YJL077C / ICS3

Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL077C / ICS3

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.28|P-value:5.25E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:5.93|P-value:1.80E-9 ID:SGTC_147|Compound:4466-0538|FD-Score:3.92|P-value:4.96E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.54|P-value:2.03E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.17|P-value:1.72E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.49|P-value:2.66E-4 ID:SGTC_228|Compound:caffeine|FD-Score:4.97|P-value:3.96E-7 ID:SGTC_229|Compound:benomyl|FD-Score:5.08|P-value:2.18E-7 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:7.48|P-value:4.99E-14 ID:SGTC_244|Compound:nsc-207895|FD-Score:-4.80|P-value:8.13E-7 ID:SGTC_253|Compound:dyclonine|FD-Score:-3.16|P-value:7.86E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.10|P-value:9.54E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.84|P-value:6.73E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.45|P-value:3.11E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.43|P-value:3.23E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.84|P-value:6.14E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:-4.23|P-value:1.17E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-4.21|P-value:1.32E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:3.30|P-value:5.24E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.28|P-value:1.05E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.97|P-value:4.01E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.23|P-value:6.13E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.71|P-value:1.13E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-4.75|P-value:1.06E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.62|P-value:1.50E-4 ID:SGTC_1523|Compound:st012844|FD-Score:5.19|P-value:1.25E-7 ID:SGTC_1567|Compound:st069303|FD-Score:3.46|P-value:2.93E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.19|P-value:7.67E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.63|P-value:1.54E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.20|P-value:1.49E-5 ID:SGTC_1994|Compound:st072947|FD-Score:3.40|P-value:3.65E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.10|P-value:9.53E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.17|P-value:7.68E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.35|P-value:7.63E-6 ID:SGTC_2429|Compound:5902844|FD-Score:-4.53|P-value:3.02E-6 ID:SGTC_2430|Compound:5571206|FD-Score:3.54|P-value:2.18E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.67|P-value:1.68E-6 ID:SGTC_2620|Compound:irigenin|FD-Score:5.06|P-value:2.46E-7 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.48|P-value:4.17E-6 ID:SGTC_2704|Compound:st078022|FD-Score:3.78|P-value:8.73E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.97|P-value:4.06E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.35|P-value:4.32E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.35|P-value:4.42E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-4.08|P-value:2.25E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.44|P-value:2.91E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.86|P-value:5.68E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.14|P-value:8.38E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-4.62|P-value:1.94E-6 ID:SGTC_2958|Compound:9077254|FD-Score:3.67|P-value:1.32E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.44|P-value:2.88E-4 ID:SGTC_3208|Compound:9114115|FD-Score:9.56|P-value:9.03E-22 ID:SGTC_3222|Compound:9128301|FD-Score:3.61|P-value:1.70E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.23|P-value:6.63E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.26|P-value:1.16E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.28|P-value:5.25E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:5.93|P-value:1.80E-9 ID:SGTC_147|Compound:4466-0538|FD-Score:3.92|P-value:4.96E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.54|P-value:2.03E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.17|P-value:1.72E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.49|P-value:2.66E-4 ID:SGTC_228|Compound:caffeine|FD-Score:4.97|P-value:3.96E-7 ID:SGTC_229|Compound:benomyl|FD-Score:5.08|P-value:2.18E-7 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:7.48|P-value:4.99E-14 ID:SGTC_244|Compound:nsc-207895|FD-Score:-4.80|P-value:8.13E-7 ID:SGTC_253|Compound:dyclonine|FD-Score:-3.16|P-value:7.86E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.10|P-value:9.54E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.84|P-value:6.73E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.45|P-value:3.11E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.43|P-value:3.23E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.84|P-value:6.14E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:-4.23|P-value:1.17E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-4.21|P-value:1.32E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:3.30|P-value:5.24E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.28|P-value:1.05E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.97|P-value:4.01E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.23|P-value:6.13E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.71|P-value:1.13E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-4.75|P-value:1.06E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.62|P-value:1.50E-4 ID:SGTC_1523|Compound:st012844|FD-Score:5.19|P-value:1.25E-7 ID:SGTC_1567|Compound:st069303|FD-Score:3.46|P-value:2.93E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.19|P-value:7.67E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.63|P-value:1.54E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.20|P-value:1.49E-5 ID:SGTC_1994|Compound:st072947|FD-Score:3.40|P-value:3.65E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.10|P-value:9.53E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.17|P-value:7.68E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.35|P-value:7.63E-6 ID:SGTC_2429|Compound:5902844|FD-Score:-4.53|P-value:3.02E-6 ID:SGTC_2430|Compound:5571206|FD-Score:3.54|P-value:2.18E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.67|P-value:1.68E-6 ID:SGTC_2620|Compound:irigenin|FD-Score:5.06|P-value:2.46E-7 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.48|P-value:4.17E-6 ID:SGTC_2704|Compound:st078022|FD-Score:3.78|P-value:8.73E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.97|P-value:4.06E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.35|P-value:4.32E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.35|P-value:4.42E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-4.08|P-value:2.25E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.44|P-value:2.91E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.86|P-value:5.68E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.14|P-value:8.38E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-4.62|P-value:1.94E-6 ID:SGTC_2958|Compound:9077254|FD-Score:3.67|P-value:1.32E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.44|P-value:2.88E-4 ID:SGTC_3208|Compound:9114115|FD-Score:9.56|P-value:9.03E-22 ID:SGTC_3222|Compound:9128301|FD-Score:3.61|P-value:1.70E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.23|P-value:6.63E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.26|P-value:1.16E-5

Top fitness defect scores for YJL077C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3208 9114115 9.56 49.5 µM 9.03E-22 2 5.88E-22
2 SGTC_238 5hr heat shock (37°C) + nsc-638432 7.48 8.9 µM 4.99E-14 heat shock/prefoldin 12 3.76E-14
3 SGTC_73 0327-0325 5.93 16.2 µM 1.80E-9 DNA damage response 15 1.48E-9
4 SGTC_1523 st012844 5.19 44.7 µM 1.25E-7 60S ribosome export 4 1.07E-7
5 SGTC_229 benomyl 5.08 22.9 µM 2.18E-7 tubulin folding & SWR complex 20 1.87E-7
6 SGTC_2620 irigenin 5.06 100.0 µM 2.46E-7 12 2.12E-7
7 SGTC_228 caffeine 4.97 993.1 µM 3.96E-7 5 3.43E-7
8 SGTC_2435 5706476 4.67 10.6 µM 1.68E-6 16 1.47E-6
9 SGTC_2626 ethyl orsellinate 4.48 100.0 µM 4.17E-6 23 3.68E-6
10 SGTC_2422 chlorphenesin carbamate 4.35 384.2 µM 7.63E-6 19 6.77E-6
11 SGTC_1160 4092-0570 4.28 10.5 µM 1.05E-5 plasma membrane duress 31 9.36E-6
12 SGTC_3319 9138450 4.26 16.8 µM 1.16E-5 17 1.03E-5
13 SGTC_1734 st037168 4.20 69.4 µM 1.49E-5 16 1.33E-5
14 SGTC_217 ketoconazole 4.17 989.0 nM 1.72E-5 ergosterol depletion effects on membrane 17 1.54E-5
15 SGTC_1206 3978-0017 3.97 132.0 µM 4.01E-5 ERG2 34 3.61E-5
16 SGTC_2713 st079149 3.97 53.4 µM 4.06E-5 18 3.66E-5
17 SGTC_147 4466-0538 3.92 29.2 µM 4.96E-5 ergosterol biosynthesis 21 4.48E-5
18 SGTC_314 1671-0008 3.84 2.7 µM 6.73E-5 59 6.10E-5
19 SGTC_2704 st078022 3.78 71.1 µM 8.73E-5 17 7.93E-5
20 SGTC_1232 0279-0259 3.71 161.0 µM 1.13E-4 26 1.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 9.82E-14 YPR201W ARR3 hom Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
0.110 1.55E-10 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.108 3.35E-10 YOR161C PNS1 hom Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport
0.100 5.68E-9 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.096 2.15E-8 YER178W PDA1 hom E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
0.094 5.62E-8 YBR227C MCX1 hom Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins
0.091 1.28E-7 YKR065C PAM17 hom Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
0.088 3.50E-7 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.088 3.72E-7 YOR052C YOR052C hom Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress
0.087 3.92E-7 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.087 5.01E-7 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.084 9.67E-7 YIL131C FKH1 hom Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication
0.082 1.93E-6 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.080 3.12E-6 YNL327W EGT2 hom Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
0.080 3.68E-6 YKL186C MTR2 het mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA