YJL078C / PRY3

Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL078C / PRY3

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:-2.95|P-value:7.51E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:2.82|P-value:8.16E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-2.89|P-value:9.59E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.74|P-value:7.13E-8 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.37|P-value:8.81E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.16|P-value:3.30E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.33|P-value:1.02E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.35|P-value:9.43E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:-2.92|P-value:8.39E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.17|P-value:2.03E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.04|P-value:3.48E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.92|P-value:6.50E-6 ID:SGTC_899|Compound:1083-0020|FD-Score:5.24|P-value:3.13E-9 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.05|P-value:5.22E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.43|P-value:1.07E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.22|P-value:1.66E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.63|P-value:2.63E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:-3.35|P-value:1.53E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.38|P-value:1.35E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.03|P-value:1.26E-8 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.63|P-value:4.50E-5 ID:SGTC_1638|Compound:st008370|FD-Score:2.85|P-value:7.24E-4 ID:SGTC_1783|Compound:st039459|FD-Score:2.80|P-value:8.69E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.47|P-value:3.50E-7 ID:SGTC_1941|Compound:st076221|FD-Score:7.11|P-value:1.99E-15 ID:SGTC_1944|Compound:st076371|FD-Score:-4.33|P-value:1.40E-6 ID:SGTC_1953|Compound:st076800|FD-Score:-3.70|P-value:3.18E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.48|P-value:5.19E-5 ID:SGTC_2248|Compound:tofa|FD-Score:2.80|P-value:8.65E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.51|P-value:2.78E-7 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.13|P-value:2.35E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.15|P-value:2.20E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.38|P-value:1.08E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:-2.96|P-value:7.21E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.73|P-value:1.67E-5 ID:SGTC_2781|Compound:5567276|FD-Score:4.74|P-value:7.20E-8 ID:SGTC_2783|Compound:7738165|FD-Score:-3.54|P-value:6.73E-5 ID:SGTC_2788|Compound:5282734|FD-Score:6.72|P-value:5.66E-14 ID:SGTC_2809|Compound:7964133|FD-Score:-5.23|P-value:7.21E-9 ID:SGTC_2939|Compound:9044578|FD-Score:3.13|P-value:2.37E-4 ID:SGTC_3086|Compound:9117350|FD-Score:2.83|P-value:7.71E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.19|P-value:2.93E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.47|P-value:8.96E-5 ID:SGTC_3301|Compound:9125354|FD-Score:3.43|P-value:6.47E-5 ID:SGTC_5|Compound:0352-0601|FD-Score:-2.95|P-value:7.51E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:2.82|P-value:8.16E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-2.89|P-value:9.59E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.74|P-value:7.13E-8 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.37|P-value:8.81E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.16|P-value:3.30E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.33|P-value:1.02E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.35|P-value:9.43E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:-2.92|P-value:8.39E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.17|P-value:2.03E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.04|P-value:3.48E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.92|P-value:6.50E-6 ID:SGTC_899|Compound:1083-0020|FD-Score:5.24|P-value:3.13E-9 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.05|P-value:5.22E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.43|P-value:1.07E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.22|P-value:1.66E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.63|P-value:2.63E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:-3.35|P-value:1.53E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.38|P-value:1.35E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.03|P-value:1.26E-8 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.63|P-value:4.50E-5 ID:SGTC_1638|Compound:st008370|FD-Score:2.85|P-value:7.24E-4 ID:SGTC_1783|Compound:st039459|FD-Score:2.80|P-value:8.69E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.47|P-value:3.50E-7 ID:SGTC_1941|Compound:st076221|FD-Score:7.11|P-value:1.99E-15 ID:SGTC_1944|Compound:st076371|FD-Score:-4.33|P-value:1.40E-6 ID:SGTC_1953|Compound:st076800|FD-Score:-3.70|P-value:3.18E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.48|P-value:5.19E-5 ID:SGTC_2248|Compound:tofa|FD-Score:2.80|P-value:8.65E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.51|P-value:2.78E-7 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.13|P-value:2.35E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.15|P-value:2.20E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.38|P-value:1.08E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:-2.96|P-value:7.21E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.73|P-value:1.67E-5 ID:SGTC_2781|Compound:5567276|FD-Score:4.74|P-value:7.20E-8 ID:SGTC_2783|Compound:7738165|FD-Score:-3.54|P-value:6.73E-5 ID:SGTC_2788|Compound:5282734|FD-Score:6.72|P-value:5.66E-14 ID:SGTC_2809|Compound:7964133|FD-Score:-5.23|P-value:7.21E-9 ID:SGTC_2939|Compound:9044578|FD-Score:3.13|P-value:2.37E-4 ID:SGTC_3086|Compound:9117350|FD-Score:2.83|P-value:7.71E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.19|P-value:2.93E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.47|P-value:8.96E-5 ID:SGTC_3301|Compound:9125354|FD-Score:3.43|P-value:6.47E-5

Top fitness defect scores for YJL078C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1941 st076221 7.11 61.8 µM 1.99E-15 sphingolipid biosynthesis & PDR1 25 5.85E-13
2 SGTC_2788 5282734 6.72 71.4 µM 5.66E-14 7 9.35E-12
3 SGTC_899 1083-0020 5.24 478.0 µM 3.13E-9 4 7.90E-8
4 SGTC_1456 k015-0012 5.03 13.0 µM 1.26E-8 13 2.50E-7
5 SGTC_263 alizarin 4.74 107.9 µM 7.13E-8 iron homeostasis 39 1.05E-6
6 SGTC_2781 5567276 4.74 71.4 µM 7.20E-8 26 1.06E-6
7 SGTC_2407 paclitaxel 4.51 400.0 µM 2.78E-7 22 3.25E-6
8 SGTC_1932 st074806 4.47 40.9 µM 3.50E-7 13 3.93E-6
9 SGTC_893 0958-0369 3.92 48.9 µM 6.50E-6 24 4.42E-5
10 SGTC_2753 fluvastatin 3.73 17.1 µM 1.67E-5 azole & statin 44 9.67E-5
11 SGTC_1157 4092-0394 3.63 27.6 µM 2.63E-5 37 1.41E-4
12 SGTC_2022 5136654 3.48 200.0 µM 5.19E-5 33 2.47E-4
13 SGTC_3301 9125354 3.43 19.8 µM 6.47E-5 27 2.96E-4
14 SGTC_273 hydroxyurea 3.37 18.1 mM 8.81E-5 heme biosynthesis & mitochondrial translocase 51 3.83E-4
15 SGTC_581 0958-0271 3.35 211.0 µM 9.43E-5 80 4.05E-4
16 SGTC_575 k072-0246 3.33 11.9 µM 1.02E-4 42 4.34E-4
17 SGTC_1140 3229-1848 3.22 3.0 µM 1.66E-4 23 6.48E-4
18 SGTC_891 0929-0073 3.17 133.0 µM 2.03E-4 54 7.66E-4
19 SGTC_2604 4'-hydroxychalcone 3.15 11.3 µM 2.20E-4 77 8.17E-4
20 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.13 92.6 µM 2.35E-4 60 8.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 9.13E-19 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.127 1.38E-13 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.124 6.49E-13 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.122 1.21E-12 YNR015W SMM1 hom Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs
0.121 1.63E-12 YAL025C MAK16 het Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
0.111 1.02E-10 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.105 1.01E-9 YPL137C GIP3 hom Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication
0.102 2.83E-9 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.100 7.10E-9 YDR073W SNF11 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions
0.099 1.04E-8 YMR194C-B CMC4 hom Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs
0.097 1.69E-8 YGL141W HUL5 hom Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
0.096 2.35E-8 YMR281W GPI12 het ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
0.095 3.57E-8 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.092 8.01E-8 YNL278W CAF120 hom Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication
0.091 1.23E-7 YKL031W_d YKL031W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species