.64E-4 45 0.00132
15 SGTC_1347 1493-0251 3.00 600.0 nM 2.66E-4 mitochondrial response to ROS 51 0.00133
16 SGTC_984 1492-0255 2.98 2.9 µM 2.94E-4 SWF1 & branched chain AA biosynthesis 67 0.00144
17 SGTC_2690 usnic acid 2.96 100.0 µM 3.16E-4 78 0.00152
18 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 2.93 100.0 µM 3.66E-4 81 0.00170
19 SGTC_1601 4'-hydroxyflavanone 2.89 55.5 µM 4.35E-4 RPP1 & pyrimidine depletion 79 0.00194
20 SGTC_304 1310-0298 2.87 97.0 µM 4.71E-4 cell wall 134 0.00207

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.296 1.50E-68 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.272 3.63E-58 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.265 5.70E-55 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.219 1.18E-37 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.216 9.01E-37 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.216 9.52E-37 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.213 1.24E-35 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.211 5.43E-35 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.210 1.21E-34 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.209 1.50E-34 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.206 1.44E-33 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.204 8.16E-33 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.203 1.60E-32 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.203 1.45E-32 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.200 1.04E-31 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins