YIL099W / SGA1

Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL099W / SGA1

Click on Significant Values for Screen Details ID:SGTC_351|Compound:caspofungin|FD-Score:3.30|P-value:2.98E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.38|P-value:2.21E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.57|P-value:9.55E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:-2.98|P-value:9.02E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.42|P-value:1.89E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.14|P-value:5.02E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-4.98|P-value:9.56E-8 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.61|P-value:8.65E-5 ID:SGTC_1516|Compound:st013856|FD-Score:5.04|P-value:8.07E-8 ID:SGTC_1527|Compound:coumarin|FD-Score:3.34|P-value:2.63E-4 ID:SGTC_1623|Compound:st003709|FD-Score:2.99|P-value:9.57E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.24|P-value:3.73E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.32|P-value:2.57E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.88|P-value:2.49E-5 ID:SGTC_2018|Compound:5133068|FD-Score:3.24|P-value:3.84E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.79|P-value:3.15E-7 ID:SGTC_2051|Compound:5263410|FD-Score:5.86|P-value:5.21E-10 ID:SGTC_2054|Compound:5233173|FD-Score:6.66|P-value:2.00E-12 ID:SGTC_2056|Compound:5235370|FD-Score:-4.19|P-value:5.77E-6 ID:SGTC_2057|Compound:5236571|FD-Score:-4.25|P-value:4.47E-6 ID:SGTC_2081|Compound:5214970|FD-Score:2.98|P-value:9.73E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-4.61|P-value:7.14E-7 ID:SGTC_2089|Compound:5281248|FD-Score:-3.23|P-value:3.64E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.04|P-value:7.82E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.23|P-value:2.59E-8 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.58|P-value:9.54E-7 ID:SGTC_2585|Compound:alliin|FD-Score:4.10|P-value:9.94E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.22|P-value:4.07E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.12|P-value:5.94E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.07|P-value:7.13E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.14|P-value:5.03E-4 ID:SGTC_2914|Compound:7968218|FD-Score:-2.95|P-value:9.91E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.26|P-value:3.28E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-2.97|P-value:9.49E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.13|P-value:5.18E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.30|P-value:2.98E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.38|P-value:2.21E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.57|P-value:9.55E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:-2.98|P-value:9.02E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.42|P-value:1.89E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.14|P-value:5.02E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-4.98|P-value:9.56E-8 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.61|P-value:8.65E-5 ID:SGTC_1516|Compound:st013856|FD-Score:5.04|P-value:8.07E-8 ID:SGTC_1527|Compound:coumarin|FD-Score:3.34|P-value:2.63E-4 ID:SGTC_1623|Compound:st003709|FD-Score:2.99|P-value:9.57E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.24|P-value:3.73E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.32|P-value:2.57E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.88|P-value:2.49E-5 ID:SGTC_2018|Compound:5133068|FD-Score:3.24|P-value:3.84E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.79|P-value:3.15E-7 ID:SGTC_2051|Compound:5263410|FD-Score:5.86|P-value:5.21E-10 ID:SGTC_2054|Compound:5233173|FD-Score:6.66|P-value:2.00E-12 ID:SGTC_2056|Compound:5235370|FD-Score:-4.19|P-value:5.77E-6 ID:SGTC_2057|Compound:5236571|FD-Score:-4.25|P-value:4.47E-6 ID:SGTC_2081|Compound:5214970|FD-Score:2.98|P-value:9.73E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-4.61|P-value:7.14E-7 ID:SGTC_2089|Compound:5281248|FD-Score:-3.23|P-value:3.64E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.04|P-value:7.82E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.23|P-value:2.59E-8 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.58|P-value:9.54E-7 ID:SGTC_2585|Compound:alliin|FD-Score:4.10|P-value:9.94E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.22|P-value:4.07E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.12|P-value:5.94E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.07|P-value:7.13E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.14|P-value:5.03E-4 ID:SGTC_2914|Compound:7968218|FD-Score:-2.95|P-value:9.91E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.26|P-value:3.28E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-2.97|P-value:9.49E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.13|P-value:5.18E-4

Top fitness defect scores for YIL099W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2054 5233173 6.66 129.0 µM 2.00E-12 mitochondrial response to ROS 13 1.33E-11
2 SGTC_2051 5263410 5.86 176.0 µM 5.21E-10 4 2.26E-9
3 SGTC_2419 paclitaxel 5.23 166.5 µM 2.59E-8 10 8.34E-8
4 SGTC_1516 st013856 5.04 110.0 µM 8.07E-8 2 2.39E-7
5 SGTC_2019 4016004 4.79 108.0 µM 3.15E-7 10 8.39E-7
6 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.58 100.0 µM 9.54E-7 5 2.34E-6
7 SGTC_2585 alliin 4.10 100.0 µM 9.94E-6 20 2.04E-5
8 SGTC_1514 1189-1591 3.61 158.0 µM 8.65E-5 50 1.52E-4
9 SGTC_821 1114-0266 3.42 29.2 µM 1.89E-4 39 3.13E-4
10 SGTC_532 1548-0774 3.38 215.0 µM 2.21E-4 36 3.61E-4
11 SGTC_1527 coumarin 3.34 137.0 µM 2.63E-4 46 4.24E-4
12 SGTC_351 caspofungin 3.30 25.0 nM 2.98E-4 cell wall 152 4.76E-4
13 SGTC_1753 st043925 3.24 64.0 µM 3.73E-4 24 5.88E-4
14 SGTC_2018 5133068 3.24 143.0 µM 3.84E-4 56 6.03E-4
15 SGTC_2589 lobaric acid 3.22 100.0 µM 4.07E-4 50 6.36E-4
16 SGTC_2757 clomiphene 3.12 4.2 µM 5.94E-4 fatty acid desaturase (OLE1) 83 9.04E-4
17 SGTC_2889 9059656 3.07 52.0 µM 7.13E-4 31 0.00107
18 SGTC_2287 7945887 3.04 168.8 µM 7.82E-4 33 0.00117
19 SGTC_1623 st003709 2.99 20.3 µM 9.57E-4 calcium & mitochondrial duress 138 0.00141
20 SGTC_2081 5214970 2.98 32.3 µM 9.73E-4 67 0.00143

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 9.33E-22 YGR039W_d YGR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
0.158 3.19E-20 YOR186W_p YOR186W_p hom Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication
0.137 1.43E-15 YBR105C VID24 hom GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles
0.135 3.35E-15 YNR013C PHO91 hom Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
0.123 9.52E-13 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.120 3.15E-12 YDL031W DBP10 het Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
0.119 4.80E-12 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.111 9.92E-11 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.110 1.49E-10 YJL146W IDS2 hom Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.108 3.11E-10 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.103 2.29E-9 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 5.87E-9 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.100 6.34E-9 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.099 1.06E-8 YGR026W_p YGR026W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.097 1.96E-8 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress