YIL116W / HIS5

Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL116W / HIS5

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.39|P-value:2.48E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.06|P-value:9.09E-4 ID:SGTC_394|Compound:menadione|FD-Score:4.21|P-value:8.63E-6 ID:SGTC_401|Compound:neomycin|FD-Score:3.51|P-value:1.74E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:9.13|P-value:5.38E-21 ID:SGTC_456|Compound:gingerol|FD-Score:4.15|P-value:1.15E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.49|P-value:1.88E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.39|P-value:2.74E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.35|P-value:3.27E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.13|P-value:6.44E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.34|P-value:2.97E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:4.25|P-value:7.16E-6 ID:SGTC_1097|Compound:itavastatin|FD-Score:-3.06|P-value:8.31E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.29|P-value:3.94E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.28|P-value:4.22E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:6.02|P-value:3.88E-10 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.64|P-value:1.04E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.08|P-value:7.59E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.39|P-value:2.71E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:4.56|P-value:1.64E-6 ID:SGTC_1622|Compound:st003707|FD-Score:3.04|P-value:9.79E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.95|P-value:2.87E-5 ID:SGTC_1886|Compound:st057356|FD-Score:-3.07|P-value:8.10E-4 ID:SGTC_1908|Compound:st060353|FD-Score:7.61|P-value:3.70E-15 ID:SGTC_1989|Compound:st071868|FD-Score:3.21|P-value:5.45E-4 ID:SGTC_1990|Compound:st072050|FD-Score:4.79|P-value:5.00E-7 ID:SGTC_2037|Compound:5169046|FD-Score:4.59|P-value:1.39E-6 ID:SGTC_2112|Compound:5488546|FD-Score:-4.39|P-value:3.21E-6 ID:SGTC_2114|Compound:5491910|FD-Score:3.98|P-value:2.47E-5 ID:SGTC_2116|Compound:5511452|FD-Score:-4.31|P-value:4.81E-6 ID:SGTC_2125|Compound:5246583|FD-Score:-3.81|P-value:4.50E-5 ID:SGTC_2160|Compound:5660466|FD-Score:3.87|P-value:3.99E-5 ID:SGTC_2218|Compound:6965428|FD-Score:3.13|P-value:7.11E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.31|P-value:3.30E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-7.44|P-value:1.15E-14 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.91|P-value:2.36E-7 ID:SGTC_2257|Compound:7960413|FD-Score:-5.42|P-value:1.37E-8 ID:SGTC_2310|Compound:7668677|FD-Score:-4.22|P-value:7.34E-6 ID:SGTC_2355|Compound:9061122|FD-Score:6.98|P-value:5.16E-13 ID:SGTC_2360|Compound:9040895|FD-Score:-3.42|P-value:2.20E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-4.08|P-value:1.37E-5 ID:SGTC_2421|Compound:5690543|FD-Score:3.08|P-value:8.65E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-5.86|P-value:9.29E-10 ID:SGTC_2436|Compound:5633522|FD-Score:-3.18|P-value:5.42E-4 ID:SGTC_2480|Compound:5767542|FD-Score:4.01|P-value:2.13E-5 ID:SGTC_2487|Compound:5918373|FD-Score:3.13|P-value:7.18E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.71|P-value:6.99E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-5.44|P-value:1.18E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.57|P-value:1.22E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.89|P-value:9.19E-10 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.21|P-value:5.32E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.33|P-value:3.48E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.05|P-value:1.85E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-3.22|P-value:4.59E-4 ID:SGTC_2818|Compound:7996756|FD-Score:5.14|P-value:7.81E-8 ID:SGTC_2822|Compound:7994718|FD-Score:-3.62|P-value:1.01E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.21|P-value:5.39E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.70|P-value:7.15E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.48|P-value:1.72E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.77|P-value:5.43E-5 ID:SGTC_2953|Compound:9074162|FD-Score:3.86|P-value:4.12E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.18|P-value:5.36E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.06|P-value:9.06E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.39|P-value:2.48E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.06|P-value:9.09E-4 ID:SGTC_394|Compound:menadione|FD-Score:4.21|P-value:8.63E-6 ID:SGTC_401|Compound:neomycin|FD-Score:3.51|P-value:1.74E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:9.13|P-value:5.38E-21 ID:SGTC_456|Compound:gingerol|FD-Score:4.15|P-value:1.15E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.49|P-value:1.88E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.39|P-value:2.74E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.35|P-value:3.27E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.13|P-value:6.44E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.34|P-value:2.97E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:4.25|P-value:7.16E-6 ID:SGTC_1097|Compound:itavastatin|FD-Score:-3.06|P-value:8.31E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.29|P-value:3.94E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.28|P-value:4.22E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:6.02|P-value:3.88E-10 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.64|P-value:1.04E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.08|P-value:7.59E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.39|P-value:2.71E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:4.56|P-value:1.64E-6 ID:SGTC_1622|Compound:st003707|FD-Score:3.04|P-value:9.79E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.95|P-value:2.87E-5 ID:SGTC_1886|Compound:st057356|FD-Score:-3.07|P-value:8.10E-4 ID:SGTC_1908|Compound:st060353|FD-Score:7.61|P-value:3.70E-15 ID:SGTC_1989|Compound:st071868|FD-Score:3.21|P-value:5.45E-4 ID:SGTC_1990|Compound:st072050|FD-Score:4.79|P-value:5.00E-7 ID:SGTC_2037|Compound:5169046|FD-Score:4.59|P-value:1.39E-6 ID:SGTC_2112|Compound:5488546|FD-Score:-4.39|P-value:3.21E-6 ID:SGTC_2114|Compound:5491910|FD-Score:3.98|P-value:2.47E-5 ID:SGTC_2116|Compound:5511452|FD-Score:-4.31|P-value:4.81E-6 ID:SGTC_2125|Compound:5246583|FD-Score:-3.81|P-value:4.50E-5 ID:SGTC_2160|Compound:5660466|FD-Score:3.87|P-value:3.99E-5 ID:SGTC_2218|Compound:6965428|FD-Score:3.13|P-value:7.11E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.31|P-value:3.30E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-7.44|P-value:1.15E-14 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.91|P-value:2.36E-7 ID:SGTC_2257|Compound:7960413|FD-Score:-5.42|P-value:1.37E-8 ID:SGTC_2310|Compound:7668677|FD-Score:-4.22|P-value:7.34E-6 ID:SGTC_2355|Compound:9061122|FD-Score:6.98|P-value:5.16E-13 ID:SGTC_2360|Compound:9040895|FD-Score:-3.42|P-value:2.20E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-4.08|P-value:1.37E-5 ID:SGTC_2421|Compound:5690543|FD-Score:3.08|P-value:8.65E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-5.86|P-value:9.29E-10 ID:SGTC_2436|Compound:5633522|FD-Score:-3.18|P-value:5.42E-4 ID:SGTC_2480|Compound:5767542|FD-Score:4.01|P-value:2.13E-5 ID:SGTC_2487|Compound:5918373|FD-Score:3.13|P-value:7.18E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.71|P-value:6.99E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-5.44|P-value:1.18E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.57|P-value:1.22E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.89|P-value:9.19E-10 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.21|P-value:5.32E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.33|P-value:3.48E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.05|P-value:1.85E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-3.22|P-value:4.59E-4 ID:SGTC_2818|Compound:7996756|FD-Score:5.14|P-value:7.81E-8 ID:SGTC_2822|Compound:7994718|FD-Score:-3.62|P-value:1.01E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.21|P-value:5.39E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.70|P-value:7.15E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.48|P-value:1.72E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.77|P-value:5.43E-5 ID:SGTC_2953|Compound:9074162|FD-Score:3.86|P-value:4.12E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.18|P-value:5.36E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.06|P-value:9.06E-4

Top fitness defect scores for YIL116W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_419 nsc-638432 9.13 893.0 µM 5.38E-21 DNA damage response 1 3.42E-20
2 SGTC_1908 st060353 7.61 56.5 µM 3.70E-15 RPP1 & pyrimidine depletion 4 1.32E-14
3 SGTC_2355 9061122 6.98 103.1 µM 5.16E-13 2 1.49E-12
4 SGTC_1212 0520-0165 6.02 585.0 µM 3.88E-10 5 8.49E-10
5 SGTC_2582 agaric acid 5.89 100.0 µM 9.19E-10 redox potentiating 163 1.94E-9
6 SGTC_2818 7996756 5.14 13.0 µM 7.81E-8 6 1.37E-7
7 SGTC_1990 st072050 4.79 59.8 µM 5.00E-7 5 8.15E-7
8 SGTC_2037 5169046 4.59 200.0 µM 1.39E-6 60S ribosome export 7 2.18E-6
9 SGTC_1582 3',3',6'-trihydroxyflavone 4.56 74.0 µM 1.64E-6 6 2.54E-6
10 SGTC_898 1000-0849 4.25 28.3 µM 7.16E-6 3 1.05E-5
11 SGTC_394 menadione 4.21 8.3 µM 8.63E-6 superoxide 23 1.25E-5
12 SGTC_456 gingerol 4.15 170.0 µM 1.15E-5 16 1.65E-5
13 SGTC_2804 7954240 4.05 19.5 µM 1.85E-5 28 2.60E-5
14 SGTC_2480 5767542 4.01 37.2 µM 2.13E-5 10 2.98E-5
15 SGTC_2114 5491910 3.98 81.2 µM 2.47E-5 11 3.44E-5
16 SGTC_1711 st032263 3.95 62.8 µM 2.87E-5 17 3.97E-5
17 SGTC_2160 5660466 3.87 132.9 µM 3.99E-5 60S ribosome export 17 5.45E-5
18 SGTC_2953 9074162 3.86 66.5 µM 4.12E-5 26 5.61E-5
19 SGTC_1453 4237-0541 3.64 195.0 µM 1.04E-4 heme biosynthesis & mitochondrial translocase 34 1.36E-4
20 SGTC_401 neomycin 3.51 50.0 µM 1.74E-4 17 2.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 1.06E-16 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.130 4.01E-14 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.122 1.60E-12 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.119 4.61E-12 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.117 1.18E-11 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.117 1.32E-11 YGL252C RTG2 hom Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
0.113 5.52E-11 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.112 9.42E-11 YOR364W_d YOR364W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.110 1.57E-10 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.108 3.34E-10 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.108 3.66E-10 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.108 3.72E-10 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.108 4.16E-10 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.104 1.47E-9 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.104 1.54E-9 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p