YIR035C_p

Putative cytoplasmic short-chain dehydrogenase/reductase

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR035C / YIR035C

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.13|P-value:3.56E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-2.95|P-value:9.28E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-6.31|P-value:9.47E-12 ID:SGTC_131|Compound:0141-0277|FD-Score:-2.96|P-value:8.84E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-5.40|P-value:4.78E-9 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.33|P-value:2.14E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.17|P-value:3.06E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:2.93|P-value:7.47E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.19|P-value:2.86E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:2.92|P-value:7.98E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.06|P-value:4.69E-4 ID:SGTC_442|Compound:cape|FD-Score:-3.49|P-value:1.09E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.13|P-value:4.62E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.39|P-value:1.63E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-3.15|P-value:4.31E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.17|P-value:3.01E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.52|P-value:5.60E-7 ID:SGTC_610|Compound:4215-0184|FD-Score:3.20|P-value:2.67E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.76|P-value:2.42E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-9.89|P-value:2.70E-26 ID:SGTC_759|Compound:3486-0358|FD-Score:3.16|P-value:3.13E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:7.86|P-value:1.49E-17 ID:SGTC_843|Compound:0310-0051|FD-Score:3.41|P-value:1.12E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.63|P-value:5.95E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.14|P-value:3.94E-6 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.14|P-value:3.91E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:-4.21|P-value:3.97E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.25|P-value:2.20E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.50|P-value:1.04E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:2.86|P-value:9.95E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.74|P-value:3.76E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.08|P-value:5.49E-6 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.07|P-value:5.96E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.30|P-value:1.78E-6 ID:SGTC_1673|Compound:st016611|FD-Score:2.95|P-value:6.96E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.74|P-value:2.69E-5 ID:SGTC_1748|Compound:st037455|FD-Score:3.27|P-value:2.05E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-3.29|P-value:2.50E-4 ID:SGTC_1821|Compound:st053465|FD-Score:2.98|P-value:6.38E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.29|P-value:2.48E-4 ID:SGTC_1992|Compound:st073643|FD-Score:4.60|P-value:3.58E-7 ID:SGTC_2308|Compound:7584454|FD-Score:9.54|P-value:6.83E-25 ID:SGTC_2315|Compound:7733312|FD-Score:4.00|P-value:7.84E-6 ID:SGTC_2343|Compound:7990716|FD-Score:2.94|P-value:7.28E-4 ID:SGTC_2362|Compound:9071156|FD-Score:2.95|P-value:6.95E-4 ID:SGTC_2403|Compound:6032726|FD-Score:2.88|P-value:9.14E-4 ID:SGTC_2421|Compound:5690543|FD-Score:6.07|P-value:3.41E-11 ID:SGTC_2426|Compound:5582046|FD-Score:3.68|P-value:3.54E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:-4.49|P-value:9.42E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.57|P-value:5.87E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.41|P-value:1.53E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.41|P-value:1.13E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.41|P-value:1.17E-4 ID:SGTC_3032|Compound:9089427|FD-Score:2.92|P-value:7.98E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.18|P-value:2.89E-4 ID:SGTC_3123|Compound:9126162|FD-Score:2.95|P-value:6.96E-4 ID:SGTC_3180|Compound:9109287|FD-Score:2.90|P-value:8.39E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.81|P-value:1.97E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.30|P-value:1.79E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.68|P-value:3.54E-5 ID:SGTC_3268|Compound:9137683|FD-Score:3.35|P-value:1.47E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:3.13|P-value:3.56E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-2.95|P-value:9.28E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-6.31|P-value:9.47E-12 ID:SGTC_131|Compound:0141-0277|FD-Score:-2.96|P-value:8.84E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-5.40|P-value:4.78E-9 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.33|P-value:2.14E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.17|P-value:3.06E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:2.93|P-value:7.47E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.19|P-value:2.86E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:2.92|P-value:7.98E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.06|P-value:4.69E-4 ID:SGTC_442|Compound:cape|FD-Score:-3.49|P-value:1.09E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.13|P-value:4.62E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.39|P-value:1.63E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-3.15|P-value:4.31E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.17|P-value:3.01E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.52|P-value:5.60E-7 ID:SGTC_610|Compound:4215-0184|FD-Score:3.20|P-value:2.67E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.76|P-value:2.42E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-9.89|P-value:2.70E-26 ID:SGTC_759|Compound:3486-0358|FD-Score:3.16|P-value:3.13E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:7.86|P-value:1.49E-17 ID:SGTC_843|Compound:0310-0051|FD-Score:3.41|P-value:1.12E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.63|P-value:5.95E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.14|P-value:3.94E-6 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.14|P-value:3.91E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:-4.21|P-value:3.97E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.25|P-value:2.20E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.50|P-value:1.04E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:2.86|P-value:9.95E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.74|P-value:3.76E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.08|P-value:5.49E-6 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.07|P-value:5.96E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.30|P-value:1.78E-6 ID:SGTC_1673|Compound:st016611|FD-Score:2.95|P-value:6.96E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.74|P-value:2.69E-5 ID:SGTC_1748|Compound:st037455|FD-Score:3.27|P-value:2.05E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-3.29|P-value:2.50E-4 ID:SGTC_1821|Compound:st053465|FD-Score:2.98|P-value:6.38E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.29|P-value:2.48E-4 ID:SGTC_1992|Compound:st073643|FD-Score:4.60|P-value:3.58E-7 ID:SGTC_2308|Compound:7584454|FD-Score:9.54|P-value:6.83E-25 ID:SGTC_2315|Compound:7733312|FD-Score:4.00|P-value:7.84E-6 ID:SGTC_2343|Compound:7990716|FD-Score:2.94|P-value:7.28E-4 ID:SGTC_2362|Compound:9071156|FD-Score:2.95|P-value:6.95E-4 ID:SGTC_2403|Compound:6032726|FD-Score:2.88|P-value:9.14E-4 ID:SGTC_2421|Compound:5690543|FD-Score:6.07|P-value:3.41E-11 ID:SGTC_2426|Compound:5582046|FD-Score:3.68|P-value:3.54E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:-4.49|P-value:9.42E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.57|P-value:5.87E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.41|P-value:1.53E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.41|P-value:1.13E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.41|P-value:1.17E-4 ID:SGTC_3032|Compound:9089427|FD-Score:2.92|P-value:7.98E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.18|P-value:2.89E-4 ID:SGTC_3123|Compound:9126162|FD-Score:2.95|P-value:6.96E-4 ID:SGTC_3180|Compound:9109287|FD-Score:2.90|P-value:8.39E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.81|P-value:1.97E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.30|P-value:1.79E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.68|P-value:3.54E-5 ID:SGTC_3268|Compound:9137683|FD-Score:3.35|P-value:1.47E-4

Top fitness defect scores for YIR035C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2308 7584454 9.54 197.6 µM 6.83E-25 1 7.42E-22
2 SGTC_773 4358-1457 7.86 44.6 µM 1.49E-17 7 1.86E-15
3 SGTC_2421 5690543 6.07 90.7 µM 3.41E-11 3 6.57E-10
4 SGTC_1992 st073643 4.60 23.3 µM 3.58E-7 mitochondrial processes 7 2.12E-6
5 SGTC_594 1487-1584 4.52 10.8 µM 5.60E-7 16 3.12E-6
6 SGTC_1655 st012546 4.30 55.1 µM 1.78E-6 21 8.55E-6
7 SGTC_1077 5-fluorocytosine 4.14 377.0 nM 3.91E-6 exosome 12 1.70E-5
8 SGTC_1041 0206-0046 4.14 107.0 µM 3.94E-6 29 1.71E-5
9 SGTC_1589 2',5'-dimethoxyflavone 4.08 47.2 µM 5.49E-6 14 2.29E-5
10 SGTC_2315 7733312 4.00 200.0 µM 7.84E-6 24 3.12E-5
11 SGTC_3234 9132280 3.81 49.5 µM 1.97E-5 22 7.00E-5
12 SGTC_704 1310-0270 3.76 142.0 µM 2.42E-5 38 8.35E-5
13 SGTC_1693 xanthone 3.74 101.9 µM 2.69E-5 DNA damage response 20 9.17E-5
14 SGTC_2426 5582046 3.68 32.2 µM 3.54E-5 40 1.17E-4
15 SGTC_3249 9135183 3.68 49.5 µM 3.54E-5 60S ribosome export 18 1.17E-4
16 SGTC_2538 3',7'-epoxycaryophyllan-6-one 3.57 100.0 µM 5.87E-5 36 1.81E-4
17 SGTC_843 0310-0051 3.41 143.0 µM 1.12E-4 28 3.20E-4
18 SGTC_2938 9059746 3.41 27.3 µM 1.13E-4 fatty acid desaturase (OLE1) 58 3.22E-4
19 SGTC_2964 9083345 3.41 53.4 µM 1.17E-4 40 3.30E-4
20 SGTC_3268 9137683 3.35 49.5 µM 1.47E-4 19 4.05E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 6.26E-31 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.193 1.45E-29 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.186 1.77E-27 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.176 9.08E-25 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.170 4.52E-23 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.169 6.26E-23 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.161 6.80E-21 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.157 6.86E-20 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.154 2.62E-19 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.150 2.88E-18 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.148 6.56E-18 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.142 1.61E-16 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.135 4.68E-15 YOR033C EXO1 hom 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress
0.125 4.13E-13 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.125 4.28E-13 YJR018W_d YJR018W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data