YJL051W / IRC8

Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL051W / IRC8

Click on Significant Values for Screen Details ID:SGTC_337|Compound:1315-0038|FD-Score:3.17|P-value:1.35E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.17|P-value:1.36E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-2.71|P-value:8.18E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.80|P-value:6.20E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:3.02|P-value:2.58E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-2.77|P-value:6.62E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.39|P-value:1.80E-7 ID:SGTC_543|Compound:3844-1095|FD-Score:3.26|P-value:9.09E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:3.43|P-value:4.11E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.89|P-value:3.91E-6 ID:SGTC_597|Compound:k018-0003|FD-Score:3.70|P-value:1.06E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:2.83|P-value:5.68E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.62|P-value:1.57E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.01|P-value:2.39E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.62|P-value:1.58E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:2.92|P-value:4.04E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.08|P-value:1.97E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:2.81|P-value:6.18E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.75|P-value:6.70E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:-2.98|P-value:2.70E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.17|P-value:1.34E-4 ID:SGTC_1826|Compound:st055655|FD-Score:2.82|P-value:5.88E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.71|P-value:9.82E-6 ID:SGTC_2013|Compound:4024628|FD-Score:3.71|P-value:9.67E-6 ID:SGTC_2014|Compound:4013930|FD-Score:2.75|P-value:7.89E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.30|P-value:6.35E-5 ID:SGTC_2057|Compound:5236571|FD-Score:2.82|P-value:5.96E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.05|P-value:2.29E-4 ID:SGTC_2237|Compound:6667747|FD-Score:-2.75|P-value:7.05E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.60|P-value:1.52E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-5.83|P-value:7.20E-12 ID:SGTC_2346|Compound:9031566|FD-Score:-2.77|P-value:6.46E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-2.85|P-value:4.63E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.92|P-value:3.45E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.34|P-value:5.47E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:3.41|P-value:4.39E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.27|P-value:8.60E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.90|P-value:3.03E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.28|P-value:7.09E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.44|P-value:3.88E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.15|P-value:1.28E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.81|P-value:5.90E-6 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.86|P-value:4.50E-6 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-2.86|P-value:4.46E-4 ID:SGTC_3103|Compound:9120822|FD-Score:2.77|P-value:7.30E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.78|P-value:6.14E-4 ID:SGTC_3286|Compound:9117135|FD-Score:2.96|P-value:3.37E-4 ID:SGTC_3290|Compound:9121031|FD-Score:2.86|P-value:5.07E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-2.83|P-value:4.99E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.17|P-value:1.35E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.17|P-value:1.36E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-2.71|P-value:8.18E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.80|P-value:6.20E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:3.02|P-value:2.58E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-2.77|P-value:6.62E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.39|P-value:1.80E-7 ID:SGTC_543|Compound:3844-1095|FD-Score:3.26|P-value:9.09E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:3.43|P-value:4.11E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.89|P-value:3.91E-6 ID:SGTC_597|Compound:k018-0003|FD-Score:3.70|P-value:1.06E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:2.83|P-value:5.68E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.62|P-value:1.57E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.01|P-value:2.39E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.62|P-value:1.58E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:2.92|P-value:4.04E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.08|P-value:1.97E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:2.81|P-value:6.18E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.75|P-value:6.70E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:-2.98|P-value:2.70E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.17|P-value:1.34E-4 ID:SGTC_1826|Compound:st055655|FD-Score:2.82|P-value:5.88E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.71|P-value:9.82E-6 ID:SGTC_2013|Compound:4024628|FD-Score:3.71|P-value:9.67E-6 ID:SGTC_2014|Compound:4013930|FD-Score:2.75|P-value:7.89E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.30|P-value:6.35E-5 ID:SGTC_2057|Compound:5236571|FD-Score:2.82|P-value:5.96E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.05|P-value:2.29E-4 ID:SGTC_2237|Compound:6667747|FD-Score:-2.75|P-value:7.05E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.60|P-value:1.52E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-5.83|P-value:7.20E-12 ID:SGTC_2346|Compound:9031566|FD-Score:-2.77|P-value:6.46E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-2.85|P-value:4.63E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.92|P-value:3.45E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.34|P-value:5.47E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:3.41|P-value:4.39E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.27|P-value:8.60E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.90|P-value:3.03E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.28|P-value:7.09E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.44|P-value:3.88E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.15|P-value:1.28E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.81|P-value:5.90E-6 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.86|P-value:4.50E-6 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-2.86|P-value:4.46E-4 ID:SGTC_3103|Compound:9120822|FD-Score:2.77|P-value:7.30E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.78|P-value:6.14E-4 ID:SGTC_3286|Compound:9117135|FD-Score:2.96|P-value:3.37E-4 ID:SGTC_3290|Compound:9121031|FD-Score:2.86|P-value:5.07E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-2.83|P-value:4.99E-4

Top fitness defect scores for YJL051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_550 4123-0385 3.89 25.7 µM 3.91E-6 TSC3-RPN4 27 5.10E-5
2 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.86 100.0 µM 4.50E-6 38 5.67E-5
3 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 3.81 100.0 µM 5.90E-6 60S ribosome export 23 6.97E-5
4 SGTC_366 0181-0206 3.80 4.3 µM 6.20E-6 Golgi 48 7.24E-5
5 SGTC_2013 4024628 3.71 200.0 µM 9.67E-6 53 1.02E-4
6 SGTC_1911 st060208 3.71 74.3 µM 9.82E-6 42 1.03E-4
7 SGTC_597 k018-0003 3.70 82.8 µM 1.06E-5 RNA pol III & RNase P/MRP 16 1.09E-4
8 SGTC_961 1252-1571 3.62 372.0 µM 1.57E-5 42 1.47E-4
9 SGTC_1125 tnp00248 3.62 1.3 µM 1.58E-5 45 1.48E-4
10 SGTC_2586 curcumin 3.44 80.0 µM 3.88E-5 iron homeostasis 80 2.94E-4
11 SGTC_545 4218-0007 3.43 221.0 µM 4.11E-5 45 3.07E-4
12 SGTC_2516 gossypol 3.41 71.5 µM 4.39E-5 30 3.23E-4
13 SGTC_2535 4',4'-dimethoxydalbergione 3.27 51.2 µM 8.60E-5 DNA damage response 35 5.41E-4
14 SGTC_543 3844-1095 3.26 191.0 µM 9.09E-5 ERG2 76 5.64E-4
15 SGTC_1628 st004252 3.17 77.7 µM 1.34E-4 54 7.61E-4
16 SGTC_337 1315-0038 3.17 354.0 µM 1.35E-4 amide catabolism 54 7.65E-4
17 SGTC_359 0081-0058 3.17 15.9 µM 1.36E-4 60S ribosome export 93 7.68E-4
18 SGTC_1224 0823-0416 3.08 294.0 µM 1.97E-4 45 0.00102
19 SGTC_2058 5236698 3.05 133.0 µM 2.29E-4 67 0.00114
20 SGTC_373 0844-0104 3.02 25.9 µM 2.58E-4 ERAD & cell cycle 107 0.00125

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.61E-28 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.188 4.10E-28 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.167 2.17E-22 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.166 4.24E-22 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.165 6.60E-22 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.158 4.47E-20 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.156 1.11E-19 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.152 9.64E-19 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.147 9.60E-18 YPR037C ERV2 hom Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
0.144 4.35E-17 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.142 1.32E-16 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.140 4.35E-16 YLR154C RNH203 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
0.137 1.49E-15 YBL070C_d YBL070C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.129 6.08E-14 YDR109C_p YDR109C_p hom Putative kinase
0.128 9.37E-14 YLR349W_d YLR349W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C