YIL105C / SLM1

Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL105C / SLM1

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:4.21|P-value:1.26E-5 ID:SGTC_57|Compound:miconazole|FD-Score:3.37|P-value:3.53E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.81|P-value:7.67E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:4.30|P-value:8.31E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:15.10|P-value:4.68E-51 ID:SGTC_150|Compound:3970-0969|FD-Score:5.69|P-value:6.67E-9 ID:SGTC_178|Compound:4092-0806|FD-Score:3.97|P-value:3.55E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:5.83|P-value:2.91E-9 ID:SGTC_207|Compound:4185-0010|FD-Score:3.70|P-value:1.04E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.14|P-value:7.94E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.45|P-value:2.71E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:5.98|P-value:1.20E-9 ID:SGTC_312|Compound:4092-0653|FD-Score:3.40|P-value:3.19E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.77|P-value:7.98E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:5.77|P-value:4.24E-9 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.13|P-value:8.21E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:12.40|P-value:2.35E-35 ID:SGTC_486|Compound:niguldipine|FD-Score:4.03|P-value:2.76E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:3.27|P-value:5.09E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:4.51|P-value:3.20E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:5.89|P-value:2.10E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.87|P-value:7.91E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:26.70|P-value:1.34E-154 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.42|P-value:4.23E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.24|P-value:7.98E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:5.67|P-value:7.38E-9 ID:SGTC_710|Compound:3448-4187|FD-Score:3.36|P-value:3.75E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.30|P-value:6.56E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.51|P-value:2.17E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.25|P-value:5.46E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:-4.00|P-value:4.67E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:3.12|P-value:8.45E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.38|P-value:3.47E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.39|P-value:5.70E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.42|P-value:2.96E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.54|P-value:2.80E-6 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.12|P-value:8.55E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.43|P-value:4.15E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.97|P-value:3.40E-7 ID:SGTC_1530|Compound:rhein|FD-Score:4.13|P-value:1.76E-5 ID:SGTC_1531|Compound:st059297|FD-Score:3.59|P-value:1.61E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.65|P-value:1.27E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:18.60|P-value:4.10E-76 ID:SGTC_1712|Compound:st032288|FD-Score:8.75|P-value:1.50E-18 ID:SGTC_1720|Compound:st037298|FD-Score:3.21|P-value:6.35E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.27|P-value:5.17E-4 ID:SGTC_1792|Compound:st045773|FD-Score:5.88|P-value:2.19E-9 ID:SGTC_1859|Compound:st055998|FD-Score:3.10|P-value:9.08E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:4.69|P-value:1.38E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:8.74|P-value:1.62E-18 ID:SGTC_1909|Compound:st060837|FD-Score:-4.20|P-value:1.97E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.40|P-value:3.23E-4 ID:SGTC_2021|Compound:4019055|FD-Score:9.22|P-value:2.39E-20 ID:SGTC_2144|Compound:5628481|FD-Score:3.50|P-value:2.25E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.16|P-value:7.59E-4 ID:SGTC_2184|Compound:6075246|FD-Score:5.56|P-value:1.38E-8 ID:SGTC_2394|Compound:5221648|FD-Score:-3.30|P-value:6.56E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.28|P-value:4.86E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.11|P-value:3.34E-16 ID:SGTC_2777|Compound:climbazole|FD-Score:3.32|P-value:4.33E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.78|P-value:7.62E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-3.76|P-value:1.22E-4 ID:SGTC_2896|Compound:9052656|FD-Score:8.62|P-value:4.57E-18 ID:SGTC_2935|Compound:9038016|FD-Score:4.22|P-value:1.18E-5 ID:SGTC_2999|Compound:9069765|FD-Score:4.15|P-value:1.62E-5 ID:SGTC_3007|Compound:9078383|FD-Score:3.85|P-value:5.62E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.90|P-value:4.62E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-3.83|P-value:9.07E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:4.21|P-value:1.26E-5 ID:SGTC_57|Compound:miconazole|FD-Score:3.37|P-value:3.53E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.81|P-value:7.67E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:4.30|P-value:8.31E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:15.10|P-value:4.68E-51 ID:SGTC_150|Compound:3970-0969|FD-Score:5.69|P-value:6.67E-9 ID:SGTC_178|Compound:4092-0806|FD-Score:3.97|P-value:3.55E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:5.83|P-value:2.91E-9 ID:SGTC_207|Compound:4185-0010|FD-Score:3.70|P-value:1.04E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.14|P-value:7.94E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.45|P-value:2.71E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:5.98|P-value:1.20E-9 ID:SGTC_312|Compound:4092-0653|FD-Score:3.40|P-value:3.19E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.77|P-value:7.98E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:5.77|P-value:4.24E-9 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.13|P-value:8.21E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:12.40|P-value:2.35E-35 ID:SGTC_486|Compound:niguldipine|FD-Score:4.03|P-value:2.76E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:3.27|P-value:5.09E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:4.51|P-value:3.20E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:5.89|P-value:2.10E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.87|P-value:7.91E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:26.70|P-value:1.34E-154 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.42|P-value:4.23E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.24|P-value:7.98E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:5.67|P-value:7.38E-9 ID:SGTC_710|Compound:3448-4187|FD-Score:3.36|P-value:3.75E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.30|P-value:6.56E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.51|P-value:2.17E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.25|P-value:5.46E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:-4.00|P-value:4.67E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:3.12|P-value:8.45E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.38|P-value:3.47E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.39|P-value:5.70E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.42|P-value:2.96E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.54|P-value:2.80E-6 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.12|P-value:8.55E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.43|P-value:4.15E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.97|P-value:3.40E-7 ID:SGTC_1530|Compound:rhein|FD-Score:4.13|P-value:1.76E-5 ID:SGTC_1531|Compound:st059297|FD-Score:3.59|P-value:1.61E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.65|P-value:1.27E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:18.60|P-value:4.10E-76 ID:SGTC_1712|Compound:st032288|FD-Score:8.75|P-value:1.50E-18 ID:SGTC_1720|Compound:st037298|FD-Score:3.21|P-value:6.35E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.27|P-value:5.17E-4 ID:SGTC_1792|Compound:st045773|FD-Score:5.88|P-value:2.19E-9 ID:SGTC_1859|Compound:st055998|FD-Score:3.10|P-value:9.08E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:4.69|P-value:1.38E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:8.74|P-value:1.62E-18 ID:SGTC_1909|Compound:st060837|FD-Score:-4.20|P-value:1.97E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.40|P-value:3.23E-4 ID:SGTC_2021|Compound:4019055|FD-Score:9.22|P-value:2.39E-20 ID:SGTC_2144|Compound:5628481|FD-Score:3.50|P-value:2.25E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.16|P-value:7.59E-4 ID:SGTC_2184|Compound:6075246|FD-Score:5.56|P-value:1.38E-8 ID:SGTC_2394|Compound:5221648|FD-Score:-3.30|P-value:6.56E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.28|P-value:4.86E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.11|P-value:3.34E-16 ID:SGTC_2777|Compound:climbazole|FD-Score:3.32|P-value:4.33E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.78|P-value:7.62E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-3.76|P-value:1.22E-4 ID:SGTC_2896|Compound:9052656|FD-Score:8.62|P-value:4.57E-18 ID:SGTC_2935|Compound:9038016|FD-Score:4.22|P-value:1.18E-5 ID:SGTC_2999|Compound:9069765|FD-Score:4.15|P-value:1.62E-5 ID:SGTC_3007|Compound:9078383|FD-Score:3.85|P-value:5.62E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.90|P-value:4.62E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-3.83|P-value:9.07E-5

Top fitness defect scores for YIL105C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_582 0987-0078 26.70 156.0 µM 1.34E-154 calcium & mitochondrial duress 1 3.42E-157
2 SGTC_1597 7-benzyloxygramine 18.60 47.5 µM 4.10E-76 calcium & mitochondrial duress 5 2.97E-77
3 SGTC_146 3448-8650 15.10 53.1 µM 4.68E-51 NEO1-PIK1 6 9.44E-52
4 SGTC_467 ro 31-8220 12.40 72.8 µM 2.35E-35 calcium & mitochondrial duress 3 8.81E-36
5 SGTC_2021 4019055 9.22 173.0 µM 2.39E-20 endomembrane recycling 14 1.56E-20
6 SGTC_1712 st032288 8.75 53.4 µM 1.50E-18 calcium & mitochondrial duress 36 1.04E-18
7 SGTC_1877 wortmannin 8.74 25.0 µM 1.62E-18 20 1.13E-18
8 SGTC_2896 9052656 8.62 71.4 µM 4.57E-18 endomembrane recycling 12 3.23E-18
9 SGTC_2688 kanamycin b 8.11 96.7 µM 3.34E-16 calcium & mitochondrial duress 59 2.51E-16
10 SGTC_308 4092-1169 5.98 104.0 µM 1.20E-9 plasma membrane duress 19 1.11E-9
11 SGTC_528 3492-0019 5.89 172.0 µM 2.10E-9 calcium & mitochondrial duress 126 1.95E-9
12 SGTC_1792 st045773 5.88 43.6 µM 2.19E-9 4 2.04E-9
13 SGTC_187 1488-2104 5.83 32.7 µM 2.91E-9 calcium & mitochondrial duress 17 2.72E-9
14 SGTC_346 4513-0042 5.77 7.2 µM 4.24E-9 azole & statin 12 3.97E-9
15 SGTC_150 3970-0969 5.69 77.2 µM 6.67E-9 25 6.29E-9
16 SGTC_658 3253-0951 5.67 102.0 µM 7.38E-9 calcium & mitochondrial duress 19 6.96E-9
17 SGTC_2184 6075246 5.56 200.0 µM 1.38E-8 3 1.32E-8
18 SGTC_1495 4469-0029 4.97 237.0 µM 3.40E-7 72 3.35E-7
19 SGTC_58 0957-0393 4.81 9.0 µM 7.67E-7 cell wall 304 7.63E-7
20 SGTC_1876 myriocin 4.69 605.0 nM 1.38E-6 21 1.38E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.470 2.63E-183 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.439 5.78E-158 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.370 2.15E-109 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.370 2.77E-109 YBR109C CMD1 het Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
0.344 4.35E-94 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.339 9.81E-91 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.321 5.00E-81 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.313 4.94E-77 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.311 7.06E-76 YIL154C IMP2' hom Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
0.303 4.32E-72 YGR285C ZUO1 hom Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
0.292 9.41E-67 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.287 1.46E-64 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.273 1.56E-58 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.265 6.93E-55 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.254 2.08E-50 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage