YJL054W / TIM54

Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL054W / TIM54

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:8.26|P-value:9.63E-18 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.26|P-value:4.15E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.34|P-value:2.93E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.72|P-value:5.91E-7 ID:SGTC_150|Compound:3970-0969|FD-Score:7.86|P-value:3.23E-16 ID:SGTC_157|Compound:1348-1695|FD-Score:4.14|P-value:1.04E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:7.28|P-value:3.58E-14 ID:SGTC_168|Compound:3970-0862|FD-Score:8.64|P-value:3.06E-19 ID:SGTC_184|Compound:1494-0393|FD-Score:7.45|P-value:9.40E-15 ID:SGTC_197|Compound:4544-0043|FD-Score:13.50|P-value:3.64E-44 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.18|P-value:8.36E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:15.90|P-value:1.28E-60 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.38|P-value:2.53E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:-5.28|P-value:3.00E-8 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.59|P-value:1.08E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.19|P-value:5.35E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:4.08|P-value:1.36E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:3.75|P-value:5.75E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:3.46|P-value:1.87E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.02|P-value:9.60E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:4.13|P-value:1.05E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:4.13|P-value:1.06E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.24|P-value:4.19E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.75|P-value:5.78E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:3.53|P-value:1.39E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-4.11|P-value:1.22E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.58|P-value:1.13E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:10.30|P-value:2.42E-26 ID:SGTC_515|Compound:4092-1064|FD-Score:3.72|P-value:6.53E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:7.52|P-value:5.27E-15 ID:SGTC_526|Compound:4469-0568|FD-Score:5.65|P-value:3.11E-9 ID:SGTC_558|Compound:k064-0027|FD-Score:3.38|P-value:2.53E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.85|P-value:3.95E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:4.47|P-value:2.17E-6 ID:SGTC_689|Compound:0833-0039|FD-Score:3.38|P-value:2.47E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.31|P-value:3.33E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.37|P-value:2.58E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.09|P-value:7.30E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.86|P-value:2.83E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.79|P-value:4.98E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.19|P-value:9.48E-11 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.95|P-value:2.36E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.01|P-value:9.73E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.91|P-value:5.89E-10 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.38|P-value:3.38E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.98|P-value:2.18E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.98|P-value:2.13E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.02|P-value:9.41E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.10|P-value:6.55E-36 ID:SGTC_1889|Compound:st059080|FD-Score:3.17|P-value:5.58E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.60|P-value:1.12E-6 ID:SGTC_2248|Compound:tofa|FD-Score:12.40|P-value:8.18E-38 ID:SGTC_2264|Compound:7948757|FD-Score:-3.45|P-value:1.98E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-5.03|P-value:1.18E-7 ID:SGTC_2267|Compound:7931562|FD-Score:-4.93|P-value:2.13E-7 ID:SGTC_2268|Compound:7933382|FD-Score:-3.77|P-value:5.41E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-3.18|P-value:5.55E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.42|P-value:1.12E-14 ID:SGTC_2363|Compound:9053361|FD-Score:3.06|P-value:8.07E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.13|P-value:6.35E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.79|P-value:4.33E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.50|P-value:1.90E-32 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.35|P-value:2.87E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.45|P-value:2.50E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.70|P-value:2.17E-45 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-6.01|P-value:3.46E-10 ID:SGTC_2671|Compound:danthron|FD-Score:6.07|P-value:2.14E-10 ID:SGTC_2679|Compound:rapamycin|FD-Score:10.50|P-value:1.68E-27 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.13|P-value:6.52E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.27|P-value:3.84E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.33|P-value:3.04E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.76|P-value:5.56E-5 ID:SGTC_2896|Compound:9052656|FD-Score:5.87|P-value:7.66E-10 ID:SGTC_2911|Compound:7942208|FD-Score:-4.17|P-value:9.32E-6 ID:SGTC_2991|Compound:9074669|FD-Score:5.25|P-value:3.29E-8 ID:SGTC_3072|Compound:9116419|FD-Score:-3.02|P-value:9.72E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.05|P-value:8.57E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.27|P-value:3.88E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.01|P-value:9.56E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.53|P-value:1.39E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.95|P-value:2.38E-5 ID:SGTC_3327|Compound:9140648|FD-Score:-3.71|P-value:6.94E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:8.26|P-value:9.63E-18 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.26|P-value:4.15E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.34|P-value:2.93E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.72|P-value:5.91E-7 ID:SGTC_150|Compound:3970-0969|FD-Score:7.86|P-value:3.23E-16 ID:SGTC_157|Compound:1348-1695|FD-Score:4.14|P-value:1.04E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:7.28|P-value:3.58E-14 ID:SGTC_168|Compound:3970-0862|FD-Score:8.64|P-value:3.06E-19 ID:SGTC_184|Compound:1494-0393|FD-Score:7.45|P-value:9.40E-15 ID:SGTC_197|Compound:4544-0043|FD-Score:13.50|P-value:3.64E-44 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.18|P-value:8.36E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:15.90|P-value:1.28E-60 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.38|P-value:2.53E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:-5.28|P-value:3.00E-8 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.59|P-value:1.08E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.19|P-value:5.35E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:4.08|P-value:1.36E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:3.75|P-value:5.75E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:3.46|P-value:1.87E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.02|P-value:9.60E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:4.13|P-value:1.05E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:4.13|P-value:1.06E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.24|P-value:4.19E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.75|P-value:5.78E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:3.53|P-value:1.39E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-4.11|P-value:1.22E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.58|P-value:1.13E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:10.30|P-value:2.42E-26 ID:SGTC_515|Compound:4092-1064|FD-Score:3.72|P-value:6.53E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:7.52|P-value:5.27E-15 ID:SGTC_526|Compound:4469-0568|FD-Score:5.65|P-value:3.11E-9 ID:SGTC_558|Compound:k064-0027|FD-Score:3.38|P-value:2.53E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.85|P-value:3.95E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:4.47|P-value:2.17E-6 ID:SGTC_689|Compound:0833-0039|FD-Score:3.38|P-value:2.47E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.31|P-value:3.33E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.37|P-value:2.58E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.09|P-value:7.30E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.86|P-value:2.83E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.79|P-value:4.98E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.19|P-value:9.48E-11 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.95|P-value:2.36E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.01|P-value:9.73E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.91|P-value:5.89E-10 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.38|P-value:3.38E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.98|P-value:2.18E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.98|P-value:2.13E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.02|P-value:9.41E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.10|P-value:6.55E-36 ID:SGTC_1889|Compound:st059080|FD-Score:3.17|P-value:5.58E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.60|P-value:1.12E-6 ID:SGTC_2248|Compound:tofa|FD-Score:12.40|P-value:8.18E-38 ID:SGTC_2264|Compound:7948757|FD-Score:-3.45|P-value:1.98E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-5.03|P-value:1.18E-7 ID:SGTC_2267|Compound:7931562|FD-Score:-4.93|P-value:2.13E-7 ID:SGTC_2268|Compound:7933382|FD-Score:-3.77|P-value:5.41E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-3.18|P-value:5.55E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.42|P-value:1.12E-14 ID:SGTC_2363|Compound:9053361|FD-Score:3.06|P-value:8.07E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.13|P-value:6.35E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.79|P-value:4.33E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.50|P-value:1.90E-32 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.35|P-value:2.87E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.45|P-value:2.50E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.70|P-value:2.17E-45 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-6.01|P-value:3.46E-10 ID:SGTC_2671|Compound:danthron|FD-Score:6.07|P-value:2.14E-10 ID:SGTC_2679|Compound:rapamycin|FD-Score:10.50|P-value:1.68E-27 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.13|P-value:6.52E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.27|P-value:3.84E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.33|P-value:3.04E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.76|P-value:5.56E-5 ID:SGTC_2896|Compound:9052656|FD-Score:5.87|P-value:7.66E-10 ID:SGTC_2911|Compound:7942208|FD-Score:-4.17|P-value:9.32E-6 ID:SGTC_2991|Compound:9074669|FD-Score:5.25|P-value:3.29E-8 ID:SGTC_3072|Compound:9116419|FD-Score:-3.02|P-value:9.72E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.05|P-value:8.57E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.27|P-value:3.88E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.01|P-value:9.56E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.53|P-value:1.39E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.95|P-value:2.38E-5 ID:SGTC_3327|Compound:9140648|FD-Score:-3.71|P-value:6.94E-5

Top fitness defect scores for YJL054W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_227 fluconazole 15.90 33.5 µM 1.28E-60 azole & statin 6 1.87E-57 0.40
2 SGTC_2651 1327-0036 13.70 5.0 µM 2.17E-45 7 4.85E-43 0.09
3 SGTC_197 4544-0043 13.50 41.6 µM 3.64E-44 endomembrane recycling 2 7.00E-42 1.88
4 SGTC_2248 tofa 12.40 1.1 µM 8.18E-38 sphingolipid biosynthesis & PDR1 5 7.17E-36 1.75
5 SGTC_1844 rapamycin 12.10 4.0 nM 6.55E-36 7 4.54E-34 1.15
6 SGTC_2582 agaric acid 11.50 100.0 µM 1.90E-32 redox potentiating 7 8.59E-31 2.23
7 SGTC_2679 rapamycin 10.50 1.0 nM 1.68E-27 8 4.13E-26 0.88
8 SGTC_457 grayanotoxin iii 10.30 135.0 µM 2.42E-26 2 5.16E-25 2.41
9 SGTC_168 3970-0862 8.64 530.5 µM 3.06E-19 5 2.72E-18 0.07
10 SGTC_58 0957-0393 8.26 9.0 µM 9.63E-18 cell wall 16 7.12E-17 0.45
11 SGTC_150 3970-0969 7.86 77.2 µM 3.23E-16 3 1.98E-15 1.62
12 SGTC_525 k781-2675 7.52 26.7 µM 5.27E-15 redox potentiating 9 2.78E-14 0.33
13 SGTC_184 1494-0393 7.45 24.7 µM 9.40E-15 5 4.82E-14 0.50
14 SGTC_2322 7413319 7.42 38.2 µM 1.12E-14 ERAD & cell cycle 8 5.68E-14 1.01
15 SGTC_163 1327-0036 7.28 7.5 µM 3.58E-14 27 1.71E-13 0.67
16 SGTC_1230 0170-0365 6.19 3.8 µM 9.48E-11 endomembrane recycling 12 2.97E-10 0.32
17 SGTC_2671 danthron 6.07 100.0 µM 2.14E-10 DNA damage response 7 6.42E-10 0.31
18 SGTC_1317 1273-0028 5.91 910.0 nM 5.89E-10 azole & statin 7 1.68E-9 0.55
19 SGTC_2896 9052656 5.87 71.4 µM 7.66E-10 endomembrane recycling 10 2.15E-9 2.04E-4
20 SGTC_526 4469-0568 5.65 170.0 µM 3.11E-9 azole & statin 2 8.11E-9 9.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.597 1.98E-323 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.485 1.47E-197 YKL028W TFA1 het TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
0.288 8.36E-65 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.258 3.00E-52 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.255 5.46E-51 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.240 3.70E-45 YDL147W RPN5 het Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein
0.239 1.23E-44 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.238 1.86E-44 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.236 8.70E-44 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.230 1.16E-41 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.230 3.32E-41 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.224 3.00E-39 YOR132W VPS17 hom Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes
0.222 8.04E-39 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.222 1.17E-38 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.219 8.65E-38 YER177W BMH1 hom 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress