YJL065C / DLS1

Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL065C / DLS1

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:4.19|P-value:9.01E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:4.90|P-value:5.83E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:3.81|P-value:3.31E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:4.20|P-value:8.58E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.61|P-value:6.22E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:4.03|P-value:1.59E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.76|P-value:1.02E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.45|P-value:3.41E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:5.11|P-value:2.42E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.54|P-value:7.02E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:5.70|P-value:1.66E-7 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.93|P-value:2.24E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.56|P-value:7.40E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.47|P-value:9.66E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.69|P-value:4.37E-4 ID:SGTC_1711|Compound:st032263|FD-Score:4.01|P-value:1.68E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.77|P-value:3.78E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.23|P-value:7.88E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.86|P-value:2.79E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.75|P-value:3.96E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.27|P-value:6.65E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-3.64|P-value:5.13E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.63|P-value:5.90E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.55|P-value:7.68E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.93|P-value:5.10E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:4.19|P-value:9.01E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:4.90|P-value:5.83E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:3.81|P-value:3.31E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:4.20|P-value:8.58E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.61|P-value:6.22E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:4.03|P-value:1.59E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.76|P-value:1.02E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.45|P-value:3.41E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:5.11|P-value:2.42E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.54|P-value:7.02E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:5.70|P-value:1.66E-7 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.93|P-value:2.24E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.56|P-value:7.40E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.47|P-value:9.66E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.69|P-value:4.37E-4 ID:SGTC_1711|Compound:st032263|FD-Score:4.01|P-value:1.68E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.77|P-value:3.78E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.23|P-value:7.88E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.86|P-value:2.79E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.75|P-value:3.96E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.27|P-value:6.65E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-3.64|P-value:5.13E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.63|P-value:5.90E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.55|P-value:7.68E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.93|P-value:5.10E-6

Top fitness defect scores for YJL065C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_960 1222-0186 5.70 7.7 µM 1.66E-7 10 5.90E-9
2 SGTC_899 1083-0020 5.11 478.0 µM 2.42E-6 6 1.62E-7
3 SGTC_3211 9128781 4.93 49.5 µM 5.10E-6 39 4.07E-7
4 SGTC_66 0109-0187 4.90 42.4 µM 5.83E-6 23 4.80E-7
5 SGTC_431 k089-0097 4.76 107.0 µM 1.02E-5 iron homeostasis 18 9.62E-7
6 SGTC_453 enantio-paf c16 4.45 10.0 µM 3.41E-5 109 4.23E-6
7 SGTC_2701 st077767 4.27 14.7 µM 6.65E-5 35 9.65E-6
8 SGTC_2394 5221648 4.23 200.0 µM 7.88E-5 17 1.19E-5
9 SGTC_144 4161-2749 4.20 112.4 µM 8.58E-5 DNA intercalators 22 1.32E-5
10 SGTC_62 0180-0423 4.19 3.2 µM 9.01E-5 60S ribosome export 13 1.40E-5
11 SGTC_175 3793-3120 4.03 23.7 µM 1.59E-4 13 2.81E-5
12 SGTC_1711 st032263 4.01 62.8 µM 1.68E-4 16 3.01E-5
13 SGTC_1213 1315-0166 3.93 115.0 µM 2.24E-4 30 4.32E-5
14 SGTC_2603 homopterocarpin 3.86 100.0 µM 2.79E-4 43 5.64E-5
15 SGTC_131 0141-0277 3.81 33.9 µM 3.31E-4 42 6.96E-5
16 SGTC_1943 st076331 3.77 65.2 µM 3.78E-4 17 8.19E-5
17 SGTC_2679 rapamycin 3.75 1.0 nM 3.96E-4 158 8.67E-5
18 SGTC_2791 5663188 3.63 71.4 µM 5.90E-4 RPP1 & pyrimidine depletion 32 1.42E-4
19 SGTC_145 3737-0113 3.61 38.4 µM 6.22E-4 DNA intercalators 92 1.51E-4
20 SGTC_1249 0481-0015 3.56 10.2 µM 7.40E-4 35 1.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.03E-19 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.148 8.08E-18 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.145 2.77E-17 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.142 1.15E-16 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.128 1.25E-13 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.116 1.99E-11 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.115 3.01E-11 YBL029W_p YBL029W_p hom Non-essential protein of unknown function
0.114 4.17E-11 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.114 4.22E-11 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.114 4.46E-11 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.112 7.18E-11 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.110 1.64E-10 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.110 2.12E-10 YBL008W-A_p YBL008W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.109 2.31E-10 YDR436W PPZ2 hom Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.108 3.14E-10 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data