YJL055W_p

Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL055W / YJL055W

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:5.71|P-value:6.85E-9 ID:SGTC_66|Compound:0109-0187|FD-Score:4.94|P-value:4.69E-7 ID:SGTC_75|Compound:0159-0059|FD-Score:4.54|P-value:3.27E-6 ID:SGTC_322|Compound:k048-0136|FD-Score:3.32|P-value:4.92E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.23|P-value:6.63E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.11|P-value:9.67E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.13|P-value:9.30E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.75|P-value:1.15E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:3.40|P-value:3.65E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.55|P-value:3.05E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.59|P-value:1.83E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.96|P-value:4.18E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.58|P-value:1.89E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.41|P-value:3.50E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.94|P-value:4.53E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.82|P-value:7.32E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.19|P-value:1.55E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:-3.29|P-value:5.26E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:-3.85|P-value:6.39E-5 ID:SGTC_1434|Compound:4073-0095|FD-Score:6.42|P-value:8.92E-11 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.96|P-value:4.25E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.92|P-value:5.18E-7 ID:SGTC_1524|Compound:corynanthine|FD-Score:6.16|P-value:4.50E-10 ID:SGTC_1578|Compound:josamycin|FD-Score:4.00|P-value:3.51E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.37|P-value:4.11E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.12|P-value:9.76E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.69|P-value:1.60E-6 ID:SGTC_1822|Compound:st052468|FD-Score:3.98|P-value:3.77E-5 ID:SGTC_1914|Compound:st062367|FD-Score:3.29|P-value:5.47E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.19|P-value:1.58E-5 ID:SGTC_1967|Compound:st070177|FD-Score:3.37|P-value:4.01E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-3.31|P-value:4.96E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.66|P-value:1.38E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.54|P-value:2.22E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-5.27|P-value:7.58E-8 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.44|P-value:3.04E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-6.31|P-value:1.64E-10 ID:SGTC_2585|Compound:alliin|FD-Score:3.32|P-value:4.81E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.11|P-value:9.77E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.85|P-value:6.48E-5 ID:SGTC_2893|Compound:9048488|FD-Score:3.20|P-value:7.47E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.91|P-value:5.12E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-4.34|P-value:7.84E-6 ID:SGTC_2932|Compound:9016711|FD-Score:10.80|P-value:3.84E-27 ID:SGTC_2939|Compound:9044578|FD-Score:6.14|P-value:5.07E-10 ID:SGTC_3295|Compound:9122362|FD-Score:5.70|P-value:7.28E-9 ID:SGTC_3349|Compound:9149703|FD-Score:5.14|P-value:1.67E-7 ID:SGTC_47|Compound:0149-0135|FD-Score:5.71|P-value:6.85E-9 ID:SGTC_66|Compound:0109-0187|FD-Score:4.94|P-value:4.69E-7 ID:SGTC_75|Compound:0159-0059|FD-Score:4.54|P-value:3.27E-6 ID:SGTC_322|Compound:k048-0136|FD-Score:3.32|P-value:4.92E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.23|P-value:6.63E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.11|P-value:9.67E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.13|P-value:9.30E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.75|P-value:1.15E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:3.40|P-value:3.65E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.55|P-value:3.05E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.59|P-value:1.83E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.96|P-value:4.18E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.58|P-value:1.89E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.41|P-value:3.50E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.94|P-value:4.53E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.82|P-value:7.32E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.19|P-value:1.55E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:-3.29|P-value:5.26E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:-3.85|P-value:6.39E-5 ID:SGTC_1434|Compound:4073-0095|FD-Score:6.42|P-value:8.92E-11 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.96|P-value:4.25E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.92|P-value:5.18E-7 ID:SGTC_1524|Compound:corynanthine|FD-Score:6.16|P-value:4.50E-10 ID:SGTC_1578|Compound:josamycin|FD-Score:4.00|P-value:3.51E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.37|P-value:4.11E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.12|P-value:9.76E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.69|P-value:1.60E-6 ID:SGTC_1822|Compound:st052468|FD-Score:3.98|P-value:3.77E-5 ID:SGTC_1914|Compound:st062367|FD-Score:3.29|P-value:5.47E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.19|P-value:1.58E-5 ID:SGTC_1967|Compound:st070177|FD-Score:3.37|P-value:4.01E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-3.31|P-value:4.96E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.66|P-value:1.38E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.54|P-value:2.22E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-5.27|P-value:7.58E-8 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.44|P-value:3.04E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-6.31|P-value:1.64E-10 ID:SGTC_2585|Compound:alliin|FD-Score:3.32|P-value:4.81E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.11|P-value:9.77E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.85|P-value:6.48E-5 ID:SGTC_2893|Compound:9048488|FD-Score:3.20|P-value:7.47E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.91|P-value:5.12E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-4.34|P-value:7.84E-6 ID:SGTC_2932|Compound:9016711|FD-Score:10.80|P-value:3.84E-27 ID:SGTC_2939|Compound:9044578|FD-Score:6.14|P-value:5.07E-10 ID:SGTC_3295|Compound:9122362|FD-Score:5.70|P-value:7.28E-9 ID:SGTC_3349|Compound:9149703|FD-Score:5.14|P-value:1.67E-7

Top fitness defect scores for YJL055W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2932 9016711 10.80 44.5 µM 3.84E-27 6 1.95E-27
2 SGTC_1434 4073-0095 6.42 163.0 µM 8.92E-11 1 6.90E-11
3 SGTC_1524 corynanthine 6.16 62.1 µM 4.50E-10 5 3.54E-10
4 SGTC_2939 9044578 6.14 71.4 µM 5.07E-10 14 4.00E-10
5 SGTC_47 0149-0135 5.71 24.2 µM 6.85E-9 TSC3-RPN4 3 5.57E-9
6 SGTC_3295 9122362 5.70 53.6 µM 7.28E-9 2 5.91E-9
7 SGTC_3349 9149703 5.14 23.0 µM 1.67E-7 4 1.41E-7
8 SGTC_66 0109-0187 4.94 42.4 µM 4.69E-7 21 4.00E-7
9 SGTC_1442 4112-3290 4.92 3.0 µM 5.18E-7 1 4.42E-7
10 SGTC_679 0422-0091 4.75 41.4 µM 1.15E-6 Golgi 13 9.92E-7
11 SGTC_1739 st037196 4.69 92.5 µM 1.60E-6 9 1.38E-6
12 SGTC_1002 4049-0206 4.55 172.0 µM 3.05E-6 16 2.65E-6
13 SGTC_75 0159-0059 4.54 199.0 µM 3.27E-6 fatty acid desaturase (OLE1) 14 2.85E-6
14 SGTC_1370 2001-0092 4.19 44.6 µM 1.55E-5 22 1.37E-5
15 SGTC_1952 st077036 4.19 64.1 µM 1.58E-5 28 1.40E-5
16 SGTC_1578 josamycin 4.00 24.2 µM 3.51E-5 13 3.14E-5
17 SGTC_1822 st052468 3.98 42.0 µM 3.77E-5 10 3.38E-5
18 SGTC_1148 3909-7663 3.96 27.7 µM 4.18E-5 17 3.74E-5
19 SGTC_1441 4106-0040 3.96 13.0 µM 4.25E-5 9 3.81E-5
20 SGTC_1287 0971-0001 3.94 34.6 µM 4.53E-5 sphingolipid biosynthesis & PDR1 45 4.07E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.73E-17 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.100 6.25E-9 YKR003W OSH6 hom Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion
0.100 6.86E-9 YKL096W CWP1 hom Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance
0.095 3.68E-8 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.093 6.21E-8 YML125C PGA3 het Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication
0.093 7.85E-8 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.090 1.78E-7 YJR006W POL31 het Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair
0.082 1.82E-6 YKL046C DCW1 hom Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
0.078 5.97E-6 YLL056C_p YLL056C_p hom Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
0.076 9.68E-6 YNR003C RPC34 het RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
0.075 1.31E-5 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.072 2.66E-5 YNR001C CIT1 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
0.072 2.85E-5 YOL129W VPS68 hom Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria
0.071 4.36E-5 YMR173W-A_d YMR173W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W
0.070 4.82E-5 YPR052C NHP6A hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress